• 대한족부족관절학회지
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• 제14권2호
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• pp.146-150
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• 2010

Purpose: Pilon fracture has several serious complications such as joint stiffness, arthrosis and delayed angular deformity. We report short-term results of new treatment modality using distracted dynamic external fixators and early controlled ankle motion. Materials and Methods: Eight cases of severe pilon fractures for which we tried small plate fixation and additional distracted dynamic external fixators from July 2007 to June 2009 were included. Half passive continuous ankle joint motion was allowed under free hinged ring fixators after the operation. The external fixators were removed after two or three months from the surgery. We investigated joint space by radiograph, joint pain, range of motion, patient's satisfaction of treatment protocol. Results: Joints were distracted when external fixators were applied and mean 28% of space loss developed after removal of external fixators. In most of cases, satisfactory alignments were maintained. Regarding range of joint motion, mean dorsiflexion angle was 15 degrees and mean plantarflexion angle was 32 degree in the condition of wearing external fixators. There was mean 8% reduction of range of motion but no further progression of ankle stiffness after removal of external fixators. Dorsiflexion was not improved after that, but plantarflexion angle was improved 10% even after removal of external fixators. Patients were generally in compliance with the treatment protocols with high level of satisfaction. Conclusion: We got good results with distracted dynamic external fixators and early continuous half-passive joint motion for pilon fractures in terms of joint pain and range of motion. Therefore we suggest this new protocol as an alternative modality for severe pilon fractures.

• 산업경영시스템학회지
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• 제45권4호
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• pp.42-52
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• 2022

North Korea continues to upgrade and display its long-range rocket launchers to emphasize its military strength. Recently Republic of Korea kicked off the development of anti-artillery interception system similar to Israel's "Iron Dome", designed to protect against North Korea's arsenal of long-range rockets. The system may not work smoothly without the function assigning interceptors to incoming various-caliber artillery rockets. We view the assignment task as a dynamic weapon target assignment (DWTA) problem. DWTA is a multistage decision process in which decision in a stage affects decision processes and its results in the subsequent stages. We represent the DWTA problem as a Markov decision process (MDP). Distance from Seoul to North Korea's multiple rocket launchers positioned near the border, limits the processing time of the model solver within only a few second. It is impossible to compute the exact optimal solution within the allowed time interval due to the curse of dimensionality inherently in MDP model of practical DWTA problem. We apply two reinforcement-based algorithms to get the approximate solution of the MDP model within the time limit. To check the quality of the approximate solution, we adopt Shoot-Shoot-Look(SSL) policy as a baseline. Simulation results showed that both algorithms provide better solution than the solution from the baseline strategy.

• 한국식품위생안전성학회지
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• 제2권1호
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• pp.9-14
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• 1987

식품의 상품화에 따라 식품 첨가물의 사용이 증가되고 있다. 식품 첨가물로서 색소는 고유의 색소를 보존하기 어려운 식품에 따라 사용되며 tar 색소, 식물성 색소 및 광물성 색소로 나눌 수 있는데 tar 색소는 독성이 강한 것이 많으므로 현재 15종만이 법적으로 허용되어 있다. 이중 azo 화합물인 amaranth, tartrazine, sunset yellow, allura red에 대하여 흰 주위 hepatic azo reductase의 활성을 측정 비교하였고 이에 대한 flavin의 효과를 보았다. 1. Amaranth를 기질로 사용하여 kinetic constants $Km=645\;\mu\textrm{M}$, Vmax=50 n mol/min/mg protein의 값을 얻었다. 2. Amaranth의 농도를 일정하게 하고 FAD의 농도를 증가시켰을 때 hepatic azo reductase의 활성은 현저히 증가하였으나 NADPH-generating system에 의한 환원은 작은 증가를 나타냈다. 3. 기타 식용 azo 색소 tartrazine, sunset yellow, allura red를 기지로 azo reductase activity를 측정한 결과 sunset yellow는 amaranth와 비슷한 환원활성은 나타냈고, tartrazine은 보다 낮은 환원활성을 allura red는 보다 높은 환원활성을 나타냈으며, $300\;\mu\textrm{M}-FAD$에 의해 기질 모두에서 환원활성이 증가함을 알 수 있었다.

