• The Journal of Korean Medical History
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• v.22 no.1
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• pp.47-55
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• 2009

The Sa-am acupuncture is the acupuncture method created during Chosun Dynasty. It is a unique acupuncture method that was created solely in Korea. Its theories are based on the 69th article of "Classic of Difficult Issues", or Nanjing (難經), which says "tonify its mother when deficiency occurs, and purgate its son when excess occurs" (虛則補其母, 實則瀉其子); the concept of "controlling the viscera which restrains the target" "抑其官" was added to this theory to form the principle of Sa-am acupuncture. It is significant that it turns to the basic principles of the Five Viscera and Six Bowels rather than the 體針 or 阿是針 of the existing acupuncure. Sa-am acupuncture was established in the middle of Chosun Dynasty and was popularized to the practitioners of Korean Medicine through transcripts and printed books. The medical books of at the time of Japanese imperialism that introduced Sa-am acupuncture are "經絡學總論", "舍岩鍼灸訣", "經濟要訣", "靑囊訣", "察病要訣", "濟世寶鑑", "經驗寢具編", and "舍岩 靑囊訣". The magazine that mentions the Sa-am acupuncture is "韓方醫藥". The books on Traditional Medicine that is related to Sa-am acupuncture were of great help in reconstruction of Sa-am acupuncture after the liberation of Korea and explaining the principle of Sa-am acupunture in various angles.

• Journal of Microbiology and Biotechnology
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• v.14 no.1
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• pp.121-127
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• 2004

Amphotericin B (AmB), an amphipathic polyene macrolide, is an antifungal drug produced by Streptomyces nodosus. Recently, AmB has been shown to exert antiviral activity against rubella virus and human immunodeficiency virus by different mechanisms. In this study, we evaluated the antiviral effect of AmB against Japanese encephalitis virus (JEV) and investigated which step of the viral life cycle was inhibited by AmB to understand the mechanism of antiviral action of AmB. AmB reduced both plaque size and number in the infected cells in a dose-dependent manner. In addition, a 200-fold reduction of infectious virus titer was observed by treatment of infected cells with $5\mug/ml$ of AmB. AmB acted at the post virus-infection step, but not during adsorption of virus to host cells. Western blot analysis revealed that the accumulated level of JEV envelope protein dramatically decreased in the infected cells by treatment with $5-10\mug/ml$ of AmB. Our results indicate that AmB inhibits the replication of JEV at the postinfection step by interfering with viral replication and/or by inhibiting the synthesis of viral proteins.

• The Korea Journal of Herbology
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• v.38 no.1
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• pp.45-53
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• 2023

Objectives : Network pharmacology-based research is one of useful tool to predict the possible efficacy and molecular mechanisms of natural materials with multi compounds-multi targeting effects. In this study, we investigated the functional underlying mechanisms of Astragalus membranaceus Bunge (AM) on its anti-obesity effects using a network pharmacology analysis. Methods : The constituents of AM were collected from public databases and its target genes were gathered from PubChem database. The target genes of AM were compared with the gene set of obesity to find the correlation. Then, the network was constructed by Cytoscape 3.9.1. and functional enrichment analysis was conducted to predict the most relevant pathway of AM. Results : The result showed that AM network contained the 707 nodes and 6867 edges, and 525 intersecting genes were exhibited between AM and obesity gene set, indicating that high correlation with the effects of AM on obesity. Based on GO biological process and KEGG Pathway, 'Response to lipid', 'Cellular response to lipid', 'Lipid metabolic process', 'Regulation of chemokine production', 'Regulation of lipase activity', 'Chemokine signaling pathway', 'Regulation of lipolysis in adipocytes' and 'PPAR signaling pathway' were predicted as functional pathways of AM on obesity. Conclusions : AM showed high relevance with the lipid metabolism related with the chemokine production and lipolysis pathways. This study could be a basis that AM has promising effects on obesity via network pharmacology analysis.

• International Journal of Contents
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• v.2 no.4
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• pp.1-7
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• 2006

The goal of Ambient Intelligence (AmI) is to build a smart environment for users where they are supported in some of their activities by many interaction mechanisms. The diversity of AmI characteristics requires special support from Operating Systems (OSes). In this paper, in order to support a conscious choice of an operating system for any specific AmI application, features requested by AmI systems were characterized and defined considering various applications. Then, characteristics of existing Operating Systems have been investigated in the context of AmI application support to relate their key characteristics to the typical requirements of AmI systems. Qualitative mapping table between AmI characteristics and as features has been proposed with an illustration of how to use it. As no as completely covers the range of characteristics required by AmI systems, challenging issues are summarized for the development of a new as and a product line of OSes.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05c
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• pp.559-564
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• 1996

다작용기 유기인산 추출제인 octyl(phenyl)-N, N-diisobutyl carbamoylmethylphosphine oxide(CMPO)의 Am(III)에 대한 추출특성을 조사하였다. 0.2M CMPO-1.4M TBP/n-dodecane 추출제, 추출온도 30 $^{\circ}C$, 수용액의 질산농도 2M인 조건에서 Am(III)은 95.8%가 추출되었다. CMPO 추출제에 첨가되는 TBP 농도가 0.5M 까지는 Am(III)의 추출율이 감소시키는 영향을 나타냈으나, 0.5M 이상인 영역에서는 Am(III) 추출율에 미치는 영향이 작게 나타났다. 그리고 Am(III) 추출에 미치는 옥살산농도의 영향은 옥살산농도가 증가할수록 Am(III)의 추출율이 감소하였으며 추출온도가 높을수록 Am(III) 추출율이 감소하는 실험결과를 얻었다. CMPO 추출제는 제 3상을 매우 잘 형성하여 특징을 나타냈으며 이를 방지할 수 있는 조건을 규명하였다.

