• Structural Engineering and Mechanics
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• 제33권2호
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• pp.113-136
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• 2009

The seismic induced interaction between multistory structures with unequal story heights (inter-story pounding) is studied taking into account the local response of the exterior beam-column joints. Although several parameters that influence the structural pounding have been studied sofar, the role of the joints local inelastic behaviour has not been yet investigated in the literature as key parameter for the pounding problem. Moreover, the influence of the infill panels as an additional parameter for the local damage effect of the joints on the inter-story pounding phenomenon is examined. Thirty six interaction cases between a multistory frame structure and an adjacent shorter and stiffer structure are studied for two different seismic excitations. The results are focused: (a) on the local response of the critical external column of the multistory structure that suffers the hit from the slab of the adjacent shorter structure, and (b) on the local response of the exterior beam-column joints of the multistory structure. Results of this investigation demonstrate that the possible local inelastic response of the exterior joints may be in some cases beneficial for the seismic behaviour of the critical column that suffers the impact. However, in all the examined cases the developing demands for deformation of the exterior joints are substantially increased and severe damages can be observed due to the pounding effect. The presence of the masonry infill panels has also been proved as an important parameter for the response of the exterior beam-column joints and thus for the safety of the building. Nevertheless, in all the examined inter-story pounding cases the presence of the infills was not enough for the total amelioration of the excessive demands for shear and ductility of the column that suffers the impact.

• 농업과학연구
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• 제18권1호
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• pp.80-92
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• 1991

Since the first five-year economic plan starting in 1962, Korea has pursued the policy of economic growth emphasing on the export-oriented industrialization. As a result of export-oriented industrialization, national economy, as a whole, has leveled up. But growth gap between rural and urban area became widened due to declining agricultural sector. Therefore, at this time, development policy for the agriculture should be changed into the broader plan including the welfare of rural residents in order to improve their living conditions. The results of this study are summarized as follows ; 1. The results of survey shows that only 15.5% of rural residents satisfy their rural lives and that 62.8% of residents want to leave their town. Difficulty of educating their children in rural area is found to be major reasons for moving out 2. The results of surveying the demand for rural development by rural residents are figured as follows ; (1) Industrial-economic development - Agricultural development : 38.4% - Rural industrialization development : 23.4% - Farm machinization : 162% (2) Social development for rural residents - Improvement of rural welfare : 33.4% - Expansion rural organization for development : 25.8% - Improvement of educational circumstances : 20.1% (3) Living conditions - Amelioration of community and housing facilities : 55.1% - Disposal facilities for trash : 20.5% As the surveying results show, it can be concluded that rural residential area development project must be enforced to meet demand for the development for rural residents.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4393-4402
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• 2012

Colon cancer is the third most common malignant neoplasm in the world and it remains an important cause of death, especially in western countries. The toxic environmental pollutant, 1, 2-dimethylhydrazine (DMH), is also a colon-specific carcinogen. Tannic acid (TA) is reported to be effective against various types of chemically induced toxicity and also carcinogenesis. In the present study, we evaluated the chemopreventive efficacy of TA against DMH induced colon toxicity in a rat model. Efficacy of TA against the colon toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities, lipid peroxidation, histopathological changes and expression of early molecular markers of inflammation and tumor promotion. DMH treatment induced oxidative stress enzymes (p<0.001) and an early inflammatory and tumor promotion response in the colons of Wistar rats. TA treatment prevented deteriorative effects induced by DMH through a protective mechanism that involved reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression levels and TNF-${\alpha}$ (p<0.001) release. It could be concluded from our results that TA markedly protects against chemically induced colon toxicity and acts plausibly by virtue of its antioxidant, anti-inflammatory and antiproliferative activities.

• Journal of Microbiology and Biotechnology
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• 제28권1호
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• pp.95-104
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• 2018

Biosurfactants or microbial surfactants are surface-active biomolecules that are produced by a variety of microorganisms. Biodegradability and low toxicity have led to the intensification of scientific studies on a wide range of industrial applications for biosurfactants in the field of environmental bioremediation as well as the petroleum industry and enhanced oil recovery. However, the major issues in biosurfactant production are high production cost and low yield. Improving the bioindustrial production processes relies on many strategies, such as the use of cheap raw materials, the optimization of medium-culture conditions, and selecting hyperproducing strains. The present work aims to obtain a mutant with higher biosurfactant production through applying mutagenesis on Bacillus subtilis SPB1 using a combination of UV irradiation and nitrous acid treatment. Following mutagenesis and screening on blood agar and subsequent formation of halos, the mutated strains were examined for emulsifying activity of their culture broth. A mutant designated B. subtilis M2 was selected as it produced biosurfactant at twice higher concentration than the parent strain. The potential of this biosurfactant for industrial uses was shown by studying its stability to environmental stresses such as pH and temperature and its applicability in the oil recovery process. It was practically stable at high temperature and at a wide range of pH, and it recovered above 90% of motor oil adsorbed to a sand sample.

