• 한국균학회지
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• 제17권1호
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• pp.39-47
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• 1989

54과(科) 100종(種)의 식물 추출액(抽出液)을 공시(供試)하여 Phytophthora spp.에 대한 항균성(抗菌性)을 검정(檢定)한 바 균사생장(菌絲生長) 억제효과(抑制效果)가 있는 것은 양파, 마늘, 등배나무, 호장근 및 당대황이었고 이중에서 특히 마늘과 등배나무가 가장 뚜렷하게 나타냈다. 유주자낭(遊走子囊) 발아억제효과(發芽抑制效果)는 P. capsici에서 마늘, 등배나무 및 당대황이 뚜렷했고 P. nicotiana 와 P. infestans에서는 등배나무가 뚜렷했다. 또한 등배나무 추출액(抽出液)이 유묘(幼苗)에서 강(强)한 발병억제효과(發病抑制效果)를 나타냈다. 이상의 결과로 보아 항균물질(抗菌物質)은 분비(分泌)하는 능력을 가진 길항식물(拮抗植物)을 이용하여 토양전래성(土壤傳來性) 병원균(病原菌)을 저지(沮止)할 가능성이 있다고 믿는다.

• 한국생물환경조절학회:학술대회논문집
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• 한국생물환경조절학회 1996년도 국제심포지움 21세기 첨단식물생산시스템의 실용화
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• pp.117-128
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• 1996

A garlic (Allium sativum L.) is an important and useful vegetable such that it is not only most used for spices but also exploited for health foods and pharmaceuticals. The garlic is a kind of vegetable propagated vegetatively through cloves. Therefore, development of new varieties of garlics is possible only through selection breeding because cross breeding is impossible. (omitted)

• Mycobiology
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• 제33권3호
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• pp.137-141
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• 2005

High performance liquid chromatographic (HPLC) analysis of mycelia of Sclerotium rolfsii grown in broth medium supplemented with garlic (Allium sativum) and onion (Allium cepa) was carried out to estimate qualitative and quantitative changes in phenolic acids. Several phenolic acids, such as gallic, chlorogenic; ferulic, o-coumaric and cinnamic acids were detected in varied amounts in mycelia grown on such media as compared to control. Phenolic acids represents a wide range of secondary metabolite found in the cells of plants and microbes including fungi. The growth characters of S. rolfsii in various supplements also varied from thin and transparent to thick and opaque.

• 한국환경농학회지
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• 제34권3호
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• pp.217-222
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• 2015

BACKGROUND: Garlic (Allium sativum) contains polyphenols and sulfur compounds that are recognized as antioxidant, antithrombotic, anticancer, antibacterial, antimicrobial, nematicidal, and insecticidal activity. For this reason, the Environmentally-friendly Agriculture Promotion Act allowed the garlic extract as commercial biopesticide material for crop protection, nine commercial biopesticides containing A. sativum extract have been marketed in Korea. METHODS AND RESULTS: The determination of allylmethyl sulfide (AMS), dimethyl disulfide (DMDS), and dipropyl sulfide (DPS) in biopesticides containing A. sativum extract was developed and validated by gas chromatography (GC) mass spectrometry (MS) with head-space sampler. The developed method was validated, and the limit of quantification (LOQ) and recovery rates of AMS, DMDS, and DPS were 0.08, 0.32, and 0.09 mg/L and 90.3-91.3, 86.2-88.3, and 87.6-89.5%, respectively. From the nine commercial biopesticide samples, contents of AMS, DMDS, and DPS were analyzed using the developed method and results showed

• Journal of Nutrition and Health
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• 제39권5호
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• pp.433-443
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• 2006

