• Biomedical Science Letters
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• v.7 no.3
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• pp.111-116
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• 2001

To investigate an effect of aging on the xylene metabolism in liver damaged animals, a study was conducted. 50% carbon tetrachloride ($CCl_4$) in olive oil (0.1 ml/100 g body weight) was intraperitoneally given to 5-week and 12-week rats 12 times every other day and then one dose of 50% xylene in olive oil (0.25 ml/100 g body weight) was intraperitoneally given to the rats, and after 24 hr, the animals were sacrificed. On the basis of the functional findings in rat liver, ie, serum levels of alanine aminotransferase activity, liver protein and malonedialdehyde contents, 5-week rats showed less liver damage than 12-week rats. The increasing rate of urinary methylhippuric acid concentration to the control was significantly higher in 5-week rats than 12-week rats in case of xylene treatment after induction of liver damage. On the other hand, liver damaged 5-week rats showed significant rise of hepatic cytochrome P45O content compared with the liver damaged 12-week rats by the xylene treatment. And increasing rate of hepatic alcohol or aldehyde dehydrogenase activities to each liver damaged animals was higher tendency in 5-week rats than 12-week rats by the xylene treatment. In conclusion, 5-week rat showed greater metabolic rate of xylene than 10-week rats in case of liver injury because 5-week rats led to a slight liver damaged compared with 12-week rats.

• Physical Therapy Korea
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• v.28 no.3
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• pp.177-185
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• 2021

Background: Muscle undergoes change continuously with aging. Sarcopenia, in which muscle mass decrease with aging, is associated with various diseases, the risk of falling, and the deterioration of quality of life. Obesity and sarcopenia also have a synergy effect on the disease of the older adults. Objects: This study examined the risk factors for sarcopenia, sarcopenic obesity, and sarcopenia without obesity and developed prediction models. Methods: This machine-learning study used the 2008-2011 Korea National Health and Nutrition Examination Surveys in the analysis. After data curation, 5,563 older participants were selected, of whom 1,169 had sarcopenia, 538 had sarcopenic obesity, and 631 had sarcopenia without obesity; the remaining 4,394 were normal. Decision tree and random forest models were used to identify risk factors. Results: The risk factors for sarcopenia chosen by both methods were body mass index (BMI) and duration of moderate physical activity; those for sarcopenic obesity were sex, BMI, and duration of moderate physical activity; and those for sarcopenia without obesity were BMI and sex. The areas under the receiver operating characteristic curves of all prediction models exceeded 0.75. BMI could predict sarcopenia-related disease. Conclusion: Risk factors for sarcopenia-related diseases should be identified and programs for sarcopenia-related disease prevention should be developed. Data-mining research using population data should be conducted to enhance the effectiveness of early treatment for people with sarcopenia-related diseases through predictive models.

• Journal of Veterinary Science
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• v.21 no.1
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• pp.7.1-7.13
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• 2020

Aging triggers cellular and molecular alterations, including genomic instability and organ dysfunction, which increases the risk of disease in mammals. Recently, due to the markedly growing number of aging dogs in the world, as much as 49% in total number of pet dogs, it is necessary to improve and maintain their quality of life by understanding of the biological effects of aging. Therefore, the aim of this study was to determine specific biomarkers in aging dogs as a means of defining a set of hematological/biochemical biomarkers that influence the aging process. Blood samples were collected from younger (1-3 years) and older (7-10 years) dogs of middle/large size. The hematological/biochemistry analysis was performed to evaluate parameters significantly associated with age. Enzyme-linked immunosorbent assay was used to target growth hormone (GH)/insulin growth factor-1 (IGF-1), one of the main regulators of the aging process. Declining levels of total protein and increased levels of glucose in young dogs was observed regardless of their body size. Notably, a significantly high concentration of GH and IGF-1 in the younger dogs compared to the older dogs was found in middle/large-sized dogs. GH and IGF-1 were also found at significantly high levels in large-sized dogs compared to middle-sized dogs, suggesting a similar trend to that of elderly humans. Consequently, glucose, total protein, GH, and IGF-1 were identified as potential biomarkers for regulating the aging process in large/middle-sized dogs. These findings provide an invaluable insight into the mechanism of aging for the field of aging research.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.4
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• pp.533-542
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• 2010

Skin aging is a natural phenomenon. There are internal and external factors of skin aging. The internal factor of skin aging is from the wearing down of the body over time. The external factors are more noticeable from habits such as smoking, excessive alcohol, malnutrition, and extended exposure to UV rays. Completely stopping skin from aging is impossible but one can slow down and treat external signs of skin aging. In western medicine, the following methods are used to reduce the appearance of skin aging: applying lotions and creams containing ingredients such as fruit acid, antioxidants, plant exracts, depigmentation, moisturizer, retinoids, and sun block; botulinum toxin injections; chemical peels, laser and other painful methods remove the top layer of skin to promote new skin growth; fillers are injected to increase soft tissue growth; surgery. In oriental medicine, the following methods are used: acupuncture into facial muscles which stimulates acupuncture point; applying topical treatments and cosmetics containing herbs are effective of preventing skin aging and wrinkles. Above all thing, medicine that helps maintain essence and blood in the skin can be fundamental.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.5
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• pp.467-479
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• 2018

