• Title/Summary/Keyword: Alkaloids

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Tricyclic Pyridone Alkaloids from Cultures of Cornus officinalis Fruits-associated Fungus, Fusarium lateritium SSF2 (산수유(Cornus officinalis) 과실에서 분리한 Fusarium lateritium SSF가 생산하는 Tricyclic Pyridone계 알칼로이드)

  • Choi, Hyun Gyu;Shim, Sang Hee
    • Korean Journal of Pharmacognosy
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    • v.48 no.4
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    • pp.268-272
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    • 2017
  • Three tricyclic pyridone alkaloids, (-)-4,6'-anhydrooxysporidinone (1), (-)-6-deoxyoxysporidinoCne (2), and (-)-sambutoxin (3) were isolated from cultures of Fusarium lateritium SSF2 derived from the fruits of Cornus officinalis. Chemical structures of the isolated compounds were determined by spectroscopic method and comparisons with reported data values. The compounds 1-3 were isolated for the first time from this fungal strain.

Phytochemical Survey of Herb Drugs (IV) (한약의 식물화학적 조사(IV))

  • 우린근;김제훈
    • YAKHAK HOEJI
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    • v.9 no.3_4
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    • pp.34-36
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    • 1965
  • As the projects of this institute, a hundred and sixtyfive species of plants which are used currently as herb drugs in Korea were screened on the presence of alkaloids, phenolic compounds, flavonoids, chalcones, lactones, glucosides, carbohydrates, terpenoids, steroids proteins, polypeptides, saponins, and organic acids, and the most reliable presence of alkaloids was detected by paper chromatograph. In this paper, presence of alkaloids is added by screening of 45 species.

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Phytochemical Survey of Herb Drugs (III) (한약의 식물화학적 조사 (III))

  • 우린근;김희숙
    • YAKHAK HOEJI
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    • v.8 no.2
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    • pp.35-36
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    • 1964
  • One of projects of this institute is phytochemical survey of the herb drugs in Korea for further study. A hundred and fifteen species of plants which are used currently as herb drugs in Korea were screened on the presence of alkaloids, phenolic compounds, flavonoids, chalcones, lactones, glucosides, carbohydrates, terpenoids, steroids, proteins, polypeptides, saponins, and organic acids, and the most reliable presence of alkaloids was detected by paper chromatography. In this paper, presence of alkaloids is also tabulated after screening other 50 species.

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Studies on the Culture of Ergot Fungus.(I) (맥각균의 배양에 관한 연구 I)

  • 김병각
    • YAKHAK HOEJI
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    • v.12 no.3_4
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    • pp.85-88
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    • 1968
  • To select sclerotia to be used for strain isolation, water-soluble and water-insoluble alkaloids contents of the sclerotia of ergot fungus were determined. The sclerotia parasitic on the genus Elymus were found to contain greater amount of the alkaloids, up to 1.44%, than the sclerotia from the genus Agropyron. The major portion of the total alkaloid contents was the water-insoluble alkaloids. No correlation was found between the alkaloid contents and the lipid contents of the sclerotia analyzed.

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Synthesis of Benzophenanthridine-Related Alkaloids (벤조펜안드리딘과 관련된 알칼로이드의 합성)

  • Kim, Sin-Kyu;Lee, Hyung-Won;Kim, In-Jong;Lee, Ma-Se
    • YAKHAK HOEJI
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    • v.36 no.3
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    • pp.250-254
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    • 1992
  • Benzo[C]phenanthidine alkaloids were found to exhibit considerably strong antileukemic activies. These alkaloids have been shown to be biosynthesized from the corresponding alkaloids throung an oxidative $C_6-N$ bond cleavage followed by recyclization between $C_6\;and\;C_{13}$ position of the protoberberine. Recently we have achieved the biomimetic transformation of protoberberine alkaloid, berberine into benzo[C]phenanthridine alkaloid, chelerythrine.

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Alkaloids from The Roots of Tabernaemontana Macrocarpa Jack

  • Husain, Khairana;Said, Ikram M.;Din, Laily B.;Takayama, Hiromitsu;Kitajima, Mariko;Aimi, Norio
    • Natural Product Sciences
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    • v.3 no.1
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    • pp.42-48
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    • 1997
  • The roots of Tabernaemontana macrocarpa Jack (Apocynaceae) yielded nine indole alkaloids which were identified as coronaridine (2), voacangine hydroxy-indolenine (3), 3-oxo-coronaridine (4), 19-R-heyneanine (7), coronaridine pseudoindoxyl (8) and voacangine pseudoindoxyl (9) while 3-(2-oxopropyl)-coronaridine (1), 3-(2-oxopropyl)-coronaridine-pseudoindoxyl (5) and 3-(2-oxopropyl)-voacangine-pseudoindoxyl (6) were isolated as artefacts formed during the isolation process. All of the alkaloids were identified by spectroscopic methods $(UV,\;MS,\;^1H-NMR\;&\;^{13}C-NMR)$ and in comparison with the literature data.

