• Journal of Hospice and Palliative Care
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• 제17권1호
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• pp.18-26
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• 2014

목적: 식욕부진은 호스피스 암환자의 흔한 증상이며 여러 문헌에서 먹는 행동(feeding behavior)을 조절하는데 있어 visfatin의 가능성을 제시하고 있다. 본 연구에서는 말기암환자에서 증가한 visfatin 농도가 식욕조절과 영양상태 항상성 조절에 관여할 것이라 가설을 세웠다. 방법: 2009년 7월부터 2010년 7월까지 13개월 동안, 만 20세 이상의 말기암환자 69명을 대상으로 혈장 visfatin 농도를 측정하였다. 나이, 성별, 체질량 지수, 활력 징후, 원발암 부위, 암 치료 경력, 투약상황, ECOG(Eastern Cooperative Oncology Group) 수행지수, 혈색소, 백혈구 수, C-반응성 단백질, 총 콜레스테롤, 알부민, 림프구수, 혈당, 혈액요소질소, 크레아티닌, TNF-${\alpha}$ (tumor necrosis factor-alpha), Interukin-6, 렙틴 등의 혈액검사를 시행하였다. 결과: 대상자의 평균 나이는 65.5세였고 단변량 분석상 맥박, ECOG 수행 지수, opioid 사용여부, visfatin 농도에 따라 식욕부진이 있는 군과 없는 군의 차이를 보였다. Visfatin 농도는 단변량 분석결과 식욕부진과 관련이 있는 것으로 나타났으나(P=0.0323) 식욕부진에 영향을 주는 인자들을 보정한 다중 로지스틱 회귀 분석 결과에서는 통계학적인 관련성이 사라졌다. 영양지표들 중 체질량 지수, 렙틴, 총 콜레스테롤과는 관련이 없었으나 림프구수(P=0.0198) 혈중 albumin 농도(P=0.0013)와 중간 정도의 음의 관련성을 나타냈다. 결론: 호스피스 암환자에서 visfatin과 식욕부진의 관련성은 통계적으로 유의하지 않았다. 향후 기전에 대한 연구와 전향적 연구가 필요할 것으로 생각된다.

• 생명과학회지
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• 제32권3호
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• pp.263-269
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• 2022

암 악액질은 암으로 인한 다기관 대사성 질환으로 식욕부진과 체중 감소가 주요 증상이다. 일반적으로 암 환자의 식욕부진과 체중감소는 항암화학요법 치료와 암 환자의 생존율에 악영향을 미치는 심각한 문제이다. 암 악액질은 일반적으로 췌장암, 폐암, 결장암 등 소화기관 암 환자의 약 80%에서 동반되는 것으로 알려져 있으며, 림프종이나 유방암 환자에서는 비교적 드물다. 암 악액질에 의한 식욕부진은 화학요법에 의해서도 일어나지만, 화학요법과는 독립적으로 발생하는 것으로 알려져 있다. 암 악액질의 발병기전으로는 종양 조직에 의해 과도하게 증가되는 염증성 사이토카인에 의한 정상 조직 기능의 저하가 주요 원인이다. 암 악액질의 메커니즘은 아직 완전히 이해되지 않았기 때문에 현재 악액질을 치료할 치료제나 진단 바이오마커가 없는 실정이다. 최근 발표된 연구에서는 암세포에서 분비되는 물질이 악액질에 의한 식욕억제를 일으키는 것이 확인되었고 그 분자생물학적 기전이 밝혀졌다. 이 물질의 발현 및 분비 증가는 암 환자의 악액질 증상과 통계적으로 상관관계가 있는 것으로 밝혀져 암악액질 진단 및 치료제 개발에 활용될 것으로 기대된다. 이 논문에서는 암 악액질의 주요증상인 섭식장애와 체중감소의 이해를 돕고자 알려진 원인과 분자 기전들의 내용을 소개하겠다.

