• The Journal of Korean Medical History
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• v.32 no.2
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• pp.19-27
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• 2019

For the purpose of searching examination in the connection with clinical medicine and the basic theory of Korean Medicine, we comparatively studied on the physiological system of Hyun-Gok (1912~1987) and the Hyunsang system of Ji-San (1927~2000). The results are as follows. The metabolism of Yin and Yang is connected 'Gallbladder (膽)'-'Bladder (膀胱)' and Man (男), Woman (女), Old aged (老), Young child (小) style. Man and Woman are divided in the body form chacteristic not by the sex. 'Gallbladder (膽)'-'Bladder (膀胱)' style are divided in the body form chacteristic by the terms of Yin (陰) and Yang (陽). 'Gallbladder (膽)' style represents excessive Yang and deficient Yin, 'Bladder (膀胱)' style represents excessive Yin and deficient Yang. The four composition factor of the body is connected Material basis (精) type, Vital energy (氣) type, Mental faculties (神) type and Blood (血) type. In the diagnosis of body form on the Hyungsang Medicine, there are several types of body shape and categories of people. The Material basis (精) type, Vital energy (氣) type, Mental faculties (神) type and Blood (血) type are classified by the four composition factor of the body. The structural-mechanics organization of five Internal Organs (臟) is connected five Internal Organs (臟) types and the running-animal (走), bird (鳥), fish (魚), turtle (甲) types in the Hyunsang system. The five Internal Organs (臟) types are percived on the ears, eyes, nose, mouth and facial complexion. And the running-animal, bird, fish, turtle types are accorded to the individual personalities and the most-developed part in the body trunk by the Organ picture (藏象) theory. The six atmospheric influences (六氣) is connected the six Kyung types (六經形). The six Kyung types are regulated by the shape of eyes and nose representing for the relation of Vital energy (氣) and Blood (血). By the comparative study on the physiological system of Hyun-Gok and the Hyunsang system of Ji-San, we can search the connection with clinical medicine and the basic theory of Korean Medicine.

• Nutrition Research and Practice
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• v.16 no.1
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• pp.1-13
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• 2022

BACKGROUND/OBJECTIVES: Bitter taste receptors are taste signaling pathway mediators, and are also expressed and function in extra-gustatory organs. Skin aging affects the quality of life and may lead to medical issues. The purpose of this study was to better understand the anti-skin aging effects of bitter taste receptors in D-galactose (D-gal)-induced aged human keratinocytes, HaCaT cells. MATERIALS/METHODS: Expressions of bitter taste receptors in HaCaT cells and mouse skin tissues were examined by polymerase chain reaction assay. Bitter taste receptor was overexpressed in HaCaT cells, and D-gal was treated to induce aging. We examined the effects of bitter taste receptors on aging by using β-galactosidase assay, wound healing assay, and Western blot assay. RESULTS: TAS2R16 and TAS2R10 were expressed in HaCaT cells and were upregulated by D-gal treatment. TAS2R16 exerted protective effects against skin aging by regulating p53 and p21, antioxidant enzymes, the SIRT1/mechanistic target of rapamycin pathway, cell migration, and epithelial-mesenchymal transition markers. TAS2R10 was further examined to confirm a role of TAS2R16 in cellular senescence and wound healing in D-gal-induced aged HaCaT cells. CONCLUSIONS: Our results suggest a novel potential preventive role of these receptors on skin aging by regulating cellular senescence and wound healing in human keratinocyte, HaCaT.

• The Journal of Pediatrics of Korean Medicine
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• v.12 no.1
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• pp.145-162
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• 1998

The purpose of this study was to determine the effects of oriental medical care on growth deficiency children. These cases were collected to investigate the effects of oriental medical care on growth deficiency children. So the cases were divided into 5 groups. The growth velocity was compared to a normal growth curve, and the results are as follows: 1. Oriental medical care was efficient when the epiphysial plates were not closed. 2. In female middle school beyond 1st grade students and in male middle school 3rd grade students who had almost closed epiphysial plates, the oriental medical care was not efficient and did not promote growth velocity. endothelium were used for the experiment using organ bath. 3. In the cases where the parent were very short, the effects of the oriental medical care to promote growth velocity was not efficient. 4. when we treated children of normal height, their growth velocity was over the normal growth curve. 5. In preschool aged children, oriental medical care was very efficient to promote children's growth. 6. The principle oriental medical care was to make balanced their body and digestive organs by using herb medicines that have the capability to promote the growth of the bones, and build strong muscles.

