• 제목/요약/키워드: Aggregates

검색결과 2,061건 처리시간 0.033초

The New Strategy of Formulation of Human Growth Hormone Aggregate within PLGA Microspheres for Sustained Release

  • 김홍기;박태관
    • 한국생물공학회:학술대회논문집
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    • 한국생물공학회 2000년도 춘계학술발표대회
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    • pp.541-545
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    • 2000
  • For the sustained release formulation of recombinant human growth hormone (rhGH), dissociable rhGH aggregates were microencapsulated within poly(D,L-lactic-co-glycolic acid) [PLGA] microparticles. rhGH aggregates with 2 - 3 m Particle diameter were first produced by adding a small volume of aqueous rhGH solution into a partially water miscible organic solvent phase(ethyl acetate) containing PLGA. These rhGH aggregates were then microencapsulated within PLGA polymer phase by extracting ethyl acetate into an aqueous phase pre-saturated with ethyl acetate. The resultant microparticles were 2 - 3 m in diameter similar to the size of rhGH aggregates, suggesting that PLGA polymer was coated around the protein aggregates. Release profiles of rhGH from these microparticles were greatly affected by changing the volume of the incubation medium. The release rhGH species consisted of mostly monomeric form with having a correct conformation. This study reveals that sustained rhGH release could be achieved by microencapsulating reversibly dissociable protein aggregates within biodegradable polymers.

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지역별 골재 품질변화가 콘크리트 물성에 미치는 영향 (Influence of Domestic Aggregates Quality on Concrete Properties)

  • 노재호;조일호;이선우;정재동
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 1993년도 봄 학술발표회 논문집
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    • pp.34-39
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    • 1993
  • Recently inappropriate aggregates are used as a raw material for ready-mixed concretes, due to the shortage of natural aggregate resources and the prohibition of their extraction for the environmental protection. We, therefore, have conducted experiments to obtain some knowledge of properties of domestic aggregates and to investigate subsequent changes in the properties of the fresh and hardened concretes. To this end, aggregates currently used in 13 domestic ready-mixed concrete plants were collected. Most of aggregate used in this experiment satisfied the KS in density and unit weight. But some of the aggregates have the particle size distribution that can effect bad influence on concrete. In this experiment the aggregates are found to have a bad particle size distribution, resulting in high amount of a unit water content and a unit cement content in concrete.

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Effects of Protein Unfolding and Soluble Aggregates Formation on the Gel Strength of Whey Proteins

  • Park, Moon-Jung;Michael E. Mangino
    • Preventive Nutrition and Food Science
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    • 제2권4호
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    • pp.281-284
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    • 1997
  • Heat-induced gelation is an important functional property of whey proteins. Preheating of calcium reduced whey was reported to increase gel strength. 5% whey-protein solutions were preheated at pH7 and at various temperatures(60~8$0^{\circ}C$) for 15 minutes. The amount of soluble aggregates and denaturation enthalpy of preheated whey proteins were measured. Preheating temperature was negatively correlated with denaturation enthalpy($R^2$=0.857, P=0.08) and positive with the amount of soluble aggregates($R^2$=0.921, P=0.002). Denaturation enthalpy was negatively correlated with gel strength($R^2$=0.93, P=0.002). Soluble aggregates and gel strength were positively correlated($R^2$=0.972, P=0.0003). The formation of three dimensional gel network requires controlled protein denaturation and aggregation. Since preheating leads to the partial denaturation of proteins and the formation of soluble aggregates, preheated whey proteins have a higher gel strength than non-preheated one.

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DNA Length Dependent Photocurrent of Diketopyrrolopyrrole Aggregates Constructed with DNA

  • Nakamura, Mitsunobu;Tsuto, Koji;Takada, Tadao;Yamana, Kazushige
    • Rapid Communication in Photoscience
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    • 제3권4호
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    • pp.67-69
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    • 2014
  • Bis(2-thienyl)-diketopyrrolopyrrole having two $Zn^{II}$-cylcens (DPPCy) was synthesized. DPP-aggregates were constructed by self-organization of DPPCy and $dT_n$-DNAs. In the presence of L-ascorbic acid as an electron sacrifice reagent, the DPP aggregates immobilized on a gold electrode exhibit good anodic photocurrent responses as well as cathodic photocurrent responses in the presence of methyl viologen. The anodic photocurrent responses depend on the DNA lengths because of the formation of uniform DPP-aggregates corresponding to the DNA lengths. The present results show that photocurrent responses of the DPP-aggregates can be controlled by DNA lengths and electron sacrifice reagents.

재생 골재의 고부가가치화에 대한 연구 (A Study on The Great Supplementary Value of Recycled Aggregates)

  • 심종성;문도영;박성재;김용재
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 2003년도 봄 학술발표회 논문집
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    • pp.41-46
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    • 2003
  • Until now, the quantity to recycle wasted concrete as the great supplementary value was very little. But considering a insufficiency of the present state of aggregates, the recycling of wasted aggregates is indispensable. This study will offer the basic application data of the recycled aggregates to make by the new attempt and offer the basic data of the great supplementary value of recycled aggregate to make good use of precast process. The result of compressive strength, tensile strength, flexural strength and drying shrinkage test of concrete by recycled aggregates were similar to the property of normal aggregate concrete, and the contrary effect of recycled aggregate by high temperature steam curing do not have been found out. Therefore the great supplementary value of recycled aggregate to make good use of precast process is possible way to be helpful to a insufficiency of the present state of aggregates.

