• 한국응용과학기술학회지
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• 제38권3호
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• pp.771-785
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• 2021

이 연구는 강직성 척추염 환자를 대상으로 12주간의 가정기반운동(home-based exercise) 프로그램을 수행하여 환자 특성별 염증관련 혈액지표, 관절가동범위, 통증척도 및 심리적인 지표 세부적이고 종합적으로 제공하고자 수행되었다. 연구의 목적을 위해 강직성 척추염을 진단받은 환자 10명을 선정하여 연령별(30대 vs. 40대 vs. 50대), 성별(남성 vs. 여성) 및 유병기간(5년 미만 vs. 5년 이상)으로 구분하였다. 가정기반 운동 프로그램은 유산소운동과 필라테스 기반 저항성 운동의 복합운동 형태로 최대심박수(maximal heart rate, MHR)의 50-70% 강도에서 주 4회, 12주 동안 수행되었다. 연구결과, 12주간의 가정기반운동 중재 후 강직성 척추염 환자의 혈중 CRP (C-reactive protein) 농도가 감소됨으로써 (-35.6%, p=.017) 혈중 염증 수치가 개선되었으며, 각 관절(고관절, 허리, 경추)의 가동성이 향상되었다(p<.05). 또한 질병활성도(Bath ankylosing spondylitis disease activity index, BASDAI)는 -67%(p=.005), 시각통증지표(Visual analogue scale, VAS)는 -64.8%(p=.005) 감소됨으로써 강직 및 통증이 전반적으로 완화되었다. 특히, 우울 정도가 -65.5%(p=.005), 불안 정도는 -55.2%(p=.008) 감소됨으로써 12주간의 가정기반운동은 신체적 변화 뿐 아니라 심리적인 요인도 개선 시켜주는 것으로 나타났다. 반면, 강직성 척추염 환자의 연령, 성별, 유병기간에 따른 운동 효과 차이는 나타나지 않았다(p>.05). 따라서 이 연구에서 적용된 12주간의 가정기반운동이 환자 특성과 상관없이 강직성 척추염 환자에게 보편적으로 사용될 수 있는 효과적인 운동프로그램이 될 수 있을 것으로 사료된다.

• 한국산학기술학회논문지
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• 제17권8호
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• pp.615-623
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• 2016

본 연구는 강직척추염 환자의 일반적 특성에 따른 건강관련 삶의 질의 차이를 알아보기 위한 서술조사연구이다. 연구대상은 2015년 1월 13일부터 2월 12일까지 G광역시 C대학병원에 강직척추염으로 진단받고 최소 4주이상의 안정적인 약물을 유지중인 만 19세 이상의 환자를 대상으로 설문조사를 통해 자료를 수집하였으며 총 275명의 자료가 분석에 포함되었다. 수집된 자료는 기술적 통계, t-test, ANOVA, Scheff-test, multiple regression를 통해 분석하였다. 연구 결과 연령(p=.008), 직업유무(p<0.001), 동반질환 수(p<0.001), 수술유무(p=0.002), 증상 발현 후 기간(p=0.010), 진단 후 기간(p=0.027), 음주(p=0.002), 적혈구 침강속도(p=0.049)는 강직척추염 환자의 건강관련 삶의 질에 유의하게 영향을 미치는 것으로 분석되었으며, 다중회귀분석 결과 교육수준, 수입, 동반질환 수, 음주가 유의미한 변수였다. 결론적으로 강직척추염 환자의 건강관련 삶을 향상시키기 위해 일반적 특성을 개선시킬 수 있는 중재 프로그램을 개발함과 동시에 인구사회학적 특징과, 임상학적 특성을 고려한 중재프로그램이 제공되어야 할 필요가 있음을 알 수 있다. 따라서 본 연구의 결과가 이러한 통합적인 중재프로그램 개발에 실제적인 근거로 활용 될 수 있을 것으로 생각된다.

