• 대한임상검사과학회지
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• 제53권3호
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• pp.241-248
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• 2021

본 연구는 고혈압이 있는 대한민국 성인에서 아스파르트산 아미노전이효소(aspartate aminotransferase, AST)/알라닌 아미노전이효소(alanine aminotransferase, ALT) 비율과 맥압(pulse pressure, PP) 사이의 관계를 평가하기 위해 수행되었다. 제6차 국민건강영양조사(KNHANES VI-3, 2015)에서 성인 1,515명의 데이터를 분석했다. 본 연구에서는 몇 가지 중요한 결과가 있다. 첫째, AST (odds ratio [OR], 1.018; 95% confidence interval [CI], 1.002~1.033), ALT (OR, 0.982; 95% CI, 0.969~0.996) 및 AST/ALT ratio (OR, 1.367; 95% CI, 1.027~1.819)는 고PP 결정하는 독립적인 요인이었다. 둘째, 관련변수(연령, 성별, 흡연, 음주, 규칙적인 운동, TC, TG, HDL-C, FBG, BMI, WC)를 조정한 후의 결과에서 AST/ALT ratio의 1 사분위에 대한 고PP의 OR을 기준으로, AST/ALT ratio의 2 사분위(OR, 1.188; 95% CI, 0.817~1.727) 및 AST/ALT ratio의 3 사분위(OR, 1.169; 95% CI, 0.800~1.710)는 유의하지 않았지만, AST/ALT ratio의 4 사분위(OR, 1.632, 95% CI, 1.113~2.393)에서 유의하게 높았다. 결론적으로, 고혈압이 있는 대한민국 성인에서 고PP은 AST/ALT ratio 및 AST와 양의 상관관계가 있었지만 ALT와 음의 상관계가 있었다.

• Environmental Analysis Health and Toxicology
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• 제13권3_4호
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• pp.63-70
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• 1998

In order to elucidate the prevalence of anti-HEV, anti-HCV and HBsAg in ALT (Alanine Aminotransferase)-elevated patient group and healthy person control group, we examined anti-HEV, anti-HCV and HBsAg in 92 persons, respectively. The prevalence of anti-HEV in ALT-elevated patient group (4.3%) was not significantly higher than that (2.2%) of healthy person control group(P>0.05). While in healthy person control group the prevalence of anti-HEV in female (2.4%) was higher than that (2.0%) in male, and in ALT-elevated group male (4.8%) was higher than female (3.3%), there were no significances. The positive rate of anti-HEV was not significantly increased with age between healthy person control and ALT-elevated patient group. The odds ratio's of HEV, HCV and HBV with ALT-elevated patient group were 2.05 (95% CI: 0.31-16.54), 8.67 (95% CI: 1.06-188.63) and 7.23 (95% CI: 2.47-22.71), respectively, but had no significance. It was turned out that HCV and HBV were significantly correlated with ALT-elevated patient group, but HEV had no significance with it in this paper.

• Journal of Nutrition and Health
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• 제42권8호
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• pp.732-739
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• 2009

Metabolic syndrome has been strongly associated with elevated alanine aminotransferase (ALT), a surrogate of nonalcoholic fatty liver disease. We investigated the relationship between metabolic syndrome and elevated ALT in the general Korean population. The study sample was comprised of 4,781 Korean adults who had participated in the 2005 Korean National Health and Nutrition Examination Survey. Metabolic syndrome was defined by National Cholesterol Education Program for Adult Treatment Panel III. Elevated ALT was defined as an enzyme activity > 40 IU/L for men, and > 31 IU/L for women. ALT was measured by enzymatic methods. Among participants, 425 (8.9%) subjects displayed elevated ALT. The odds ratios (ORs) for elevated ALT increased in subjects with obesity or one of components of metabolic syndrome such as abdominal obesity, high blood pressure, high fasting glucose, high triglyceride, and low HDL cholesterol after adjusting for age and sex. The unadjusted OR for elevated ALT increased according to the number of components of metabolic syndrome (OR = 1.5, 95% CI: 0.96-2.32 for 1 component; OR = 3.0, 95% CI: 1.98-4.61 for 2 components; OR = 6.3, 95% CI: 4.29-9.35 for ${\geq}3$ components; p for trend < 0.0001). This trend did not differ after adjustments for putative risk factors including age, sex, BMI, smoking status, and alcohol intake. Metabolic syndrome is implicated as a strong risk factor of elevated ALT in Korean adults.

