• Title/Summary/Keyword: Animal studies

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What is the Potential of Animal Models to Inform Occupational Therapy Theories and Interventions From the Perspective of Neuroscience? (신경과학적 관점으로 본 작업치료에서 동물 모델의 필요성)

  • Park, Ji-Hyuk;Ahmad, S. Omar
    • Therapeutic Science for Rehabilitation
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    • v.1 no.1
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    • pp.39-56
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    • 2012
  • Introduction : Animal studies cannot be applied directly to Occupational Therapy(OT) intervention protocol. However, animal models still provide essential evidences and knowledge to improve OT practice and to develop OT theories as well as human studies do. The purpose of this scholarly paper is to explore the potential of animal models to inform OT theory and practice particularly as it relates to neuroscience. Body : The animal models provide related knowledge for a better understanding of the mechanism of diseases and related neural networks. Based on this knowledge, researchers can test their hypothesis of neural disease. In addition, accumulated animal studies contribute to introduce the new approaches to human diseases and to improve the effectiveness of treatment. Conclusions : Animal models of neurological disease are critical and have the potential to improve OT practice and theory in many ways. Therefore, OT researchers need to pay more attention to animal models in addition human studies.

Effect of Diet on Enzyme Profile, Biochemical Changes and In sacco Degradability of Feeds in the Rumen of Buffalo

  • Kamra, D.N.;Saha, Sudipto;Bhatt, Neeru;Chaudhary, L. C.;Agarwal, Neeta
    • Asian-Australasian Journal of Animal Sciences
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    • v.16 no.3
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    • pp.374-379
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    • 2003
  • Four rumen fistulated Murrah buffaloes were used to study the effect of four diets differing in roughage to concentrate ratio on rumen biochemical changes, microbial enzyme profile and in sacco degradability of feed in a $4{\times}4$ Latin Square design. The animals were fed four diets consisting of 80:20, 70:30, 60:40 and 50:50 ratios of wheat straw and concentrate mixtures, respectively. Wheat straw and concentrate mixture were mixed with water (0.6 l/kg feed) and complete feed mixture was offered to the animals at 8:00 h and 16:00 h in two equal parts. The variation in pH of rumen liquor (difference of maximum and minimum during 0-8 h post feeding) increased with increasing level of concentrate mixture in the diet. There was no effect of diet composition on volatile fatty acids, total nitrogen and trichloro-acetic acid precipitable nitrogen in the rumen liquor, but ammonia nitrogen increased with increasing level of concentrate mixture in the ration. Major portions of all fibre degrading enzymes were present in the particulate material (PM) of the rumen contents, but protease was absent in PM fraction. The activities of micro-crystalline cellulase, acetyl esterase and protease increased with increase in the level of concentrate mixture, but the activities of other enzymes (carboxymethylcellulase, filter paper degrading activity, xylanase, $\beta$-glucosidase and $\beta$-xylosidase) were not affected. The in sacco degradability and effective degradability of feeds increased with increasing level of concentrate mixture in the ration.

Comparative Study between Swamp Buffalo and Native Cattle in Feed Digestibility and Potential Transfer of Buffalo Rumen Digesta into Cattle

  • Wanapat, M.;Nontaso, N.;Yuangklang, C.;Wora-anu, S.;Ngarmsang, A.;Wachirapakorn, C.;Rowlinson, P.
    • Asian-Australasian Journal of Animal Sciences
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    • v.16 no.4
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    • pp.504-510
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    • 2003
  • Rumen ecology plays an important role in the fermentation process and in providing end-products for ruminants. These studies were carried out to investigate variations in rumen factors namely pH, $NH_3-N$ and microorganisms in cattle and swamp buffaloes. Furthermore, studies on diurnal patterns of rumen fermentation and the effect of rumen digesta transfer from buffalo to cattle was conducted. Based on these studies, diurnal fermentation patterns in both cattle and buffaloes were revealed. It was found that rumen NH3-N was a major limiting factor. Rumen digesta transfer from buffalo to cattle from buffalo to cattle was achievable. Monitoring rumen digesta for 14d after transfer showed an improved rumen ecology in cattle as compared to that of original cattle and buffalo. It is probable that buffalo rumen digesta could be transferred. However, further research should be undertaken in these regards in order to improve rumen ecology especially for buffalo-based rumen.

Serum biochemical profiles of repeat breeder holstein friesian cows

  • Jung, Moo Young;Kang, Seogjin;Lim, Dong-Hyeon;Kim, Tae-Il;Lee, Kyoungseok;Ha, Seungmin
    • Korean Journal of Veterinary Service
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    • v.44 no.4
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    • pp.239-246
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    • 2021
  • The fertility of dairy cows has been declining worldwide. The number of services per conception has increased, and repeat breeder (RB) cows are considered important in the dairy industry. However, there has been little research on RB cows in Korea. The objective of this study was to investigate the relationship between serum biochemical profiles and RB Holstein cattle in Korea and compare the results with those of studies conducted abroad. In addition, we investigated hidden factors that are needed for RB cattle to become pregnant. Overall, 34 Korean Holstein Friesian cows were divided into three groups: pregnant with normal cycling (PNC), pregnant with repeat breeder (PRB), and non-pregnant with repeat breeder (NRB). Blood samples were collected from the jugular vein, and serum parameters (ALT, AST, ALP, GGT, LD, CK, TP, ALB, GLOB, TBIL, BUN, CRE, GLU, TC, TG, NEFA, CA, MG, and IP) were analyzed. GGT levels were significantly different among groups (P=0.01). The concentration of GGT was the highest in the NRB and the lowest in the PNC. In contrast to the findings of other studies, there were no differences in GLU, TP, TC, and BUN levels. This study is the first to investigate serum biochemistry in RB cattle and provides results that differ from those of previous studies; these findings would help establish a novel approach to improve fertility of RB cattle.