• Journal of The Korea Institute of Healthcare Architecture
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• v.12 no.3
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• pp.15-26
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• 2006

Nowadays, it has been changed in medical environments which are the increase of the aged and chronic disease, development of medical system and technology, the open of medical markets according to negotiation of DDA(Doha Development Agenda) and FTA(Free Trade Agreement) and so on. The changes of medical system and function are caused by changes of medical environments. This study is to analyze the spatial changes of general hospital O. P. D. in Korea based on changes of the medical system and function. In conclusion, the O. P. D. in general hospital has been changed by stages as follows; First, subdivision and specialization of medical organization systems. Second, diversification of specialized centers based on medical cooperated systems. At last, integration of E&T faculties and specialized centers which have similar functions. According to the spatial changes of outpatient department, the types of E&T faculties and specialized centers has been changed by diverse forms as follows; E&T faculties and specialized centers focused on disease, organs, classes and so on.

• Korean Journal of Veterinary Research
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• v.57 no.3
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• pp.181-187
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• 2017

Antihypertensive effects of ethanol extracts of Aralia elata (Miq.) Seem. (AE) were investigated in spontaneously hypertensive rats (SHR). SHR aged 14 weeks were treated for 8 weeks with AE (10 or 50 mg/kg/day) or amlodipine besylate (Am; 10 mg/kg/day) orally. Hypertension results in injury to several organs and can produce a significant increase in malondialdehyde (MDA) content as a result of lipid peroxidation and endothelial dysfunction. In this study, oral administration of AE and Am significantly reduced systolic blood pressure, organ weight index, and MDA content in tissues but increased significantly the plasma nitrite and nitrate concentrations. The endothelium-dependent relaxant activities of acetylcholine ($10^{-10}-10^{-3}M$) in norepinephrine (NE)-precontracted aorta were increased in AE- and Am-treated rats. Particularly strong endothelium-dependent relaxant activities were observed in AE-treated (50 mg/kg) rats. The endothelium-independent relaxant activities of sodium nitroprusside ($10^{-10}-10^{-3}M$) in NE-precontracted aorta were not changed. The results of this study suggest that AE has both antihypertensive and end-organ protective effects in SHR.

• 제어로봇시스템학회:학술대회논문집
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• 1995.10a
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• pp.248-251
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• 1995

Nowadays, the internal images of a human body can be easily provided by the ultrasound imaging, the X-ray CT, or the MRI device, among which the ultrasound imaging device has good resolution for soft tissues of a human body compared with the other devices. Furthermore, the use of ultrasound imaging devices will increase in future especially in the obstetrics, territory, since it does not give harm to the human body. Although several techniques have been investigated until now in order to extract organs from ultrasound images, very few of them have achieved satisfactory results because of low contrast and high noise nature of images. This paper proposes a technique for automatic extraction of the gall bladder area from ultrasound images. The proposed technique first extracts a small reliable area of a gall bladder from an ultrasound image employing smoothing, binarization, expanding and shrinking, and labeling, and then expands the area referring to the binarized version of the original image. The technique is examined its performance by real ultrasound images of a gall bladder and satisfactory results are obtained. Some problems to be solved are discussed finally.

• The Journal of Internal Korean Medicine
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• v.19 no.1
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• pp.343-352
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• 1998

This study involved 45 man-smoker outpatients of Han-lim oriental medical hospital from Feb. 1, 1998 to May 31, 1998. The results of this study are as follows ; 1. In sex distinction, the average age was 51.9 years with persons aged 25 to 83 years. 40's and 50's are the most as 12 persons (26.7%) respectively, and in order of the next 30's and 60's are 7 persons (15.55%) respectively, more than 71 years are 5 persons (11.10%), less than 30 years are 2 persons. 2. In occupational distinction, farmers are the most as 20 persons (44.4%), and then common desk workers are 11 persons (24.44%), fishermen are 8 persons (17.78%), the others are 6 persons (13.34%) in that order. 3. In the distinction of chief complaint, cough 39 persons (88.67 %), sputum 29 persons (64.44%), dyspnea 13 persons (28.89%), loss of appetite 7 persons (15,56%), chest pain 5 persons (11.11%) in that order 4. the effects after dosage are as follows ; favorable turn of sputum is the most 89.66%, cough 64.10%, chest pain 60%, dypsnea 53.85%, loss of appetite 28.57%. As a whole, more than 68.32% was improved. As the above, it was thought that Kwarujisiltang administration was evidently effective on a chronic disease of the respiratory organs.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.9
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• pp.1304-1307
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• 2001

