• Title/Summary/Keyword: Ageing data

Search Result 207, Processing Time 0.024 seconds

Role of Recombinant PnTx2-6 Protein as a Mediator of Vasodilation in Blood Vessels

  • Park, Seung-Won;Kim, Seong Ryul;Goo, Tae-Won;Choi, Kwang-Ho
    • International Journal of Industrial Entomology and Biomaterials
    • /
    • v.35 no.1
    • /
    • pp.39-44
    • /
    • 2017
  • The venome of Phoneutria nigriventer spider has been shown to have side effects including severe painful erections that last for hours. PnTx2-6, a toxin from P. nigriventer spider venom, modulates voltage gated $Na^+$ channels and activation of nitric oxide (NO) production. NO is essential for the regulation of blood flow and pressure. Therefore, PnTx2-6 is expected to be effective not only for erectile dysfunction but also for cardiovascular diseases. A previously has reported cDNA clone for PnTx2-6 toxin, which was expressed in E. coli cytoplasm. We created the same clone and expressed it in a bacterial expression system. PnTx2-6 increased the genes expression of superoxide dismutase 1, glutathione peroxidase 1, and sulfiredoxin 1. We hypothesized that recombinant PnTx2-6 may indirectly regulate blood flow and pressure, resulting in NO production in human umbilical vein endothelial cells (HUVEC). These data suggest differential regulation of the vascular ageing process, which may contribute to the anatomic heterogeneity of atherosclerosis. The results of this study may be used for the emergency treatment of sudden cardiovascular disease caused by ageing.

Effects of additional electrical stimulation and pre-rigor conditioning temperature on the ageing potential of hot-boned bovine muscles

  • Balan, Prabhu;Farouk, Mustafa M.;Staincliffe, Maryann;Stuart, Adam D;Kemp, Robert;Craigie, Cameron
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.33 no.10
    • /
    • pp.1642-1655
    • /
    • 2020
  • Objective: The aim of this study is to characterize the impact of additional electrical stimulation (AES) and various pre-rigor holding temperatures (for 3 h) on the ageing-potential of hot boned bovine M. longissimus lumborum (LL). Methods: Paired LL loins from 12 bulls were hot-boned within 40 min of slaughter, immediate AES applied and subjected to various holding temperatures (5℃, 15℃, 25℃, and 35℃) for 3 h. Results: AES did not accelerate the rate of rigor attainment, but the 3 h pre-rigor holding temperature did. Shear force values decreased as the pre-rigor holding temperatures increased. AES and holding for 3 h (at 25℃) resulted in higher water-holding capacity. Conclusion: Data confirmed that AES did not influence the various meat quality parameters in the present study, but pre-rigor holding temperature (25℃) alone or in combination with AES resulted in superior meat quality.

Contact between Never Married Children and Their Parents: Moderating Effects of Children's Gender (비혼자녀와 부모의 접촉: 자녀의 성별에 따른 차이)

  • Choi, Heejeong
    • Journal of Families and Better Life
    • /
    • v.34 no.5
    • /
    • pp.151-166
    • /
    • 2016
  • This study examined frequency of contact between parents and their non-coresident, never-married daughters and sons compared to children in other marital statuses. Despite an increasing number of never married adults, little is known about the extent to which they may be willing to remain connected to and exchange support with their parents. The data were drawn from first wave of the Korean Longitudinal Study of Ageing (KLoSA, 2006). For analyses, respondents who had at least one non-coresident child aged 40 or older were selected, resulting in the analytic sample of 2,755 parents with 7,741 children. Both sibling fixed effects regression models and regression models with robust standard errors were estimated using the xtreg and reg procedures in STATA. Findings revealed significant marital status by gender interaction effects on face-to-face contact. Never-married daughters were more likely to see their parents compared to their married, divorced, or widowed counterparts. Never-marred sons, on the other hand, reported slightly lower levels of in-person contact with their parents in comparison to married sons and lower levels of contact compared to divorced or widowed sons. More frequent contact via phone, mail, or email was reported in daughter-parent relationship compared to son-parent relationship, but no significant marital status by gender interactions were observed.