The aging process induces a plethora of changes in the body including alterations in hormonal regulation and metabolism in various organs including the heart. Aging is associated with marked increase in the vulnerability of the heart to ischemia-reperfusion injury. Furthermore, it significantly hampers the development of adaptive response to various forms of conditioning stimuli (pre/post/remote conditioning). Aging significantly impairs the activation of signaling pathways that mediate preconditioning-induced cardioprotection. It possibly impairs the uptake and release of adenosine, decreases the number of adenosine transporter sites and down-regulates the transcription of adenosine receptors in the myocardium to attenuate adenosine-mediated cardioprotection. Furthermore, aging decreases the expression of peroxisome proliferator-activated receptor gamma co-activator 1-alpha ($PGC-1{\alpha}$) and subsequent transcription of catalase enzyme which subsequently increases the oxidative stress and decreases the responsiveness to preconditioning stimuli in the senescent diabetic hearts. In addition, in the aged rat hearts, the conditioning stimulus fails to phosphorylate Akt kinase that is required for mediating cardioprotective signaling in the heart. Moreover, aging increases the concentration of $Na^+$ and $K^+$, connexin expression and caveolin abundance in the myocardium and increases the susceptibility to ischemia-reperfusion injury. In addition, aging also reduces the responsiveness to conditioning stimuli possibly due to reduced kinase signaling and reduced STAT-3 phosphorylation. However, aging is associated with an increase in MKP-1 phosphorylation, which dephosphorylates (deactivates) mitogen activated protein kinase that is involved in cardioprotective signaling. The present review describes aging as one of the major confounding factors in attenuating remote ischemic preconditioning-induced cardioprotection along with the possible mechanisms.

• Fashion & Textile Research Journal
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• v.6 no.1
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• pp.102-108
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• 2004

The anthropometric measurement and the photometric measurement for have been conducted 358 children from 4 years old to 6 years old to design children's clothing. The characteristics of body type were grasped among total 44 measurement items according to the aging, being extracted seven factors from factor analysis. From cluster analysis among the seven factors the three body types were classified. Type 1 shows low fat body with a small figure and short upper body. The body has a round belly and waist. Type 2 shows the fattest body with an average height. The body has been backed with lower shoulders. Type 3 shows common fat body with a high height and a big figure. The body shows crooked round back with a big upper body and rising shoulders.

• Journal of the Korea Convergence Society
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• v.13 no.5
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• pp.61-67
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• 2022

This study is a qualitative content analysis study in which one-on-one interview was applied to analyze the meaning of well-aginfor instructors who teach well-aging-related lectures. In this study, five experts were asked the following questions. 'What do you think are the conditions for well-aging?', and 'What do you think is necessary to realize well-aging?'. As a result, 3 core themes and 6 sub-theme were analyzed. The core theme collections were 'life faithful to the basics', 'a balanced life without omissions', and 'life appropriate for age'. The subjects of this study emphasized the integrated harmony of body, mind, society, spirituality, and economy based on health in well-aging. It was emphasized that for well-aging, not only middle-aged people but also all age groups need to recognize and prepare for it. In the future, well-aging education will require a continuous education course tailored to each age group.

• Journal of the Korea Society of Computer and Information
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• v.25 no.11
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• pp.157-166
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• 2020

In this study, I tried to develop ZIGTECHnology clothing for renovation that can correct the body shape of elderly women according to aging and delay the change of body shape. Develop and suggest corrective clothing for elderly women with easy movement that can alleviate symptoms and delay changes in body shape by analyzing body types for each symptom, such as bending of shoulders, back and waist caused by aging and diseases such as spinal curvature. As a result of the wear evaluation of the developed ZIGTECHnology clothing designs 1, 2, and 3, in terms of functionality, Design 1 was evaluated as excellent by reducing the back angle by 3.17°, but design 3 was evaluated as the most excellent considering the fit. In the clothing of elderly women, the need for clothing that complements physical shortcomings increases, so it is thought that continuous development of body shape relief devices should be made.

• Journal of Fashion Business
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• v.14 no.4
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• pp.132-145
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• 2010

These days, the aging population is becoming a critical social issue; the activation of the silver industry for the Y-O generation, meaning the young-old group of aged 55-64, is accelerating now. Pants are very important item to this generation, since they pursue active life with an exercise and leisure activities. Therefore, the physical, psychological, and social characters as well as the changed life style of women in the Y-O generation were reviewed, based on former studies and books. The consumer's patterns and actual wearing conditions about slacks were researched and analyzed through the survey toward 300 women aged 55-65 living in Seoul. Based on this research, information was provided for the development of slacks pattern which is suitable to the deformed body and aesthetic consciousness of the Y-O generation.

• Proceedings of the Korean Society of Computer Information Conference
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• 2020.07a
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• pp.143-144
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• 2020

본 연구에서는 사이즈코리아에서 2015년 이루어진 제7차 인체치수조사 데이터 중 60대 남성의 치수와 2014년에 이루어진 고령자인체치수조사 데이터의 70대와 80대 남성의 치수를 분석하여 신체적인 노화가 주로 나타나는 연령 구간과 노화에 따른 노년 남성 체형의 변화에 대한 특성을 살펴보고자 하였다. 노년 남성의 경우 대체로 66-68세 사이와 75-77세 사이 그리고 84-85세 사이에 급격한 노화현상이 나타나게 되고 60대와 70대에는 서서히 노화가 진행되다가 대체로 80대에 들어서면서 노화가 심화되어 신체적으로 체형의 변화가 급격히 나타나게 된다. 연령의 증가에 따른 노화의 현상으로 신체의 둘레, 너비, 높이 등에서는 변화가 심화되나 둘레, 너비, 높이에 비해 두께의 경우에는 변화가 크지 않은 것으로 분석되었다. 또, 노년 여성의 경우에는 등이 굽는 현상이 나타났으나 노년 남성의 경우에는 여성과는 반대로 뒤로 젖혀진 체형이 나타나 차이가 발견되었다. 따라서 의복패턴 제작 시 앞중심길이와 등길이 설정에 있어서 노년 여성과는 반대로 등 길이를 짧게 하는 패턴상의 수정이 요구된다.