• Annals of Geriatric Medicine and Research
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• 제22권4호
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• pp.208-208
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• 2018

• Genomics & Informatics
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• 제21권2호
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• pp.23.1-23.9
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• 2023

The mammalian sirtuin family, consisting of SIRT1-SIRT7, plays a vital role in various biological processes, including cancer, diabetes, neurodegeneration, cardiovascular disease, cellular metabolism, and cellular homeostasis maintenance. Due to their involvement in these biological processes, modulating sirtuin activity seems promising to impact immuneand aging-related diseases, as well as cancer pathways. However, more understanding is required regarding the safety and efficacy of sirtuin-targeted therapies due to the complex regulatory mechanisms that govern their activity, particularly in the context of multiple targets. In this study, the interaction landscape of the sirtuin family was analyzed using a systems biology approach. A sirtuin protein-protein interaction network was built using the Cytoscape platform and analyzed using the NetworkAnalyzer and stringApp plugins. The result revealed the sirtuin family's association with numerous proteins that play diverse roles, suggesting a complex interplay between sirtuins and other proteins. Based on network topological and functional analysis, SIRT1 was identified as the most prominent among sirtuin family members, demonstrating that 25 of its protein partners are involved in cancer, 22 in innate immune response, and 29 in aging, with some being linked to a combination of two or more pathways. This study lays the foundation for the development of novel therapies that can target sirtuins with precision and efficacy. By illustrating the various interactions among the proteins in the sirtuin family, we have revealed the multifaceted roles of SIRT1 and provided a framework for their possible roles to be precisely understood, manipulated, and translated into therapeutics in the future.

• 가족자원경영과 정책
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• 제14권4호
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• pp.323-340
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• 2010

Many social and environmental changes have emerged due to the increasing size of the aging generation. This study explored the current status of the information leisure activity of the aging generation (computer use activity, internet service participation, social community participation and blogging, UCC, etc.) and the need for serious games among elderly consumers. It analyzed the current status of serious game and information leisure span as determined by experts on elderly care at the aging welfare institute. The research methods involved applying content analysis and focus group interviews. The results were as follows: The elderly are willing to enjoy the internet and economics networks. In particular, economic investment, economic news, health, meetings, and communication are the main internet search categories. The results for serious games are less interesting than those for IT participation. The components of usefulness in terms of serious games, as identified by care experts, are simplicity, a user-friendly interface, efficacy, and certainty in using the game device. Care experts recognize that serious games represent a supplementary device to traditional physical and emotional therapy.

• 문화기술의 융합
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• 제1권1호
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• pp.69-72
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• 2015

최근 한국에서 저출산, 핵가족화, 1인 가족 증가 등의 사회적 병리 현상과 더불어 고령화가 급속히 진행되고 있다. 한국의 고령화 추이는 일본의 고령화 추이와 유사하게 나타나고 있어, 향후 더 심화된 고령화가 나타날 것으로 보인다. 그러나 한국은 아직 고령화 문제에 대한 연구가 매우 부족하여 향후 고령화가 급속도로 진행시 많은 문제가 발생할 것으로 예상된다. 이에 고령화에 대해 대비하고 있는 일본의 장례문화 중 한국의 장례에 도입할 수 있는 적합한 문화를 비교하여 고령화에 맞춰 대비할 필요가 있다. 일본의 고령화에 따라 나타나는 장례문화는 슈카츠(終活), 직장(直葬), 가족장(家族葬) 등이 있다. 이 중, 핵가족화 및 1인 가족 증가 등에 따른 소규모 장례문화가 확산될 것으로 예상되어 일본의 '가족장(家族葬)'이 한국에 도입하기에 적합할 것으로 보인다. 급속히 고령화되어가는 한국 사회와 고령화에 따른 변화된 장례문화의 제시는 필수적이며, '가족장(家族葬)' 제도의 도입은 향후 발생할 한국 내의 고령화에 따른 장례문화를 선도하는데 중요한 지침이 될 것으로 기대한다.

