• Advances in nano research
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• 제5권2호
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• pp.127-140
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• 2017

Metal nanoparticles have been intensively studied within the past decade. Nano-sized materials have been an important subject in basic and applied sciences. Zinc oxide nanoparticles have received considerable attention due to their unique antibacterial, antifungal, and UV filtering properties, high catalytic and photochemical activity. In this study, microbiological aspects of scale formation in PVC pipelines bacteria and fungi were isolated. In the emerging issue of increased multi-resistant properties in water borne pathogens, zinc oxide (ZnO) nanoparticle are being used increasingly as antimicrobial agents. Thus, the minimum bactericidal concentration (MBC) and minimum fungal concentration of ZnO nanoparticles towards pathogens microbe were examined in this study. The results obtained suggested that ZnO nanoparticles exhibit a good anti fungal activity than bactericidal effect towards all pathogens tested in in-vitro disc diffusion method (170 ppm, 100 ppm and 30 ppm). ZnO nanoparticles can be a potential antimicrobial agent due to its low cost of production and high effectiveness in antimicrobial properties, which may find wide applications in various industries to address safety issues. Stable ZnO nanoparticles were prepared and their shape and size distribution characterized by Dynamic light scattering (35.7 nm) and transmission electron microscopic TEM study for morphology identification (20 nm), UV-visible spectroscopy (230 nm), X-ray diffraction (FWHM of more intense peak corresponding to 101 planes located at $36.33^{\circ}$ using Scherrer's formula), FT-IR (Amines, Alcohols, Carbonyl and Nitrate ions), Zeta potential (-28.8). The antimicrobial activity of ZnO nanoparticles was investigated against Bacteria and Fungi present in drinking water PVC pipelines biofilm. In these tests, Muller Hinton agar plates were used and ZnO nanoparticles of various concentrations were supplemented in solid medium.

• Journal of Veterinary Science
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• 제22권2호
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• pp.27.1-27.13
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• 2021

Background: Ozone is an antimicrobial agent that in experimental and case-control studies has been found to exert a positive effect on wound healing. Wild and pet chelonians frequently present insidious wounds exhibiting secondary infections and/or delayed healing. Objectives: Evaluate the effects of topical ozonated sunflower oil on second-intention healing of acute experimental skin wounds in red-eared sliders (Trachemys scripta elegans). Methods: Randomised within-subject controlled study; Group 1 (n = 24) was used to assess clinical healing features; Group 2 (n = 12) was used for histological evaluation in which two sets of wounds were biopsied at 2, 7, 14, 21, 28 and 42 days over the course of the cicatrisation process. A single 6 mm diameter wound was made on each rear limb and topical ozonated (950 peroxide value) and non-ozonated sunflower oil were applied daily for one week on treated and contralateral control wounds, respectively. Results: Mean wound size was significantly lower in the ozone-treated group at day 28 (p < 0.0001) with differences of clinical relevance (74.04% vs. 93.05% reduction of initial wound size). Histologically, the acute inflammatory reaction was enhanced in treated wounds, with significantly higher numbers of heterophils (p = 0.0016), lymphocytes (p < 0.001) and fibroblasts (p < 0.001). Conclusions: Daily topical application of ozonated sunflower oil over the course of one week improved the healing of acute, full-thickness skin wounds in chelonians. This clinical outcome was histologically correlated with an enhanced acute inflammatory reaction, as well as the production and remodelling of collagen fibres.

• 비교문화연구
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• 제39권
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• pp.329-354
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• 2015

The major goals of this paper are to identify the degree into which the meanings of 'see' verb can be extended, focusing on the extended meanings shown in the expressions that denote our instinctive actions for survival, such as eating or drinking, etc., and to clarify the doubt on whether any syntactic pattern can be associated with the meaning in the process of meaning extension of 'see' verb. For doing this task, this paper picked out 2,000 examples randomly from COCA (Corpus of Contemporary American English), in which the verb 'see' is used. This paper classified the sentences into thirteen different sentence types, according to the syntactic patterns. This research showed that these thirteen syntactic types lead us to figure out the process of the meaning extension of the verb 'see'. With this result, this paper made an attempt to provide the four steps toward the meaning extension of verb 'see'. The verb 'see' in the first step denotes the meaning of purely seeing the visualized objects. This verb in the second step expresses the shifted function, under which the agent in the subject position takes the seeing action as a secondary task in order to carry out other main task. The verb in the third step denotes the extended meanings irrelevant to the seeing action, because the sentences on this step do not contain any visualized objects. In the last step this verb functions as conventional implicature whose meaning does not contribute to the whole meaning of a sentence. In addition, this paper identified that the syntactic properties are deeply associated with the process of meaning extension of the verb 'see', and tried to formalize this relationship between the syntax and semantics within the framework of Construction Grammar based on A. Goldberg.

