• Journal of Korean Foot and Ankle Society
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• v.14 no.2
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• pp.146-150
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• 2010

Purpose: Pilon fracture has several serious complications such as joint stiffness, arthrosis and delayed angular deformity. We report short-term results of new treatment modality using distracted dynamic external fixators and early controlled ankle motion. Materials and Methods: Eight cases of severe pilon fractures for which we tried small plate fixation and additional distracted dynamic external fixators from July 2007 to June 2009 were included. Half passive continuous ankle joint motion was allowed under free hinged ring fixators after the operation. The external fixators were removed after two or three months from the surgery. We investigated joint space by radiograph, joint pain, range of motion, patient's satisfaction of treatment protocol. Results: Joints were distracted when external fixators were applied and mean 28% of space loss developed after removal of external fixators. In most of cases, satisfactory alignments were maintained. Regarding range of joint motion, mean dorsiflexion angle was 15 degrees and mean plantarflexion angle was 32 degree in the condition of wearing external fixators. There was mean 8% reduction of range of motion but no further progression of ankle stiffness after removal of external fixators. Dorsiflexion was not improved after that, but plantarflexion angle was improved 10% even after removal of external fixators. Patients were generally in compliance with the treatment protocols with high level of satisfaction. Conclusion: We got good results with distracted dynamic external fixators and early continuous half-passive joint motion for pilon fractures in terms of joint pain and range of motion. Therefore we suggest this new protocol as an alternative modality for severe pilon fractures.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.45 no.4
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• pp.42-52
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• 2022

North Korea continues to upgrade and display its long-range rocket launchers to emphasize its military strength. Recently Republic of Korea kicked off the development of anti-artillery interception system similar to Israel's "Iron Dome", designed to protect against North Korea's arsenal of long-range rockets. The system may not work smoothly without the function assigning interceptors to incoming various-caliber artillery rockets. We view the assignment task as a dynamic weapon target assignment (DWTA) problem. DWTA is a multistage decision process in which decision in a stage affects decision processes and its results in the subsequent stages. We represent the DWTA problem as a Markov decision process (MDP). Distance from Seoul to North Korea's multiple rocket launchers positioned near the border, limits the processing time of the model solver within only a few second. It is impossible to compute the exact optimal solution within the allowed time interval due to the curse of dimensionality inherently in MDP model of practical DWTA problem. We apply two reinforcement-based algorithms to get the approximate solution of the MDP model within the time limit. To check the quality of the approximate solution, we adopt Shoot-Shoot-Look(SSL) policy as a baseline. Simulation results showed that both algorithms provide better solution than the solution from the baseline strategy.

• Journal of Food Hygiene and Safety
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• v.2 no.1
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• pp.9-14
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• 1987

With the market of food products, the use of food additives is on the increase. The dye as food additives, can be used for some foods which are difficult to preserve their own colors. It can be also classified as tar dye, vegetable dye and mineral dye. Because tar dye has dense toxicity, only 15 articles among them are legally allowed to be used. Among the allowed articles, the azo compound amaranth, tartrazine, sunset yellow, and allura red, were used in determining and comparing rat hepatic azo reductase activity and we observed the flavin's effects as follows: 1. Investigation with amaranth as substrate gave an apparent Km of $645\;\mu\textrm{M}$ and Vmax of 50 n mol/min/mg protein. 2. On investigation using a fixed amaranth concentration over a range of flavin concentration, FAD significantly increased the activity of the azo reductase compared with only minor increases in reaction mediated by the NADPH-generating system alone. 3. On investigation with amaranth, tartrazine, sunset yellow allura red as electron acceptor in the absence or presence of 300 mM-FAD, sunset yellow was reduced at a rat similar to amaranth, tartrazine was reduced at a slower rate and allura red was reduced a little more rapidly.