• 한국노년학
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• 제27권2호
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• pp.299-322
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• 2007

본 연구에서는 노인에 대한 부정적인 스테레오타입을 전달하는 기존 노년 담론의 대안으로써 제시되고 있는, 신노년 담론이 대중매체를 통해 어떻게 구성되고 유포되는지 살펴보고자 하였다. 구체적으로 대표적인 대중매체의 하나인 신문매체의 기사들을 분석하여, 새롭게 부각되는 노년층의 문화가 어떠한 테마를 중심으로 소개되고 있으며, 이러한 테마들이 모여서 구성하는 신노년 담론의 특징과 그 의미는 무엇인가를 비판적으로 고찰하였다. 분석에 사용된 신문매체는 조선일보, 동아일보, 한겨레신문이며, 1997년부터 2006년까지 최근 10년 동안 발행된 신문 중에서, '노인' 또는 '노년'을 주제로 한 신문기사 1725건을 분석의 대상으로 선정하였다. 각 신문매체들은 신노년층 노인들의 모습을 건강과 젊음을 유지하고, 자원봉사나 유급노동, 학습 등으로 끊임없이 활동하면서 자립성을 유지하고 사회에 기여하는 모습으로 그리고 있으며, 신노인과 구노인의 대립항적인 담론구성 방식을 통해 신노년층 노인들의 라이프스타일을 고령화시대에 바람직한 삶의 모습으로 제시하고 있다. 이러한 신노년 담론이 가지고 있는 한계점들과 이데올로기적 특성을 논의하였다.

• 한국간호교육학회지
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• 제27권4호
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• pp.392-401
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• 2021

Purpose: This study was conducted to identify the relationship of health status, aging anxiety, social networking, generativity, and happiness and to investigate the main factors influencing happiness of late middle-aged adults. Methods: The study collected data from a total of 153 middle-aged men and women aged 50 to 64 years old from a consumer panel of Macromill-Embrain, the biggest online survey provider in Korea. The data were analyzed using descriptive statistics, Pearson's correlation coefficient and a stepwise multiple regression using the SPSS 22.0 program. Results: The subjects' happiness mean score was 16.17±9.29. Statistically significant differences in happiness were found according to education (F=4.38, p=.014), economic status (t=5.13, p<.001), and religion (t=2.18, p=.031). Happiness was correlated significantly with health status (r=.41, p<.001), aging anxiety (r=-.62, p<.001), family support (r=.43, p<.001), friend support (r=.36, p<.001) and generativity (r=.63, p<.001). The factors influencing happiness of late middle-aged adults were generativity (𝛽=.37, p<.001), aging anxiety (𝛽=-.35, p<.001), family support (𝛽=.20, p<.001), and economic status (𝛽=.13, p=.033). The explanatory power of the model was 58.0%. Conclusion: This study will be used as basic data when developing a nursing intervention program for successful aging by identifying factors that affect the happiness of late middle-aged adults.

• 한국생활과학회지
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• 제13권1호
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• pp.17-27
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• 2004

The purpose of this study was to examine whether the intergenerational program affected the children's perceptions on the elderly and aging. This study also investigated how the children evaluated the program. The study methods was one group pretest-posttest design. The subjects were 30 elementary school children from 1st to 3rd grade. The intergenerational program was composed of 6 activities: recreation activity for rapport, making a kite, gardening, learning old customs, education of traditional manner, and making rice-cakes. It was executed for two weeks. Data for children's perceptions on the elderly and aging were collected by the interview using questionnaire at pretest-posttest. The results of the qualitative data analysis showed that the children's perception on the elderly and aging changed more positively after the program. There were significant differences between pre- and post-test on the children's perceptions of aging and intellectual aspects of the elderly. Most of the children evaluated the program very positively.

• 대한의생명과학회지
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• 제12권4호
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• pp.337-341
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• 2006

Platelets clearly play an important role in inflammatory responses. In this study, we aimed to evaluate the relationship between aging and platelet activation. A total number of 799 persons (383 males and 416 females), who were apparently healthy and aged more than 20 years were recruited by a health promotion center in a community-based hospital in Seoul, Korea. We collected material data about their medical history and health behavior. Platelet parameters including mean platelet component (MPC), mean platelet volume (MPV), and platelet component distribution width (PCDW) were determined within 1 hour after blood collection using the ADVIA 120 automated hematology analyzer. The MPC of the women ($27.2{\pm}1.2$) was significantly love. than that of the men ($27.5{\pm}1.3$). The MPC of all participants was found to decrease with increasing age (P<0.01). Study participants in their twenties had the highest MPC ($27.7{\pm}1.1$), followed by those in their thirties ($27.6{\pm}1.1$), forties ($27.4{\pm}1.3$), fifties ($27.2{\pm}1.3$), sixties ($27.2{\pm}1.2$) and seventies ($27.1{\pm}1.2$). Multiple regression analysis showed that aging and gender were related with MPC after adjusting for confounding factors, including age, gender, smoking habit, hypertension, diabetes, body mass index and total cholesterol level. The this study shows that aging is related to platelet activation. Future research will need to determine the implications of increased platelet activation with aging, especially regarding the increased incidence of cardiovascular diseases and related mortalities that occur in older age groups.

