• Asian Pacific Journal of Cancer Prevention
• /
• 제13권6호
• /
• pp.2775-2780
• /
• 2012

In recent years there has been a substantial increase in the use of functional foods for disease control. Fruits and vegetables produce phytochemicals such as flavonoids and antioxidants which can lower oxidative stress and reduce the risk of chronic ailments like cancer. The aim of the present study was to investigate the antioxidant capacity and the possible protective effects of Amaranthus paniculatus leaves on the antioxidant defense system in Ehrlich's ascites carcinoma (EAC)-treated mice. Oral administration of the leaf extract at different doses caused a significant decrease in tumor volume, viable cell count and tumor weight and elevated the life span of EAC bearing mice. It also showed an improved antioxidant potential as evidenced by a significant increase in the cellular antioxidant defense system such as catalase, superoxide dismutase and reduced glutathione and also significantly reduced the levels of TBARS. The levels of RBC, hemoglobin and lymphocyte count were altered in EAC bearing mice and were reverted back to near normal levels after the treatment with the leaf extracts. Their adequate content of total phenolics and flavonoids, DPPH scavenging activity which further suggests that the extracts exert a significant protection against oxidative stress conditions.

• 한국식품과학회지
• /
• 제21권4호
• /
• pp.511-514
• /
• 1989

야생식용 산채류인 이고들빼기와 개비름의 휘발성 풍미성분을 수증기 증류법으로 추출하여 GC와 GC-GMS 조합에 의하여 분석하였다. 이고들빼기에서는 alcohols류 10종, esters류 2종, aldehydes류 6종, ketones류 5종, hydrocarbons류 3충, acids류 2종 및 기타 3종의 총 31성분이 확인되었다. 개비름에서는 alcohols류 12종, esters류 4종, aldehydes류 5종, ketones류 9종, hydrocarbons류 7종, acids류 3종, phenols 2종 및 기타 6종으로 총 48성분이 확인되었다.

• Journal of Plant Biotechnology
• /
• 제49권1호
• /
• pp.99-105
• /
• 2022

This study assessed the antioxidant and anti-inflammatory activities of leaf extracts from grain amaranths (Amaranthus spp.). Among all the extracts, the ethanol extract of Amaranthus cruentus leaves (Ar) exhibited the highest antioxidant activity, including the DPPH free radical scavenging activity and ORAC. In addition, Ar strongly inhibited nitric oxide production by suppressing the MEK/ERK signaling pathway in lipopolysaccharide-stimulated RAW264 murine macrophages. HPLC analysis revealed 13 polyphenolic compounds in the leaf extracts of grain amaranth and indicated that Ar contained more rutin than the other extracts. Taken together, these results show the impact of species diversity on the phytochemical contents and bioactivities of plant extracts and suggest that the nonedible parts, such as leaves, of A. cruentus should be considered for use as crude drugs and dietary health supplements.

• 환경생물
• /
• 제34권4호
• /
• pp.240-245
• /
• 2016

본 연구에서 외래식물인 청비름(Amaranthus viridis L.)의 현재의 잠재 서식지와 RCP 4.5와 RCP 8.5에 의한 미래의 분포 확산을 MaxEnt 모델을 활용하여 예측하였다. 청비름의 잠재 서식지는 연평균기온, 고도, 12월의 강수량의 환경변수가 85% 이상의 기여도를 보여 가장 중요한 변수로 분석되었고 AUC도 0.95로 모형의 설명력이 높게 나타났다. 제주도와 남해안 및 중남부 서해안을 중심으로 분포하고 있는 청비름은 RCP 4.5에서는 확산이 크게 나타나지 않으나, RCP 8.5 시나리오는 잠재 서식지가 전국으로 확산되는 것으로 나타났고 현재에 비하여 2090년대 잠재 서식지 비율이 약 4.8배 증가하는 것으로 분석되었다. 이러한 시나리오 별 차이는 향후 청비름의 확산이 기후변화 양상에 따라 가변적일 수 있음을 보여준다. 청비름은 많은 종자 생산과 차량의 이동이나 사람의 이동 중에 쉽게 확산되는 특성이 있어 잠재서식지 비율의 증가는 실제 확산으로 이어질 수 있을 것으로 파악된다. 빠르게 확산될 수 있을 것이다. 같은 비름속의 개비름과 가는털비름은 이미 전국에 분포하고 있어 관리가 어려운 실정이고 기후변화에 의한 온도 상승은 청비름 또한 전국적으로 확산될 가능성을 가지고 있어 장기적인 관심과 관리기술 개발이 필요한 시점이다. 본 연구에서 수행한 지역별 예측은 향후 관리 계획 설정 등에 활용 가능할 것으로 판단된다.

