• Nutrition Research and Practice
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• 제18권1호
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• pp.110-118
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• 2024

BACKGROUND/OBJECTIVES: Depression and anxiety are common mental health problems. Anthocyanins from berries might have an inhibitory effect on monoamine oxidase (MAO) enzymes and alleviate various mood and anxiety symptoms. This study examined the effects of a daily supplement of an anthocyanin-rich product on mental health problems. SUBJECTS/METHODS: This study was a secondary analysis from a randomized, 6-week, open-label trial in 300 healthy participants aged 18-60 years who consumed 1 or 2 servings of anthocyanin-rich mulberry milk daily. The General Health Questionnaire-28 (GHQ-28) and Hospital Anxiety and Depression Scale (HADS) were used to monitor mental health problems. In addition, the saliva activity levels of MAO-A, MAO-B, and cortisol were examined at the baseline and after 6 weeks. RESULTS: The total scores of the GHQ-28 and HADS and all their subscales decreased in both groups (all P < 0.05). The cortisol, MAO-A, and MAO-B activities decreased significantly (all P < 0.05), but there were no significant differences between the groups (all P > 0.05). Significant correlations were noted between the decreased activity level of MAO-A enzyme and decreased scores from the GHQ-28 somatic subscale and the HADS depression subscale (all P < 0.05). CONCLUSIONS: Daily consumption of anthocyanin-rich mulberry milk possibly improves mental health problems by reducing depressive and anxiety symptoms in the working population. The suppression of MAO-A activity is a possible underlying mechanism.

• Child Health Nursing Research
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• 제16권1호
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• pp.66-72
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• 2010

Purpose: This study was done to identify factors associated with fatigue in pediatric patients with cancer in order to develop nursing interventions for this population. Methods: The participants were 95 pediatric cancer patients admitted to a university medical center in Seoul, Korea, and 95 parents. The $PedsQL^{TM}$, Multidimensional Fatigue Scale developed by Varni (2002) was used to measure fatigue. Data were analyzed with the SAS program and t-test, analysis of variance (ANOVA), Pearson correlation coefficients, and multiple regression were used to identify the association of factors with fatigue. Results: The mean score for fatigue was 30.42 in the pediatric cancer patients and 34.77 in the parents. Fatigue was higher in patients living with a single parent, in patients whose father had a lower education and those patients with a fever. Pain, frequency and intensity of nausea and vomiting, depression, anxiety, and disruption of usual activity were positively associated with fatigue. The predictive factors for fatigue were disruption of usual activity, depression and living with or without parents. Conclusion: Pediatric patients with cancer experienced fatigue during their diagnosis and treatment. Of the multiple factors associated with fatigue, the association between disruption of usual activity and fatigue was the highest indicating a need to be concerned with this factor when providing interventions to alleviate fatigue.

• 한국컴퓨터정보학회논문지
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• 제25권4호
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• pp.79-86
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• 2020

본 논문에서는 비등방성 특징 기반의 다익스트라 알고리즘(Dijkstra algorithm)을 이용한 효율적인 감성 완화 프레임워크를 제안한다. 감성을 완화시키는 것은 감성 분석만큼이나 중요하며, 사람의 우울함이나 외로움을 자동으로 완화시켜줄 수 있는 프레임워크로써 인간과 컴퓨터의 상호작용(HCI, Human-Computer Interaction)측면에서도 매우 중요한 의미를 갖는다. 본 논문에서는 1) 마이크로소프트의 Emotion API를 이용하여 얼굴 표정으로부터 변화하는 감정값을 계산하고, 2) 이 감정값의 차이를 이용하여 우울이나 외로움 같은 이상 감정을 인지한다. 3) 마지막으로, 감성 히스토그램과 비등방성 특성을 고려한 감정 메시 기반의 매칭 과정을 거침으로써 사용자에게 완화된 감성이 내포된 이미지들을 제시해준다. 본 논문에서 제안하는 기법은 얼굴 영상을 이용하여 사용자가 쉽게 감성의 변화를 인지하고, 완화된 감성으로 감정을 트레이닝 할 수 있는 시스템이다.

• Journal of Korean Biological Nursing Science
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• 제24권2호
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• pp.86-94
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• 2022

Purpose: Patients experiencing chemotherapy-induced peripheral neuropathy (CIPN) apply various palliative care as well as drugs in their daily life to alleviate symptoms. There is a need to identify the influence of these efforts and patients' psychosocial status on the relief of CIPN symptoms. This short-term prospective study investigated how prescription drugs, non-pharmacological behaviors (exercise, massage, and heat therapy), and psychological states (social support, depression, and anxiety) affected CIPN symptoms. Methods: Participants scheduled to receive postoperative platinum or taxane-based chemotherapy were enrolled consecutively. CIPN was measured with the Neurotoxicity-12 subscale of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity-12 instrument. Data were collected three times during the 4 or 5 cycles of chemotherapy. Results: At the end of the 2nd chemotherapy cycle, 93.1% of participants reported CIPN symptoms. Multiple regression analyses showed that a heat therapy (β= -.34, p< .001), massage (β= -.21, p= .012), and walking 5 times or more per week (β= -.26, p= .021) provided relieve for CIPN symptoms. Depression (β= .19, p= .027) significantly exacerbated CIPN symptoms. Conclusion: These results suggested that a comprehensive management program that includes walking, heat therapy, massage, and mood therapy should be encouraged. Moreover, patients should be educated at chemotherapy initiation to understand appropriate interventions that can relieve CIPN symptoms.

