• Title/Summary/Keyword: Age acceleration

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Epigenetic Age Prediction of Alzheimer's Disease Patients Using the Aging Clock (노화 시계를 이용한 알츠하이머병 환자의 후성유전학적 연령 예측)

  • Jinyoung Kim;Gwang-Won Cho
    • Journal of Integrative Natural Science
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    • v.16 no.2
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    • pp.61-67
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    • 2023
  • Human body ages differently due to environmental, genetic and pathological factors. DNA methylation patterns also differs depending on various factors such as aging and several other diseases. The aging clock model, which uses these differences to predict age, analyzes DNA methylation patterns, recognizes age-specific patterns, predicts age, and grasps the speed and degree of aging. Aging occurs in everyone and causes various problems such as deterioration of physical ability and complications. Alzheimer's disease is a disease associated with aging and the most common brain degenerative disease. This disease causes various cognitive functions disabilities such as dementia and impaired judgment to motor functions, making daily life impossible. It has been reported that the incidence and progression of this disease increase with aging, and that increased phosphorylation of Aβ and tau proteins, which are overexpressed in this disease and accelerates epigenetic aging. It has also been reported that DNA methylation is significantly increased in the hippocampus and entorhinal cortex of Alzheimer's disease patients. Therefore, we calculated the biological age using the Epi clock, a pan-tissue aging clock model, and confirmed that the epigenetic age of patients suffering from Alzheimer's disease is lower than their actual age. Also, it was confirmed to slow down aging.

Gait Feature Vectors for Post-stroke Prediction using Wearable Sensor

  • Hong, Seunghee;Kim, Damee;Park, Hongkyu;Seo, Young;Hussain, Iqram;Park, Se Jin
    • Science of Emotion and Sensibility
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    • v.22 no.3
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    • pp.55-64
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    • 2019
  • Stroke is a health problem experienced by many elderly people around the world. Stroke has a devastating effect on quality of life, causing death or disability. Hemiplegia is clearly an early sign of a stroke and can be detected through patterns of body balance and gait. The goal of this study was to determine various feature vectors of foot pressure and gait parameters of patients with stroke through the use of a wearable sensor and to compare the gait parameters with those of healthy elderly people. To monitor the participants at all times, we used a simple measuring device rather than a medical device. We measured gait data of 220 healthy people older than 65 years of age and of 63 elderly patients who had experienced stroke less than 6 months earlier. The center of pressure and the acceleration during standing and gait-related tasks were recorded by a wearable insole sensor worn by the participants. Both the average acceleration and the maximum acceleration were significantly higher in the healthy participants (p < .01) than in the patients with stroke. Thus gait parameters are helpful for determining whether they are patients with stroke or normal elderly people.

An Experimental Study of Chloride Acceleration on the Seawater Resistance of Fly Ash Antiwashout Underwater Concrete (플라이애쉬 수중불분리성 콘크리트의 내해수성에 관한 염화물 촉진 시험)

  • Kwon, Jung-Hyun;Kim, Bong-Ik
    • Journal of Ocean Engineering and Technology
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    • v.19 no.6 s.67
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    • pp.29-34
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    • 2005
  • This paper describes the effect of fly ash replacement on seawater resistance of anti-washout underwater concrete, which was replaced cement by fly ash from $0\%$ to $50\%$. The experimental work was performed to find out the variations of length and weight of specimens, using a chloride acceleration test in $40\^{\circ}$C The results shaw that the admixture using fly ash on an anti-washcout underwater concrete in the sea environment makes it more durable for the attacks of chloride by seawater. Also, the length of specimens of anti-washout underwater concrete, at age 180 days, increased substantially, compared with normal concrete; however, the mixture in which cement was replaced $50\%$ of fly ash shows $93\%$ reduction of the expansion, compared with the normal anti "washout underwater concrete specimen.