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산업쓰레기 소각재를 이용한 인공골재의 품질특성 (The Quality Characteristics of Artificial Aggregates Using Bottom ash from Industrial Waste Incinerator)

  • 김재신;고대형;문경주;백명종;소양섭
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 2000년도 봄 학술발표회 논문집
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    • pp.257-262
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    • 2000
  • The purpose of this study is grasping quality aggregate using Bottom Ash of Industrial Waste Incinerator, and is evaluating possibility of application as construction materials. Cement and Fly ash is used with binder of aggregates using bottom ash. It is tested for basic property and strength of artificial aggregates, and the results are compared with crushed stone and elution tests is done for environmental safety. In the results of tests, it is confirmed that basic property and strength are lowe than crushed stone but the aggregates have possibility of application as artificial lightweight aggregates. When it is manufactured with aggregates, it is sage environmentally because of protecting elution of harmful heavy metals.

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골재의 암석학적 특징이 콘크리트 기본특성에 미치는 영향 (The Study of the Basic Physical Properties in the Concrete Used Aggregates with the Different Mineralogical Features)

  • 엄태선;최상흘
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 1996년도 가을 학술발표회 논문집
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    • pp.1-9
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    • 1996
  • The aggregates with the different mineralogical features are studied how to affect the basic physical properties of concretes according to the changes of the chemical composition, mineralogical composition, crystal size, the standard qualities in the aggregates in using chemical analysis, X.R.D. DT-TGA, polarized light microscope, streoscopic microscope, standard test method of aggregates & concretes. At this studies, we found that aggregates without the seathered mineral such as muscovite & kaolin mineral etc, is superior to the others with the weathered mineral, even if it's standard qualities are inferiored to the other's. For examples, in manufacturing high strength concretes. The strength of concretes used aggregates without weathered mineral are improved about 15% than the other's and also. For general mixture to manufacture remicon, more about 10-20% than the other's strength and workability.

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잔골재 혼합사용이 석회암 굵은 골재 사용 초고강도 콘크리트의 유동특성에 미치는 영향 (Effect of Mixed Use of Fine Aggregates on the Flowability of Ultra High Strength Concrete)

  • 이홍규;김민영;이순재;조만기;한민철;한천구
    • 한국건축시공학회:학술대회논문집
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    • 한국건축시공학회 2015년도 춘계 학술논문 발표대회
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    • pp.73-74
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    • 2015
  • As this study is one related to ultra high strength concrete using crushed coarse limestone aggregates among the series of experiments for improving the economic inefficiency of the ultra high strength concretes used for high rise structures, it has analyzed the flowability of ultra high strength concrete according to the variation of blended fine aggregates. As a result of analyzing the characteristics of fresh concrete, it is determined that the application of ultra high strength concrete would be difficult in case of a mix using blended fine aggregates as lower flowability than the mix using limestone crushed fine aggregate only was shown in all mixes using blended fine aggregates.

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순환골재 치환률에 따른 철근콘크리트 보의 휨거동에 관한 실험적 연구 (Experimental Study of Flexural Behavior of Reinforced Concrete Beams with Different Types of Coarse Aggregates)

  • 이영오;전에스더;윤현도;유영찬;김긍환;최기선
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 2006년도 추계 학술발표회 논문집
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    • pp.45-48
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    • 2006
  • This study is to evaluate flexural behavior of RC beam with different types of coarse aggregates, so called natural or recycled aggregate. Two reinforced concrete beams were manufactured with different replacement level of recycled coarse aggregates : Concrete made with 0% of coarse aggregates, concrete made with 100% of recycled coarse aggregates. From the test, the general flexural performances of RC beams with different types of coarse aggregates such as cracking moment, crack patterns, maximum moment/crack width are discussed.

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순환골재 사용에 따른 도로포장용 투수성 콘크리트의 공학적 특성 (Engineering Characteristics of Permeability Concrete for Road Pavement by Recycled Aggregates)

  • 김영철;손호정;이용길;권춘우;공태웅;유성룡
    • 한국건축시공학회:학술대회논문집
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    • 한국건축시공학회 2013년도 춘계 학술논문 발표대회
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    • pp.229-231
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    • 2013
  • In this study, the qualitative characteristics of the permeability concrete by the changes in the grading of the recycled aggregates were analyzed and its results are as follows. First, the compressive strength represented the low range of strengths comparing with the typical concrete, and the high compressive strengths were represented as the aggregates with small grading of 2.5mm were used. The bending strengths did not satisfy the targeted range, and the permeability coefficient represented to be good when the aggregates with single grading greater than 5.0mm and the mixed aggregates of 5.0mm with 10.0mm.

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