• 대한한방내과학회지
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• 제43권4호
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• pp.542-558
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• 2022

Objectives: The purpose of this study was to assess the effect of Yigong-san on anorexia in children by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: Eleven electronic databases were searched on May 30, 2022 to collect relevant studies. All studies published up to the search date were considered. RCTs reporting the effect of Yigong-san on the treatment of anorexia in children were included. The primary outcome was an improvement in clinical anorexia symptoms after treatment. In this meta-analysis, continuous and binary outcomes were assessed, and the data were presented as the mean difference and risk ratio with their 95% confidence intervals. The risk of bias was assessed using the Cochrane Collaboration's risk of bias tool. Results: A total of nine studies were included in this systematic review. The treatment group (Yigong-san only or Yigong-san plus conventional treatment) showed a statistically significant effect compared to the control group (conventional treatment only) in total effective rate (Yigong-san only: RR 1.26, 95% CI 1.17, 1.36, I²=0%; Yigong-san plus conventional treatment: RR 1.32, 95% CI 1.18, 1.47, I²=0%), clinical symptoms, some of the anthropometric outcomes, and biological markers related to appetite and growth in children with anorexia. No serious adverse events related to Yigong-san were reported. Conclusions: Yigong-san showed statistically significant effects as a treatment for anorexia in children. However, the number of studies included in the meta-analysis was insufficient, and the herbs contained in the Yigong-san used in the included studies were not standardized. Future research should focus on the implementation of methodologically robust clinical research.

• 대한간호학회지
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• 제43권3호
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• pp.361-369
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• 2013

Purpose: The purpose of this study was to examine the effect of anorexia and neuropathic pain induced by cisplatin on hindlimb muscles of rats. Methods: Adult male Sprague-Dawley rats were divided into two groups, a cisplatin-treated group (n=10) and a control group (n=10). In the cisplatin-treated group, cisplatin at a dose of 2 mg/kg was injected intraperitoneally two times a week up to a cumulative dose of 20 mg/kg over 5 weeks, and in the control group saline (0.9% NaCl) was injected intraperitoneally at the same dose and duration as the cisplatin-treated group. At 34 days all rats were anesthetized, after which the soleus and plantaris muscles were dissected. Withdrawal threshold, body weight, food intake, activity, muscle weight, Type I and II fiber cross-sectional areas and myofibrillar protein content of the dissected muscles were determined. Results: Compared with the control group, the cisplatin-treated group showed significant decreases (p<.05) in withdrawal threshold, activity, food intake, body weight, Type I and II fiber cross-sectional areas, myofibrillar protein content and weight of the soleus and plantaris muscles. Conclusion: Muscular atrophy in hindlimb occurs due to anorexia and neuropathic pain induced by the cisplatin treatment.

• 대한간호학회지
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• 제39권3호
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• pp.433-445
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• 2009

Purpose: The purpose of this study was to assess changes in pain, fatigue, anorexia, anxiety and quality of life(QOL) in patients with cancer who were on chemotherapy. Methods: Symptoms and QOL were examined both before chemotherapy and after 2 cycles of chemotherapy. The participants were 76 cancer patients receiving chemotherapy in one of 7 hospitals. Results: The patients experienced a mean of 2.22-2.23 symptoms out of 4 symptoms. Patients who were female, or suffered from breast or colorectal cancer experienced more symptoms. Fatigue at present, and most severe fatigue and anorexia in the previous 3 weeks increased significantly. Anxiety and QOL decreased significantly after 2 cycles of chemotherapy. Number of symptoms, anorexia at present, most severe anorexia in past 3 weeks, and anxiety had negative correlations. QOL before chemotherapy showed a positive correlation with QOL after 2 cycles of chemotherapy. In a regression analysis, anxiety, QOL at baseline, income, and the most severe pain in the past 3 weeks were significant predictors of QOL. Conclusion: Physical and psychological factors were significant predictors of both QOL and each subscale, and these factors correlated with each other. These results demonstrate the needs for early assessment and intervention from the start of chemotherapy to decrease symptoms and improve QOL.

• 대한한방소아과학회지
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• 제25권2호
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• pp.1-7
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• 2011

Objectives: This study is to report a treatment case of the Krabbe Disease with herbal medicine and acupuncture. The purpose of this study is to report clinical effects of an oriental medical treatment on the Krabbe Disease patient who also has stool problem, sleep disorder, and anorexia. Methods: Herbal medicine and acupuncture are performed on the patient with the general symptoms such as constipation, sleep disorder, anorexia, and coldness of feet. Results: Only treated by oriental medicine, the patient's constipation, sleep disorder, anorexia, and coldness of feet vanish, and the patient maintains her condition for a month. Conclusions: This study shows that oriental medical treatments are effective in treating the general symptoms that a Krabbe Disease patients has. To be more accurate, further studies are necessary.