Fall Direction Detection using the Components of Acceleration Vector and Orientation Sensor on the Smartphone Environment (스마트폰 환경에서 가속도 벡터의 성분과 방향센서를 활용한 넘어지는 방향 측정)

  • Lee, Woosik;Song, Teuk Seob;Youn, Jong-Hoon
    • Journal of Korea Multimedia Society
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    • v.18 no.4
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    • pp.565-574
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    • 2015
  • Falls are the main cause of serious injuries and accidental deaths in people over the age of 65. Due to widespread adoption of smartphones, there has been a growing interest in the use of smartphones for detecting human behavior and activities. Modern smartphones are equipped with a wide variety of sensors such as an accelerometer, a gyroscope, camera, GPS, digital compass and microphone. In this paper, we introduce a new method that determines the fall direction of human subjects by analyzing the three axis components of acceleration vector.

TWO-FLUID CLOSURE PARAMETERS FOR DIFFUSIVE ACCELERATION OF COSMIC RAYS

  • KANG HYESUNG
    • Journal of The Korean Astronomical Society
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    • v.26 no.1
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    • pp.1-12
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    • 1993
  • In order to explore the time dependence of the closure parameters of the two-fluid calculations for supernova remnants and the terminal shocks of stellar winds, we have considered a simple model in which the time evolution of the cosmic-ray distribution function was followed in the test-particle limit using the Bohm diffusion model. The particles are mostly accelerated to relativistic energy either in the free expansion phase of the SNRs or in the early phase of the stellar winds, so the evolution of the closure parameters during these early stages is substantial and should be followed correctly. We have also calculated the maximum momentum which is limited by either the age or the curvature of these spherical shocks. We found that SNRs expanding into the medium where the gas density decreases with the distance from the explosion center might be necessary to explain the observed power-law distribution of the galactic cosmic rays. The energy loss due to the escaping energetic particles has been estimated for the terminal shocks of the stellar winds.

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Analysis of Kinematic Variables according to Ground Slope Angle during Golf Putting (골프 퍼팅 시 지면 경사도에 따른 운동학적 변인 분석)

  • Park, Jun-Sung;Shin, Sung-Hoon;Lim, Young-Tae
    • Korean Journal of Applied Biomechanics
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    • v.31 no.1
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    • pp.44-49
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    • 2021
  • Objective: The purpose of this study was to analyze kinematic variables according to ground slope angle during golf putting. Method: 26 collegiate golfers (age: 22.54±2.15 kg, height: 174.64±6.07 cm, weight: 71.35±9.27 kg, handicap: 5.11±4.50) were participated, and 8 motion capture cameras (250 Hz), Nexus, and Kwon3DXP software were used to collect data. It was performed repeated measures ANOVA and Bonferroni adjustment. Alpha set at .05. Results: Body alignments were not significantly different at address. Putter head trajectory and loft angle were significantly different, and AP direction of acceleration of putter head was significantly different. However, ML and SI direction of acceleration of putter head were not significantly different. Conclusion: Therefore, it was identified that ground slope angle was affected the kinematic variables during putting, and it will be performed that correlation analysis between putting success rate and kinematic variables according to ground slope angle during golf putting.

Early-age Properties of Mortar Containing Calcium Chloride (염화칼슘을 첨가한 모르타르의 초기 재령 특성)

  • Oh, Sang-Hyuk;Choi, Seul-Woo;Lee, Kwang-Myong;Kim, Joo-Hyung
    • Proceedings of the Korea Concrete Institute Conference
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    • 2010.05a
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    • pp.387-388
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    • 2010
  • In this study, early-age properties of mortar containing calcium chloride as an accelerator was investigated. The time of setting of the mortar by ultrasonic tester and penetrometer was assessed to prove its acceleration effect on hydration and the compressive strength was also measured to examine the effect of calcium chloride on the early-age strength.

