• Proceedings of the Korea Information Processing Society Conference
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• 2018.10a
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• pp.218-221
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• 2018

최근 악성코드의 수가 급격하게 증가하고 있으며 단순히 악성 행위를 하는 것 뿐 아니라 안티디버깅과 같은 다양한 분석 방지 기능을 탑재하여 악성코드의 분석을 어렵게 한다. 역공학 방지 기법이 적용된 지능형 악성코드를 기존 분석 도구를 사용하여 분석하면 악성행위를 하지 않거나 임의로 자기 자신을 종료시키는 방식으로 분석이 용이하지 않다. 이러한 지능형 악성코드들은 분석하기 어려울 뿐만아니라 기존 백신의 탐지 기능에 전혀 제약을 받지 않는다. 본 논문은 이와 같은 최신 지능형 악성코드에 보다 빠르게 대처하기 위해 역공학 방지 기법이 적용된 악성코드들이 메모리상에서 종료되지 않고 정상 동작하여 악성행위를 자동으로 파악할 수 있는 동적 코드 계측 프레임워크를 제안한다. 또한, 제안한 프레임워크를 개념 검증하기 위해 프로토타입을 설계 및 구현하고, 실험을 통해 그 유효성을 확인한다.

• BMB Reports
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• v.54 no.1
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• pp.44-58
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• 2021

Natural killer (NK) cells, key antitumor effectors of the innate immune system, are endowed with the unique ability to spontaneously eliminate cells undergoing a neoplastic transformation. Given their broad reactivity against diverse types of cancer and close association with cancer prognosis, NK cells have gained considerable attention as a promising therapeutic target for cancer immunotherapy. NK cell-based therapies have demonstrated favorable clinical efficacies in several hematological malignancies but limited success in solid tumors, thus highlighting the need to develop new therapeutic strategies to restore and optimize anti-tumor activity while preventing tumor immune escape. The current therapeutic modalities yielding encouraging results in clinical trials include the blockade of immune checkpoint receptors to overcome the immune-evasion mechanism used by tumors and the incorporation of tumor-directed chimeric antigen receptors to enhance NK cell anti-tumor specificity and activity. These observations, together with recent advances in the understanding of NK cell activation within the tumor microenvironment, will facilitate the optimal design of NK cell-based therapy against a broad range of cancers and, more desirably, refractory cancers.

• Parasites, Hosts and Diseases
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• v.50 no.1
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• pp.45-51
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• 2012

Fascioliasis is one of the public health problems in the world. Cysteine proteinases (CP) released by $Fasciola$ $gigantica$ play a key role in parasite feeding, migration through host tissues, and in immune evasion. There has been some evidence from several parasite systems that proteinases might have potential as protective antigens against parasitic infections. Cysteine proteinases were purified and tested in vaccine trials of sheep infected with the liver fluke. Multiple doses (2 mg of CP in Freund's adjuvant followed by 3 booster doses 1 mg each at 4 week intervals) were injected intramuscularly into sheep 1 week prior to infect orally with 300 $F.$ $gigantica$ metacercariae. All the sheep were humanely slaughtered 12 weeks after the first immunization. Changes in the worm burden, ova count, and humoral and cellular responses were evaluated. Significant reduction was observed in the worm burden (56.9%), bile egg count (70.7%), and fecel egg count (75.2%). Immunization with CP was also found to be associated with increases of total IgG, $IgG_1$, and $IgG_2$ ($P$<0.05). Data showed that the serum cytokine levels of pro-inflammatory cytokines, IL-12, IFN-${\gamma}$, and TNF-${\alpha}$, revealed significant decreases ($P$<0.05). However, the anti-inflammatory cytokine levels, IL-10, TGF-${\beta}$, and IL-6, showed significant increases ($P$<0.05). In conclusion, it has been found that CP released by $F.$ $gigantica$ are highly important candidates for a vaccine antigen because of their role in the fluke biology and host-parasite relationships.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.29 no.1
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• pp.45-55
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• 2019

DEX file and share objects (also known as the SO file) are important components that define the behaviors of an Android application. DEX file is implemented in Java code, whereas SO file under ELF file format is implemented in native code(C/C++). The two layers - Java and native can communicate with each other at runtime. Malicious applications have become more and more prevalent in mobile world, they are equipped with different evasion techniques to avoid being detected by anti-malware product. To avoid static analysis, some applications may perform malicious behavior in native code that is difficult to analyze. Existing researches fail to extract the call relationship which includes both Java code and native code, or can not analyze multi-DEX application. In this study, we design and implement a system that effectively extracts the call relationship between Java code and native code by analyzing DEX file and SO file of Android application.