• 한국작물학회:학술대회논문집
• /
• 한국작물학회 2019년도 추계학술대회
• /
• pp.165-165
• /
• 2019

• 생명과학회지
• /
• 제6권1호
• /
• pp.1-5
• /
• 1996

Using differential hybridization, a cDNA clone was isolated fortuitously from Amaranthus viridis and sequenced. This nucleotide sequence exhibited 55.1% identity with vma6 which encodes the 36-kD subunit of the vacuolar proton transporting ATPase in Saccharmoyces cerevisiae. The predicted open reading frame encodes a protein of 221 amino acid sequence with a calculated molecular weight of 25,452 and reveals high levels of similarity with subunit D polypeptide of vacuolar H -ATP(e.g., 48.5, 52.1 and 49.3% identity to the vacuolar 36-kD chain of yeast, vacuolar 32-kD polypeptide IV of human and vacuolar 28-kD protein of bovine chromaffin granules, respectively). The hydropathy index computation revealed that this predicted protein is a peripheral protein. These results indicated that the predicted protein may play a sturctural role in the vaculor H -ATPase as does gamma subunit in V-type ATPase.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2000년도 춘계총회 및 학술대회
• /
• pp.179.2-179.2
• /
• 2000

• Applied Biological Chemistry
• /
• 제37권6호
• /
• pp.516-521
• /
• 1994

새로운 17종의 imazapyr 유도체인 3-(N-methyl-N(X)-치환-phenylaminooxoacetyl)-2-(4-isopropyl-5-oxo-2-imidazoline-2-yl)pyridine, 6을 합성하고 3-(N-methyl-N(X)-치환-phenylaminooxoacetyl group중의 X-치환기 변화에 따른 구조와 옥수수(Zea mays L.)와 참비듬(Amaranthus viridis L.)에 대한 발아 전의 제초활성에 미치는 관계(SAR)를 검토 한 바, 옥수수의 경우에는 MR상수의 적정값(optimal value)이 $5.56\;cm^3/mol$이었으므로 이 값보다 크거나 작을수록 제초활성이 작았다. 참비듬의 경우에는 $L_1$상수의 적정값이 3.34 A이므로 이 값에 가까울수록 제초활성이 클 것임을 알 수 있었다. 특히, 2,5-difluoro group 치환체, 6i는 참비듬에 가장 큰 제초활성을 나타내었으나 옥수수에는 가장 작은 제초활성을 미치므로써 현저하게 두 초종간에 선택성을 나타내는 화합물이었다.

• Journal of Microbiology and Biotechnology
• /
• 제25권6호
• /
• pp.795-802
• /
• 2015

This study investigates the bioactivity of tannin from amaranth (Amaranthus caudatus L.) extracts. The antioxidant activities of the extracts from amaranth leaves, flowers, and seeds were evaluated. Tannin from leaves of amaranth has been evaluated for superoxide scavenging activity by using DPPH and ABTS⁺ analysis, reducing power, protective effect against H₂O₂-induced oxidative damage in L-132 and BNL-CL2 cells, and inhibition of superoxide radical effects on HL-60 cells. At a concentration of 100 µg/ml, tannin showed protective effects and restored cell survival to 69.2% and 41.8% for L-132 and BNL-CL2 cells, respectively. Furthermore, at the same concentration, tannin inhibited 41% of the activity of the superoxide radical on HL-60 cells and 43.4% of the increase in nitric oxide levels in RAW 264.7 cells. The expression levels of the antioxidant-associated protein SOD-1 were significantly increased in a concentration-dependent manner in RAW 264.7 cells treated with tannin from amaranth leaves. These results suggest that tannin from the leaves of Amaranthus caudatus L. is a promising source of antioxidant component that can be used as a food preservative or nutraceutical.

• 한국작물학회:학술대회논문집
• /
• 한국작물학회 2022년도 추계학술대회
• /
• pp.294-294
• /
• 2022

To date, there have been no reports on the cloning and characterization of a gene encoding SQS from Amaranthus, although there have been some reports on methods of extracting and purifying squalene from Amaranthus seeds. In this study, we monitored the expression pattern of the amaranth SQS gene in seeds at different developmental stages and in different tissues. The transcript expression pattern of the SQS gene was investigated using total RNA isolated from seeds at different stages of development. There were low levels of SQS transcripts at the early stage of seed development, and the levels remained low until the middle developmental stage. The expression of SQS increased rapidly to reach a peak at the mid-late developmental stage, and then declined dramatically. This pattern of expression was consistent with the results of RT-PCR analyses. All RNA samples generated a fragment of the expected size (183-bp). The amaranth SQS was expressed at low levels during the initial to middle stages of seed development, and its expression level increased at the mid-late development stage. Also The tissue-specific expression of amaranth SQS was determined by quantifying its mRNA in total RNA isolated from the leaves, petioles, stems, and roots of seedlings at the four- and six-leaf stages. Using qRT-PCR and RT-PCR analysis, we detected amaranth SQS transcripts in some of the tissues at the six-leaf stage, but in none of the tissues from plants at the four-leaf stage. SQS transcripts accumulated in almost equal amounts in stems and roots, while a lower level accumulated in leaves and petioles during seedling development at the four- to six-leaf stages. This study provides useful information about the molecular characterization of the SQS clone isolated from grain amaranth. A basic understanding of these characteristics will contribute to further studies on the amaranth SQS.