• 대한의용생체공학회:의공학회지
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• 제14권3호
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• pp.235-242
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• 1993

In the early stage of sacroilitis, it is'difficult to detect sacroiliac(Sl) abnormalities by conventional plain X-ray even though there are characteristic symptoms of ankylosing spondylitis. 3 dimensional volume rendering from the CT image was performed to make an early de tection of the structural changes of Sl joint. 2 cases who had clinical impression of ankylosing spondylitis without sacroilitis in plane X-ray and 1 case of typical ankylosing spondylitis as well as 1 case of normal control were studied. The Sl Joints were separated and each joint surface of sacrum and ilium was independently reconstructed by a special 3D manipulation program. All 2 patiant who complained of inflammatory lower back pain with no abnormal findings in the plain X-ray showed structural changes in 3 dimensionally reconstructed surface Image of the Sl joint compared to the normal control. Authors tried several parameters, such as fourler analysis of each surface and the mean and variance of Sl joint gap. We couldn't tell the statistical significance because of the limited number of cases. However, the parameters showed difference according to the progression of disease.

• Imaging Science in Dentistry
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• 제30권3호
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• pp.217-222
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• 2000

A 31-year-old male with the complaint of severe limitation of mouth opening was referred to our department of Chonbuk National University Hospital. The physical status of the patient was hyposthenic. Extraoral examination showed no condylar movement of the both temporomandibular joints, no pain, no facial swelling or paresthesia. Intraoral examination showed several cervical caries on the upper anterior teeth, and gingival swelling on the whole dentition. Transcranial view showed no condylar movement, and narrowing of joint spaces. Chest P-A view showed straightening of thoracic, lumbar spine, and squaring of vertebrae of the same spines. Conventional lateral radiograph of cervical spine showed calcification of the intervertebral ligament. Computed tomograph showed extensive bone formation between temporal bone and the condylar head at both sides. Laboratory findings showed positive reaction on HLA-B27 histocompatibility antigen and increased level of IgA, IgG, ESR. Based on the clinical, radiographic, and the laboratary findings, final diagnosis was made as bony ankylosis of the both temporomandibular joints secondary to ankylosing spondylitis.

• Journal of Korean Neurosurgical Society
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• 제50권1호
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• pp.54-56
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• 2011

Ankylosing spondylitis (AS) is frequently associated with inflammatory lesions of the spine and continuous fatigue stress fractures; however, an association with an intraspinal synovial cyst has not been previously reported. A 55-year-old man with a five year history of AS who presented with back pain and a right radiculopathy was admitted to the hospital. Five years previously, he underwent a percutaneous vertebroplasty for an osteoporotic L1 compression fracture, and was diagnosed with AS at that time. Plain radiographs showed aggravated kyphosis and a stress fracture through the ossified posterior element, below the prior vertebroplasty. Magnetic resonance images revealed a right foraminal cystic lesion at the L2-L3 level with effacement of the nerve root. A 1.6 cm cystic lesion that appeared to arise from the L2-L3 facet joint without direct communication was excised from the L2-L3 foramen. Pathological examination confirmed synovial cyst. The patient's symptoms resolved immediately after surgery except for a mild dysesthesia of the right leg. We report herein a rare case of foraminal synovial cyst associated with AS accompanying posterior element fracture with a review of literature.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권6호
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• pp.455-461
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• 2012

Ankylosing spondylitis (AS) is a chronic autoimmune disease mainly involving the axial skeleton. The pathology of the disease is usually found at the sacroiliac joint, and half of the patients experience cervical spine invasion, but eventually, the whole spine is affected. The involvement of the temporomandibular joint (TMJ) in AS has not been investigated very well. A review of the literature revealed that there are only a few studies of TMJ involvement in AS that combined clinical and radiographic examinations. These studies show widely different results, ranging between 4% and 32%. We experienced Bilateral osseous ankylosis of the jaw treated by total alloplastic joint replacement in AS, and offer a case report.