• Parasites, Hosts and Diseases
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• v.39 no.2
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• pp.177-183
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• 2001

The objectives of the present study were to (1) determine the susceptibility of Anopheles sinensis to Korean isolates of Plasmodium vivax, (2) establish a method to collect large quantities of P. vivax sporozoites for use as antigen in seroepidemiological studies, and (3) investigate the characteristics of Korean isolates of P. vivax sporozoites. Females of Anopheles sinensis were collected at non-epidemic area, Seokwha-ri, Cheongwon-gun and Chungcheongbuk-do using tent-trap methods coupled with dry ice. The females were artificially infected with gameiocytes of P. vivax using blood obtained from P vivax malaria patients. Individual mosquitoes were infected using either a parafilm-covered glass feeding apparatus or were allowed to feed on naturally infected volunteers. Mosquitoes were sacrificed between 16 and 18 days post-feeding and an enzyme-linked immunosorbent assay (ELISA) was used to detect sporozoites. Four (33.4%) of 12 mosquitoes, which were fed on naturally infected volunteers directly, were positive for sporozoites. In cases, the mosquitoes allowed to feed on whole blood which were extract from three different patients with heparin treated vacuutainers using a parafilm-covered glass apparatus. Two of 55 (3.6%) were positive which blood sample was maintained at room temperature for 8 hours, 1 of 68 (1.5%) was positive which blood was maintained at $4^{\circ}C$ for 24 hours and 1 of 47 (2.3%) was positive at 4$^{\circ}C$ for 48 hours. The mean number of sporozoites was estimated about 818 (n=8; range of 648-1,056) based on optical density values of ELISA.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.5
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• pp.1384-1396
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• 1998

This paper ivestigates the performance of a relative rate (RR) switch algorithm for the rate-based available bit rate (ABR) flow control in asynchronous transfer mode (ATM) networks. A RR switch may notify the network congestion status to the source by suing the congestion indication (CI) bit or no increase (NI)bit in the backward RM (BRM) cells. A RR switch can be differently implemented according to the congestion detectio and notification methods. In this paper, we propose three implementation schemes for the RR switch with different congestion detection and notification methods, and analyze the allowed cell rate (ACR) of a source and the queue length of a switch in steady state. In addition, we derive the upper and lower bounds for the maximum and minimum queue lengths for each scheme respectively, and evaluate the effects of the ABR parameter values on the queue length. Furthermore, we suggest the range of the rage increase factor (RIF) and rate decrease factor (RDF) parameter values which can prevent buffer overflow and underflow at a switch.

• Toxicological Research
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• v.34 no.2
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• pp.111-125
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• 2018

Solvents can be used in the manufacture of medicinal products provided their residual levels in the final product comply with the acceptable limits based on safety data. At worldwide level, these limits are set by the "Guideline Q3C (R6) on impurities: guideline for residual solvents" issued by the ICH. Diisopropyl ether (DIPE) is a widely used solvent but the possibility of using it in the pharmaceutical manufacture is uncertain because the ICH Q3C guideline includes it in the group of solvents for which "no adequate toxicological data on which to base a Permitted Daily Exposure (PDE) was found". We performed a risk assessment of DIPE based on available toxicological data, after carefully assessing their reliability using the Klimisch score approach. We found sufficiently reliable studies investigating subchronic, developmental, neurological toxicity and carcinogenicity in rats and genotoxicity in vitro. Recent studies also investigated a wide array of toxic effects of gasoline/DIPE mixtures as compared to gasoline alone, thus allowing identifying the effects of DIPE itself. These data allowed a comprehensive toxicological evaluation of DIPE. The main target organs of DIPE toxicity were liver and kidney. DIPE was not teratogen and had no genotoxic effects, either in vitro or in vivo. However, it appeared to increase the number of malignant tumors in rats. Therefore, DIPE could be considered as a non-genotoxic animal carcinogen and a PDE of 0.98 mg/day was calculated based on the lowest No Observed Effect Level (NOEL) value of $356mg/m^3$ (corresponding to 49 mg/kg/day) for maternal toxicity in developmental rat toxicity study. In a worst-case scenario, using an exceedingly high daily dose of 10 g/day, allowed DIPE concentration in pharmaceutical substances would be 98 ppm, which is in the range of concentration limits for ICH Q3C guideline class 2 solvents. This result might be considered for regulatory decisions.

