• 대한물리의학회지
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• 제16권3호
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• pp.1-14
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• 2021

PURPOSE: This study aims to reveal the prevalence, therapeutic efficacy and undesirable side effects of cupping therapy all over the world from past to present. METHODS: This meta-analysis is based on the data obtained by scanning the keyword "cupping therapy" from the Pub-Med system, which is an international database. The date range has been set as 1950-2019. Local databases were not included. Cupping therapy studies combined with other complementary therapies such as acupuncture, moxa and hirudotherapy are also included in the meta-analysis. RESULTS: A total of 381 scientific studies were found on cupping therapy. Of these studies 127 wererandomized controlled trials (RCSs). Cupping treatment has been found effective in studies of painful conditions such as herpes zoster pain, fibromyalgia, back pain, neck pain, headache and acute injury pain. In addition, the effectiveness of cupping therapy was found to be high in studies related to bone / muscular system diseases such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout, carpal tunnel syndrome, cervical spondylosis. In addition, cupping treatment is also promising in studies on skin diseases, neurological diseases, respiratory system diseases and cardiovascular system diseases. CONCLUSION: Recently, there has been an increase in the number of RCSs related to cupping therapy. The vast majority of this increase has been made in European and American countries rather than in Far Eastern countries. Studies on cupping therapy, which have been and will be carried out in the future, will provide evidence-based indication of whether cupping therapy is effective. and it will allow more patients to benefit from this treatment, which has a very low rate of side effects and complications.

• 대한추나의학회지
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• 제4권1호
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• pp.75-88
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• 2003

Objectives : The purpose of this study is to find out the effects of Catalpa Ovata on the collagen-induced arthritis in the lewis rats. and we infere the effects of Catalpa Ovata on the rheumatoid arthritis in the human body. Methods : We investigated the effect of Catalpa Ovata on the Collagen-induced arthritis in Lewis rats via morphology, histology and serology as an experimental group, a control group, and a normal group. We feed Catalpa Ovata. only to an experimental group. Results : According to this research, the abnormal finding In Moire topography was 53.7% (1,018 students), and students needed X-ray re-examination were 11.2% (213 students). Students diagnosed scoliosis by X-ray re-examination were 1.8%. According to statistical analysis, interval between vertical base line of pelvis and vertical base line of neck, gap between left distance and right distance to the vertical base line of pelvis and difference of contour lines have strong correlations with deformity degree of the body surface examined by Moire. Conclusions : 1. The weight of an experimental group were lower than control group with statistically significant at 15 days later. 2, The paw edema volume of an experimental group were lower than control group at 10 days, 15 days later. but couldn't be found meaning. 3. The size of the tarsal joint of an experimental group were lower than control group at 5 days, 10 days, 15 days later, but couldn't be found meaning. 4. The volume of tumor necrosis factor-a at an experimental group were lower than control group with statistically significant. 5. The volume of interleukin-$1{\beta}$ at an experimental group were lower than control group with statistically significant. 6. An experimental group and a control group were showed ankylosing osteoarthritis, but an experimental group compared with a control group, alleviated In the fibrous ankylosis, destruction of articular cartilage and destruction of subchondral bony tissue. According to the above results, it might be considered that Catalpa Ovata has the suppression of the advance of the Collagen-induced arthritis and that result were presumed to bo connected with suppression of volume of the tumor necrosis $factor-{\alpha}$ and $interleukin-1{\beta}$ in the blood.

• Journal of Periodontal and Implant Science
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• 제47권5호
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• pp.328-338
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• 2017

Purpose: Chronic periodontitis is an inflammatory disease induced by pathogenic bacterial accumulation. A novel index, the periodontal inflamed surface area (PISA), represents the sum of the periodontal pocket depth of bleeding on probing (BOP)-positive sites. It is advantageous for data processing and analysis because it can be treated as a continuous variable to quantify periodontal inflammation. In the present study, we evaluated correlations between PISA and periodontal classifications, and examined PISA as an index integrating the discrete conventional periodontal indexes. Methods: This study was a cross-sectional subgroup analysis of data from a prospective cohort study investigating the association between chronic periodontitis and the clinical features of ankylosing spondylitis. Data from 84 patients without systemic diseases (the control group in the previous study) were analyzed in the present study. Results: PISA values were positively correlated with conventional periodontal classifications (Spearman correlation coefficient=0.52; P<0.01) and with periodontal indexes, such as BOP and the plaque index (PI) (r=0.94; P<0.01 and r=0.60; P<0.01, respectively; Pearson correlation test). Porphyromonas gingivalis expression and the presence of serum P. gingivalis antibodies were significant factors affecting PISA values in a simple linear regression analysis, together with periodontal classification, PI, bleeding index, and smoking, but not in the multivariate analysis. In the multivariate linear regression analysis, PISA values were positively correlated with the quantity of current smoking, PI, and severity of periodontal disease. Conclusions: PISA integrates multiple periodontal indexes, such as probing pocket depth, BOP, and PI into a numerical variable. PISA is advantageous for quantifying periodontal inflammation and plaque accumulation.