Patterns of the Change and the Predictors of the Social Exclusion of the Older People: Analysis of English Longitudinal Study of Ageing(ELSA) (노인의 사회적 배제 수준의 변화유형과 예측요인: 영국고령화패널(ELSA)분석)

  • Park, Hyunju;Chung, Soondool
    • 한국노년학
    • /
    • v.32 no.4
    • /
    • pp.1063-1086
    • /
    • 2012
  • The purpose of this study is to understand the current state of the older people's social exclusion by identifying patterns of the change in social exclusion level through a longitudinal analysis with an aim of exploring the predictors of changes. To this end, this study has adopted the panel data, the English longitudinal Study of Ageing(ELSA). The data of 7631 respondents who aged over 50 were used for the final analysis. The social exclusion of the older people was analyzed into five different sub-dimensions: social relationship; cultural activities; access to health services; financial security; and sense of loneliness. The person-centered approach that focuses on the various patterns of the trajectories of change has used semi-parametric group based model in order to estimate different trajectories among individuals. The data was analyzed using Spss 18.0 and SAS 9.2 proc traj. In results, First, semi-parametric group-based model analysis has shown that the older people are not 'homogeneous' group with similar exclusion level in every individual with same trajectories of change, but can be divided into various categories with diverse intercept and slope. Second, different trajectories in change of exclusion level help to confirm that the older people's social exclusion level increases gradually over time or remains unchanged. Third, this analysis has provided the useful guidelines to identify the high-risk groups of social exclusion. Forth, the variables that make difference in more than three dimensions include gender, age, self-perceived health, physical activity, weekly income, marital status, family relation, and beneficiary status. Implications and further suggestion were discussed.

Clothing Condition of Elderly Men Focusing on Somatotype Variation and Satisfaction with Ready-to-Wear (노년 남성의 의복착용 실태조사 -체형 변화와 기성복 만족도를 중심으로-)

  • 김희영
    • Journal of the Korean Society of Clothing and Textiles
    • /
    • v.22 no.2
    • /
    • pp.193-202
    • /
    • 1998
  • The purpose of this study was to understand clothing condition of elderly men focusing on somatotype variation and satisfaction with ready-to-wear and to provide basic data in designing ready-to-wrar for the elderly men. The questionnaire method was used and one-to-one interviews were held for the elderly residents in Seoul, Deajon, Jonju, and Yeosu areas. The total of 275 questionnaires (from 148 elderly men in the 60's, 99 in the 70's and 28 in the 80's) were collected and used for statistics. SAS package was used for the statistics and the statistics were based on frequency, X2-test, ANOVA, Duncan's multifle range test. The results of the study were as follows; 1) Height (p< .05), weight (p< .001) and Rohrer index (p< .05) decreased significantly with ageing 2) The somatotypes of 75.6% were changed and the 70's 8t the 80's showed significantly (p< .05) higher changing rate compared to the 60's and more changes took place significantly (p< .001) with ageing. 3) The most preferred out wear was suit & tie and next was jumper or shirt. 4) For the mode of getting suit, the highest number 55.3%) purchased ready-to-wear, next (32.0%) was tailored and the least (12.7%) neither purchased nor tailored. The percentage of buying ready-to-wear significantly (p< .01) decreased with ageing. The main reason for getting tailor-made was not well fitting of ready-to-wear (20.7% out of 32.0%). And for the mode of getting suit, there was significant differance with income (p< .001) and pocket money (p< .01). 5) The most important factors in suit and shirt werefirst, size (fitness) and second, comfort in movement. 6) For the wearing feeling of suit, 55.3% showed discomfort. There was significant difference according to the age (p< .05) and pocket money (p< .05). The Discomfort increased with ageing and less pocket money. 7) 62.4% answered it uneasy to Pick out well fitting If comfortable suit. This showed their dissatisfaction with ready-to-wear. 8) As for the items of not well fitting, 64.4% answered in jacket, 60.8% in trousers, 46.0% in shirt. The above result shows that elderly men's somatotype changes as they age, suit is found uncomfortable and it's not easy for elders to pick out comfortable ready-to-wear. So, they seem to have a certain dissatisfaction in ready to wear. Therefore, there is a need for reorganization of size and developing pattern design according to measurement of elderly men.

  • PDF

Integrated driver with optical compensation for improved uniformity of emissive displays

  • Maeyaert, Stefaan;Bakeroot, Benoit;Doutreloigne, Jan;Monte, Ann;Bauwens, Pieter;Calster, Andre Van
    • 한국정보디스플레이학회:학술대회논문집
    • /
    • 2008.10a
    • /
    • pp.692-695
    • /
    • 2008
  • Large area emissive displays have problems with nonuniform pixel characteristics and their individual ageing. A pixel integrated driver with pixel based optical feedback is presented to solve these problems. Photodetectors, optical feedback circuit and data handling capabilities are integrated in a high voltage CMOS technology.