• 한국산학기술학회논문지
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• 제16권7호
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• pp.4798-4804
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• 2015

본 연구는 지역사회에 거주하는 치매환자에게 인지작업치료 프로그램을 적용한 후 인지기능과 우울, 수부기능에 대한 효과를 알아보고자 하였다. 연구방법은 2012년 9월에서 12월까지 일개광역지역 소재 요양원에 입소한 환자를 중심으로 실험군 12명, 대조군 9명의 전체 21명을 대상으로 10주 동안 신체활동을 포함한 현실인식 훈련, 점진적 단어소실기법, 수공예를 이용한 작업치료 중심의 인지프로그램을 실시하였다. 실험군에서 인지기능, 우울정도, 수부근력과 수부조화운동에서 치료 전에 비해 치료 후에 유의한 호전을 보였다(p<.05). 그 결과 본 인지작업치료프로그램은 치매환자에서 우울감소와 수부근력 및 수부조화운동, 인지기능 회복을 위한 유용한 중재적 방법으로 생각된다. 치매는 주로 증상을 호전시키는 것이 목적이기 때문에 조기발견과 조기중재를 통해서 환자의 잔존기능 유지와 사회복귀를 위한 다양한 인지 훈련 프로그램의 개발이 필요하다.

• Journal of Microbiology and Biotechnology
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• 제27권4호
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• pp.660-667
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• 2017

PineXol, extracted from Korean red pine bark, has beneficial effects, such as antioxidant, antiinflammatory, and antilipogenic activities in vitro. We tested the hypothesis that PineXol supplementation could have anti-obesity effects on mice fed a high-fat diet (HFD). Four-week-old male C57BL/6 mice were fed normal chow (18% kcal from fat) or a HFD (60% kcal from fat). HFD-fed animals were also subjected to PineXol treatment at a dose of 10 or 50 mg/kg body weight (BW) (PX10 or PX50, respectively) body weight. The body weight and body fat mass in the PX50 group were statistically lower than those in the HFD group (p < 0.05 and p < 0.001, respectively). The concentration of hepatic triglycerides, total cholesterol, and low-density lipoprotein cholesterol were reduced in the PX50 group compared with the HFD group (p < 0.01). Acetyl CoA carboxylase (p < 0.01), elongase of very long chain fatty acids 6 (p < 0.01), stearoyl CoA desaturase 1 (p < 0.05), microsomal triglyceride transfer protein (p < 0.01), and sterol regulatory element-binding protein 1 (p < 0.05) were significantly decreased in the PX50 group compared with that in the HFD group. In white adipose tissue, CCAAT-enhancer-binding protein alpha (p < 0.05), peroxisome proliferator-activated receptor gamma (p < 0.001), and perilipin (p < 0.01) were decreased in the PX50 group compared with those in the HFD group. Therefore, the current study implies the potential of PineXol for the prevention and/or amelioration of obesity, in part by inhibition of both hepatic lipid synthesis and adipogenesis in white adipose tissue.

• 한국전문물리치료학회지
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• 제27권2호
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• pp.126-132
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• 2020

Background: Augmented somatosensory feedback stimulates the mechanoreceptor to deliver information on bodily position, improving the postural control. The various types of such feedback include ankle-foot orthoses (AFOs) and vibration. The optimal feedback to mitigate postural sway remains unclear, as does the effect of augmented somatosensory feedback on muscle co-contraction. Objects: We compared postural sway and ankle muscle co-contraction without feedback (control) and with either of two forms of somatosensory feedback (AFOs and vibration). Methods: We recruited 15 healthy subjects and tested them under three feedback conditions (control, AFOs, vibration) with two sensory conditions (eyes open, or eyes closed and the head tilted back), in random order. Postural sway was measured using a force platform; the mean sway area of the 95% confidence ellipse (AREA) and the mean velocity of the center-of-pressure displacement (VEL) were assessed. Co-contraction of the tibialis anterior and gastrocnemius muscles was measured using electromyography and converted into a co-contraction index (CI). Results: We found significant main effects of the three feedback states on postural sway (AREA, VEL) and the CI. The two sensory conditions exerted significant main effects on postural sway (AREA and VEL). AFOs reduced postural sway to a level significantly lower than that of the control (p = 0.014, p < 0.001) or that afforded by vibration (p = 0.024, p < 0.001). In terms of CI amelioration, the AFOs condition was significantly better than the control (p = 0.004). Vibration did not significantly improve either postural sway or the CI compared to the control condition. There was no significant interaction effect between the three feedback conditions and the two sensory conditions. Conclusion: Lower-extremity devices such as AFOs enhance somatosensory perception, improving postural control and decreasing the CI during static standing.