• Journal of the Korean Geographical Society
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• v.49 no.5
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• pp.716-727
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• 2014

Yeon-Am's observation of natural objects will be able to contribute to the cultivation of the observation skills. In this study, I analysed Yeon-Am's observation skills in the book "Yorha Ilgi". Yeon-Am's observation skills are as follows. First, Yeon-Am observed a specific and detailed. Second, Yeon-Am was examined by utilizing the five senses and presented its risks and limitations. Third, Yeon-Am observed with the equality between man and nature and looked at the same level of human and nature. Fourth, Yeon-Am expressed those observed by utilizing the shaping techniques vividly. Fifth, Yeon-Am found a variety of features by a variety of perspectives. The orgin of Yeon-Am's writing is based on specific and detailed observations of the natural objects, joining nature, shaping techniques and diversity in perspective.

• YAKHAK HOEJI
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• v.40 no.2
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• pp.202-211
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• 1996

Experiments were performed on male Sprague-Dawley rats to investigate the immunobiological effects on route of administration of amygdalin(AM). Rats were administered orally at 12.5, 25, or 50mg/kg/day of AM or injected wtih 25,50, or 100mg/kg/day of AM intravenously for 2 weeks. Rats were immunized and challenged with sheep red blood cells(SRBC). The results of this study were summarized as follows;(1) In oral administration of AM, body weight gains were significantly increased by 50mg/kg AM as compared with controls, the relative weights of liver and thymus also were significantly increased by 12.5 and 25mg/kg AM. However, 2-mercaptoethanol-resistant hemagglutination titier (2-MER HA), Plaque forming cells (PFC) and rosette forming cells (RFC) were non-dose dependently decreased. Phagocytic activity and delayed-type hypersensitivity (DTH) reaction also were significantly decreased by 50mg/kg AM. (2) In intravenous injection of AM, body weight gains, hemagglutination titer (HA), 2MER-HA, DTH reaction, PFC, RFC and circulating leukocytes were not influenced by AM. However, the relative weights of liver, spleen and thymus were significantly enhanced 100mg/kg AM. These results indicated that oral administration of AM non-dose dependently suppresses humoral and cell-mediated immunity in SD rats, and that intravenous injection of AM is unaffected humoral and cell-mediated immunity, however, the high dose of it significantly enhances phagocytic activity.

• The Korean Journal of Mycology
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• v.22 no.2
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• pp.160-171
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• 1994

Microscopic observations of arbuscular mycorrhizae (AM) were done with the colonizations of AM and the determinations of chitin in the plant roots of Sorghum bicolor, Cassia mimosoides, Capsicum annuum and Allium fistulosum. The intercellular and intracellular hyphae, arbuscules and vesicles were microscopically observed, according to increases of colonization of AM in the roots of four plants. The growth of AM fungi appeared sigmoid with the cultivation days after inoculation. The growth of AM fungi were inversely influenced by the additions of commercial fertilizers, P

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.6
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• pp.313-327
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• 2017

The purpose of this study is to predict the effects of macroscopic and integrative therapies by finding active ingredients, potential targets of Astragalus membranaceus (Am) and Cornus officinalis (Co) for diabetic nephropathy. We have constructed network pharmacology-based systematic and network methodology by system biology, chemical structure, chemogenomics. We found several active ingredients of Astragalus membranaceus (Am) and Cornus officinalis (Co) that were speculated to bind to specific receptors which had been known to have a role in the progression of diabetic nephropathy. Four components of Am and eleven components of Co could bind to iNOS; two ingredients of Am and six ingredients of Co could docking to cGB-PDE; one component of Am and nine components of Co could bind to ACE; three ingredients of Co with neprilysin; three components of Co with ET-1 receptor; four ingredients of Am and fourteen ingredients of Co with mineralocorticoid receptor; one component of Am and seven components of Co with interstitial collagenase; one ingredient of Am and ten ingredients of Co with membrane primary amine oxidase; one component of Am and four components of Co with JAK2; two ingredients of Am and one ingredient of Co with MAPK 12; one component of Am and five components of Co could docking to TGF-beta receptor type-1. From this work we could speculate that the possible mechanisms of Am and Co for diabetic nephropathy are anti-inflammatory, antioxidant and antihypertensive effects.

• Journal of the Korean Institute of Telematics and Electronics
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• v.10 no.1
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• pp.18-26
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• 1973

In AM detection system, when the ratio of the frequency of the carrier to that of the modulating signal becomes less than a ratio of approximately 10:1, AM detectors become unable to detect the impressed signal in a satisfactory waveform. The failure of detecting such a super wide-band AM signal resulting from charging and discharging transient phenomena in associated diode circuit during the detecting of AM signal, has been a cause of limiting the channel capacity in AM or FM super multiplexing systems. This Paper presents the "Poly-phase Envelope Detection System" as a suitable method to solve the problem and the analyses of the system suggested. This system will make it possible to take the envelope out of the impressed AM signal to any desired degree of accuracy even when the ratio of the frequency of the carrier to that of the modulating signal approaches unity. Experiments were carried out to verify the validity of the theory of Poly-phase Envelope Detection System by adopting the frequency conversion method from among the two proposals.proposals.