• 대한방사선기술학회지:방사선기술과학
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• 제14권2호
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• pp.33-36
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• 1991

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1807-1810
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• 2014

Background: It is known that inducible nitric oxide synthase (iNOS)/nitric oxide (NO) plays an integral role during intestinal inflammation, an important factor for colon cancer development. Natural compounds from Curcuma longa L. (Zingiberaceae) have long been a potential source of bioactive materials with various beneficial biological functions. Among them, a major active curcuminoid, demethoxycurcumin (DMC) has been shown to possess anti-inflammatory properties in lipopolysaccharide (LPS)-activated macrophages or microglia cells. However, the role of DMC on iNOS expression and NO production in an in vitro inflamed human intestinal mucosa model has not yet been elucidated. This study concerned inhibitory effects on iNOS expression and NO production of DMC in inflamed human intestinal Caco-2 cells. An in vitro model was generated and inhibitory effects on NO production of DMC at 65 ${\mu}M$ for 24-96 h were assessed by monitoring nitrite levels. Expression of iNOS mRNA and protein was also investigated. DMC significantly decreased NO secretion by 35-41% in our inflamed cell model. Decrease in NO production by DMC was concomitant with down-regulation of iNOS at mRNA and protein levels compared to proinflammatory cytokine cocktail and LPS-treated controls. Mechanism of action of DMC may be partly due to its potent inhibition of the iNOS pathway. Our findings suggest that DMC may have potential as a therapeutic agent against inflammation-related diseases, especially in the gut.

• 한국임상보건과학회지
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• 제5권4호
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• pp.981-990
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• 2017

본 연구는 보건계열 학생들의 구직효능감과 취업스트레스와의 관련성을 파악하여 취업스트레스를 대처할 수 있는 방안을 모색하기 위한 기초자료를 제공하고자 실시되었다. 연구대상은 경남지역 소재 M대학교 보건계열 3학년 학생으로 치위생과 90명, 안경광학과 50명, 물리치료과 80명, 작업치료과 60명 총 269명을 대상으로 하여 구조화된 설문지를 자기기입 방식으로 조사 분석하였다. 수집된 자료는 IBM SPSS ver. 20.0 통계프로그램을 이용하여 분석한 결과는 다음과 같다. 1. 보건계열 학생에서 남자인 경우, 경제수준이상 인 경우, 전공만족도가 불만족인 경우 구직효능감이 높게 나타났으며, 취업스트레스는 물리치료과 학생에서 높게 나타났다. 2. 취업스트레스에 영향을 미치는 요인으로는 자아존중감이 높은 경우, 고용정보관리기술이 높은 경우, 남자의 경우, 경력유동화능력이 낮은 경우의 순으로 취업스트레스에 영향을 미치는 것으로 밝혀졌다. 이상의 결과에서 보건계열 학생들의 취업스트레스에 영향을 미치는 요인을 감소시키기 위해서는 신입생부터 효과적인 면접기술능력과 본인의 개인적 성향과 특성을 정확히 파악 할 수 있는 교육과정을 통해 자신에게 적합한 구직기술을 향상시켜야 한다. 이를 위해서는 혁신적인 교육과정개발과 현장실습 규정을 보완하여 현장실습 시 관찰시간 보다는 실습 양을 증가시켜 확고한 구직동기에 의한 취업부담감을 해결하고, 학교에서는 취업에서 비교우위에 있을 수 있는 자기개발의 기회제공 및 경제적 지원이 뒷받침 되어야 할 것이다.

• 한국치위생학회지
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• 제16권4호
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• pp.643-649
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• 2016

Objectives: The purpose of the study was to investigate the relationship between professor trust and learning flow in allied health students and to provide the basic data for the improvement of curriculum and teaching method. Methods: A self-reported questionnaire was filled out by 263 allied health students. The questionnaire consisted of 27 questions of professor trust by Likert 5 scale and 29 questions of learning flow by Likert 6 scale. Cronbach's alpha in this study was 0.97 in professor trust, 0.96 in learning flow. The data were analyzed using descriptive statistics, independent t-test, one-way ANOVA, correlation and stepwise multiple regressions. Results: The score was 3.72 in professor trust and 3.46 in learning flow. There were positive correlations between learning flow and professor trust including intimacy, professional, teaching skills and leadership. Stepwise multiple regression analysis revealed that learning flow was related with professor trust. Conclusions: The learning flow depends on professor trust. Based on the research, improvement directions that put strong emphasis on low section of professor trust and learning flow must be placed.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1289-1295
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• 2012

The use of herbal products as radiosensitizers is a promising approach to increase the efficacy of radiotherapy. However, adverse effects related to the use of herbal medicine on radiotherapy are not well characterized. The present study concerns the impact of Derris scandens Benth extract on the radiosensitivity of Hep-2 laryngeal cancer cells. Pretreatment with D. scandens extract prior to gamma irradiation significantly increased clonogenic survival and decreased the proportion of radiation-induced abnormal nuclei of Hep-2 cells. Furthermore, the extract was found to enhance radiation-induced G2/M phase arrest, induce Akt activation, and increase motility of Hep-2 cells. The study thus indicated that D. scandens extract potentiates radioresistance of Hep-2 cells, further demonstrating the importance of cellular background for the adverse effect of D. scandens extract on radiation response in a laryngeal cancer cell line.

• Child Health Nursing Research
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• 제26권4호
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• pp.463-469
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• 2020

Reduction of the under-5 mortality rate is a target of the Sustainable Development Goals. Therefore, this study aimed to estimate under-5 child mortality rates in 52 low-migration countries using population data. The study utilized population data from the US Census Bureau from 1990 to 2015. The method involved first estimating mortality rates for countries with negligible net migration and then applying these rates to countries with matching mortality profiles, where it is reasonable to assume that migration is negligible for children under the age of 5 years. The highest child mortality was concentrated in the African region, followed by Asia and the Western region. However, steady progress in child mortality trends was concentrated in low-income countries. This simple method demonstrated that child mortality has significantly improved in high-income countries, followed by middle- and low-income countries. To reduce the under-5 mortality rates even further in these 52 countries, there is a need to accelerate equitable plans and policies related to child health to promote children's longevity and survival.

• 대한방사선기술학회지:방사선기술과학
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• 제14권1호
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• pp.73-93
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• 1991

• 대한방사선기술학회지:방사선기술과학
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• 제15권2호
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• pp.83-86
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• 1992

• 한국치위생학회지
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• 제16권2호
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• pp.261-268
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• 2016

Objectives: The purpose of this study is to investigate the awareness and needs of English learning in allied health science college students. Methods: A self-reported questionnaire was filled out by 600 health science college students in Seoul, Gyeonggi and Incheon province. The questionnaire consisted of purpose of English learning, attitude and motivation. Data were analyzed by SPSS 19.0 program. Results: Most of the students took English classes(96%) and the English class was mainly done by instruction-centered learning (43.6%). Many students felt the needs of English and they thought English was the most important tool for getting a job(70.7%). Nonetheless most of the students lacked in confidence and interest in English learning due to the surrounding pressure(51.2%). Too much surrounding pressure can cause students lose their zest in English learning. Conclusions: It is need to seek for a curriculum consisting of practical purposes to meet the needs of health science college students about English learning.

• 대한방사선기술학회지:방사선기술과학
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• 제17권2호
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• pp.51-56
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• 1994