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A study on Body Shape Variation of Female in the Growth Period for the Establishment of the Apparel Sizing system -From the View Point of Obesity/Leanness- (의복 치수 규격 설정을 위한 성장기 여학생의 체형변화에 관한 연구 -비만, 수척의 관점에서-)

  • 노희숙;이순원
    • Journal of the Korean Society of Clothing and Textiles
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    • v.19 no.3
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    • pp.516-524
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    • 1995
  • The purpose of this study was to analyze the variation of body shape and to. divide growth period into some age groups based on body type. Duncan Test, Heath-Carter's somatotyping method and allottery equation (y=baa) were applied to semiautomatic data concerning obesity/leakiness. The materials were 309 females aged from 12 to 17 years old. The following results were obtained: 1. In the Developmental trend of the human body, the 12-13 age groups belonged to the acceleration stage of adolescent growth spurt. The 14-15 age groups belonged to the latter period of adolescent growth. The 16-17 age groups belonged to the termination stage of adolescent growth. 2. In the Heath-Carter's somatotyping method, the average somatotype changed into M.M- C-C-M-D with age. 3. In the alphamerical analysis, the first critical point appeared at the stature 146 Cm in case of weight, LBM and fat. The second critical point appeared at the stature 154-157 Cm in case of LBM and Fat. All the three measurement showed positive allotmentty.

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Changes in Impact Characteristics of the Body by Different Heel Strike Patterns during Running (달리기 시 착지 유형에 따른 인체에 미치는 충격의 변화)

  • Young-Seong Lee;Sang-Kyoon Park
    • Korean Journal of Applied Biomechanics
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    • v.33 no.4
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    • pp.164-174
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    • 2023
  • Objective: The aim of this study was to quantitatively analyze the impact characteristics of the lower extremity on strike pattern during running. Method: 19 young subjects (age: 26.53 ± 5.24 yrs., height: 174.89 ± 4.75 cm, weight: 70.97 ± 5.97 kg) participated in this study. All subjects performed treadmill running with fore-foot strike (FFS), mid-foot strike (MFS), and rear-foot strike (RFS) to analyze the impact characteristics in the lower extremity. Impact variables were analyzed including vertical ground reaction force, lower extremity joint moments, impact acceleration, and impact shock. Accelerometers for measuring impact acceleration and impact shock were attached to the heel, distal tibia, proximal tibia, and 50% point of the femur. Results: The peak vertical force and loading rate in passive portion were significantly higher in MFS and FFS compared to FFS. The peak plantarflexion moment at the ankle joint was significantly higher in the FFS compared to the MFS and RFS, while the peak extension moment at the knee joint was significantly higher in the RFS compared to the MFS and FFS. The resultant impact acceleration was significantly higher in FFS and MFS than in RFS at the foot and distal tibia, and MFS was significantly higher than FFS at the proximal tibia. In impact shock, FFS and MFS were significantly higher than RFS at the foot, distal tibia, and proximal tibia. Conclusion: Running with 3 strike patterns (FFS, MFS, and RFS) show different impact characteristics which may lead to an increased risk of running-related injuries (RRI). However, through the results of this study, it is possible to understand the characteristics of impact on strike patterns, and to explore preventive measures for injuries. To reduce the incidence of RRI, it is crucial to first identify one's strike pattern and then seek appropriate alternatives (such as reducing impact force and strengthening relevant muscles) on that strike pattern.

The Characteristics of Strength Development and Curing Cycle of the Steam Cured Concrete (증기양생 콘크리트의 양생온도주기와 강도발현 특성)

  • Kim, Kwang-Don;Kim, Choon-Ho
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.14 no.5
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    • pp.63-71
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    • 2010
  • This paper is about a research of steam curing which is one of the curing methods for accelerating the early-age strength of pre-cast concrete. With cylinder mold and mock-up specimen, the research was executed to study the best cycle of steam curing temperature through quantifying cycle of steam curing and maximum temperature, while the required strength is developed under the early-age. Moreover, causes and measurements for the high temperature of concrete, which is due to the steam curing, and the crack, which occurs when removing steel form, are stated. Ultimately, the economical method of producing, which satisfies early-age strength development and quality assurance while manufacturing PC structure, is stated.