• 대한교통학회지
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• 제18권3호
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• pp.55-76
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• 2000

실시간 통행시간관련자료의 집계시간간격은 보다 신뢰성있는 통행시간정보제공과 교통정보센터의 효율적인 운영을 위해 매우 중요한 요소이다. 그러나 대부분의 기존 VDS 및 TCS교통정보 데이터는 통계학적·공학적 차원에서의 합리적인 연구나 검증없이 경험적 간격으로 집계되고 있다. 본 연구의 목적은 링크 및 교통축(Corridor) 통행시간 산정 및 예측시의 최적 집계 시간간격을 결정할 수 있는 통계학적 모형을 개발하고 실제 도로망에서 수집되는 통행시간자료에 적용하는 것이다 첫째로, 본 연구는 링크 및 교통축 통행시간 산정 및 예측으로 인한 오차를 계량화하는 통계학적 모형을 제시하고, 제시된 모형의 의미를 교통류이론 측면과 통행시간정보 이용자측면에서 살펴보았다. 둘째로, 미국 Texas, Houston의 도시고속도로에서 AVI시스템을 통해 수집된 통행시간자료를 제시된 모형에 적용하였다. 적용결과 링크통행시간 산정을 위한 최적 집계시간간격보다 링크통행시간예측을 위한 최적 집계시간간격이 큰 것으로 나타났으며, 교통축 통행시간 산정 및 예측을 위한 최적 집계시간간격은 교통축을 구성하는 링크간의 상관관계 (Correlation)에 큰 영향을 받는 것으로 분석되었다.

• Bulletin of the Korean Chemical Society
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• 제35권5호
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• pp.1440-1448
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• 2014

Co(II)-tetrasulfonated phthalocyanine (CoTSP) is known to be aggregated to dimer at high concentration levels in water. A study on the aggregation of CoTSP using multivariate curve resolution analysis of the visible absorbance spectra over a concentration range of 30, 40 and 50 ${\mu}M$ in the presence of dimethyl sulfoxide (DMSO), dimethyl formamide (DMF), acetonitrile (AN) and ethanol (EtOH) in the concentration range of 0 to 3.57 M is conducted. A hard modeling-based multivariate curve resolution method was applied to determine the dissociation constants of the CoTSP aggregates at various temperatures ranging from 25, 45 and $65^{\circ}C$ and in the presence of various co-solvents. Dissociation constant for aggregation was increased and then decrease by temperature and concentration of phthalocyanine, respectively. Utilizing the vant Hoff relation, the enthalpy and entropy of the dissociation equilibriums were calculated. For the dissociation of both aggregates, the enthalpy and entropy changes were positive and negative, respectively. Molecular dynamics simulation of cosolvent effect on CoTSP aggregation was done to confirm spectroscopy results. Results of radial distribution function (RDF), root mean square deviation (RMSD) and distance curves confirmed more effect of polar solvent to decrease monomer formation.

• Journal of Ginseng Research
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• 제17권2호
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• pp.131-134
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• 1993

Panaxadiol (PD) from Korean red ginseng C.A. Meyer did not control the concentration of cytosolic free $Ca^{2+}$ influxes by thrombin (5 $\mu$/ml). However, PD strongly inhibited the synthesis of thromboxane. $A_2$ (TX$A_2$) in the aggregation of human platelets induced by thrombin (5 $\mu$/ml). These rexults suggest that PD blocks the any Pathway transforming to TX$A_2$ from arachidonic acid (AA) which release out of plasma membrane phospholipids by $Ca^{2+}$-dependent phospholipase C or phospholipase $A_2$. It may be also concluded that PD has the antiplatelet function by inhibiting the synthesis of TX$A_2$, which known to be the potent stimulator of the aggregation of human platelet.

• 정보과학회 논문지
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• 제44권7호
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• pp.703-709
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• 2017

아웃소싱 데이터베이스란 데이터 관리 및 질의 처리 등의 계산량이 많은 작업을 제 3자 서버에 위탁하는 것이다. 이를 통해 데이터 소유자는 비싼 인프라를 구축하지 않고 빅데이터를 관리할 수 있으며 여러 사용자로부터 받는 질의들을 빠르게 처리할 수 있다. 하지만 보안 위협이 항상 존재하는 네트워크의 특성상 제 3자 서버를 완전히 신뢰하기 어렵고, 그 서버가 처리한 결과도 신뢰하기 어렵다. 이처럼 신뢰할 수 없는 서버가 처리한 질의 결과가 정확한지 확인하는 것을 질의 인증이라고 하며 구간 질의, kNN 질의, 함수 질의 등 다양한 질의에 대한 인증 기법들이 연구되었다. 하지만 빅데이터 분석에 있어 활용도가 높은 집계 질의에 대한 깊이 있는 질의 인증 연구는 이루어지지 않았으며 기존 연구는 고차원이거나 서로 다른 값이 많은 데이터에 대해 비효율적이다. 본 연구에서는 집계 질의 인증을 위한 자료구조를 제안하고 이를 활용한 효율적인 증거 생성 방법과 증명 방법을 제안한다. 그리고 데이터의 상이 값 수, 레코드 개수, 차원 크기 등을 변경하며 진행한 실험 결과를 통해 제안한 기법의 성능이 우수함을 보였다.