• Journal of Gynecologic Oncology
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• 제29권6호
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• pp.93.1-93.11
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• 2018

The introduction of checkpoint inhibitors revolutionized immuno-oncology. The efficacy of traditional immunotherapeutics, like vaccines and immunostimulants was very limited due to persistent immune-escape strategies of cancer cells. Checkpoint inhibitors target these escape mechanisms and re-direct the immune system to anti-tumor toxicity. Phenomenal results have been reported in entities like melanoma, where no other therapy was able to demonstrate survival benefit, before the introduction of immunotherapeutics. The first experience in ovarian cancer (OC) was reported for nivolumab, a fully human anti-programmed cell death protein 1 (PD1) antibody, in 2015. While the data are extraordinary for a mono-immunotherapeutic agent and very promising, they do not match up to the revolutionary results in entities like melanoma. The key to exceptional treatment response in OC, could be the identification of the most immunogenic patients. We hypothyse that BRCA mutation could be a predictor of improved response in OC. The underlying DNA-repair-deficiancy should result in increased immunogenicity because of higher mutational load and more neoantigen presentation. This hypothesis was not tested to date and should be subject to future trials. The present article gives an overview of the immunologic background of checkpoint inhibition (CI). It presents current data on nivolumab and other checkpoint-inhibitors in solid tumors and OC specifically and depicts important topics in the management of this novel substance group, such as side effect control, diagnostic PD-1/programmed cell death-ligand 1 (PD-L1) expression assessment and management of pseudoprogression.

• 영어영문학
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• 제55권1호
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• pp.153-176
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• 2009

This paper attempts an allegorical reading of female sexuality in Henry James' The Aspern Papers, wherein the narrator reveals his obsession with the love letters of the dead poet, Jeffrey Aspern. Not only the old papers, but does he also fetishize female protagonists in order to maintain his belief in the "great poet." Discussing such fetishistic elements in the novella is in order firstly to reveal the self-splitting logic of phallocentric language, and secondly to analyze the limitation of such language, which resonates with the Freudian construction of female sexuality as critically presented by Irigary. The first part of this study explains the binary structure of The Aspern Papers crystalized in the symbolic courtship in the Bordereaus' garden. It also represents the psychological mindset of the narrator/protagonist: symbolically located "outside," the narrator describes the two Bordereaus as being closed "inside" in a dark mansion, concealing the precious papers from him and the public. In other words, the women are nothing but the obstacle for the self-elected agent, the narrator, from the publication of the language and ideas of the "great man". The women are associated with secrecy and surreptitiousness, while the man with transparency and the truth. Second part of this paper mimics this In/Out binary as a means to reveal insufficiency, if not impropriety, of the predominant discourse of female sexuality constructed and controlled from the male perspective. Employing Irigary's argument, this paper reads the female characters as allegory for female sexual organs, which explains the narrator's inevitable failure. That is, female sexuality is something that cannot be articulated by the intruding language of a masculine subject. since the female sex as such is not only plural but also harmonious and self-contained,

• 한국축산식품학회지
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• 제43권6호
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• pp.1087-1110
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• 2023

The growing demand for sustainable food production and the rising consumer preference for fresh, healthy, and safe food products have been driving the need for innovative methods for processing and preserving food. In the meat industry, this demand has led to the development of new interventions aimed at extending the shelf life of meats and its products while maintaining their quality and nutritional value. Cold plasma has recently emerged as a subject of great interest in the meat industry due to its potential to enhance the microbiological safety of meat and its products. This review discusses the latest research on the possible application of cold plasma in the meat processing industry, considering its effects on various quality attributes and its potential for meat preservation and enhancement. In this regard, many studies have reported substantial antimicrobial efficacy of cold plasma technology in beef, pork, lamb and chicken, and their products with negligible changes in their physicochemical attributes. Further, the application of cold plasma in meat processing has shown promising results as a potential novel curing agent for cured meat products. Understanding the mechanisms of action and the interactions between cold plasma and food ingredients is crucial for further exploring the potential of this technology in the meat industry, ultimately leading to the development of safe and high-quality meat products using cold plasma technology.

