• The Korean Journal of Physiology
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• v.13 no.1_2
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• pp.23-28
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• 1979

The following results were drawn from the experiment conducted to see the effect of ginseng alcohol extract on the mitochondrial oxidation of the rat liver. 1) Mitochondrial oxygen consumption increased in the low concentration and decreased in the high concentration of ginseng alcohol extract. 2) When the mitochondria was destroyed mechanically or was swollen by low concentration of $AgNO_3$, mitochondrial oxygen consumption was inhibited in all concentration of ginseng alcohol extract. 3) Oxygen consumption of intact mitochondria increased in the low concentration but decreased in the high concentration of sodium deoxycholate. 4) Ginseng alcohol extract inhibited cytochrome oxidase activities of liver mitochondria. These results suggest that low concentration of ginseng alcohol extract activates the oxygen consumption of liver mitochondria by increasing the permeability of the mitochondrial membrane and high concentration of the extract inhibit the oxygen consumption by inhibiting the enzyme activity related to respiration.

• Korean Journal of Food Science and Technology
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• v.29 no.1
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• pp.167-172
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• 1997

Effect of combined preparation (DWP715) containing Alaska pollack extract, maltol, ascorbic acid and nicotinamide on decreasing of blood alcohol was evaluated in human blood. Treatment of DWP715 prior to administration of 25% alcohol (100 mL) decreased alcohol concentration in blood and showed significant difference after 2 hours. The pharmacokinetic parameters such as area under the concentration-time curve (AUC), $C_{max},\;T_{max}\;and\;T_{1/2}$ were also decreased and delayed when compared with control values. Effects of DWP715 on anti-fatigue and anti-oxidation activities were also studied in the restraint stress model using various parameters (GOT, GPT, LDH values and organ weights) on mild condition and examined through the content of lipid peroxide induced by 2% $CCl_4$ in mouse livers. While GPT level, thymus and adrenal weight were not influenced by DWP715 dosing, LDH, GOT level and spleen weight used as a parameter against fatigue and stress states were recovered almost to the nomal level. Furthermore, lipid peroxidation due to $CCl_4$ was significantly inhibited by DWP715 treatment. These results suggest that DWP715 seems to metabolize the blood alcohol rapidly and to restore the damaged liver and fatigue conditions which was caused by alcohol metabolism to normal condition.

• International Journal of Oral Biology
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• v.31 no.3
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• pp.107-112
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• 2006

Aldehyde dehydrogenase (ALDH) plays an important role in alcohol metabolism; ALDH is responsible for the oxidation of acetaldehyde generated during alcohol oxidation. ALDH is also known to oxidize various other endogenous and exogenous aldehydes. Cytochrome P-450 2E1 (CYP2E1), a liver microsomal enzyme, also metabolizes acetaldehyde and ethanol and can be induced by other inducers including acetone and ethanol. We examined single nucleotide polymorphisms (SNP) of ALDH and CYP2E1 genotypes in Korean. Restriction fragment length polymorphism (RFLP) method was used to determine ALDH and CYP2E1 SNP. Mutation in ALDH was 60% (heterozygote 46.7% and homozygote 13.3%) among 15 cases. CYP2E1 mutation was 52.7% (heterozygote 47.4% and homozygote 5.3%) among 19 cases.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.144-145
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• 2003

Hangover is associated with ethanol metabolism in body after the ingestion of an alcoholic beverage. Especially. The metabolism in liver is forcused by many researcher because, alcohol (approximately 90％) is metabolized by the liver. Ethanol metabolism in liver involves both liver alcohol dehydrogenase(ADH) which actalyzes the oxidation of ethanol to acetaldehyde, and liver aldehyde dehydrogenase(ALDH) which metabilized rapidly acetaldehyde, product of ethanol oxidation, to acetate. (omitted)

• 한국신재생에너지학회:학술대회논문집
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• 2011.11a
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• pp.140.1-140.1
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• 2011