한국산 식용 및 약용식물의 항당뇨 효과 탐색 연구로 본 연구에서는 Allium속 식물 중 식품으로 다양하게 사용하고 있는 5가지 양파, 파, 마늘, 부추 및 산마늘을 냉동건조하고 분말화하여 첨가한 식이를 STZ로 유발시킨 당뇨 흰쥐에게 28일간 섭취시킨 후 혈장 포도당, 지질 함량 및 간장내 무기질 함량을 분석하여 다음과 같은 결과를 얻었다. 1) STZ에 의한 당뇨유발로 당뇨대조군의 체중은 감소하였으나 당뇨실험군의 체중은 증가하는 경향을 보였고 특히 마늘섭취군에서는 유의적인 체중 증가를 나타내었다. 식이이용효율에서도 당뇨대조군은 다식현상으로 식이섭취량은 체중증가량이 적어 음 (-)의 식이효율을 나타내었고 양파섭취군과 마늘섭취군 및 부추섭취군은 유의적으로 높은 식이효율을 보였다. 2) 장기의 무게는 당뇨대조군과 당뇨실험군에 비해 마늘섭취군의 신장 무게가 유의적으로 낮아 신장 비대를 엊제한 것으로 나타났으며 다른 장기에서는 유의적인 차이를 보이지 않았다. AST 활성도는 실험군간에 유의성이 없는 결과를 나타내었으나 ALT 활성도는 마늘섭취군에서 유의적으로 낮은 수준을 나타내었다. 3) 당뇨대조군은 고혈당이 지속된 반면 마늘섭취군의 혈당은 실험 1주째부터 유의적으로 낮은 수준을 보여 혈당 억제 효과를 나타내었으며 부추섭취군도 실험 4주째에는 유의적으로 낮은 수준의 혈당을 나타내었다. 간장 글리코겐 함량은 정상군에 비해 모든 당뇨유발군이 유의적으로 낮은 함량을 나타내었으나 당뇨대조군에 비해 Allium속 식물의 섭취는 모두 높은 수치를 보이었다. 4) 혈장 내 콜레스테롤, 중성지방, 유리지방산, HDL-콜레스테롤 함량은 각 실험군간의 유의차가 없었으며 폐의 MDA 함량은 당뇨대조군에 비해 양파섭취군, 마늘섭취군, 부추섭취군과 산마늘섭취군에서 유의적으로 낮았다. Allium속 식물 중 마늘과 부추는 고혈당의 수준을 저하시키거나 억제시켜 혈당을 개선할 수 있으며 부추와 산마늘섭취가 혈당저하에는 관련되지 않았으나 조직의 과산화지질 감소에는 작용함을 알 수 있었다. 당뇨병의 주요증세가 고혈당 그리고 다식임에도 불구하고 급격한 체중감소를 보인다는 점에서 본 실험결과는 Allium속 식물을 당뇨동물에게 급여함으로써 체중저하를 방지하고 당대사를 개선함으로써 당뇨병의 증세가 어느 정도 호전될 수 있음을 보여준다. Allium속 식물이라도 함유된 생리활성 성분에 따라 다른 생리적 기능을 나타낼 수 있으므로 그 생리활성성분을 고려한 적절한 섭취는 그 효능을 극대화할 수 있음을 추정할 수 있으며 각 성분에 대한 생리 활성에 대해서는 더 깊은 연구가 필요하다고 사료된다. 또한 그 자체로서 항산화 작용에 관여하거나 다양한 체내 산화스트레스에 대해 영향을 받는 Cr, Zn, Fe 및 Mn과 같은 미량 원소들의 체내 반응 기작에 관해서는 앞으로 좀더 연구해야 할 과제라고 사료된다.

• Advances in Traditional Medicine
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• 제6권4호
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• pp.274-285
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• 2006

Allium sativum (Family Amaryllidaceae or Liliaceae) is used worldwide for various clinical uses like hypertension, cholesterol lowering effect, antiplatelets and fibrinolytic activity etc. Due to these common house hold uses of Allium sativum, as a herbal supplements, and failure of patients to inform their physician of the over-the-counter supplements they consume leads to drugnutrient interactions with components in herbal supplements. Today these types of interactions between a herbal supplement and clinically prescribed drugs are an increasing concern. In vitro studies indicated that garlic constituents modulated various CYP (cytochrome P450) enzymes. CYP 3A4 is abundantly present in human liver and small intestine and contributes to the metabolism of more than 50% of commonly used drugs including nifedipine, cyclosporine, erythromycin, midazolam, alprazolam, and triazolam. Extracts from fresh and aged garlic inhibited CYP 3A4 in human liver microsomes. The in vivo effects of garlic constituents are found to be species depended and the dosing regimen of garlic constituents appeared to influence the modulation of various CYP isoforms. Studies have indicated that the inhibition of various CYPs by organosulfur compounds from garlic was related to their structure also. Studies using in vitro, in vivo, animal and human models have indicated that various garlic constituents can be the substrates, inhibitors and or inducers of various CYP enzymes. The modulation of CYP enzyme activity and expression are dependent on the type and chemical structure of garlic constituents, dose regime, animal species and tissue, and source of garlic thus this review throws light on the possible herb drug interaction with the use of garlic.