  • PDF

Testing NBUCA Class of Life Distribution Using U-Test

  • Al-Nachawati, H.
    • International Journal of Reliability and Applications
    • /
    • v.8 no.2
    • /
    • pp.125-135
    • /
    • 2007
  • In this paper, testing exponentiality against new better than used in convex average and denote by (NBUCA), or its dual (NWUCA) is investigated through the U-test. The percentiles of these tests are tabulated for samples sizes n = 5(1)40. The power estimates of the test are simulated for some commonly used distributions in reliability. Pitman's asymptotic efficiency of the test is calculated and compared. Data of 40 patients suffering from blood cancer disease (Leukemia) is considered as a practical application of the proposed test in the medical sciences.

  • PDF

A comparison between the real and synthetic cohort of mortality for Korea (가상코호트와 실제코호트 사망력 비교)

  • Oh, Jinho
    • The Korean Journal of Applied Statistics
    • /
    • v.31 no.4
    • /
    • pp.427-446
    • /
    • 2018
  • Korea will have a super-aged society within only 30 years according to the United Nations' definition of an aging society and the statistics on Korea's Population projections (2016), indicates that Korea has the fastest ageing speed in the world. There is a lack of data on long-term time-series data on death as related to pension and welfare policies compared to the rapid rate of aging. This paper estimates life expectancy over 245 years (from 1955 to 2200) through past and future forecasts as well as compares the expected life expectancy of the synthetic cohort and the real cohort. In addition, an international comparisons were made to understand the level of aging in Korea. Estimates of the back-projection period were compared with previous studies and the LC model to improve accuracy and objectivity. In addition, the predictions after 2016 reflected the declined mortality rate effect of Korea using the LC-ER model. The results showed an increase in life expectancy of about 30 years over 60 years (1955-2015) with an expected life expectancy of the real cohort over the second century (1955-2155) higher than the synthetic cohort. The comparative advantage of life expectancy of real cohorts was confirmed to be a common trend among comparative countries. In addition, Japan and Korea have a higher life expectancy and starting from 85 to 90 years old, all comparative countries show that the growth rate for the life expectancy of synthetic and real cohorts is less than previous years.

Self-rated Health and Health Service Utilization of Chronic disease Patients (만성질환자별 주관적 건강상태와 의료시설 이용행태)

  • Park, Eun-Ju
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
    • /
    • v.9 no.4
    • /
    • pp.404-413
    • /
    • 2016
  • This study, based on the assumption that self-rated health status affects the use of health care utilization, aims to comprehend self-rated health status, as well as the differences in medical facility use depending on self-rated health status, and analyze according to chronic diseases to use it as the basis of a practical guide development for chronic disease patients' use of medical facilities. Used representative Korean Longitudinal Study of Ageing data to analyze 7,486 participants. There is a difference in Chronic disease patients' use of health care utilization depending on self-rated health, and this difference was the most apparent in Oriental healthcare service and dental treatment use. This study was unable to control all confounding variables affecting medical service use, so we want this studied to be used to assist future studies.

Continuous Volunteering Experience in Elderly People : A Phenomenological Research (노인의 지속적 자원봉사활동 경험 : 현상학적 연구)

  • You, Jeong-Suk;Kim, Ka-Duck
    • Korean Journal of Social Welfare
    • /
    • v.62 no.3
    • /
    • pp.247-270
    • /
    • 2010
  • The purpose of this research is to understand the meanings and essentials of the experience of continuous participation in volunteer works, from an emic perspective. To conduct an in-depth study regarding 'live experiences', this research used phenomenological research method. For the method of data collection, purposive sampling is used with some in-depth interviews of five elderly people who have participated in volunteer works from 6 years to 23 years. As a result of the analysis of the collected data, the essence of continuous participation in volunteer works appeared to be 'regained happiness of life'. Elderly people who persist in volunteering were also passionate in taking part in social activities, eager to improve their cognitive functions, and likely to put more effort in maintaining their own health in order to continue the volunteer works. These are the factors that satisfy successful ageing. This research has its object in preparing systematic support at a national level to prevent the volunteer works of the elderly people from ending up in mere personal virtue, so as to successfully manage the later stage of life.

  • PDF