• Title/Summary/Keyword: Amphiphilic copolymer

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Enhanced Hydrophilicity of Polyethersulfone Membrane by Various Surface Modification Methods (다양한 표면개질을 이용한 폴리에테르설폰 막의 친수성 향상)

  • Park, So Jung;Hwang, Jun Seok;Choi, Won-Kil;Lee, Hyung Keun;Huh, Kang Moo
    • Polymer(Korea)
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    • v.38 no.2
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    • pp.205-212
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    • 2014
  • Polyethersulfone (PES) membranes were modified by various physico-chemical modification methods to enhance the surface hydrophilicity for application as a separation membrane to separate and collect water vapor from the flue gas. Homogeneous PES flat-sheet membranes were prepared and modified by acid treatment, blending and plasma treatment for hydrophilic surface modification. The surface characteristics of the modified PES membranes were evaluated by ATR-FTIR, XPS, SEM and contact angle measurements. No significant change in hydrophilicity was observed for the PES membranes modified by acid treatment with sulfuric acid or blending with various compositions of poloxamer as an amphiphilic PEO-PPO-PEO tri-block copolymer. On the other hand, Ar plasma treatment led to a significant increase in the hydrophilicity of the surface, depending on the plasma treatment time. As a result, the PES membrane could be the most efficiently surface-treated by applying the plasma treatment for enhancing their surface hydrophilicity.

Preparation and Characterization of PEG-PLA(PLGA) Micelles for Solubilization of Rosiglitazone (Rosiglitazone 가용화를 위한 PEG-PLA(PLGA) 고분자 미셀의 제조 및 특성분석)

  • Kim, Yon-Hwan;Im, Jeong-Hyuk;Min, Hyun-Su;Kim, Jun-Ki;Lee, Yong-Kyu;Park, Go-Eun;Cho, Kwang-Jae;Huh, Kang-Moo
    • Polymer(Korea)
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    • v.34 no.3
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    • pp.274-281
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    • 2010
  • In this study, PEG-PLA(or PLGA) amphiphilic di-block copolymers were synthesized by ring opening polymerization of D,L-lactide(or glycolide) and applied to polymeric micelle system for solubilization of a rosiglitazone as diabetes drug. The drug could be efficiently loaded into the polymer micelle by solid dispersion technique, and the drug-loaded micelles were characterized and evaluated as a drug delivery carrier by fluorescence spectrometer, DSC, and DLS measurements. The colloidal stability of drug loaded micelles in aqueous media could be enhanced by addition of 2-hydroxy-N-picolylnitinamide as a hydrotropic agent. The polymer micelles also showed biocompatible and nontoxic properties in vitro cell viability using MTT assay, and the drug loaded micelles were observed to be more effective than free drug for decreasing glucose in blood of rats.