• 생물정신의학
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• 제26권2호
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• pp.39-46
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• 2019

Antidepressants are widely used to treat depression in Korea, however, only a few studies have focused on the provider of the treatment. The aim of the study is to compare the differences between patients who were prescribed antidepressants by psychiatrists and those who were prescribed antidepressants by non-psychiatrists in South Korea. Patients with a diagnosis of depressive disorder who had been newly prescribed antidepressants in 2012 were selected from the Health Insurance Review and Assessment Service database. They were classified into two groups depending on whether they received the antidepressant prescription from a psychiatrist or non-psychiatrist. Sociodemographic, clinical, and depression related cost has been investigated. Treatment resistant depression, which is defined as a failure of two antidepressant regimens to alleviate symptoms, was also investigated. Prescription adequacy was assessed based on whether a regimen was maintained for at least 4 weeks. Among the 834694 patients with pharmaceutically treated depression (PTD) examined in this study, 326122 (39.1%) were treated by psychiatrists. Patients who were treated by psychiatrists were younger and had more psychiatric comorbidities than those treated by non-psychiatrists. They had longer PTD duration (229.3 days vs. 103.0 days, p < 0.05) and a larger proportion of treatment resistant depression (9.3% of PTD) when compared to those patients treated by non-psychiatrists. The patients treated by psychiatrists had a smaller proportion of inadequate antidepressant use compared to those patients in the non-psychiatrist group (44.5% vs. 65.1%, p < 0.05). The costs related to depression corrected with PTD duration were higher in the non-psychiatrist group (32214 won vs. 56001 won, p < 0.05). Patients who receive antidepressants from psychiatrists are patients with more severe, treatment-resistant depression. Psychiatrists prescribe antidepressants more adequately and cost- effectively than non-psychiatrists.

• 대한한방내과학회지
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• 제41권2호
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• pp.141-149
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• 2020

Traumatic brain injury, which can be caused by head trauma, can damage the brain, resulting in physical disorders, such as headache, dizziness, and nausea, as well as mental health problems, such as depression, anxiety, memory loss, and personality changes that reduce a person's quality of life. Therefore, it is important to administer the best treatment at the right time. A 57-year-old patient complained of headache and depression after intracranical hemorrhage caused by a traffic accident. These symptoms are considered to be after effects of brain trauma due to increased pressure on the brain. Herbal medicine was prescribed to release internal brain pressure and acupuncture was applied to ease frontal and occipital head muscle tension. Objective scales were conducted at baseline, and at one month, two months, and four months. It was observed that the degree of headache and depression improved after treatment. This study is meaningful in that it found that Korean medicine treatments help alleviate the after effects of traumatic brain injury.

• 여성건강간호학회지
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• 제24권1호
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• pp.49-57
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• 2018

Purpose: Postpartum fatigue can impact maternal well-being and has been associated with levels of perceived self-care. This study aimed to examine the relationship among fatigue, depressive mood, self-care agency, and self-care action among postpartum women in Bangladesh. Methods: A descriptive cross sectional survey was done with 124 first-time mothers from two tertiary hospitals in Dhaka, Bangladesh. The Modified Fatigue Symptoms checklist, Denyes' Self Care Instrument, the Edinburgh Postnatal Depression Scale, and items on sociodemographic and delivery-related characteristics, were used in Bengali via translation and back-translation process. Results: High fatigue levels were found in 18.5% (n=23) and 73.4% had possible depression (n=91). There was a significant negative relationship between fatigue and self-care agency (r=-.31, p<.001), and self-care action (r=-.21, p<.05). Fatigue differed by level of self-care agency (t=4.06, p<.001), self-care action (t=2.36, p=.023), newborn's APGAR score (t=-2.93, p=.004), parental preparation class participation (F=15.53, p<.001), and postpartum depressive mood (t=-4.64, p<.001). Conclusion: Findings suggest that high level of self-care efficacy and behaviors can contribute to fatigue management, and highlight the need for practical interventions to better prepare mothers for postpartum self-care, which may, in turn, alleviate postpartum fatigue.