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Biosynthesis of Ergot Alkaloids (맥각 알칼로이드의 생합성)

  • Kim, Byong-Kak
    • Korean Journal of Pharmacognosy
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    • v.4 no.1
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    • pp.1-7
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    • 1973
  • Recent findings that agroclavine strongly inhibits: lactation and that ergocornine and ergonovine induce regression or inhibition of pituitary tumor growth in rats revealed new pharmacological activities in addition to the well-known activities of ergot alkaloids. Clavicipitic acid, isochanoclavine (I) and chanoclavine (II) are newly isolated alkaloids. It was already established that tryptophan, mevalonic acid and methionine are biosynthetic precursors of ergoline, a basic structure of the alkaloids, which is formed via $4-({\gamma},{\gamma}-dimethylallyl)-tryptophan$, mediated by dimethylallylpyrophosphate: tryptophan dimethylallyl transferase. Chanoclavine-I appears to be an intermediate to agroclavine which is converted to elymoclavine. Agroclavine and elymoclavine were also found to be hydroxylated by peroxidase to setoclavine and penniclavine, respectively. Elymoclavine is converted to ergotamine and lysergic acid ${\alpha}-hydroxyethylamide$, respectively. Pyruvate and alanine were found to be incorporated into the two-carbon unit of the ${\alpha}-hydroxyethyl$ moiety of the latter. Lysergylalanine is converted to ergometrine, but not to lysergic acid ${\alpha}-hydroxyethylamide$.

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Tiliacosine and Tiliasine, two New Bisbenzylisoquinoline Alkaloids from Tiliacora racemosa

  • Seal, Tapan;Patra, Amarendra;Mukhopadhayay, Gobinda;Mukherjee, Biswapati
    • Natural Product Sciences
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    • v.7 no.3
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    • pp.83-86
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    • 2001
  • Two new bisbenzylisoquinoline alkaloids tiliacosine (1) and tiliasine (2) were isolated from the leaves of Tiliacora racemosa Colebr.. The structures of these alkaloids were established on the basis of spectral evidence and by the correlation of their $^1H-NMR$ spectral data with those of the congeners N-methyltiliamosine (3), tiliamosine (4) and tiliacorine (5).

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NMR Assignments of Rotameric Aporphine Alkaloids from Liriodendron tulipifera

  • Park, InWha;Na, MinKyun
    • Natural Product Sciences
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    • v.26 no.2
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    • pp.171-175
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    • 2020
  • Liriodendron tulipifera, belonging to the family Magnoliaceae, is commonly called tulip tree. Four N-acetylated aporphine alkaloids, N-acetylnornuciferine (1), N-acetylanonaine (2), N-acetyl-3-methoxynornuciferine (3), and N-acetyl-3-methoxynornantenine (4) were isolated from the roots of L. tulipifera. Although the purity of each compound (1 - 4) was determined to be 97, 96, 99, and 98%, respectively, the 1H and 13C NMR spectroscopic data of the aporphine alkaloids 1 - 4 displayed all signals in duplicate, indicating the presence of two rotamers due to restricted rotation of N-COCH3 functionality in solution status. The absolute configurations of 1 - 4 w ere established by measuring specific rotation and comparison with the reported data. This is the first report on the 1H and 13C NMR assignments of N-acetyl-3-methoxynornuciferine (3) and N-acetyl-3-methoxynornantenine (4). This study provides advanced NMR spectroscopic data for the structure determination of rotameric aporphine alkaloids.

EFFECTS OF SPIRAMINE ALKALOIDS ON THE PLATELET AGGREGATION

  • jiang, Hao-Xiao
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1998.11a
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    • pp.66-71
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    • 1998
  • Spiraea japonica L. F., a plant species belongs to the Spiraea genus of Rosaceae family, has seven varieties. There are all varieties distributed in Yunnan province of China, and S. japonica var. acuminata and S. japonica var. fortunei were used as the folk medicines to treat malaria and inflammation etc.. Since 1960s, Japanese and Russian scholars obtained C$\_$20/-diterpenoid alkaloids from S. japonica L.F., also Chinese scholars got a series of Hetisine-type C$\_$20/-diterpenoid alkaloids from S. japonica var. fortunei in 1985. Since then, we started the chemical and pharmaceutical studies of this complex. Here we wish to report the bioactive effects of spiramine alkaloids and their derivatives on the platelet aggregation induced by AA, PAF, or ADP.

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