• 대한핵의학회지
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• 제16권2호
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• pp.63-70
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• 1982

To evaluate the diagnostic usefulness and significance of quantitative sacroiliac joint scintigraphy in the assessment of sacroiliitis, we measured Sacroiliac Joint/Sacrum Uptake Ratio(SIS Ratio) by region of interest(ROI) method using $^{99m}Tc-methylene$ diphosphonate. The observed results were as follows: 1. Using ROI method, the SIS ratios for the control group of 65 persons were $1.05{\pm}0.08$(left) and $1.06{\pm}0.07$(right) which were narrower in range than those of slice method $(mean{\pm}S.D.)$. 2. The effects of age, gender and laterality on SIS ratio were not significant. 3. In left side, one of 6 patients with rheumatoid arthritis had SIS ratio in excess of 2 standard deviation of normal control group, and remainder had SIS ratios within normal limit. In right side, 3 patients had SIS ratios in excess of 2 standard deviation of normal control group, and remainder, within normal limit. 4. In both sacroiliac joint, 2 of 3 patients having sacroiliitis clinically with Reiter's syndrome whose pelvis A-P X-ray findings showed normal had high SIS ratios (left/right; 1.31/1.69, 1.90/1.80), but SIS ratio of one patient who had no evidence of sacroiliitis clinically was within normal limit. 5. In 6 patients with ankylosing spondylitis in both sacroiliac joints, 4 whose pelvis A-P Xray findings showed severe sclerotic change of sacroiliac joints had SIS ratio within normal limit or below that of normal control group, and SIS ratios of 2 patients whose pelvis A-P X-ray findings showed were increased. 6. 4 of 5 patients with low back pain of which cause could not be evaluated clinically and radiologically had SIS ratios in excess of that of normal control group. It would be concluded that quantitative sacroiliac joint scintigraphy is useful and sensitive screening method in the diagnosis as well as in the assessment clinical activity of sacroiliitis.

• 대한족부족관절학회지
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• 제12권2호
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• pp.197-202
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• 2008

Purpose: Haglund's disease represents a painful heel caused by mechanically induced inflammation of the retrocalcaneal bursa and insertional Achilles tendinosis may coexist. Traditional open surgery can cause complications such as skin breakdown, painful scar and altered sensation around the heel. Endoscopic treatment offers the advantages that are related to minimally invasive procedure and we evaluate the clinical results and operative techniques of endoscopic decompression of retrocalcaneal space for Haglund's disease. Materials and Methods: Our retrospective study included seven heels in six consecutive patients for which nonoperative treatment had failed and endoscopic decompression was performed. The mean age was forty-one years (range, 28 to 53 years). All of the patients had typical complaints of inflammation of the retrocalcaneal bursa and Fowler-Philip angle of more than $75^{\circ}$ and positive parallel pitch lines were present on the lateral calcaneal radiograph. The endoscopic procedure consists of the resection of inflamed retrocalcaneal bursa and enough bone to prevent impingement of the bursa between the calcaneus and Achilles tendon. All patients were evaluated with radiologic angle, visual analogue scale (VAS) for pain and Ogilvie-Harris functional score. The mean follow-up was 18 months (range, 15 to 21 months). Results: The mean operation time was 61 minutes (range, 50 to 85 minutes). VAS for pain and Fowler-Philip angle were decreased from preoperative 8.7 and $82^{\circ}$ to postoperative 2.3 and $57^{\circ}$, respectively. One patient with ankylosing spondylitis had a fair result, 2 patients had good results and the remaining 3 patients had excellent results according to Ogilvie-Harris functional score. There were no surgical complications such as infection, Achilles tendon avulsion or abnormal heel sensation. Conclusion: The endoscopic decompression for Haglund's disease was demonstrated to have several advantages including low morbidity, allowance of functional rehabilitation, short recovery time and quick sports resumption. However a comparative study is needed to determine the value of endoscopic decompression and particular caution should be exerted for the enthesiopathy.