최근 자동차용 휘발유에 메탄올을 불법 혼합시켜 유통시키는 사례가 빈번히 적발되고 있다. 정상적인 연료에 알코올이 불법 혼합될 경우, 장치 내 고무류와 금속류를 부식시키며, 독성가스인 알데하이드를 배출시키는 것으로 알려져 있다. 또한 에탄올의 경우 흡습성이 높아 자체적으로 수분을 생성시킬 수 있으며 정상 휘발유보다 증기압이 높기 때문에 밀폐공간에서 화재 및 질식의 위험이 있을 수 있다. 현재 휘발유 내에 알코올 성분을 분석하기 위한 분석법으로는 Gas Chromatography가 이용되고 있으나 고가의 장비와 긴 분석시간으로 인해서 유사석유의 판별여부가 효율적으로 이루어지지 않고 있다. 본 연구에서는 화학절 식별제인 크롬산($CrO_3$)을 이용하여 휘발유 내 알코올 성분을 정성 정량 분석하였다. 환원된 3가 크롬은 용액상에서 붉은색을 나타내므로 육안으로도 알코올의 존재여부를 간단히 확인할 수 있으며, UV-Vis Spectrophotometry를 통해 휘발유 내 알코올의 농도에 따라 흡광도값이 증가하는 것을 확인할 수 있었다.

• Bulletin of the Korean Chemical Society
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• v.30 no.1
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• pp.57-60
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• 2009

Alcohol oxidase catalyzes the oxidation of short lines alcohol to aldehyde. In this study, alcohol oxidase from Hansenula polymorpha (HpAOD) was induced by addition of 0.5% methanol as the carbon source and purified to electrophoretic homogeneity by column chromatographies. The purified HpAOD was immobilized with DEAE-cellulose particles and its biochemical properties were compared with those of free enzyme. The substrate specificity and the optimum pH of immobilized enzyme were similar to those of free enzyme. On the other hand, the Km values of free and immobilized enzymes for ethanol were 6.66 and 14.65 mM, respectively. The optimum temperature for free enzyme was ${50^{\circ}C}$, whereas that for immobilized enzyme was ${65^{\circ}C}$. Immobilized enzyme showed high stability against long storage. Immobilized enzyme was also tested for the enzymatic determination of ethanol by the colorimetric method. We detected 1 mg/liter ethanol ($1{\times}10^{-4}$% ethanol) by 2,6- dichloroindophenol system. Therefore, the present study demonstrated that immobilized HpAOD has high substrate specificity toward ethanol and storage stability, which may be of considerable interest for alcohol biosensor and industrial application.

• Bulletin of the Korean Chemical Society
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• v.23 no.9
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• pp.1285-1290
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• 2002

Various nitrobenzaldehydes were simultaneously allylated and reduced using indium in the presence of HCl in aqueous media to give compounds having both functionality of homoallylic alcohol and aromatic amine. Sequential protection of the amino gro up and oxidation of the anilinyl homoallylic alcohol provided useful precursors of heterocyclic compounds such as dihydroindolones and dihydroquinolones, which could be efficiently synthesized through intramolecular cyclization reaction.

• Bulletin of the Korean Chemical Society
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• v.26 no.11
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• pp.1872-1874
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• 2005

• Journal of Microbiology
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• v.37 no.1
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• pp.41-44
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• 1999

Human mitochondrial aldehyde dehydrogenase 2 (ALDH2) is mainly responsible for oxidation of acetaldehyde generated during alcohol oxidation in vivo. A full-length cDNA of human liver ALDH2 was successfully expressed using a vaccinia virus-T7 RNA polymerase system. The expressed ALDH2 had an enzymatic activity as high as the native human liver ALDH2 enzyme.

• Journal of Convergence for Information Technology
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• v.11 no.9
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• pp.109-114
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• 2021

Cr(VI)-quinoline compound[(C₉H₇NH)₂Cr₂O₇] was synthesized by the reaction between of quinoline and chromium(VI) trioxide, and structure was FT-IR, elemental analysis. The oxidation ability of benzyl alcohol greatly depends upon the dielectric constant of the used organic solvent, where carbon tetrachloride was worst and N,N'-dimethylformamide was best solvent. Noticeably, in N,N'-dimethylformamide solvent, Cr(VI)-quinoline compound oxidized substituted benzyl alcohols. The Hammett reaction constant(ρ)=-0.69(303K). As a resuit, Cr(VI)-quinoline compound was found as efficicent oxidizing agent that converted benzyl alcohol, allyl alcohol, primary alcohol and secondary alcohols to the corresponding aldehydes or ketones. Cr(VI)-quinoline compound was selective oxidizing agent of benzyl alcohol, allyl alcohol and primary alcohol in the presence of secondary alcohol ones.