• Parasites, Hosts and Diseases
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• 제39권2호
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• pp.177-183
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• 2001

The objectives of the present study were to (1) determine the susceptibility of Anopheles sinensis to Korean isolates of Plasmodium vivax, (2) establish a method to collect large quantities of P. vivax sporozoites for use as antigen in seroepidemiological studies, and (3) investigate the characteristics of Korean isolates of P. vivax sporozoites. Females of Anopheles sinensis were collected at non-epidemic area, Seokwha-ri, Cheongwon-gun and Chungcheongbuk-do using tent-trap methods coupled with dry ice. The females were artificially infected with gameiocytes of P. vivax using blood obtained from P vivax malaria patients. Individual mosquitoes were infected using either a parafilm-covered glass feeding apparatus or were allowed to feed on naturally infected volunteers. Mosquitoes were sacrificed between 16 and 18 days post-feeding and an enzyme-linked immunosorbent assay (ELISA) was used to detect sporozoites. Four (33.4%) of 12 mosquitoes, which were fed on naturally infected volunteers directly, were positive for sporozoites. In cases, the mosquitoes allowed to feed on whole blood which were extract from three different patients with heparin treated vacuutainers using a parafilm-covered glass apparatus. Two of 55 (3.6%) were positive which blood sample was maintained at room temperature for 8 hours, 1 of 68 (1.5%) was positive which blood was maintained at $4^{\circ}C$ for 24 hours and 1 of 47 (2.3%) was positive at 4$^{\circ}C$ for 48 hours. The mean number of sporozoites was estimated about 818 (n=8; range of 648-1,056) based on optical density values of ELISA.

• 한국통신학회논문지
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• 제23권5호
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• pp.1384-1396
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• 1998

본 논문에서는 ATM망에서 ABR (Available Bit Rate) 흐름제어를 위한 RR (Relative Rate) 스위치 알고리즘의 성능을 해석하였다. RR 스위치는 망의 폭주상황을 BRM (Backward Resource Management) 셀의 CI(Congestion Indication) 비트와 NI(No Increase) 비트를 이용하여 송신원에 전달하는 방식이다. 이러한 RR 스위치는 폭주 판단 (congestion detection)과 폭주 통지(congestion notification) 방법에 따라 여러 방식 으로 구현될 수 있다. 본 논문에서는 폭주 판단과 통지 방법에 따른 세 가지 방식의 RR 스위치 알고리즘의 구현 방식을 제안하고, 평형 상태에서 송신원의 ACR (Allowed Cell Rate)과 스위치의 큐 길이의 변화를 유체흐름 근사법(fluid flow approxim­a ation)을 이용하여 해석하였다. 이를 이용하여 RR 스위치에 대한 평형상태에서의 큐 길이의 최대값과 최소값에 대한 상.하한치를 유도하고, ABR 파라미터들의 변화에 따른 큐 길이의 영향을 분석하였다. 또한, 버퍼 고갈에 의한 링크 이용 효율의 저하와 버퍼 범람에 의한 셀 손실을 동시에 방지할 수 있는 RIF(Rate Increase Factor)와 RDF(Rate Decrease Factor) 파라미터의 선택영역을 제시하였다.

• Toxicological Research
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• 제34권2호
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• pp.111-125
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• 2018

Solvents can be used in the manufacture of medicinal products provided their residual levels in the final product comply with the acceptable limits based on safety data. At worldwide level, these limits are set by the "Guideline Q3C (R6) on impurities: guideline for residual solvents" issued by the ICH. Diisopropyl ether (DIPE) is a widely used solvent but the possibility of using it in the pharmaceutical manufacture is uncertain because the ICH Q3C guideline includes it in the group of solvents for which "no adequate toxicological data on which to base a Permitted Daily Exposure (PDE) was found". We performed a risk assessment of DIPE based on available toxicological data, after carefully assessing their reliability using the Klimisch score approach. We found sufficiently reliable studies investigating subchronic, developmental, neurological toxicity and carcinogenicity in rats and genotoxicity in vitro. Recent studies also investigated a wide array of toxic effects of gasoline/DIPE mixtures as compared to gasoline alone, thus allowing identifying the effects of DIPE itself. These data allowed a comprehensive toxicological evaluation of DIPE. The main target organs of DIPE toxicity were liver and kidney. DIPE was not teratogen and had no genotoxic effects, either in vitro or in vivo. However, it appeared to increase the number of malignant tumors in rats. Therefore, DIPE could be considered as a non-genotoxic animal carcinogen and a PDE of 0.98 mg/day was calculated based on the lowest No Observed Effect Level (NOEL) value of $356mg/m^3$ (corresponding to 49 mg/kg/day) for maternal toxicity in developmental rat toxicity study. In a worst-case scenario, using an exceedingly high daily dose of 10 g/day, allowed DIPE concentration in pharmaceutical substances would be 98 ppm, which is in the range of concentration limits for ICH Q3C guideline class 2 solvents. This result might be considered for regulatory decisions.