• Journal of Life Science
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• v.28 no.4
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• pp.488-495
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• 2018

The p53 gene plays a critical role in the transcriptional regulation of cellular response to stress, DNA damage, hypoxia, and tumor development. Keeping in mind the recently discovered manifold physiological functions of p53, its involvement in the regulation of cancer is not surprising. In about 50% of all human cancers, inactivation of p53's protein function occurs either through mutations in the gene itself or defects in the mechanisms that activate it. This disorder plays a crucial role in tumor evolution by allowing the evasion of a p53-dependent response. Many recent studies have focused on directly targeting p53 mutants by identifying selective, small molecular compounds to deplete them or to restore their tumor-suppressive function. These small molecules should effectively regulate various interactions while maintaining good drug-like properties. Among them, the discovery of the key p53-negative regulator, MDM2, has led to the design of new small molecule inhibitors that block the interaction between p53 and MDM2. Some of these small molecule compounds have now moved from proof-of-concept studies into clinical trials, with prospects for further, more personalized anti-carcinogenic medicines. Here, we review the structural and functional consequences of wild type and mutant p53 as well as the development of therapeutic agents that directly target this gene, and compounds that inhibit the interaction between it and MDM2.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.4031-4036
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• 2012

Background: The negative signaling provided by interactions of the co-inhibitory molecule, programmed death-1 (PD-1), and its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), is a critical mechanism contributing to tumor evasion; blockade of this pathway has been proven to enhance cytotoxic activity and mediate antitumor therapy. Here we evaluated the anti-tumor efficacy of AAV-mediated delivery of the extracellular domain of murine PD-1 (sPD-1) to a tumor site. Material and Methods: An rAAV vector was constructed in which the expression of sPD-1, a known negative regulator of TCR signals, is driven by human cytomegalovirus immediate early promoter (CMV-P), using a triple plasmid transfection system. Tumor-bearing mice were then treated with the AAV/sPD1 construct and expression of sPD-1 in tumor tissues was determined by semi quantitative RT-PCR, and tumor weights and cytotoxic activity of splenocytes were measured. Results: Analysis of tumor homogenates revealed sPD-1 mRNA to be significantly overexpressed in rAAV/sPD-1 treated mice as compared with control levels. Its use for local gene therapy at the inoculation site of H22 hepatoma cells could inhibit tumor growth, also enhancing lysis of tumor cells by lymphocytes stimulated specifically with an antigen. In addition, PD-1 was also found expressed on the surfaces of activated CD8+ T cells. Conclusion: This study confirmed that expression of the soluble extracellular domain of PD-1 molecule could reduce tumor microenvironment inhibitory effects on T cells and enhance cytotoxicity. This suggests that it might be a potential target for development of therapies to augment T-cell responses in patients with malignancies.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.21 no.4
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• pp.61-75
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• 2011

Recently, there is significant increasing of massive attacks, which try to infect PCs that visit websites containing pre-implanted malicious code. When visiting the websites, these hidden malicious codes can gain monetary profit or can send various cyber attacks such as BOTNET for DDoS attacks, personal information theft and, etc. Also, this kind of malicious activities is continuously increasing, and their evasion techniques become professional and intellectual. So far, the current signature-based detection to detect websites, which contain malicious codes has a limitation to prevent internet users from being exposed to malicious codes. Since, it is impossible to detect with only blacklist when an attacker changes the string in the malicious codes proactively. In this paper, we propose a novel approach that can detect unknown malicious code, which is not well detected by a signature-based detection. Our method can detect new malicious codes even though the codes' signatures are not in the pattern database of Anti-Virus program. Moreover, our method can overcome various obfuscation techniques such as the frequent change of the included redirection URL in the malicious codes. Finally, we confirm that our proposed system shows better detection performance rather than MC-Finder, which adopts pattern matching, Google's crawling based malware site detection, and McAfee.