• 전기학회논문지
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• 제66권5호
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• pp.833-842
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• 2017

In this study, the design methodology of radial basis function neural networks based on incremental K-means clustering is introduced for learning and processing the big data. If there is a lot of dataset to be trained, general clustering may not learn dataset due to the lack of memory capacity. However, the on-line processing of big data could be effectively realized through the parameters operation of recursive least square estimation as well as the sequential operation of incremental clustering algorithm. Radial basis function neural networks consist of condition part, conclusion part and aggregation part. In the condition part, incremental K-means clustering algorithms is used tweights of the conclusion part are given as linear function and parameters are calculated using recursive least squareo get the center points of data and find the fitness using gaussian function as the activation function. Connection s estimation. In the aggregation part, a final output is obtained by center of gravity method. Using machine learning data, performance index are shown and compared with other models. Also, the performance of the incremental K-means clustering based-RBFNNs is carried out by using PSO. This study demonstrates that the proposed model shows the superiority of algorithmic design from the viewpoint of on-line processing for big data.

• 약학회지
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• 제44권6호
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• pp.558-565
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• 2000

SK-1080 is one of the newly developed orally active nonpeptide angiotensinII $AT_1-receptor$ antagonist that selectively acts at $AT_1$ receptor with high affinity. The cardiac effect on ischemia/reperfusion injury of SK-1080 was compared with those of losartan, a prototype of this class, in isolated rat hearts. Isolated perfused rat heart was pretreated with drug for 10 min and then subjected to global ischemia for 30 min followed by reperfusion with- or without drug for 30 min. The possible additive effect of SK-1080 on the platelet aggregation and coagulation in human blood was also studied. We investigated whether SK-1080 effects the platelet aggregation induced by ADP, a platelet agonist partially dependent on $thromboxaneA_2$. The clotting times in the prothrombin time (PT) and activated partial thromboplastin time (APTT) were also examined in human plasma in vitro as coagulation screening test. SK-1080 improved reperfusion function (LVDP, left ventricular developed pressure; PRP, rate-pressure product) in a dose-dependent manner. SK-1080 reduced ADP-induced platelet aggregation compared with vehicle but less than losartan, and did not affect clotting times.

• 한국전자통신학회논문지
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• 제9권6호
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• pp.689-694
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• 2014

MANET에서 DDoS 공격은 네트워크 기능을 수행해야하는 노드를 무력화시켜 네트워크 전체를 마비시키거나 노드의 위치에 따라 네트워크를 분리시키는 치명적인 결과를 초래할 수 있다. 짧은 길이의 데이터를 일정길이의 데이터로 모아서 전송하는 패킷취합전송은 MANET 환경에서 전송성능이 개선되는 효과를 보이고 있다. 본 논문에서는 이러한 MANET 환경에서 DDoS 공격이 패킷취합전송의 전송성능에 미치는 영향을 종단간 관점에서 측정하고 분석한다. 종단간 성능측정에는 NS-2를 기반으로 구축한 MANET 시뮬레이터를 이용하였으며, MOS, 연결율, 지연 및 패킷손실율을 측정 대상 성능 파라미터로 사용하였다. 음성서비스인 VoIP 트래픽을 측정대상 트래픽으로 사용했다. 본 논문의 결과로서 DDoS 공격이 있는 MANET에서 패킷취합수가 4이상일 때 전송품질 유지에 유리함을 확인하였다.

• Biomolecules & Therapeutics
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• 제19권4호
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• pp.472-476
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• 2011

Hypercholesterolemia indirectly increases the risk of arterial and venous thrombosis by enhancing the ability of platelets to aggregate. Yacon (Smallanthus sonchifolius) is composed of fructooligosaccharides, proteins, minerals and phenolic compounds, and has potential benefits for the management of diabetes. This study investigated whether the consumption of yacon in the diet inhibits platelet aggregation under hypercholesterolemic conditions. Male New Zealand white rabbits were fed one of five dietary interventions: a normal control diet, 0.5% cholesterol diet, 0.5% cholesterol diet+a low dose of yacon (0.5 g/kg body weight given orally each day), 0.5% cholesterol diet+a high dose of yacon (2.5 g/kg body weight given orally each day), or a 0.5% cholesterol diet+lovastatin (2 mg/kg body weight given orally each day). After 8 weeks, blood was collected to measure the amount of collagen- and thrombin-induced platelets present. Yacon inhibited the platelet aggregation induced by low doses of agonists (0.5 ${\mu}g/mL$ collagen and 0.02 units/ml thrombin) in a concentration-dependent manner. In addition, yacon concentration-dependently inhibited collagen-induced arachidonic acid liberation. Moreover, n-hexane, chloroform and ethyl acetate fractions showed a marked and selective inhibition of the platelet aggregation induced by collagen, again in a dose-dependent manner. These fractions, especially that of chloroform, significantly suppressed platelet aggregation. The results of this study demonstrate that when yacon is added to a cholesterol-enriched diet, cholesterol-induced platelet aggregation returns to control levels. This may also be beneficial in preventing atherosclerosis and reducing risk factors for coronary artery disease and stroke.

