• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.9
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• pp.1738-1743
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• 2017

This paper presents an efficient image stitching method using preprocessing in order to generate a super resolution image. Two-dimensional (2D) scanners are consistently used in various areas but they have limitations such as paper sizes and materials. To overcome these problem with low-cost, an efficient imaging stitching method is proposed for producing a super resolution panorama image. To scan a very large sized paper using mobile phones, a simple portable cradle which fixes height is employed producing an input image set. To improve matching performance, a preprocessing method is introduced before searching correspondences. Then alpha blending is applied to an input image set to produce a super resolution panorama image. The proposed method is faster and easier than the existing method which is employed by Open CV. Experiment results show that the proposed method is three times faster and performs better than the existing method.

• Imaging Science in Dentistry
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• v.45 no.3
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• pp.141-145
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• 2015

Purpose: This study evaluated the diagnostic accuracy of the reverse contrast mode in intraoral digital radiography for the detection of proximal dentinal caries, in comparison with the original digital radiographs. Materials and Methods: Eighty extracted premolars with no clinically apparent caries were selected, and digital radiographs of them were taken separately in standard conditions. Four observers examined the original radiographs and the same radiographs in the reverse contrast mode with the goal of identifying proximal dentinal caries. Microscopic sections $5{\mu}m$ in thickness were prepared from the teeth in the mesiodistal direction. Four slides prepared from each sample used as the diagnostic gold standard. The data were analyzed using SPSS (${\alpha}=0.05$). Results: Our results showed that the original radiographs in order to identify proximal dentinal caries had the following values for sensitivity, specificity, positive predictive value, negative predictive value, and accuracy, respectively: 72.5%, 90%, 87.2%, 76.5%, and 80.9%. For the reverse contrast mode, however, the corresponding values were 63.1%, 89.4%, 87.1%, 73.5%, and 78.8%, respectively. The sensitivity of original digital radiograph for detecting proximal dentinal caries was significantly higher than that of reverse contrast mode (p<0.05). However, no statistically significant differences were found regarding specificity, positive predictive value, negative predictive value, or accuracy (p>0.05). Conclusion: The sensitivity of the original digital radiograph for detecting proximal dentinal caries was significantly higher than that of the reversed contrast images. However, no statistically significant differences were found between these techniques regarding specificity, positive predictive value, negative predictive value, or accuracy.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.205.1-205.1
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• 2012

러시아 발사체 드네프르에 의해 발사될 과학기술위성 3호의 주탑재체 다목적적외선영상시스템, MIRIS (Multipurpose InfraRed Imaging System)는 한국천문연구원에서 주관하여 개발되었다. 그 구성 카메라인 EOC (Earth Observation Camera)는 한반도재난감시를 수행하고, SOC (Space Observation Camera)는 우리 은하 평면의 근적외선 서베이 관측을 통해 $360^{\circ}{\times}6^{\circ}$ Paschen-${\alpha}$ 방출선 지도를 작성하고 I, H 밴드 필터를 이용해서 황도 남북극에 대한 적외선우주배경복사를 관측한다. MIRIS 비행모델이 제작 완료되었고, 그 구성 기기인 SOC, EOC, 전장박스에 대한 최종 우주환경시험을 수행하였다. 과학기술위성 3호의 비행모델 우주환경시험은 진동시험과 열진공시험으로 이뤄지며, 그 시험 규격은 문서에 규정된 Acceptance Level로 수행된다. 충격시험은 공학인증모델을 통해 검증되었다. 열진공시험은 한국천문연구원에서 수행되었으며, 진동시험은 한국과학기술원 인공위성센터에서 수행되었다. 또한 전체 위성이 조립된 후 과학기술위성 3호의 열진공시험은 한국항공우주연구원에서 수행되었다. 이 발표에서는 MIRIS 비행모델에 대한 환경시험과정 및 결과를 보고하고, 과학기술위성이 전체적으로 조립된 후의 MIRIS 진동 및 열진공 시험 결과도 함께 논의한다.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.1
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• pp.64.1-64.1
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• 2011

MIRIS (Multipurpose Infra-Red Imaging System), is a small infrared space telescope which is being developed by KASI, as the main payload of Science and Technology Satellite 3 (STSAT-3). Two wideband filters (I and H) of the MIRIS enables us to study the cosmic infrared background by detecting the absolute background brightness. The narrow band filter for Paschen ${\alpha}$ emission line observation will be employed to survey the Galactic plane for the study of warm ionized medium and interstellar turbulence. The opto-mechanical design of the MIRIS is optimized to operate around 200K for the telescope, and the cryogenic temperature around 90K for the sensor in the orbit, by using passive and active cooling technique, respectively. The engineering and qualification model of the MIRIS has been fabricated and successfully passed various environmental tests, including thermal, vacuum, vibration and shock tests. The flight model was also assembled and is in the process of system optimization to be launched in 2012 by a Russian rocket. The mission operation scenario and the data reduction software is now being developed. After the successful mission of FIMS (the main payload of STSAT-1), MIRIS is the second Korean space telescope, and will be an important step towards the future of Korean space astronomy.