• 한국동물학회지
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• 제33권3호
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• pp.297-302
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• 1990

본 연구는 인삼 사포닌이 수영으로 훈련된 웅성 흰 쥐의 혈청 alanine aminotransferase 활성에 미치는 영향을 연구하였다. 훈련군은 50일간 수영훈련시켰으며, 인삼군은 체중 Kg 당 150mg의 인삼 사포닌을 2주간 구강 투여하였다. 인삼 사포닌을 투여한 훈련군은 수영훈련 종료일 직전 2주간에 걸쳐 체중 Kg 당 150mg의 인삼 사포닌을 구강 투여하였다. 훈련군의 혈청 ALT 활성과 인삼군의 혈청 ALT 활성은 대조군 보다 각각 약 72.89%와 57.14%로 유의성 있게 증가하였다. 실험군인 인삼 투여 훈련군과 인삼 비투어 훈련군의 혈청 ALT 활성은 대조군인 비투여 및 비훈련군 보다 각각 79.31% 및 69.66%로 유의성 있게 증가하였다. 인삼 투여훈련군을 인삼 비투어 훈련군과 비교하여 본다면 인삼 사포닌의 영향은 무의성으로 나타났다. 따라서 훈련 및 인삼 사포닌은 각각 흰 쥐의 혈청 ALT 활성을 뚜렷하게 증가시키나, 인삼 투여 훈련군의 경우 인삼 사포닌은 훈련으로 인해 증가된 흰 쥐의 혈청 ALT 활성을 더욱 상승시키지는 않는 것으로 생각된다.

• 한국임상약학회지
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• 제3권1호
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• pp.45-53
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• 1993

Biphenyl Dimethyl dicarboxylate(DDB) has been regarded as a safe, effective drug for decreasing serum aminotransferase levels from elevated serum aminotransferase levels, which cause acute or chronic hepatitis and chronic liver diseases. This study was designed to low dose(22.5mg/day) & short-term therapy effectiveness for 4 weeks of DDB in 30 chronic hepatitis patients with elevated serum aminotransferases. The following results were observed. 1. Serum alanine aminotransferase(ALT) levels significantly decresed from 173. $97\pm130.62(U/L)$ of pretreatment level to $32.23\pm19.22(U/L)$ after treatment for 4 weeks(p<0.00l) and normalized patients by $73\%$ 2. Serum aspartate (AST) aminotransferase levels significantly decreased from $94.90\pm49.17(U/L)$ of pretreatment level to $45.30\pm23.25(U/L)4 after treatment(p0<0.01). 3. However, no significant effects in the serum AST & ALT changes by which cause hepatitis and hepatitis duration (p>0.05). 4. No significant adverse effects were observed except for mild epigastric discomfort in one patient during DDB treatment It is suggested that DDB small dosage administration can result effectively decreasing serum aminotransferase levels from chronic hepatitis patients with elevated serum aminotransferase levels.

• Clinical and Experimental Pediatrics
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• 제59권9호
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• pp.362-367
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• 2016

Purpose: This study aimed to investigate the clinical significance of serum alanine aminotransferase (ALT) levels in children with nonalcoholic fatty liver disease (NAFLD) and the effect of lifestyle intervention on NAFLD. Methods: The clinical data of 86 children diagnosed with NAFLD were reviewed retrospectively. Forty-six patients belonged to the elevated ALT group and 40 to the normal ALT group. The clinical parameters of patients with NAFLD were also compared based on the status of ALT levels after lifestyle intervention. Results: Patients with elevated ALT had significantly higher body mass index (BMI) scores than those with normal ALT (P<0.05). Of all the patients with elevated ALT, 89% exhibited moderate or severe degree of fatty change in the liver on ultrasonographic examination, whereas most patients with normal ALT exhibited mild or moderate degree changes. Liver biopsy was performed in 15 children with elevated ALT and all showed mild histological changes. Of all patients with elevated ALT, 49% achieved normal ALT levels after lifestyle intervention. Those with more severe histological changes tended to have continuously increasing ALT levels. There was no correlation between the normalization of posttreatment ALT level and BMI, as well as ultrasonographic findings at diagnosis. Conclusion: ALT elevation in NAFLD is highly associated with higher BMI scores and more severe degree of fatty changes on ultrasonographic examination. Lifestyle intervention can significantly improve ALT in children with NAFLD. The degree of histologic changes appears to be a predictor of the treatment response to NAFLD.

• 대한임상검사과학회지
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• 제49권4호
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• pp.374-381
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• 2017

LAP 지수는 공복시 중성지방 농도와 허리둘레의 조합으로 과도한 지방축적을 평가하는 지표이다. 이 연구는 LAP 지수와 ALT간의 관련성과 LAP 지수가 ALT에 미치는 영향에 대해 알아 보고자 간질환의 병력이 없는 건강한 성인남성을 대상으로 횡단면 연구를 실시하였다. 2015년 1월부터 2017년 6월까지 경기지역 종합병원에서 건강검진을 시행한 20세 이상 70세 이하의 성인 남성 13,854명을 연구 대상자로 하였다. LAP 지수는 남성의 경우 [허리둘레(cm)-65]${\times}$[중성지방(mmol/L)]으로 산출하였으며, 혈청 ALT 농도의 이상치는 남성 40 IU/L 이상인 경우를 기준으로 설정하였다. 모든 대상자들은 인체측정학적 지표와 생리학적 검사를 실시하였다. LAP 분위수가 증가할수록 ALT는 통계적으로 유의한 증가를 보였다(p<0.001). LAP 지수는 ALT와 상관관계를 보였으며(r=0.238, p<0.001), 특히 인슐린(r=0.449, p<0.001) 및 HDL-콜레스테롤(r=-0.369, p<0.001)과 상관성이 높게 나타났다. 또한 LAP 지수는 ALT에 영향을 미치는 요인이었으며(p<0.001), LAP 지수가 높을수록 ALT가 상승할 위험이 높게 나타났다(p<0.001). 결론적으로 LAP 지수는 한국 성인남성에서 ALT 상승을 예측하는 지표로 나타났다.

