• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7651-7656
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• 2013

Background: Breast cancer is the most common malignancy among women in both developed and developing countries. The burden is increasing in low-income and middle-income countries (LMCs) and threatens the public health of such societies. Introduction of expensive monoclonal antibodies to cancer treatment regimens poses a real challenge in the health systems of LMCs. Despite controversy of cost-effectiveness of bevacizumab in breast cancer, some studies indicate gain of patients from this drug. The present study aimed to propose a priority setting model for administration of anti-angiogenic agents in breast cancer via assessment of tumor angiogenesis by the microvessel density (MVD) method and associations with clinicopathological characteristics (including simultaneous mutations of TP53 and HER-2 genes). Materials and Methods: Age, axillary lymph nodes status, tumor size, stage and grade, estrogen and progesterone receptors status, HER-2/neu status (by immunohistochemistry and FISH test), TP53 mutation, Ki-67 (for proliferation assay) and CD34 (for angiogenesis assay) were assessed in 111 breast cancer patients. The molecular subtype of each tumor was also determined and correlations of simultaneous mutations of HER-2 and p53 genes with angiogenesis and other clinicopathological characteristics were evaluated. Results: There were significant associations between simultaneous mutations of HER-2 and p53 genes and all other parameters except tumor size. The degree of angiogenesis in the ERBB2 subtype was greater than the others. Younger patients showed a higher angiogenesis rate rather those older than 50 years. Conclusions: Our results demonstrated that patients with simultaneous mutations of HER-2 and p53 genes, those with ERBB2 molecular subtype and also younger women (often triple negative) seem more eligible for obtaining anti-angiogenic agents. These results suggest a model for priority setting of patients with breast cancer for treatment with anti-angiogenic drugs in LMCs.

• The Korean Journal of Physiology and Pharmacology
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• 제12권2호
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• pp.83-87
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• 2008

The fyn-related kinase (FRK) belongs to the tyrosine kinase family of protein kinases. Recent studies have shown that Frk affects pancreatic beta cell number during embryogenesis and promotes beta cell cytotoxic signals in response to streptozotocin. To investigate the genetic association between FRK polymorphisms and the risk of obesity in Korean population, single nucleotide polymorphisms (SNPs) in the FRK gene region were selected and analyzed. The body mass index (BMI) was calculated, and biochemical data (systolic blood pressure, diastolic blood pressure, hemoglobin A1C, triglyceride, total cholesterol, high density lipoprotein, and low density lipoprotein) of blood sample from each subject were also measured. One hundred fifty five healthy control and 204 overweight/obesity subjects were recruited. Genotype frequencies of six SNPs [rs6568920 (+8391G>A), rs3756772 (+56780A>G), rs3798234 (+75687C>T), rs9384970 (+68506G>A), rs1933739 (+72978G>A), and rs9400883 (+75809A>G)] in the FRK gene were determined by Affymetrix Targeted Genotyping Chip data. According to the classification of Korean Society for the Study of Obesity, control (BMI 18 to < 23) and overweight/obesity (BMI$\geq$23) subjects were recruited. For the analysis of genetic data, EM algorithm, SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs were used. Multiple logistic regression analysis (codominant, dominant, and recessive models) was performed. Age and gender as covariates were adjusted. For biochemical data, Student's t test was used. The mean value of BMI in the control and overweigh/obesity groups was 21.1${\pm}$1.2 (mean${\pm}$SD) and 25.6${\pm}$2.0, respectively. All biochemical data of the overweight/obesity group were statistically significance, compared with the control group. Among six SNPs, two linkage disequilibrium (LD) blocks were discovered. One block consisted of rs1933739 and rs9400883, and the other comprised rs3756772 and rs3798234. One SNP (rs9384970, +68506G>A) showed an association with overweight/obesity in the codominant model (p=0.03). Interestingly, the AA genotype distribution in the overweight/obesity group (n=7, 3.5%) was higher than those in the control group (n=1, 0.6%), which is not found in either Japanese or Chinese subjects. Therefore, the AA genotype of rs9384970 may be a risk factor for development of obesity in Korean population. The results suggest that FRK may be associated with overweight/obesity in Korean population.

• Nutrition Research and Practice
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• 제9권4호
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• pp.433-438
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• 2015

BACKGROUND/OBJECTIVES: Breast milk is the best available food for optimum growth and development of infants and the breastfeeding rate is increasing in Korea. The purpose of this study is to measure the concentrations of macronutrients and to evaluate their changes according to lactation period in breast milk from lactating Korean women. SUBJECTS/METHODS: Milk samples were obtained from 2,632 healthy lactating women (mean age; $32.0{\pm}3.3years$), where the lactating period was up to a period of 8 months, who also volunteered to participate in the Human Milk Macronutrient Analysis Research. Lactose, protein, fat and water content in the breast milk samples were analyzed with infrared spectrometry using MilkoScan FT-2. RESULTS: The mean macronutrient composition per 100 mL of mature breast milk was 7.1 g for lactose, 1.4 g for protein and 3.0 g for fat, and energy content was 61.1 kcal. The protein concentration was significantly lower in milk samples at 1-2 weeks (2.0 g/dL) to 2-3 months (1.4 g/dL) than those at 0-1 week (2.2 g/dL), but it was similar among samples from 3-4 months to 7-8 months (1.3 g/dL). Mean lipid levels varied among different lactational period groups (2.7-3.2 g/dL), but presented no significant difference. Lactose concentration in the milk samples did not differ with lactation period. Maternal body mass index was positively related to protein and lipid breast milk contents, but was negatively related to lactose content. General linear models examining the associations between maternal variables and milk macronutrient content revealed that lactation period had a major impact on protein and lipid, but not on lactose content in breast milk. CONCLUSIONS: These results warrant future studies to explore factors that may be associated with changes in macronutrient content in human milk.