• Journal of the Korean Society of Physical Medicine
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• v.9 no.2
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• pp.233-242
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• 2014

PURPOSE: The purpose of this study was to determine the correlation between the hip adductor muscles and abdominal muscles during bridge exercise. METHOD: Participants who met the criteria for this study(n=36) were divided into the three groups. The first experimental group performed normal bridge exercises and the second group performed bridge exercises with the contraction of the hip adductor muscles and the control group didn't perform any exercise. Transversus abdominis muscle thickness was measured by ultrasound imaging with a special transducer head device, at pre exercise, after 2 weeks, 4 weeks, and 6 weeks. RESULT: Data were analyzed using repeated ANOVA with the level of significance set at ${\alpha}=.05$. Transversus abdominis muscle thickness was influenced by contraction of the hip adductor muscles during bridge exercise in people without lower back pain. Compared with normal bridge exercise, transversus abdominis muscle thickness significantly increased in thickness during bridge exercise with contraction of the hip adductor muscles(p<.05). CONCLUSION: The results from this study showed that contraction of the hip adductor muscles during bridge exercise increased change in the transversus abdominis muscle thickness. These results can be a good source to prevent low back pain due to hip adductor weakness. Therefore, inducing activation of hip adductor with abdominal stabilizing exercise is more effective in patients with low back pain.

• Imaging Science in Dentistry
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• v.49 no.1
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• pp.65-70
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• 2019

Purpose: To determine whether calcified carotid atherosclerotic plaques(CCAPs) and mineralized laryngeal cartilages (MLCs) were more frequently detected on digital or film-based panoramic radiographs. The clinical relevance of this question is that some radiopacities seen on digital radiographs may correspond to medium-density tissues that are not necessarily mineralized. Materials and Methods: Data were collected from panoramic radiographs and the respective reports issued by 2 private oral radiology centers. A total of 388 radiographs and reports were divided into film-based (group A) and digital (group D) radiographs. The frequencies of CCAPs and MLCs were analyzed using the Fisher exact test, and odds ratios were also calculated (${\alpha}=1%$). Results: The mean age of patients whose reports and radiographs showed CCAPs and/or MLCs ranged from 50.1 to 54.1 years. There was a predominance of females. A higher frequency of CCAPs and MLCs was observed in group D than in group A at both centers(P<0.01). CCAPs and MLCs were detected 4 times more frequently in group D than in group A at one of the centers. Conclusion: CCAPs and MLCs were more frequently detected on digital than on film-based panoramic radiographs. Further studies are needed to determine whether such radiopacities do indeed correspond to mineralized, rather than medium-density, tissues.

• Journal of Biomedical Engineering Research
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• v.44 no.3
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• pp.167-175
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• 2023

Chest PA is the basic examination of radiographic imaging. Moreover, Chest PA's demands are constantly increasing because of the Increase in respiratory diseases. However, it is not meeting the demand due to problems such as a shortage of radiological technologist, sexual shame caused by patient contact, and the spread of infectious diseases. There have been many cases of using artificial intelligence to solve this problem. Therefore, the purpose of this research is to build an artificial intelligence dataset of Chest PA and to find a posture evaluation method. To construct the posture dataset, the posture image is acquired during actual and simulated examination and classified correct and incorrect posture of the patient. And to evaluate the artificial intelligence posture method, a posture estimation algorithm is used to preprocess the dataset and an artificial intelligence classification algorithm is applied. As a result, Chest PA posture dataset is validated with in over 95% accuracy in all artificial intelligence classification and the accuracy is improved through the Top-Down posture estimation algorithm AlphaPose and the classification InceptionV3 algorithm. Based on this, it will be possible to build a non-face-to-face automatic Chest PA examination system using artificial intelligence.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.6 no.2
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• pp.92-101
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• 2020