• Applied Biological Chemistry
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• 제11권
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• pp.167-171
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• 1969

마늘(Allium Sativum L.) 재배(栽培)에 있어서 몇가지 환경조건(環境條件) 즉 통기조건(通氣條件)(완전통기(完全通氣) 및 불완전통기(不完全通氣)) 및 시비량(施肥量)(다비구(多肥區), 관구(慣行區) 및 무비구(無肥區))을 달리했을때 마늘의 생육(生育) 및 인산흡수(燐酸吸收)(표식중과석(標識重過石))에 미치는 영향(影響)을 조사(調査)하였다. 1) 생장(生長)에 있어서 비료(肥料)의 시용수준(施用水準)에 관계(關係)없이 불완전통기구(不完全通氣區)가 초장(草長)이 길었다. 2) 생체중(生體重)은 초장(草長)과 비슷한 경향(傾向)을 보였으나 건물중(乾物重)은 처리간(處理間)에 차이(差異)가 없었다. 3) 인산흡수(燐酸吸收)는 불규칙(不規則)하나마 불완전통기구(不完全通氣區)가 전체적(全體的)으로 증가(增加)하는 경향(傾向)을 보였다. 이상(以上)으로 볼때 마늘의 생육(生育) 및 구(球)의 발육(發育)에 있어서 불완전통기(不完全通氣)가 좋은 결과(結果)를 가져왔다.

• Nutritional Sciences
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• 제8권3호
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• pp.169-174
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• 2005

This study investigated the effect of allium vegetable intake on the storage and utilization of energy substrates before, during, and after exercise in tissues of rats. Ninety mts were fed either a control diet or a diet with added allium sativum (AS), allium cepa (AC), allium fistulosum (AF), or allium tuberosum (AT) for 4 weeks and then subdivided into 3 groups: before-exercise (BE) during-exercise (DE) after-exercise (AE). The DE group exercised on treadmill for 1 hour just before being sacrificed at the end of the 4th week of the dietary treatment Rats in the AE group were allowed to recuperate for 2 horns after being exercised like the DE group. Pyriooxal 5'-phospwe (PLP) levels were compared in plasma, liver and skeletal muscle of rats. There was no difference between AS animals and control animals in plasma PLP levels regardless of exercise. The plasma PLP levels of AC animals were higher than those of control animals before exercise but this PLP was decreased with exercise and lower than that of control animals after exercise. The plasma PLP levels of AF animals were higher than those of control animals during exercise but there was no difference before and after exercise. The plasma PLP levels of AT animals were higher than those of control animals regardless of exercise. Compared to those of control mts, the PLP levels of liver and muscle were significantly lower in AS, AC, AF and AT mts before exercise. The levels of liver PLP were significantly decreased in control mts while not changed in AS, AC, AF and AT mts during exercise. The levels of liver PLP tended to decrease in AS, AC and AF mts after exercise. The levels of muscle PLP were significantly decreased in control rats, while not changed in AS, AC and AF mts during exercise. The levels of muscle PLP were decreased in control mts but not changed in AS, AC and AF mts after exercise. Thus, it is suggested that the changes of PLP concentrations in plasma and tissues induced by exercise are affected by allium vegetable diet and demonstrated that allium vegetable intake induced an alteration in the redistribution of PLP among tissues.

• Nutritional Sciences
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• 제6권3호
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• pp.155-159
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• 2003

Ninety rats were fed either a control diet or one of several allium vegetable diets (allium sativum (AS), allium cepa (AC), allium fistulosum (AF) or aliium tuberosum (AT) for 4 weeks and were separated into 3 groups : non-exercise (NE), exercise (EX), and exercise and recuperation (ER), The EX group was exercised on a treadmill for 1 hour just before sacrifice at the end of 4th week of diet intake and the ER group was recuperated for 2 hours after exercise. The levels of glucose (GLU), (PRO), triglyceride (TG), free fatty arid (FFA) and hemoglobin (Hb) were compared in plasma. In the U group, GLU levels of AS and AC tended to be higher than those of the control group. There were no differences in GLU levels between the control group and the allium vegetable groups in EX, whereas GLU levels of AS, AF and AT tended to be lower than that of control group in ER. There were no differences in PRO among the groups NE, EX and ER. TG and EEh levels of AS, AC, AF and AT tended to be lower than those of the control group in NE, EX and ER. Hb levels of AS, AC, AF and AT were lower than that of the control group in U and ER and tended to be lower than that of EX. These results suggest that allium vegetable diets have the potential to enhance the capacity to oxidize fatty acid and to recover triglyceride after recuperation, although there is compensation among stored fuel utilization during exercise

• 한국식품영양학회지
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• 제10권3호
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• pp.325-329
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• 1997

서산 6쪽 마늘 중의 inulinase를 추출하여 황산암모늄 침전가 Sephadex G-150여과 등을 통하여 9.1%의 수율로 부분정제하였다. 부분 정제된 inulinase는 4$0^{\circ}C$와 pH 6.0에서 inulin을 가장 잘 분해시켰고 7$0^{\circ}C$ 이하와 pH 5.0~8.0에서 안정하였다. 또한 이 효소는 Al3+, Mn2+, Hg2+, Cd2+ 및 EDTA에 의하여 심하게 실활되었고 inulin에 대한 Km값은 0.22%이었다.