• 대한예방한의학회지
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• 제23권1호
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• pp.61-72
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• 2019

Introduction : The aim of this study was to investigate menstrual pattern according to Mibyeong Index(MBI) and compare Mibyeong symptom score according to severity of menstrual pain. Mibyeong Index was designed to measure inconvenience and resilience of subject's complains including four physical symptoms(fatigue, pain, low sleep quality, indigestion) and mental distress including anxiety, anger, depression. Method : We used the clinical data of Korean medicine Date Center(KDC) for subjects who participated in the study of 'Clinical research for collecting of clinical cases based on the personal type of Mibyeng' conducted in Seoul, from June 26, 2015 to June 26, 2017. A total of 566 fertile women aged 30 to 50 who completed the questionnaires were included in this study. In this study, we used items of Mibyeong Index and the menstrual pattern by self-report questionnaires. The date were analyzed through Kruskal Wallis test, Pearson's chi-square test, and one-way ANOVA using SPSS statistics 19.0. Results : Mibyeong status was significantly associated with severity of menstrual pain(p<0.001), worst day of menstrual pain(p<0.05), and type of menstrual pain(low back pain, nausea, depression, and none (respectively, p<0.05)). In addition, The 7-subtype score (fatigue (p<0.001), pain(p<0.001), low sleep quality(p<0.001), indigestion(p<0.001), anxiety(p<0.05), anger(p<0.05) and depression(p<0.05)) of Mibyeong index and total score of Mibyeong Index (p<0.001) showed significant difference for severity of menstrual pain. Conclusion : This result indicates that a close relationship between Mibyeong status and severity of menstrual pain. Further studies are needed but, we hope that this results will be used as the basic data to improve mibyeong status through health care to alleviate dysmenorrhea.

• 디지털융복합연구
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• 제19권12호
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• pp.541-548
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• 2021

본 연구는 노인차별경험이 자살생각에 미치는 영향과 상실감 및 우울감의 매개효과를 검증함으로써 노인차별경험, 상실감, 우울감이 자살생각으로 이어지는 경로를 분석하였다. 연구대상은 경기도 31개 시군구 노인복지관을 대상으로 지역별·유형별 층화표집 방법을 활용하여 노인복지관(10개소) 이용자인 65세 이상 노인 400명 대상으로 1:1 심층면접 조사하여 총 360부를 최종 분석하였다. SPSS 25.0과 AMOS 23.0을 활용하여 빈도분석, 기술통계분석, 상관분석, 구조방정식과 Bootstrapping의 분석방법을 통해서 검증하였다. 연구 결과 첫째, 노인차별경험이 많을수록 자살생각이 증가하는 것으로 나타났다. 둘째, 노인의 차별경험이 자살생각에 미치는 영향에서 상실감이 부분매개 효과가 있음을 확인하였다. 셋째, 우울감은 노인의 차별경험과 자살생각 간에 부분매개 역할을 하는 것으로 나타났다. 이러한 연구 결과를 토대로 노인자살을 예방하기 위해 노인차별경험과 상실감 및 우울감이 자살생각으로 연쇄되는 것을 완화할 수 있는 정책적·실천적 제언을 하였다.

• Journal of Hospice and Palliative Care
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• 제22권1호
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• pp.30-38
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• 2019

목적: 본 연구는 선행연구와 문헌고찰을 토대로 노인의 죽음불안을 결정짓는 요인들을 Belsky(1980)의 생태학적 이론에 근거하여 우울, 자아통합감, 영적안녕감의 개인유기체 요인과 미시체계 요인으로는 가족지지, 그리고 외체계 요인으로는 사회적연락망, 노인차별경험, 가족주의가치관의 요인들로 가설적 모형을 구축하여 죽음불안에 영향을 미치는 경로를 분석하고자 시행되었다. 방법: 연구대상자는 B광역시의 16개 구(區) 중 10개 구에 소재한 경로당을 이용하는 65세에서 85세 미만의 재가노인이었다. 연구 참여가 가능한 노인은 설문지의 내용을 읽고 이해하며 그에 응답할 수 있는 능력을 가진 자로서 본 연구의 목적을 이해하여 연구 참여에 동의한 후 설문에 참여하였다. 총 189부를 최종 자료 분석에 사용하였다. 자료는 SPSS-WIN 20.0과 AMOS 20.0 프로그램을 이용하여 분석하였으며, 통계처리에 대한 유의 수준은 P<0.05로 설정하였다. 결과: 개인유기체 요인 중 우울은 죽음불안에 직접적인 영향을 미치는 것으로 나타났다(${\beta}=0.32$, P<0.001). 미시체계 요인인 가족지지는 죽음불안에 대한 직접(${\beta}=-0.15$, P=0.026), 간접효과(${\beta}=-0.06$, P=0.022) 및 총 효과(${\beta}=-0.21$, P=0.006) 모두 통계적으로 유의하게 나타났다. 외체계 요인들 중 사회적연락망(${\beta}=0.21$, P=0.003)과 가족주의가치관(${\beta}=0.23$, P=0.009)은 죽음불안에 직접적인 영향을 미치는 것으로 나타났다. 결론: 노인의 죽음 불안에 영향을 미치는 요인으로 개인유기체 요인 중 우울, 미시체계 요인인 가족지지, 그리고 외체계 요인인 사회적 연락망 및 가족주위 가치관이 확인되었다. 비록 자아통합감, 영적 안녕감 및 노인차별경험이 죽음불안에 직접적인 영향이 없는 것으로 확인되었으나 노인의 개인유기체, 미시체계 및 외체계 요인들과 상호작용하는 것이 확인되어 노인의 죽음불안에 대한 중재개발에 있어서 개인과 가정 그리고 사회적 환경을 고려한 생태학적 접근이 필요한 것으로 여겨진다.