• 한국사회복지학
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• 제64권2호
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• pp.85-109
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• 2012

본 연구는 50대 레즈비언의 생애사연구로서, 연구참여자가 '지식의 주체'라는 페미니스트 인식론적 입장으로부터 '레즈비언 정체성'과 '레즈비언의 삶'에 관한 지식을 생산하고자 하였다. 구술자는 동성애 섹슈얼리티가 본질적이고 태생적인 것이 아니라 "만들어진 것"이라는 생애사적 관점을 견지했으며, 구술자가 들려준 생애이야기는 동성애에 할당된 사회적 의미를 체현하고 '순응하는 몸'인 동시에 억압과 차별을 인식하고 타개하고자 실천하는 '저항하는 몸'에 관한 것이었다. 이 생애이야기에는 섹스-젠더-섹슈얼리티의 자연화된 고리를 끊어낼 만큼 고통스러웠던 화상과 '불완전한 몸'이라는 자의식으로부터 상처받은 삶의 굴곡뿐만 아니라, 이를 넘어 타자에게 진정으로 공감하고 위로하는 "복받은 몸"으로 의미를 재구성하는 놀라운 탄력성까지 오롯이 담겨져 있었다. 이렇게 연구참여자를 비정상과 병리 등의 의미가 부착된 이분법적 구분의 '성적 소수자'가 아니라, 사회적 불평등과 억압에서도 자신의 삶을 탄력적으로 살아가며 일상의 실천으로 변화를 만들어내는 주체적인 행위자로서 이해하는 것은 사회복지 이론과 실천에서 전혀 다른 전망을 요구한다. "젠더와 섹슈얼리티를 어떻게 배치해할 것인가?"에 대한 전환적인 모색은 새로운 시대에 당면한 사회복지학이 제시해야 하는 중대한 전망이며, 이는 '성적 소수자'에게만 할당된 이슈가 아니라, 사회의 권력관계와 위계구조를 조직하고 억압과 불평등을 영속화하는 섹슈얼리티와 이에 연동하는 젠더에 관한 '우리 모두'의 아젠다인 것이다.

• 통상정보연구
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• 제15권2호
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• pp.261-283
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• 2013

ISBP745에서는 기존 ISBP에서는 규정하고 있지 않던 해상운송장 및 도로, 철도, 내수로 운송서류를 규정하여 규정의 폭을 넓혔다. 종래의 ICC Opinion과 다르거나 없었던 ISBP745의 주요 개정사항을 요약하면 다음과 같다. 첫째, 운송루트가 복합운송이면서 선하증권을 요구한 경우 UCP600 제19조 복합운송서류 규정이 적용되는 것으로 종래의 ICC Opinion과는 다르게 개정되었다. 둘째, 신용장에서 착하인도 대리점의 주소와 명칭의 운송서류 기재를 요구할 때 이 주소가 최종목적지 또는 하역항에 위치 할 필요가 없을 뿐만 아니라 동일 국가에 위치할 필요도 없다는 규정이 신설되었다. 셋째, 여러 사람의 송하인과 한 사람의 수하인이 있는 LCL/FCL 운송의 경우에는 복수의 운송서류가 발행되는데 이에 대한 사례를 구체적으로 규정하고 있다. 그러나 운송업계에서 이러한 경우에 흔히 표시하고 있는 "LCL/FCL" 또는 "CFS/CY"의 기재를 복수의 운송서류가 요구되는 사례로 규정하지 않음으로써 실무적으로 혼란을 야기할 수 있다는 문제가 있다. 넷째, 신용장에서 분할선적이 허용되고, 복수의 운송서류가 하나의 표지서류에 따라 제시될 때 서류 제시기간의 기산일을 운송서류 중 최초의 선적일을 기준으로 한다는 규정이 신설되었다.