• 대한한방소아과학회지
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• 제24권3호
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• pp.138-149
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• 2010

Objectives: The purpose of this study is to estimate genetic and environmental factors which can effect growth, and predict final height using this factors. Methods: Correlation analysis and regression analysis were conducted between measurements of height and Genetic & environmental factors through survey from 1352 child & adolescent patients. Results: Factors which have correlation with height percentile are MPH(Mid-Parental Height), NBW(Neonatal body weight), anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time. MPH has moderate relation, NBW and anorexia have fair relation, and other factors have linear but poor relation. Regression equation from factors which have correlation and height percentile has 26.9% of predictive power. Regression equation considering only genetic factor has 20.4%. MPH has the most effect on height percentile. Anorexia has more effect than NBW. Other factors also have small and similar effect. Conclusions: Height of parents has the most effect on growth, anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time also has effect.

• 대한상한금궤의학회지
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• 제13권1호
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• pp.145-153
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• 2021

Objective : This study aimed to report the improvement of a patient with anorexia by treatment with Jinmu-tang (Hyunmu-tang) based on the disease pattern identification diagnostic system (DPIDS) of the Shanghanlun provisions. Methods : We evaluated the progress of symptoms, patient compliance, and presence of side effects after the patient was administered Jinmu-tang. The clinical response was estimated according to the number of meals a day, the size of meals, the number of complaints of abdominal pain in a week, and a Likert scale. Results : According to the DPIDS, the patient was diagnosed according to provision 316 with soyinbing. After administration of Jinmu-tang for 45 days, the number of meals a day and the size of meals increased, the number of complaints of abdominal pain in a week decreased, and the Likert scale score decreased from 3 to 0. Conclusions : This case report suggests that the word "腹痛" (abdominal pain) in the 316th Shanghanlun provision indicates anxiety about abdominal pain, which affected anorexia in this case.

• 사상체질의학회지
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• 제35권1호
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• pp.46-55
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• 2023

Objectives The purpose of this case study was to report a case of anorexia and fatigue after getting vaccinated COVID-19 treated based on Sasang Constitutional Medicine. Methods The patient was hospitalized for 4 days and treated with herbal medicine and moxibustion. The patient was asked to score for daily energy level out of 100 on his own and we used Karnofsky Performance Score(Karnofsky PS) on daily health status to evaluate the clinical effects. We also checked daily amount of meal and evaluated original symptoms such as insomnia, gastric discomfort, bowel movement and dysuria in four stages. Results At initial, the patient could only eat one spoon of a meal and was unable to carry on herself without any assistance, so she used a wheelchair on the day of admission. When discharged, the patient can eat half of a meal at each mealtime and perform normal activities by herself. Discussion This case demonstrates that Sasang constitutional approach to anorexia and fatigue caused by COVID-19 vaccination can be an useful treatment.

• 턱관절균형의학회지
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• 제13권1호
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• pp.1-12
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• 2023

Objectives: This study was performed to review the research trends in the treatment of anorexia nervosa (AN) in Traditional Chinese Medicine (TCM). Methods: Studies were searched through The China National Knowledge Infrastructure (CNKI) database. The search term for the subject were 'Eating Disorder', and 'Anorexia Nervosa'. Clinical research that conducted TCM treatment for AN patients were included. Studies were analyze according to study design, therapy method, diagnostic criteria, population and intervention. Results: 23 articles were selected. According to study design, studies were classified into two randomized controlled trial (RCT), three single group before-and-after studies, and 18 case reports. According to therapy method, they included 19 herbal medicine studies, two acupuncture treatment studies, and two complex treatment studies. The most common pattern identification was 'liver depression with spleen deficiency' (肝鬱脾虛), and the most used herb was 'Root of Bupleurum falcatum' (柴胡). Most of the studies showed effective results in increasing appetite and weight. Conclusions: The results of our study demonstrate that TCM treatments for AN has been effective in alleviating chief symptoms. However, in terms of evidence-based medicine, lack of RCT on TCM treatments for AN and absence of objective diagnostic criteria in case reports are limitations. Therefore well-designed further clinical studies should be performed based on the results of this study are recommended.