• 한방재활의학과학회지
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• 제23권4호
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• pp.59-71
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• 2013

Objectives The aim of this review is to figure out which acupoints are frequently used to treat low back pain and which exercises are effective to low back pain. Methods We searched the three electronic database (RISS, KISS, KTKP) and manually checked related Korean journals and reference lists up to June 2013. We investigated the frequency of acupoints for using treatment of low back pain. We Introduce exercise therapies we can do easily at home without professional skills for treatment low back pain. Results We included 72 articles in this study. The most frequently adopted acupoints were BL25, BL23, BL24, GB30, BL40, BL26, BL60, GB34, BL52, BL57, GB39. The most frequently adopted meridian pathways were BL, GB, GV, ST. The most frequently adopted disease causing low back pain were HIVD (Herniated intervertebral disc), Lumbar sprain, Spinal stenosis, Compression fracture, Cauda equina syndrome, Spondylolisthesis, Ankylosing spondylitis. There are many exercise therapies (Lumbar stabilizing exercise, Resistance exercise, Bareunmom physical exercise, Mckenzie exercise, Williams exercise, Emblass exercise, Swiss ball exercise, Thera band exercise, Yoga) for treatment low back pain. Conclusions These results suggest that most frequently adopted acupoints were foot taeyang urinary bladder channel acupoints. Beacuse foot taeyang urinary bladder channel is passes through the waist, it will be effective for treatment of low back pain. Also exercise therapy is effective for enhance Muscular strength. In order to treatment of low back pain, Acupuncture treatment is also important, as well as exercise therapy.

• 대한의생명과학회지
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• 제2권2호
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• pp.223-229
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• 1996

HLA-class I 항원의 HLA-B 유전자좌에 존재하는 HLA-B27 유전자는 임상적으로 강직성 척수염과 강한 관련성이 있음이 보고되고 있으며, 현재 HLA 유전자중 질병과의 관련성을 보기 위한 검사로 임상에서 가장 널리 사용되고 있다. 대부분의 검사실에서는 현재까지 혈청학적 검사방법을 이용하여 HLA-B27 검사를 실시하고 있는데, 이 방법은 시약이 고가이고, 검체의 안정성과 보관이 어려우며, 분석시간이 오래 걸리는 등 불편한 점이 있고, 또한 현재에도 계속 새로운 HLA-B27 대립유전자가 발견되고 있으므로 위음성의 가능성도 배제할 수 없어, 보다 정확한 검사방법이 요구되고 있다. 최근 HLA-B27 대림유전자의 염기배열이 대부분 밝혀져 혈청학적 방법 대신 DNA를 이용한 typing방법이 보고되고 있다. 저자들은 HLA-B2l 대립 유전자에 공통으로 존재하는 염기배열 부분을 선택하여 group specific PCR(Polymerase Chain Reaction)을 실시하고 그 유용성을 검토하였다. 혈청학적 방법으로 HLA B-27 형이 확인된 검체 56 개와 4 개의 표준세포주 (HOM-2, JESTHOM, WT24, BTB)를 이용하여 혈청학적 방법과 DNA typing을 비교한 결과, 두 방법사이에 완벽한 일치를 나타내었다. 따라서 group specific PCR을 이용한 HLA-B27 DNA typing은 검체 및 시약의 안정성이 높고, 경제적이며 신속한 검사가 가능하므로 임상에서 활용성이 매우 클 것으로 사료된다.

• IMMUNE NETWORK
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• 제21권6호
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• pp.43.1-43.14
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• 2021

Group 3 innate lymphoid cells (ILC3), which express IL-22 and IL-17A, has been introduced as one of pathologic cells in axial spondyloarthritis (axSpA). Dyslipidaemia should be managed in axSpA patients to reduce cardiovascular disease, and dyslipidaemia promotes inflammation. This study aimed to reveal the role of circulating ILC3 in axSpA and the impact of dyslipidaemia on axSpA pathogenesis. AxSpA patients with or without dyslipidaemia and healthy control were recruited. Peripheral blood samples were collected, and flow cytometry analysis of circulating ILC3 and CD4⁺ T cells was performed. The correlation between Ankylosing Spondylitis Disease Activity Score (ASDAS)-C-reactive protein (CRP) and circulating immune cells was evaluated. The effect of oxidized low-density lipoprotein cholesterol (oxLDL-C) on immune cell differentiation was confirmed. AxSpA human monocytes were cultured with with oxLDL-C, IL-22, or oxLDL-C plus IL-22 to evaluate osteoclastogenesis using tartrate-resistant acid phosphatase (TRAP) staining and real-time quantitative PCR of osteoclast-related gene expression. Total of 34 axSpA patients (13 with dyslipidaemia and 21 without) were included in the analysis. Circulating IL-22⁺ ILC3 and Th17 were significantly elevated in axSpA patients with dyslipidaemia (p=0.001 and p=0.034, respectively), and circulating IL-22⁺ ILC3 significantly correlated with ASDAS-CRP (Rho=0.4198 and p=0.0367). Stimulation with oxLDL-C significantly increased IL-22⁺ ILC3, NKp44^- ILC3, and Th17 cells, and these were reversed by CD36 blocking agent. IL-22 and oxLDL-C increased TRAP⁺ cells and osteoclast-related gene expression. This study suggested potential role of circulating IL-22⁺ ILC3 as biomarker in axSpA. Furthermore, dyslipidaemia augmented IL-22⁺ ILC3 differentiation, and oxLDL-C and IL-22 markedly increased osteoclastogenesis of axSpA.