• 대한수의학회지
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• 제34권3호
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• pp.619-626
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• 1994

The purpose of present study was to examine pharmacological effect of Artemisia Iwayomogi methanol extract(AIME) on biochemical parameters(activities of AST, ALT, LDH, and ALP, contents of total bilirubin, total protein, albumin and A/G ratio in serum and levels of hepatic microsomal lipid peroxide and glucose-6-phosphatase activities) against hepatic injury by carbon tetrachloride($CCl_4$) in rats. Increased AST, ALT and LDH activities by $CCl_4$ were decreased in AIMS treatment group at 48 or 72 hours. Together, increased ALP activity by $CCl_4$ almost returned toward normal value in AIME treatment group at 72 hours. Serum total bilirubin contents increased to 87, 79 and 31% compared with normal group by $CCl_4$ which were decreased to 64, 42 and 26% in AIME treatment group at 24, 48 and 72 hours, respectively. Decreased contents of total protein and albumin, and A/G ratio by $CCl_4$ were recovered in AIME treatment group. Hepatic microsomal lipid peroxide levels(nmol malonic dialdehyde/100mg protein) increased to 140, 95 and 78% compared with normal group by $CCl_4$ which were decreased to 107, 74 and 65% in AIME treatment group at 24, 48 and 72 hours, separately. Hepatic microsomal glucose-6-phosphatase activities decreased to 60, 50 and 53% compared with normal group by $CCl_4$ at 24, 48 and 72 hours, respectively, which were increased at 72 hours in AIME treatment group. In conclusion, AIME enhanced the amelioration process from $CCl_4$-induced lipid peroxidation, degeneration of liver cell, and impairment of protein and bilirubin metabolisms.

• 대한수의학회지
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• 제48권4호
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• pp.413-421
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• 2008

It was previously found that PG102, a water-soluble extract derived from Actinidia arguta, was able to modulate Th1/Th2 pathways and suppress IgE production resulting in dramatic amelioration of atopic dermatitis in NC/Nga mouse and hairless rat models. In order to evaluate the subacute toxicity of PG102, female and male SD rats were daily fed with various doses of PG102 for 4 weeks. Six week old SD rats were randomly divided into 4 groups and orally administrated with 100-, 300-, and 1,000- mg/kg of PG102 as well as the vehicle only. At the end of the study, no significant differences in the body and organ weights were observed between control and treated rats of both genders. Hematological and blood chemical analysis showed little differences between the animal groups. Neither gross abnormalities nor histopathological changes were found. PG102 produced little or no subacute toxicity and could be used as a safe nutraceutical for the treatment of individuals with allergic diseases including atopic dermatitis.

• Journal of Nutrition and Health
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• 제16권4호
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• pp.253-262
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• 1983

A survey was undertaken to investigate relationship between nutritional status and physical growth and behavior of school children. Dietary intakes, environmental factors, physical growth, personality, and cognitive development were measured in 323 children of 4 th and 6th grader in the urban and rural arcas. The results are summarized as follows : 1) The average intakes of the food groups and nutrients except ascorbic acid were lower in rural children. Comparing the intakes of the rural children with RDA of the Korean children, 64.0% of them in protein, 99.3% in calcium, 84.6% in iron, and 73.5% in riboflavin consumed less than 75% of RDA. Environmental factors were significantly related to the nutrient intakes 2) Height, weight, and head circumference were significantly related to the nutrient intakes. Retarded growth due to malnutrition was supposed in the $rural^{1)}$ area. 3) Some domains of personality were significantly related to nutrient intakes. 4) Environmental factors, physical growth, and nutrient intakes made independent contribution to variation in cognitive performance and their relative importance depended on the particular cognitive domain when stepwise multiple regression analyses were undertaken. Environmental stimulation was largely associated with verbal usage, and economic status and nutrient intakes with numerical reasoning. Above findings support that nutritional deprivation retards brain growth and performance on various cognitive dimensions of children. Therefore, amelioration of the several adverse social, economical, environmental influences as well as the improvement of dietary intake is required to bring about a substantial enhancement of the physical growth and the mental development of children.