• Journal of Astronomy and Space Sciences
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• 제22권2호
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• pp.139-146
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• 2005

A model of advection-dominated accretion flows has been highlighted in the last decade. Most of calculations are based on self-similar solutions of equations governing the accreting flows. We revisit self-similar solutions of the simplest form of advection-dominated accretion flows. We explore the parameter space thoroughly and seek another category of self-similar solutions. In this study we allow the parameter f less than zero, which denotes the fraction of energy transported through advection. We have found followings: 1. For f > 0, in real ADAF solutions the ratio of specific heats ${\gamma}$ satisfies 1 < ${\gamma}$ < 5/3 for O ${\leq}$ f ${\leq}$ 1. On the other hands, in wind solutions a rotating disk does not exist. 2. For f < 0, in real ADAF solutions with ${\epsilon}$ greater than zero ${\gamma}$ requires rather exotic range, that is, ${\gamma}$ < 1 or ${\gamma}$ > 5/3. When -5/2 < ${\epsilon}$' < 0, however, allowable ${\gamma}$ can be found in ${\gamma}$ < 5/3, in which case 4{\Omega}_0$,_ is imaginary. 3. For a negative $u_0$,+ with f > 0, solutions are only allowed with exotic ${\gamma}$, that is, 1 < ${\gamma}$ or ${\gamma}$ > (5f/2-5/3)/(5f/2-1)when O < f < 2/5, (5f/2-5/3)/(5f/2-1) < ${\gamma}$ < 1 when f > 2/5. Since ${\epsilon}$' is negative, 4{\Omega}_0$,+ is again an imaginary quantity. For a negative $u_0$,+ with f < 0, ${\gamma}$ is allowed in 1 < 7 < (5|f|/2 + 5/3)/(5|f|/2 + 1). We briefly discuss physical implications of what we have found.

• Journal of Communications and Networks
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• 제5권4호
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• pp.344-353
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• 2003

Ultra-wideband (UWB) technology is gaining increasing interest for its potential application to short-range indoor wireless communications. Utilizing ultra-short pulses, UWB baseband transmissions enable rich multipath diversity, and can be demodulated with low complexity receivers. Compliance with the FCC spectral mask, and interference avoidance to, and from, co-existing narrow-band services, calls for judicious design of UWB pulse shapers. This paper introduces pulse shaper designs for UWB radios, which optimally utilize the bandwidth and power allowed by the FCC spectral mask. The resulting baseband UWB systems can be either single-band, or, multi-band. More important, the novel pulse shapers can support dynamic avoidance of narrow-band interference, as well as efficient implementation of fast frequency hopping, without invoking analog carriers.

• Biotechnology and Bioprocess Engineering:BBE
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• 제1권1호
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• pp.32-35
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• 1996

Amoving aeration-membrane (MAM) bioreactor was employed for the production of 2$\mu$g/mL of tissue type Plasminogen Activator (tPA)in serum free medium from normal human fibroblast cells. This system could maintain high cell density for long periods of steady state conditions in perfusion cultivation. Under normal operating condition, shear stress was as low as 0.65 dynes/$\textrm{cm}^2$ at the agitation speed of 80 rpm. Even though cell density gradually decreased with increasing agitation speed, tPA production increased linearly with increasing shear stress within a moderate range. This culture system allowed production of 2$\mu$g tPA/mL while maintaining a high cell denisty of 1.0$\times$107 viable cell/mL.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2009년도 추계학술대회 논문집
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• pp.338-343
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• 2009

In this paper, Verification of the qualitatively identical relationships existing between simulation data and experimental results allowed for a new analysis procedure of a planetary gear set -- in an automatic transmission -- to be conducted. Tooth profiles were found to be crucial to the gear mesh forces of the planetary gear set. Based on Kahraman's Model[8], dynamic resonances of the planetary gear set were found to be out of operating range. Most importantly, a 2DPLANETARY FEM program, an innovative design tool for planetary gear sets, was utilized.