• Journal of Oral Medicine and Pain
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• 제33권1호
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• pp.15-26
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• 2008

다양한 전신질환으로 입원한 환자들 중에서 구강질환을 진료받기 위해서 내원한 환자의 전신질환 상태와 치과적인 주소 및 진단명 그리고 치료내용을 조사하고 이와 관련된 구강내과적인 주소가 무엇인지를 관찰함으로써 입원한 전신질환자와 구강질환과의 상관관계를 파악하고자 본 연구를 시행하여 다음과 같은 결론을 얻었다. 1. 구강질환을 진료받기 위해서 내원한 환자의 전신질환은 인슐린-비의존성 당뇨병 26%, 뇌경색 25.2%, 뇌내출혈, 다발성 관절증, 고관절증 각각 4.7%, 신경근 및 신경총 장애, 고혈압성 심장 및 신장 질환, 강직성 척추염 각각 2.4% 등의 순서로 나타났다. 2. 내원한 환자의 주소는 치통 28.6%, 정기검사 23%, 치아동요 8.7%, 치아지각과민 7.1%, 치주출혈 6.4% 등의 순서로 나타났다. 3. 내원한 환자의 진단된 구강질환은 치은염 및 치주질환 28.9%, 치아우식증 17.1%, 치수 및 치근단주위의 질환 15.1%, 타액선의 질환 10.5%, 치아경조직의 기타질환 8.6% 등의 순서로 나타났다. 4. 내원한 환자의 치료내용은 치주치료 17.95%, 치료거부 16.67%, 구강건조 및 구취 제거를 위한 약물치료 13.46%, 발치치료 12.18%, 보철치료 8.97% 등의 순서로 나타났다. 5. 내원한 환자의 구강내과적인 주소는 16% 이었으며, 구강연조직질환 6.4%, 두개하악장애 5.6% 그리고 구취 4% 등의 순서로 나타났다. 이상의 결과로 입원한 전신질환자를 통해서 전신질환이 있는 환자의 구강질환과 구강질환이 있는 환자의 전신질환에 대해서는 일정부분 파악이 되었으나 향후 구강질환과 전신질환과의 상관관계에 대한 연구가 계속적으로 이루어져야 한다고 사료된다.

• 대한핵의학회지
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• 제29권1호
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• pp.84-91
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• 1995

지금까지 류마티스 관절염의 염증 정도의 평가를 위하여 많은 검사들이 사용되어져 왔다. $^{99m}Tc$-labelled HIG 스캔은 동물실험과 사람에서도 염증이나 감염병소에 집적되는 것으로 알려져 있다. 본 연구의 목적은 $^{99m}Tc$-labelled HIG 스캔을 이용하여 류마티스 관절염 환자에서 활동성 염증이 있는 군과 없는 군을 구별해 보고자 하였고 이러한 결과를 다른 임상인자와 조영증강 자기공명영상과 비교해 보았다. 11명의 활동성 염증이 있는 류마티스 관절염 환자와 활동성 염증이 없는 류마티스 관절염 환자 1명, 강직성 척수염 환자 2명 그리고 퇴행성관절염 환자 1명을 대상으로 하였다. 활동성 염증(active synovitis)은 ESR의 상당한 증가와 조영증강 자기공명영상에서 조영증강을 보이는 경우로 정의하였다. $^{99m}Tc$-labelled HIG를 정맥주사후 4시간후에 전신 및 국소영상을 얻었다. 섭취정도의 평가는 3명의 전문의에 의하여 3단계로 나누어 시각적으로 평가하였다. 모든 환자에 있어서 조영증강 자기공명영상을 같이 시행하였다. 활동성 염증이 있는 11명의 류마티스 관절염 환자중 10명에서 상당한 정도의 섭취증가를 보인 반면 활동성 염증이 없는 나머지 환자에서는 정상 또는 미미한 정도의 섭취증가만을 보였다. 본 연구에서 $^{99m}Tc$-labelled HIG 스캔을 이용하여 류마티스 관절염에 이환된 관절들의 전반적인 국소화가 가능하였고 $^{99m}Tc$-labelled HIG의 섭취정도가 다른 임상적이나 자기공명영상의 활동성 염증을 시사하는 인자들과 잘 연관되었다. 결론적으로 $^{99m}Tc$-labelled HIG 스캔은 류마티스 관절염 환자에 있어서 염증 정도를 평가해 볼 수 있는 유용한 방법이 될 수 있을 것으로 생각한다.