• 대한본초학회지
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• 제24권4호
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• pp.87-93
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• 2009

Objectives : Aconiti Lateralis Preparata Radix (附子) and Aconiti Tuber (川烏) are not commonly prescribed, but are necessary for some clinical conditions, despite of the fact that some negative effects have been known to occur with these medicines. This study shows the consequences for aspartate aminotransferase (AST), alanine aminotransferase (ALT) due to herbal medicines, including Aconiti Lateralis Preparata Radix (附子) and Aconiti Tuber (川烏). Methods : From 1st June 2007 to 10th May 2009, the results were analyzed for 64 patients belonging to the OO Oriental Medical Hospital who took herbal medicine, including Aconiti Lateralis Preparata Radix (附子) and Aconiti Tuber (川烏), more than 20 days. This is the study about the comparison and the investigation of AST, ALT. And the results were taken upon their hospitalization and to their departure. The Criteria of Diagnosis in Liver Injury of CIOMS was used as a standard for their examinations. Results : AST, ALT (total 64). The number of patients who were within normal reference value : 49. The number of patients who exceed the normal reference value after dosage, without satisfying the Criteria of Diagnosis in Liver Injury : 5. The number of patients who were recovered in normal reference value after dosage : 9. The number of patients who satisfying the Criteria of Diagnosis in Liver Injury after dosage : 1. Conclusions : This results suggest that these herbal medicines, including Aconiti Lateralis Preparata Radix (附子) and Aconiti Tuber (川烏), didn't cause adverse side-effects on AST, ALT of the patients who are taking them.

• 대한임상검사과학회지
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• 제55권1호
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• pp.9-15
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• 2023

본 연구의 목적은 당뇨 검사결과와 간기능검사와의 관계연구이다. 간성당뇨는 제2형 당뇨와는 다르게 간기능 이상으로 기인하는 것이다. 본 연구에서 간기능 검사의 주요 효소검사인 아스파르트산 아미노전이효소(aspartate aminotransferase, AST), 알라닌 아미노전이효소(alanine aminotransferase, ALT) 그리고 AST/ALT ratio (De Ritis ratio)와 당뇨관련 검사와의 관계를 주로 확인하였다. 연구 결과 AST와 글루코스(glucose) (r=0.14, P<0.01); ALT 및 글루코스(r=0.21, P<0.01); AST 및 당화혈색소(HbAlc) (r=0.15, P<0.01); ALT와 HbAlc (r=0.20, P<0.01), 모든 변수는 양의 상관관계를 나타났으며, De Ritis ratio는 글루코스 (r=-0.20, P<0.01)와 당화혈색소 (r=-0.14, P<0.01)와 음의 상관관계를 보였다. AST와 ALT 그리고 De Ritis ratio 를 독립변수로 하고 글루코스 (R²=0.05) 와 HbA1c (R²=0.04) 를 종속변수로 하여 회귀분석한 결과 독립변수는 종속변수에 통계적으로 유의하게 영향을 나타내는 것으로 나타났다. AST는 ALT 보다 혈당과 당화혈색소에서 상관관계가 낮게 나타났으며, ALT가 증가하는 것은 즉, De Ritis ratio 감소의 원인이 된다. 따라서, De Ritis ratio는 당뇨관련 검사와의 관계에서 의미가 있는 것으로 볼 수 있다.

• Advances in Traditional Medicine
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• 제3권1호
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• pp.18-20
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• 2003

The purpose of this study was to examine the effect of supplementary highly purified chitosan (HPC) on blood alcohol concentration in healthy human. The human study was performed with two sections. Each section of the study was conducted by two-phase cross-over design with a week wash-out period. All volunteers took HPC in one phase, and took a placebo in the next phase. Blood alcohol concentrations were different between in those taking HPC and in those taking the placebo in the human. And the concentration of serum aspartate aminotransferase (AST, GOT) and alanine aminotransferase (ALT, GPT), the indicator of liver cell damage, was lowered in those taking HPC, compared to those taking the placebo. In conclusion, taking HPC prior to drinking alcohol can somewhat reduce alcohol concentration in human blood and liver cell damage.