• 한국콘텐츠학회논문지
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• 제12권12호
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• pp.313-320
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• 2012

치과진료실은 다양한 종류의 병원성 미생물에 항상 노출되어 있으며, 환자의 분비물과 에어로졸 형태의 여러 경로를 통해 실내가 오염될 경우 교차감염의 매개 장소가 될 수 있다. 교차감염의 위험이 산재되어 있는 치과진료와 치과진료실에서 교차감염 방지의 주체자는 치과위생사이다. 치과위생사는 임상 전문가로 활동하기 전에 감염방지에 대한 올바른 인식을 가지고 있어야 되며, 이러한 감염방지 인식수준은 임상실습에서부터 영향을 받는다. 이에 감염방지의 인식을 조사하고자 일부 4년제 대학교 치위생학과 교육과정 중 3학년 과정에 임상실습이 정규과목으로 정해져있는 학생 314명을 대상으로 자기기입식 설문조사를 실시하였다. 자료 수집은 2011년 12월 9일부터 2012년 2월 22일까지 수행하였고, 수집된 자료 중 응답이 불성실한 11부의 설문지를 제외한 303부를 SPSS WIN 20.0을 사용하여 최종 분석하였고, 다음과 같은 결론을 얻었다. 감염질환에 관한 인식 영역에서 교내 외 실습 경험군은 감염질환 인지의 중요성 문항에서 4.89점, B형간염 예방접종 의무의 문항에서는 4.65점, B형간염 예방접종 필요성 인식의 문항에서는 4.77점, 문진 실시하여 감염방지를 실천할 수 있는지에 대한 문항에서는 4.71점, 감염방지 교육의 도움에 관한 문항에서는 4.76점으로 가장 높았으며, 유의한 차이를 보였다. 치위생학과 학생들을 위한 체계적이고 다양한 감염방지 교육 프로그램 개발과 학년에 따른 차별적인 교육이 필요하다고 사료된다.

• 약학회지
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• 제37권5호
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• pp.511-519
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• 1993

The short and variabke transit of drug throught GI tracj and the inter-and intra-subject variations of the transit restrict the sustained drug absorption after oral adminstration. These restrictions may be solved by retaining the dosage forms in the stomach. Then the dosage form will act as a platform which releases the drug slowly and makes the GI absorption occur for a long time. In this study, as the platforms, PVP hydrogels were synthesized by chemical and y-irradiation method in the cylindrical test tube. The chemical method means the synthesis of the hydrogel by heating the mixed solution of N-vinyl-2-pyrrolidone [monomer], acrylated albumin [crosslinking agent], 2, 2'-agobis(2-methylpropionitrile) [initiator] and proxyphylline [drug] at $65^{\circ}C$ for 5 hr. The $\gamma$-irradiation method means the synthesis of the hydrogel by irradiation with $^{60}$ Co $\gamma$-ray of the mixed solution of the monomer, acrylated albumin, and flurbiprofen [drug] at room temperature with total 0.2 Mrad for 3 hr. Our intention is to design the hydrogel tablet (diameter : 1.20 cm, thickness : 0.60 cm) which swells in the gastric fluid after oral administration to such a size that passing through the pylorus could be inhibited during the period of drug release. After releasing drug, the hydrogel should be degraded by the enzymeatic digestion in the stomach, or by hydrolysis and eventually solubilized. Thus, in votro tests were performed to examine the factors that affect swelling and drug release from the PVP hydrogels. Experimental results show that the hydrogels swell to a size larger than the diameter of the pylorus(l.3$\pm$0.7 cm) and the hydrogel prepared by the chemical method is digested by pepsin. But the hydrogel prepared by the $\gamma$-irradiation method was not digested by the pepsin and just collapsed with time. Thus, the swelling of the hydrogel synthesized by $\gamma$-irradiation was independent albumin acrylation time and pepsin concentration. But drug content and radiation dose affected the swelling and drug release kinetics of the hydrogel. Drug release from the hydrigels was prolonged up to about 24 hr. Therefore, it was concluded that by adjusting these factors, the albumin-crosslinked PVP hydrogel synthesized by $\gamma$-irradiation method is expected to be retained in the stomach for up to 60hr and be a potential platform of drugs for long-term GI absorption.