The laying performance of Japanese quails fed graded levels of high glucosinolate ($92.5{\mu}mole/g$) rapeseed meal (RSM) was assessed. One hundred and twenty Japanese quails aged 1 day-old were assigned at random to four dietary treatments consisting of 0, 50, 75 or 100 g/kg RSM in the diet replacing part of the soybean meal and de-oiled rice bran in a standard quail ration. 12 female representative quails from each diet were selected at random and housed in individual cages from 7-20 wk of age. The egg production, feed intake and FCR was comparable among the different dietary groups. The egg quality characteristics, organoleptic evaluation of boiled eggs as well as the haematological (haemoglobin, total erythrocyte count, total leucocyte count) and biochemical (glucose, protein, cholesterol, aspartate amino transferase, alanine amino transferase and alkaline phosphatase) constituents did not differ significantly among the groups. The gross and histopathological studies of vital organs did not reveal any appreciable changes. The feed cost was reduced by the incorporation of RSM in the diet, but only the production cost of quails fed the 75 g/kg RSM was lower in comparison to other groups. In the present study, the laying potential of Japanese quail was well-maintained up to the 100g/kg dietary level of rapeseed meal.

• Korean Journal of Animal Reproduction
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• v.10 no.1
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• pp.9-18
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• 1986

Breeding and infertility status of Holstein cows reared in pasture of High-land was investigated. The results obtained were summarized as follows; 1. Eight hundred and forty Holstein cows with heifers (12.4%), 3 years old cows (19.3), 4 years old cows (16.7%), 5 years old cows (12.5%), 6 years old cows (11.4%), 7 years old cows (13.2%), 8 years old cows (9.4%) and above 9 years old cows (5.1%) were investigated. 2. They were 72.4% of conceived cows, 8.2% of uncertain pregnancy, 7.7% of physiological empty and 11.7% of reproductive disorder. 3. The percentage of cow concepted with 1, 2, 3 and more than 4 times of A.I. was 49.2, 28.8, 14.6 and 7.4% respectively. 4. In the nutritional condition of infertile cows, excellent, good, fair and poor was 7.1, 30.6, 36.7 and 25.5%, respectively. 5. Among 98 infertile cows, distribution of reproductive disorder was 41.8, 37.8, 5.1, 5.1 and 11.2% in ovary, uterus, vagina, oviduct and others, respectively. Ovary showed higher percentage than any other reproductive organs. Among the ovarian syndromes, lutein cystic ovary, follicular cystic ovary, and persistent corpus luteum were 31.7, 26.8 and 19.5%, respectively. 6. Four years old cow showed highest distribution (16.4%) among the aged groups in disordered cows. In the syndromes of reproductive disorder, latent endometritis showed higher frequency (14.3%) than any others. 7. Infertile cows with complex syncrome of genital disease was 29.6%.

• IMMUNE NETWORK
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• v.16 no.2
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• pp.116-125
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• 2016

Medical records of 139 tumors from 114 dogs that underwent surgery from May 2010 through March 2015 were retrospectively reviewed. Among 114 dogs, females (64.9%) were significantly more common than males (35.1%) (p<0.05). Dogs aged 6 to 10 years were more presented than non-tumor patients, however, there was no significant difference. The mean age (±SD) was 10.3±3.0 years. Although we found no significant difference of breed predisposition, the most common breed was Maltese (19.3%), followed by Shih-Tzu (14.0%), and Yorkshire terrier (13.2%). Proportional morbidity ratios (PMRs) of mammary gland, oral cavity, and skin tumors were high in Poodles, Yorkshire terriers, and Golden retrievers, respectively. Mammary gland (36.0%) was the most common site, followed by skin and soft tissues (12.2%), oral cavity (10.8%), and digestive organs (8.6%), but there was no significant difference. The objectives of surgery were curative surgery (86.2%), biopsy (4.9%), and palliative surgery (6.5%). In this study, 123 of 139 tumors had histopathological diagnoses. Adenocarcinoma was the most common type (n=24), followed by adenoma (n=17), soft tissue sarcoma (n=13), benign mixed tumor (n=5), and others (n=64). Recurrence or suspected metastasis was identified in 26 dogs. Median survival times of malignant mammary gland tumors, skin and subcutaneous tumors, and splenic tumors were 1,563.0±1,201.7, 469, and 128 days, respectively.