The Journal of Korea CHUNA Manual Medicine (대한추나의학회지)

Korean Society of Chuna manual Medicine for Spine and Nerves (척추신경추나의학회)
권호 표지

Effects of Catalpa Ovata on the Collagen-induced Arthritis in Lewis Rats

개오동이 흰쥐의 Collagen 유발 관절염에 미치는 영향

  • Kim, Sun-Jung (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine Se-Myung University) ;
  • Seo, Il-Bok (Dept. of Anatomy, College of Oriental Medicine Se-Myung University Semyung University Garduate School) ;
  • Yoon, Je-Pil (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine Se-Myung University)
  • 김순중 (세명대학교 한의과대학 재활의학과교실) ;
  • 서일복 (세명대학교 한의과대학 해부학교실) ;
  • 윤제필 (세명대학교 한의과대학 재활의학과교실)
  • Published : 2003.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The purpose of this study is to find out the effects of Catalpa Ovata on the collagen-induced arthritis in the lewis rats. and we infere the effects of Catalpa Ovata on the rheumatoid arthritis in the human body. Methods : We investigated the effect of Catalpa Ovata on the Collagen-induced arthritis in Lewis rats via morphology, histology and serology as an experimental group, a control group, and a normal group. We feed Catalpa Ovata. only to an experimental group. Results : According to this research, the abnormal finding In Moire topography was 53.7% (1,018 students), and students needed X-ray re-examination were 11.2% (213 students). Students diagnosed scoliosis by X-ray re-examination were 1.8%. According to statistical analysis, interval between vertical base line of pelvis and vertical base line of neck, gap between left distance and right distance to the vertical base line of pelvis and difference of contour lines have strong correlations with deformity degree of the body surface examined by Moire. Conclusions : 1. The weight of an experimental group were lower than control group with statistically significant at 15 days later. 2, The paw edema volume of an experimental group were lower than control group at 10 days, 15 days later. but couldn't be found meaning. 3. The size of the tarsal joint of an experimental group were lower than control group at 5 days, 10 days, 15 days later, but couldn't be found meaning. 4. The volume of tumor necrosis factor-a at an experimental group were lower than control group with statistically significant. 5. The volume of interleukin-$1{\beta}$ at an experimental group were lower than control group with statistically significant. 6. An experimental group and a control group were showed ankylosing osteoarthritis, but an experimental group compared with a control group, alleviated In the fibrous ankylosis, destruction of articular cartilage and destruction of subchondral bony tissue. According to the above results, it might be considered that Catalpa Ovata has the suppression of the advance of the Collagen-induced arthritis and that result were presumed to bo connected with suppression of volume of the tumor necrosis $factor-{\alpha}$ and $interleukin-1{\beta}$ in the blood.