• Genomics & Informatics
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• 제15권2호
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• pp.65-68
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• 2017

Ankylosing spondylitis (AS) is a chronic autoinflammatory disease that affects the spine and sacroiliac joints. Regarding its etiology, although HLA-B27 is known to be the strongest genetic factor of AS, much evidence suggests the potential contribution of non-MHC genes to the susceptibility to AS. Most of these non-MHC genes have been discovered in non-Asian populations; however, just some of them have been validated in Koreans. In this study, we aimed to identify additional AS-associated single-nucleotide polymorphism (SNP) candidates by replicating the candidate SNPs in Korean AS patients and healthy controls. For this, we selected three SNPs (rs11249215 in RUNX3, rs6556416 in IL12B, and rs8070463 in TBKBP1), which were previously reported as risk factors of AS but have not been studied in Koreans, and performed genotyping assays using a total of 1138 Korean samples (572 AS patients and 566 healthy controls). Of the three SNP candidates, one SNP in RUNX3 (rs11249215) was significantly associated with the risk of AS (odds ratio, 1.31; 95% confidence interval, 1.02 to 1.68, p = 0.03). These results will be helpful in elucidating the pathogenesis of AS and may be useful for developing AS risk prediction models in Koreans.

• Journal of Yeungnam Medical Science
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• 제35권1호
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• pp.89-93
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• 2018

Idiopathic non-cirrhotic portal hypertension (INCPH) is a disease with an uncertain etiology consisting of non-cirrhotic portal hypertension and portal pressure increase in the absence of liver cirrhosis. In INCPH, patients exhibit normal liver functions and structures. The factors associated with INCPH include the following: Umbilical/portal pyremia, bacterial diseases, prothrombic states, chronic exposure to arsenic, vinyl chloride monomers, genetic disorders, and autoimmune diseases. Approximately 70% of patients present a history of major variceal bleeding, and treatment relies on the prevention of complications related to portal hypertension. Autoimmune disorders associated with INCPH are mainly systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis. To the best of our knowledge, a case of ankylosing spondylitis (AS) associated with INCPH has not been reported thus far. Therfore, we report our experience of a patient with AS accompanied by INCPH, who showed perisplenic varices with patent spleno-portal axis and hepatic veins along with no evidence of cirrhosis on liver biopsy, and provide a brief literature review.

• Clinical Pain
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• 제20권2호
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• pp.145-149
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• 2021

Ankylosing spondylitis (AS) is a chronic inflammatory disease presenting progressive spinal stiffness and sacroiliitis. Cervical spine fracture combined with AS should be treated with operation, but it is closely related with increased rates of surgical site infection, which are associated with an elevated erythrocyte sedimentation rate and elevated C-reactive protein. We report a case of delayed postoperative infection appeared in cervical paravertebral space, which was masked by laboratory findings and clinical characteristics represented in this rheumatic disease. A 53-year-old man who had medical history of AS got operation after cervical spine fracture. During hospitalization, he experienced aching pain originating from left posterior neck to shoulder, which was revealed out to be delayed postoperative infection, diagnostically obscured by elevated values of inflammatory markers. This case emphasizes detailed evaluation considering symptoms and comorbidity of the patient should be performed to apply proper management.

• 셀메드
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• 제12권3호
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• pp.14.1-14.2
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• 2022

Currently, a 70-year-old woman started suffering from S.I joint pain from 1973 and had severe pain in the S.I joint, wrist, and elbow from 1975 to 1977, and was diagnosed with spinal tuberculosis at a general hospital. From 1978 to 1987, she suffered from chronic fatigue and insomnia, and since January 1, 1988, she was unable to get up while lying down, suffering from whole body joint, muscle pain, and fibromyalgia. In May 1989, she was also diagnosed with ankylosing spondylitis through genetic testing at the Catholic St. Mary's Hospital Rheumatology Department in Korea, and was treated with sulfasalazine, analgesic, and immunosuppressant, methotrexate, for 12 years until 1999, but none of the drugs eliminated the pain. She was hospitalized and discharged repeatedly, and continued to receive salt water poultice and exercise therapy at home, but was unable to move at all. In 2000, after biologic treatment with Remicade injection (Remsima®), she was able to walk and move, and after that, she was continuously prescribed biologics. From 2015 to 2019, Enbrel® (Etanercept) injection was prescribed once a week, but the symptoms such as severe pain (joint and muscle, fibromyalgia), scleroderma, Sjogren's syndrome (dryness of eyes, nose and mouth), difficulty swallowing, chronic fatigue, and stiff body appeared. Around January 2018, hepatic indicators were high and lymphocytes became enlarged. However, most serious injuries were highly improved after the OCNT combination therapy using active phytonutrients, anthocyanin-fucoidan nanocomplex. Therefore, for patients with such experiences, OCNT treatment is proposed as an alternative.