• 대한수의학회지
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• 제36권4호
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• pp.873-886
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• 1996

For better understanding the interrelationship of hemorrhage and aggregation mechanism, cyclopiazonic acid(CPA) known as promoting the aggregation of platelet, aflatoxin $B_1(AFB_1)$ inhibiting platelet aggregation were used as toxic mycotoxins in these studies. In order to investigate the potential role of prostaglandin metabolism on the platelet aggregation, a variety of prostaglandin metabolites such as $PGF_{2{\alpha}}$, $PGE_2$ and $TXB_2$ were measured in homogenized rabbit platelets by TLC and LSC. And the role of $Ca^{{+}{+}}$ on the platelet aggregation was investigated by flow cytometer. Finally, the morphological effects of mycotoxins on platelet were determined by transmission electron microscope. The results and conclusions obtained from these studies are: 1) CPA induced no changes but $AFB_1$ increased $PGE_2$ and $TXB_2$. 2) CPA promoted ADP, collagen, thrombin, A.A., and PAF-induced $Ca^{{+}{+}}$ release. $AFB_1$, however, decreased $Ca^{{+}{+}}$ level except collagen-induced $Ca^{{+}{+}}$ release. When the calcium blocker, verapamil, was used, CPA decreased thrombin-induced $Ca^{{+}{+}}$ release and increased collagen, ADP, PAF and A.A.-induced $Ca^{{+}{+}}$ release. $AFB_1$ in contrast decreased the all factors induced $Ca^{{+}{+}}$ release. 3) $AFB_1$ did not induce any ultrastructural changes except large vacuole formation in a few platelets. And CPA also did not induce any changes except moderate shape change, indicator of platelet activation. In conclusion, CPA promoted platelet aggregation by the increases of $Ca^{{+}{+}}$ release but had no changes in A.A. metabolites. Antiaggregating effects of $AFB_1$ may be due to decreases of $Ca^{{+}{+}}$ release and increases of $PGE_2$ and $PGF_{2{\alpha}}$ formation. These data provide the basis for the future study of mobilization and function of $Ca^{{+}{+}}$ in platelet aggregation.

• Nutrition Research and Practice
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• 제13권1호
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• pp.64-69
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• 2019

BACKGROUND/OBJECTIVES: Alzheimer's disease is a neurodegenerative disease that induces symptoms such as a decrease in motor function and cognitive impairment. Increases in the aggregation and deposition of amyloid beta protein ($A{\beta}$) in the brain may be closely correlated with the development of Alzheimer's disease. In this study, the effects of an adzuki bean extract on the aggregation of $A{\beta}$ were examined; moreover, the anti-Alzheimer's activity of the adzuki extract was examined. MATERIALS/METHODS: First, we undertook thioflavin T (ThT) fluorescence analysis and transmission electron microscopy (TEM) to evaluate the effect of an adzuki bean extract on $A{\beta}_{42}$ aggregation. To evaluate the effects of the adzuki extract on the symptoms of Alzheimer's disease in vivo, $A{\beta}_{42}$-overexpressing Drosophila were used. In these flies, overexpression of $A{\beta}_{42}$ induced the formation of $A{\beta}_{42}$ aggregates in the brain, decreased motor function, and resulted in cognitive impairment. RESULTS: Based on the results obtained by ThT fluorescence assays and TEM, the adzuki bean extract inhibited the formation of $A{\beta}_{42}$ aggregates in a concentration-dependent manner. When $A{\beta}_{42}$-overexpressing flies were fed regular medium containing adzuki extract, the $A{\beta}_{42}$ level in the brain was significantly lower than that in the group fed regular medium only. Furthermore, suppression of the decrease in motor function, suppression of cognitive impairment, and improvement in lifespan were observed in $A{\beta}_{42}$-overexpressing flies fed regular medium with adzuki extract. CONCLUSIONS: The results reveal the delaying effects of an adzuki bean extract on the progression of Alzheimer's disease and provide useful information for identifying novel prevention treatments for Alzheimer's disease.