The cyclic Arg-Gly-Asp (cRGD) peptide is well-known as a binding molecule to the integrin α_vβ₃ receptor which is highly expressed on activated endothelial cells and new blood vessels in tumors. Although numerous results have been reported by the usage of cRGD peptide-based ligands for cancer diagnosis and therapy, the distinct mechanisms, and functions of cRGD-integrin binding to cancer cells are still being investigated. In this study, we evaluated the internalization efficacy of different types of cRGD peptides (monomer, dimer and tetramer form) in integrin α_vβ₃ overexpressing cancer cells. Western blot and flow cytometric analysis showed U87MG expresses highly integrin α_vβ₃, whereas CT-26 does not show integrin α_vβ₃ expression. Cytotoxicity assay indicated that all cRGD peptides (0-200 µM) had at least 70-80% of viability in U87MG cells. Fluorescence images showed cRGD dimer peptides have the highest cellular internalization compare to cRGD monomer and cRGD tetramer peptides. Additionally, transmission electron microscope results clearly visualized the endocytic internalization of integrin α_vβ₃ receptors and correlated with confocal microscopic results. These results support the rationale for the use of cRGD dimer peptides for imaging, diagnosis, or therapy of integrin α_vβ₃-rich glioblastoma.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.2
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• pp.46.3-47
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• 2021

Recently a multilayer spectral inversion (MLSI) model has been proposed to infer the physical parameters of plasmas in the solar chromosphere. The inversion solves a three-layer radiative transfer model using the strong absorption line profiles, H alpha and Ca II 8542 Å, taken by the Fast Imaging Solar Spectrograph (FISS). The model successfully provides the physical plasma parameters, such as source functions, Doppler velocities, and Doppler widths in the layers of the photosphere to the chromosphere. However, it is quite expensive to apply the MLSI to a huge number of line profiles. For example, the calculating time is an hour to several hours depending on the size of the scan raster. We apply deep neural network (DNN) to the inversion code to reduce the cost of calculating the physical parameters. We train the models using pairs of absorption line profiles from FISS and their 13 physical parameters (source functions, Doppler velocities, Doppler widths in the chromosphere, and the pre-determined parameters for the photosphere) calculated from the spectral inversion code for 49 scan rasters (~2,000,000 dataset) including quiet and active regions. We use fully connected dense layers for training the model. In addition, we utilize a skip connection to avoid a problem of vanishing gradients. We evaluate the model by comparing the pairs of absorption line profiles and their inverted physical parameters from other quiet and active regions. Our result shows that the deep learning model successfully reproduces physical parameter maps of a scan raster observation per second within 15% of mean absolute percentage error and the mean squared error of 0.3 to 0.003 depending on the parameters. Taking this advantage of high performance of the deep learning model, we plan to provide the physical parameter maps from the FISS observations to understand the chromospheric plasma conditions in various solar features.

• Biomedical Science Letters
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• v.29 no.4
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• pp.211-219
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• 2023

Caffeic acid phenethyl ester (CAPE) is an active component of propolis obtained from honeybee hives. CAPE possesses anti-mitogenic, anti-carcinogenic, anti-inflammatory, and immunomodulatory activities in diverse systems, which know as displays antioxidant activity and inhibits lipoxygenase activities, protein tyrosine kinase, and nuclear factor kappa B (NF-κB) activation. This study aimed to investigate the effect of CAPE on lipopolysaccharide (LPS)-induced human neutrophil phagocytosis. Human neutrophils were cultured with various concentrations of CAPE (1, 10, and 100 µM) with or without LPS. The pro-inflammatory proteins (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-6 and IL-8) levels were measured after 4 h incubation. To investigate the intracellular signaling pathway, we measured the levels of mitogen-activated protein kinases (MAPK), including phosphorylation of p38, extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) and c-Jun N-terminal kinase (JNK). Next, to evaluate the potential phagocytosis, neutrophils were labeled with iron particles of superparamagnetic iron oxide nanoparticles (SPIONs, 40 nm) for 1 h in culture medium containing 5 mg/mL of iron. The labeling efficiency was determined by Prussian blue staining for intracellular iron and 3T-wighted magnetic resonance imaging. CAPE decreased the activation of intracellular signaling pathways, including ERK1/2 and c-Jun, and expression of pro-inflammatory cytokines, including TNF-α and IL-6, but had no effect on the signaling pathways of p38 and cytokine IL-8. Furthermore, images obtained after mannan-coated SPION treatment suggested that CAPE induced significantly higher signal intensities than the control or LPS group. Together, these results suggest that CAPE regulates LPS-mediated activation of human neutrophils to reduce phagocytosis.