• Journal of Astronomy and Space Sciences
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• v.22 no.2
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• pp.139-146
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• 2005

A model of advection-dominated accretion flows has been highlighted in the last decade. Most of calculations are based on self-similar solutions of equations governing the accreting flows. We revisit self-similar solutions of the simplest form of advection-dominated accretion flows. We explore the parameter space thoroughly and seek another category of self-similar solutions. In this study we allow the parameter f less than zero, which denotes the fraction of energy transported through advection. We have found followings: 1. For f > 0, in real ADAF solutions the ratio of specific heats ${\gamma}$ satisfies 1 < ${\gamma}$ < 5/3 for O ${\leq}$ f ${\leq}$ 1. On the other hands, in wind solutions a rotating disk does not exist. 2. For f < 0, in real ADAF solutions with ${\epsilon}$ greater than zero ${\gamma}$ requires rather exotic range, that is, ${\gamma}$ < 1 or ${\gamma}$ > 5/3. When -5/2 < ${\epsilon}$' < 0, however, allowable ${\gamma}$ can be found in ${\gamma}$ < 5/3, in which case 4{\Omega}_0$,_ is imaginary. 3. For a negative $u_0$,+ with f > 0, solutions are only allowed with exotic ${\gamma}$, that is, 1 < ${\gamma}$ or ${\gamma}$ > (5f/2-5/3)/(5f/2-1)when O < f < 2/5, (5f/2-5/3)/(5f/2-1) < ${\gamma}$ < 1 when f > 2/5. Since ${\epsilon}$' is negative, 4{\Omega}_0$,+ is again an imaginary quantity. For a negative $u_0$,+ with f < 0, ${\gamma}$ is allowed in 1 < 7 < (5|f|/2 + 5/3)/(5|f|/2 + 1). We briefly discuss physical implications of what we have found.

• Journal of Communications and Networks
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• v.5 no.4
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• pp.344-353
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• 2003

Ultra-wideband (UWB) technology is gaining increasing interest for its potential application to short-range indoor wireless communications. Utilizing ultra-short pulses, UWB baseband transmissions enable rich multipath diversity, and can be demodulated with low complexity receivers. Compliance with the FCC spectral mask, and interference avoidance to, and from, co-existing narrow-band services, calls for judicious design of UWB pulse shapers. This paper introduces pulse shaper designs for UWB radios, which optimally utilize the bandwidth and power allowed by the FCC spectral mask. The resulting baseband UWB systems can be either single-band, or, multi-band. More important, the novel pulse shapers can support dynamic avoidance of narrow-band interference, as well as efficient implementation of fast frequency hopping, without invoking analog carriers.

• Biotechnology and Bioprocess Engineering:BBE
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• v.1 no.1
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• pp.32-35
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• 1996

Amoving aeration-membrane (MAM) bioreactor was employed for the production of 2$\mu$g/mL of tissue type Plasminogen Activator (tPA)in serum free medium from normal human fibroblast cells. This system could maintain high cell density for long periods of steady state conditions in perfusion cultivation. Under normal operating condition, shear stress was as low as 0.65 dynes/$\textrm{cm}^2$ at the agitation speed of 80 rpm. Even though cell density gradually decreased with increasing agitation speed, tPA production increased linearly with increasing shear stress within a moderate range. This culture system allowed production of 2$\mu$g tPA/mL while maintaining a high cell denisty of 1.0$\times$107 viable cell/mL.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2009.10a
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• pp.338-343
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• 2009

In this paper, Verification of the qualitatively identical relationships existing between simulation data and experimental results allowed for a new analysis procedure of a planetary gear set -- in an automatic transmission -- to be conducted. Tooth profiles were found to be crucial to the gear mesh forces of the planetary gear set. Based on Kahraman's Model[8], dynamic resonances of the planetary gear set were found to be out of operating range. Most importantly, a 2DPLANETARY FEM program, an innovative design tool for planetary gear sets, was utilized.