Keywords

References

  1. 동의재활의학과학 전국한의과대학한방재활의학교실(편)
  2. 景岳全書(上) 張介賓
  3. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis, Two cellular mechanisms explain joint destruction Ann Rheum Dis. Gay, S.;Gay, R. E. ;Koopman, W. J.
  4. Introduction to Clinical Rheumatology. Dick, W. C.;Goodacre, J.
  5. 대한내과학회지 v.36 no.6 류마티스 관절염의 면역병인의 최근 경향 김호연
  6. 의학정보 v.3 no.1 류마티스 관절염과 골관절염 박원
  7. 최신한방임상학 배원식
  8. 가정의학 의학교육연수원
  9. 내과학 이문호
  10. 최신진단과 치료 허인회
  11. 동의물리요법과학 신현대
  12. 정형외과학 대한정형외과학회
  13. 원광대학교 석사학위논문 牧丹皮가 Collagen 유발 관절염에 미치는 영향 김동혁
  14. Clinical Immunol Immunopathol. v.73 no.1 Collagen- induced arthritis as a model of rheumatoid arthritis. Durie, F. H.;Fava, R. A.;Noelle, R. J.
  15. Clin Exp Immunol. v.89 no.2 Acceleration of onset of collagen-induced arthritis by infra-articular injection of tumor necrosis factor or transforming growth factor-beta. Cooper, W. O.;Fava, R. A..;Gates, C. A.;Cremer, M. A.;Towns, A. S.
  16. J Immunol. v.141 no.3 administration with IL-1 accelerates the developement of collagen-induced arthritis in mice. Hom, J. T.;Bendele, A. M.;Carlson, D. G.
  17. Arthritis Rheum. v.32 no.5 Enhanced production of interlukin-6 in mice with type Ⅱ collagen-induced arthritis. Takai Y, Seki N, Senoh H, Yokota T, Lee F, Hmaoka T, Fujiwara H.
  18. J Clin Invest. v.89 increased binding of synovial T lymphocytes from rheumatoid arthritis to endothelial leukocyte adhesion molecule-1 (E1AM-1) and vascular cell adhesion molecula -1 (VCAM-1). Postigo, A. A.;Garcia-Vicuna, R.;diaz-Gonzalez, R.;Arroyo, A. G.
  19. 한방물리요법과학회지 v.4 no.1 大羌活湯이 제 II형 Collagen 유발 관절염의 항체에 미치는 영향 이호근
  20. 한방물리요법과학회지 v.4 no.1 桂枝芍藥知母湯이 제 II형 Collagen 유발관절염 항체에 미치는 영향 신병희
  21. 경희 한의대 논문집 v.4 仙除痛飮이 진통 소염작용에 미치는 영향 안덕균
  22. 경희대학교논문집 김성수 加味仁湯의 소염효과 및 성분에 관한 연구
  23. 鍼灸 및 斑描灸가 흰쥐의 Adjuvant 관절염에 미치는 영향 김양식
  24. 대한한의학회지 v.19 no.1 秦구가 Collagen유발 관절염의 면역반응에 미치는 영향 김성재
  25. 경희대학교 대학원 박사 논문 冬蟲夏草가 Synovial 세포증식과 Collagen 에 의해 유발된 생쥐의 관절염 억제에 미치는 영향 서영배
  26. 대한암학회지 v.24 no.6 개오동 나무 수피로 부터 Sarcoma 180암세포 독성물질의 분리 김민선
  27. 完譯 中藥大辭典 김창민
  28. 圖解 鄕藥生藥大辭典 정보섭
  29. phytochemistry. v.14 Two new flavone glycosides from Catalpa ovata. Okuda, T.;Yoshida, Y.;Ono, I.
  30. 痺證專輯 當代名醫證精華
  31. 黃帝經素問樞 馬元臺;張隱庵(合註)
  32. 中醫科學 上海中醫學院(編)
  33. 中醫科學講義 中醫學院試用敎材編輯部
  34. 中醫學論 河北中醫學院
  35. Agents Action. v.34 Development of a rapid screen for detecting and differentiating immunomodulatory vs. anti-inflammatory compounds in rats. Benslay, D. N.;Bendele, A. M.
  36. Biomed, Res. v.3 Histological, immunological and biochemical studies on type Ⅱcollagen arthritis in rats. Terato, K.;Hashida, R.;Miyamoto, K.;Morimoto, T.;Kata, Y;Kobayashi, S;Tajima, T;Otake, S;Horni H;Nagai, Y.
  37. Toxicologic pathology v.27 no.1 Animal models of Arthritis. Relevance to human disease. Alison B, Jennifer M, Ty G, Tracy M, Gina S, Elizabeth C, Michael G.
  38. Arthritis Rheum. v.20 Antigen-induced arthritis in mice. I. induction of arthritis in various strains of mice. Brackertz, D.;Mitchell, G. F.;Mackay, I. R.
  39. 흰쥐에서 TypeⅡ Collagen으로 유발된 관절염의 임상양상 및 면역반응. 박동준
  40. J.Exp. Med v.146 Autoimmunity to TypeⅡ collagen. an experimental model of arthritis. Trentham, D. E.
  41. 서울 대한 내과 학회지 v.41 no.13 흰쥐의 제2형 collagen유발 관절염의 IgG항 collagen항체의 변화 박동준
  42. Protocol for the successful induction of collagen-induced arthritis in rats: 1-5 Chondrex, LLC.
  43. Type Ⅱ collagen-induced arthritis in the diabetic-resistant biobreeding rat. Inflammatory and histopathological features of joint pathology and effects of antiinflammatory and antirheumatic drugs on this chronic arthritic process. Robert, J.;Smith.;Laurel, M. SLY.
  44. J Immunol. v.141 no.3 In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice Hom, J. T.;Bendele, A. M.;Carlson, D. G.
  45. J Immunol. v.17 no.20 Production of interleukin-1 receptor antagonist, inflammatorychemotactic protein, and prostaglandin E by rheumatoid and osteoarthritis synoviocyties- Regulation by IFN-γ and IL-4. Seitz, M.;Loetscher P.;Dewald B.;Towbin H.;Ceska M.;Bagiolini M.
  46. Arthritis Rheum v.33 Cytokines and cytokine inhibitors of antagonists in rheumatoid arthritis Arend, W. P.;Dayer, J. M.
  47. Clin Exp Immunol. v.75 Arthritogenic actions of recombinant IL-1 and tumor necrosis factor alpha in the rabbit evidence forsynergistric interaction between cytokines in vivo. Henderson, B.;Pettipher, E. R.