• Journal of Environmental Health Sciences
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• v.49 no.1
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• pp.11-21
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• 2023

Background: The need to develop alternative chemicals is increasing worldwide due to the strengthening of global chemical regulations and consumer safety awareness in the marketplace. Objectives: We aimed to review domestic and foreign technology trends for exploring alternative candidate algorithms that can be used to develop safer alternatives to strengthen global market competitiveness and protect public health in the future. Methods: We searched the current status of research trends, companies related to the development of alternative chemicals in domestic and foreign countries. For this, we referred to research papers and websites by companies and institutes related to such alternatives. Results: Among the domestic and foreign research trends, more studies in South Korea were focused on predicting molecular-based physicochemical properties and toxicity than were reporting on research exploring alternative candidates. Three web-based databases and six tools were being developed. More studies in other countries predicted information to consider in alternative development than reported on research exploring alternative candidates, and four web-based databases and three tools were being developed. Among the companies related to the development of alternative chemicals, 286 alternatives classified as 'EVALUATED ALTERNATIVE' in MARKETPLACE accounted for the most significant proportion in Europe on a continent basis, and the largest number in the United States (US) on a national basis. In South Korea, only significant companies were registered. Conclusions: In this study, it was found to be necessary to provide public technology support platforms to explore alternative candidates considering various aspects in order to support alternative development. In conclusion, exploring alternative candidate algorithms could contribute to the response to the global trends in the chemical industry and to supporting companies and researchers developing safer alternatives in the future.

• Journal of Integrative Natural Science
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• v.6 no.4
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• pp.234-243
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• 2013

N-terminal kinase-like (NTKL) protein was initially identified as a protein binding to protein kinase B (PKB, also known as Akt). Though NTKL-BP1 (NTKL-binding protein 1) has been identified as an NTKL binding protein, its functions related to binding have not yet been elucidated. Here, a new alternative spliced variant of NTKL and its association with integrin ${\beta}1$ is described, in addition to the kinase activity of NTKL and its substrate candidates. Although the phosphorylation of the candidates must be further confirmed using other experimental methods, the observation that NTKL can phosphorylate ROCK1, DYRK3, and MST1 indicates that NTKL may act as a signaling protein to regulate actin assembly, cell migration, cell growth, and to facilitate differentiation and development in an integrin-associated manner.

• Journal of Navigation and Port Research
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• v.34 no.1
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• pp.59-64
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• 2010

This study is to determine an optimal marina's construction location candidate among many alternative candidates in order to obtain the maximized efficiency under the natural conditions. To deal with marina's construction location, the optimal construction location is selected using 10 important factor analysis for 10 candidates in Yeosu city. In this paper, the new model to assign the most reasonable alternative is introduced using 0-1 integer programming. This proposed model has not been applied in the optimal marina's facility candidate selection problem yet. This paper will contribute to determine the most reasonable alternative. Also, this proposal model can be applied to other marina's facility candidate selection problem in other regions.

• Journal of KIISE:Computing Practices and Letters
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• v.15 no.4
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• pp.299-303
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• 2009

Patent information search is used for checking existence of earlier works. In patent information search, there are many reasons that fails to get appropriate information. This research proposes a method extracting alternative word candidates in order to minimize search failure due to keyword mismatch. Assuming that two words have similar meaning if they have similar co-occurrence words, the proposed method uses the concept of concentration, association word set, cosine similarity between association word sets and a ranking modification technique. Performance of the proposed method is evaluated using a manually extracted alternative word candidate list. Evaluation results show that the proposed method outperforms the document vector space model in recall.

• Journal of the Korean Society of Marine Environment & Safety
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• v.17 no.4
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• pp.323-329
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• 2011

This study is to determine an optimal yacht mooring location candidate among many alternative candidates in order to obtain the maximized efficiency under the natural conditions using integer programming. To deal with marina's construction location, the optimal construction location is selected using 21 important factors analysis for 4 candidates in the Mokpo city. The development period and the initial investment cost weight are one and half times more than the others among 21 factors. The optimal spiral analysis of weighted linear model shows that the Peace Square sea area is selected as the most optimal place among 4 candidates. This proposed model has not been applied in the optimal marina's facility candidate selection problem yet. This paper will contribute to determine the most reasonable alternative. Also, this proposal model can be applied to other marina's facility candidate selection problem in other regions.

• Journal of Surface Science and Engineering
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• v.36 no.1
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• pp.48-58
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• 2003

This paper will present an overview of toxicity of hexavalent chromium as well as effort for its replacement by a wide spectrum of alternative materials and technologies. Cr-based materials such as trivalent electrodeposit will be one of strong candidates for hard chromium by surface modification of its surface hardness. Ni-base alloy deposits has proved its application in specific mold for glass. HVOF has been studied in aircraft and military sector. There are still under way of development for commercially available alternatives. To date, no single coating has been identified as universal process as comparable to conventional hard chromium electroplating.

• Journal of KIISE:Software and Applications
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• v.36 no.10
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• pp.861-873
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• 2009

There are many reasons that fail to get appropriate information in information retrieval. Allomorph is one of the reasons for search failure due to keyword mismatch. This research proposes a method to construct alternative word candidates automatically in order to minimize search failure due to keyword mismatch. Assuming that two words have similar meaning if they have similar co-occurrence words, the proposed method uses the concept of concentration, association word set, cosine similarity between association word sets and a filtering technique using confidence. Performance of the proposed method is evaluated using a manually extracted alternative list. Evaluation results show that the proposed method outperforms the context window overlapping in precision and recall.

• Journal of Electrical Engineering and Technology
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• v.10 no.3
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• pp.895-904
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• 2015

This paper presents a probabilistic approach of reliability evaluation and economic assessment for solving transmission network expansion planning problems. Three methods are proposed for TNEP, which are reorganizing the existing power system focused on the buses of interest, selecting candidates using modified system operating state method with healthy, marginal and at-risk states, and finally choosing the optimal alternative using cost-optimization method. TNEP candidates can be selected based on the state reliability such as sufficient and insufficient indices, as proposed in this paper. The process of economic assessment involves the costs of construction, maintenance and operation, congestion, and outage. The case studies are carried out with modified IEEE-24 bus system and Jeju island power system expansion plan in Korea, to verify the proposed methodology.

• Ceramist
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• v.21 no.1
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• pp.44-54
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• 2018

Oxide semiconductor has been spotlighted as a channel material of TFTs in AMLCD as an alternative to Si, due to high mobility ( > $5cm^2/Vs$). It is also one of the strong candidates for TFTs in AMOLED because of high bias stability at amorphous phase. Beyond the advantages mentioned above, oxide semiconductor has many strengths such as transparency, low fabrication temperature and relatively low fabrication cost. For those reasons, the application of oxide semiconductor is not limited to display but can be extended to new types of electronics, for example, transient electronics for human implantable devices. From this context, oxide materials that have been used as semiconductor and insulator at transient electronics are investigated respectively, and conductor and substrate candidates are also explained, since transient electronics require systematic consideration beyond individual oxide films.

• Journal of Korean Society for Quality Management
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• v.20 no.1
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• pp.126-135
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• 1992

The decision making process for production planning in FMS usually involves multiple conflicting objectives and criteria. This study consists of prescreening and analytical phase. In the prescreening phase, criteria are used to reduce the set of alternative system configuration down to a small number of candidates. After this phase, a multiobjected programming model is formulated for each remainning configuration.