The Effect of Orally Administered Herbal Medicines in Collagen, LPS, CFA Induced Rheumatoid Like Arthritis Animal Model: A Systematic Review of Animal Study Articles Published in Korea after 2008 (Collagen, LPS, CFA로 유발된 류마티스 유사 관절염 동물실험 모델에서 한약제제 경구투여의 효과: 2008년 이후 발표된 국내 논문에 대한 체계적 문헌고찰)

  • Won, Jeong-Yoon;Jeon, Chae-Heun;Song, Ho-Joon;Jeong, Ji-Won;Kim, Tae-Gwang;Kim, Hyun-Ho;Leem, Jungtae
    • Journal of Korean Medicine Rehabilitation
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    • v.27 no.4
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    • pp.33-53
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    • 2017
  • Objectives This study was designed to review animal studies about the efficacy of herbal medicine for Rheumatoid arthritis animal model which was published in Korea after 2008. We also systematically investigated the reporting quality of the animal studies. Methods We systematically searched original articles in 8 databases since 2008. And manual searching was conducted through 10 Korean medicine journals from 2008. Studies were included if they used animal experimental model(s) with orally administered herbal medicine. Data were extracted regarding animal model, rheumatoid arthritis indicator and detail of intervention. Reporting quality of each study was also assessed by the STARA and ARRIVE guidelines. Results Nine hundred two articles were screened. Finally, 35 articles were included. 35 studies all showed that the herbal medicine used in the studies has significant effect on alleviating the macroscopic indicators, hematological indicators, histological indicators, genetic indicators, osteological indicator of Rheumatoid Arthritis and others. Species of animals was reported in 100% while ventilation and noise were reported in 0% in STRASA guidelines. Ethical statement was reported in 42.9%, experimental animals and sample size were reported in 24%, 29% and there was no study reporting funding. Conclusions These results suggest that herbal medicine might be effective treatment for Rheumatoid Arthritis. It should be improved by clinical studies. And there is a need for studying about efficacy and safety of each specific herbal medicine. And we should improve the Reporting quality of the animal studies published in Korea.

The role of long noncoding RNAs in livestock adipose tissue deposition - A review

  • Wang, Lixue;Xie, Yuhuai;Chen, Wei;Zhang, Yu;Zeng, Yongqing
    • Animal Bioscience
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    • v.34 no.7
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    • pp.1089-1099
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    • 2021
  • With the development of sequencing technology, numerous, long noncoding RNAs (lncRNAs) have been discovered and annotated. Increasing evidence has shown that lncRNAs play an essential role in regulating many biological and pathological processes, especially in cancer. However, there have been few studies on the roles of lncRNAs in livestock production. In animal products, meat quality and lean percentage are vital economic traits closely related to adipose tissue deposition. However, adipose tissue accumulation is also a pivotal contributor to obesity, diabetes, atherosclerosis, and many other diseases, as demonstrated by human studies. In livestock production, the mechanism by which lncRNAs regulate adipose tissue deposition is still unclear. In addition, the phenomenon that different animal species have different adipose tissue accumulation abilities is not well understood. In this review, we summarize the characteristics of lncRNAs and their four functional archetypes and review the current knowledge about lncRNA functions in adipose tissue deposition in livestock species. This review could provide theoretical significance to explore the functional mechanisms of lncRNAs in adipose tissue accumulation in animals.

A Review on the Role of Duckweed in Nutrient Reclamation and as a Source of Animal Feed

  • Goopy, J.P.;Murray, P.J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.16 no.2
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    • pp.297-305
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    • 2003
  • The family of lemnacae colloquially known as duckweed contains the world' smallest species of flowering plants (macrophytes). Aquatic and free-floating, their most striking qualities are a capacity for explosive reproduction and an almost complete lack of fibrous material. They are widely used for reducing chemical loading in facultative sewage lagoons, but their greatest potential lies in their ability to produce large quantities of protein rich biomass, suitable for feeding to a wide range of animals, including fish, poultry and cattle. Despite these qualities there are numerous impediments to these plants being incorporated into western farming systems. Large genetically determined variations in growth in response to nutrients and climate, apparent anti-nutritional factors, concerns about sequestration of heavy metals and possible transference of pathogens raise questions about the safety and usefulness of these plants. A clear understanding of how to address and overcome these impediments needs to be developed before duckweed is widely accepted for nutrient reclamation and as a source of animal feed.