• Bulletin of the Korean Chemical Society
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• v.31 no.9
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• pp.2473-2478
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• 2010

Novel 1'-methyl-5'-norcarbocyclic adenosine phosphonic acid analogues were synthesized using an acyclic stereoselective route from commercially available 3,3-diethoxy-propan-1-ol 4. The synthesized nucleoside phosphonate 19 and phosphonic acid 21 were subjected to antiviral screening against various viruses.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.9 no.1
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• pp.20-29
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• 2009

In this paper, by using the definition of fuzzy equivalence relations introduced by Dib and Youssef, we obtain fuzzy analogues of many results concerning ordinary equivalence relations. Moreover, we investigate fuzzy analogues of many results concerning relationships between ordinary equivalence relations and ordinary functions. In particular, we obtain the fuzzy-canonical decomposition of a fuzzy function.

• Biomolecules & Therapeutics
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• v.3 no.3
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• pp.217-222
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• 1995

Several acyclonucleoside analogues of pyrimidine base and N$^1$-derivatives of 5-fluorouracil have been synthesized and evaluated for their biological effects. When tested with in vitro Lekemia L1210 cells, the 5-fluorouracil derivatives exhibited slightly higher antitumor activity than the parent 5-fluorouracil. When tested against Herpes Simplex Virus type 1 and type 2 cultured in the Vero cell, the 5-fluorouracil derivatives showed weak antiviral activity.

• Archives of Pharmacal Research
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• v.26 no.12
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• pp.990-996
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• 2003

A novel carboacyclic nucleoside analogue, 9-[2-bromo-4-hydroxy-3-hydroxymethyl-2-butenyl] adenine, and its derivatives were designed and synthesized as open-chain analogues of neplanocin A. The syntheses were accomplished via the coupling of adenine or pyrimidine bases to the key intermediate allylic bromide 7. The bromide 7 was prepared from epichlorohydrin in a seven step process in a 54% overall yield. The synthesized compounds were evaluated for their antiviral activity against the polio virus, HSV and HIV.

• Bulletin of the Korean Chemical Society
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• v.30 no.5
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• pp.1147-1151
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• 2009

The synthetic route of novel 3′-C-methyl carbodine analogue is described. The construction of tertiary alcohol at 3′- position of carbodine analogues was successfully made via sequential [3,3]-sigmatropic rearrangement, ring-closing metathesis (RCM) and stereoselective dihydroxylation reactions starting from ethyl glycolate.

• Bulletin of the Korean Chemical Society
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• v.33 no.7
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• pp.2378-2380
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• 2012

• Bulletin of the Korean Chemical Society
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• v.31 no.12
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• pp.3826-3829
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• 2010

• Bulletin of the Korean Chemical Society
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• v.27 no.1
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• pp.59-64
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• 2006

Unlike other viral polymerases, HCV RNA-dependent RNA polymerase (RdRp) has not been successfully inhibited by nucleoside analogues presumably due to its strong substrate specificity for RNA. Thus, in order to understand the RNA-specificity of HCV RdRp, the structural characteristics of the active site was investigated. The hereto unknown 2-OH binding pocket at the active site of RdRp provides invaluable implication for the development of novel anti-HCV nucleoside analogues.

• Proceedings of the Korean Biophysical Society Conference
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• 1999.06a
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• pp.33-33
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• 1999

Mastoparan B (MP-B), an antimicrobial cationic tetradecapeptide amide isolated from the venom of the hornet Vespa basalis, is an amphiphilic ${\alpha}$-helical peptide. In order to study the relationship between the structure and biological activity, we used the three analogues by replacing amino acids with alanine (4LysAla： 4MP-B, 12-LYsAla: 12MP-B, 9TrpAla: 9Mp-B).(omitted)

• Bulletin of the Korean Chemical Society
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• v.5 no.3
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• pp.97-100
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• 1984

Two novel malyngolide analogues, (${\pm}$)-dehydromalyngolide and (${\pm}$)-isomalyngolide, of (-)-malyngolide antibiotic have been synthesized by application of our previously developed synthetic sequence for the synthesis of (${\pm}$)-malyngolide. Dehydromalyngolide was synthesized from the known lactone (4) in a 55 % overall yield in six steps, while isomalyngolide was synthesized from the readily available keto ester (11) in a 56 % overall yield in four steps.