• Child Health Nursing Research
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• 제5권3호
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• pp.292-304
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• 1999

The lengthened average span of human life by virtue of recent developments in medicine has caused the Population of elders to increase. The development of modern industrial society has transformed family structure from the large family system to that of a nuclear family. Due to the shift in family structure, the problem of support for the aged has surfaced as a nursing problem as well as a social problem. With regard to this problem, this study aims to investigate the adolescent's understanding of elders and aging. By identifying their understanding and classifying their attitude patterns, this study will help the nursing assessment of the support of elders in the family. This study employed Q-methodology and the research was conducted from December 1998 to May 1999. One method of the research included deep interviews with elders, those who are in their 50's. 40's or 30's. and the adolescent. 183 Q-Populations taken from literary works such as poems or novels were also formed as another method. Finally. 36 Q-cards were made after consultation with Professors of the nursing department. The subjects of the P- sample were 30 high sohoolboys/girls - who were in first, second, and third years. The result showed that 3 factors provided an explanation for 59.14% of the whole variables: the first factor, 41.37%; the second factor. 11.49%, and the third factor. 6.28%. These three factors were analyzed and categorized as three types. Twenty subjects out of the 30 were included in Type 1: Respecting Elders. The statements which showed the most positive consent were as follows: 'The declining age is a perfect time to prosper completing a worthy life' ; 'Getting old. one needs financial stability' and 'Elders wish the best for their children' The statements showing the most negative response were as follows: 'It is better to die than to live as an older person' ; 'Elders are insignificant' ; and 'Getting old is the worst unhappiness that tortures human.' Four subjects were included in Type 2. Resenting Elders. The statements which showed the most positive consent were as follows: 'Aging is a process of dying that nobody can escape from'. 'Elders should be concerned about his health and try to maintain their health' ; and 'When you set older. you regret about the life in the Past.' The statements showing the most negative response were as follows: 'When You get older. You should stand aloof greed and worldly things' 'When You got older, You become generous and gentle' ; and 'When You set he gets old. You change to become a comfortable and warm person.' Six out of 30 subject were included in Type 3 Caring Elders. The statements which showed the most positive consent were as follows: 'Elders should be concerned about his health and try to maintain their health' ; 'Elders wish the best for their children' ; and 'Elders deserve to be treated with filial respects.' The statements showing the most negative response were as follows 'Elders are insignificant' ; 'Elders have freedom and plenty of free time.' and 'Elders are alienated form and drove out of the society.' The above-mentioned results show that most adolescents in Korea recognize aging as the time of fruition and development: it is a time of benefiting and giving back to society. Aging can also be seen as a time of generosity and magnanimity and the time of respect and favorable treatment from society. despite the change of modern society and the ostensible transformation of a family system. Their recognition seems deeply rooted in the traditional confucian values and the dual family system which is Peculiar especially to the Korea - one which maintains both the superficial form of nuclear family and the substantial mode of the enlarged family system. In sum, many Korean adolescents attribute the meaning of the elderly and aging to the type of the respect with the elderly and the type of the elderly's caretaking.

• 한국생활과학회지
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• 제14권3호
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• pp.491-504
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• 2005

This research studies the residential environment of the elderly and its trend. Our main focus is on the residential condition and its type between parents and their child/ren in korea which has already entered the aging society. The results are as follows: (1) This paper finds that the residence type of the households with elderly people becomes multifarious, as in a two-generation household, a couple and their single child, a couple family, etc. (2) The parents living separately from their child/ren account for 63.3%, which is becoming predominant in the residence type of the elderly. On the other hand, those living with their child/ren take up merely 24.5%. Thus, we can infer that the number of the parents with the former type is on the increase. (3) The residence type in reality is different from the one intended by elderly people, so we can estimate future change in the residence type. (4) The residence type varies, as in living together with young family, living separately from young family, separation at a distance, etc. In conclusion, we need appropriate living programs for each various residence type between elderly people and their children.