• 기술혁신학회지
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• 제10권1호
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• pp.164-181
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• 2007

본 연구는 국가 경제적으로 매우 중요한 의미를 지니는 기술혁신적인 제품인 디지털 TV의 보급에 영향을 미치는 요인들에 대해 정보통신수용도를 중심으로 실증적으로 분석하였다. 이를 위해 1,000개의 가구 설문조사를 토대로 구축된 미시 데이터(micro data)를 이용하여 가구의 DTV 구매선택에 어떤 요인들이 영향을 미쳤는지를 실증적으로 분석하였으며, 이로부터 디지털 TV보급관련 정책에 함의를 찾고자 하였다. 분석 결과, 다른 설명변수의 조건이 일정할 때 가구 세대주의 학력이 높은 가구가, 소득이 높은 가구가, 통신 및 방송, 인터넷 등 정보통신 여러 부문에 대한 수용도가 높은 가구가 각각 DTV의 구매의향이 높은 것으로 나타났다. 아울러 2010년에 아날로그 방송이 중단되며 디지털방송으로 전환이 이루어진다는 정책방향을 아는 가구가 이를 알지 못하는 가구에 비해 훨씬 구매의향이 높은 것으로 나타나, 정부의 디지털전환 정책 홍보가 디지털 TV의 보급에 매우 큰 영향을 미친다는 점을 시사하고 있다. 또한 TV를 구입한지 오래될수록 디지털 TV를 구매할 확률이 높은 것으로 나타나 TV의 대체수요에 대한 인센티브를 줄 경우 더 많은 가구들이 구매할 것임을 보여 주었다. 끝으로, 디지털위성방송 시청가구가 그렇지 않은 가구에 비해 디지털 TV구매 확률이 월등히 높은 것으로 나타나 DTV 확산을 위하여는 위성방송에 대한 정책과의 연계가 효과적이라는 점을 시사하고 있다.

• Journal of Chest Surgery
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• 제49권3호
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• pp.165-170
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• 2016

Background: In elderly high-risk surgical patients, sutureless aortic valve replacement (AVR) should be an alternative to standard AVR. The potential advantages of sutureless aortic prostheses include reducing cross-clamping and cardiopulmonary bypass (CPB) time and facilitating minimally invasive surgery and complex cardiac interventions, while maintaining satisfactory hemodynamic outcomes and low rates of paravalvular leakage. The current study reports our single-center experience regarding the early outcomes of sutureless aortic valve implantation. Methods: Between October 2012 and June 2015, 65 patients scheduled for surgical valve replacement with symptomatic aortic valve disease and New York Heart Association function of class II or higher were included to this study. Perceval S (Sorin Biomedica Cardio Srl, Sallugia, Italy) and Edwards Intuity (Edwards Lifesciences, Irvine, CA, USA) valves were used. Results: The mean age of the patients was $71.15{\pm}8.60years$. Forty-four patients (67.7%) were female. The average preoperative left ventricular ejection fraction was $56.9{\pm}9.93$. The CPB time was $96.51{\pm}41.27minutes$ and the cross-clamping time was $60.85{\pm}27.08minutes$. The intubation time was $8.95{\pm}4.19hours$, and the intensive care unit and hospital stays were $2.89{\pm}1.42days$ and $7.86{\pm}1.42days$, respectively. The mean quantity of drainage from chest tubes was $407.69{\pm}149.28mL$. The hospital mortality rate was 3.1%. A total of five patients (7.69%) died during follow-up. The mean follow-up time was $687.24{\pm}24.76days$. The one-year survival rate was over 90%. Conclusion: In the last few years, several models of valvular sutureless bioprostheses have been developed. The present study evaluating the single-center early outcomes of sutureless aortic valve implantation presents the results of an innovative surgical technique, finding that it resulted in appropriate hemodynamic conditions with acceptable ischemic time.

• 대한인간공학회지
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• 제34권3호
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• pp.279-291
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• 2015

Objective: The purpose of the study is to evaluate appropriate weight for aged farmers in manually handling livestock feed in bags using ergonomic methods. Background: In the livestock industry in South Korea, despite the trend of aging of labor manpower, heavy items are still manually handled in many farms. In particular, among stockbreeding works, the handling of feed in bags weighing 25~30kg is reported as a cause of frequent injuries and musculoskeletal system diseases. However, studies on the standard for recommended weight allowed considering the physical characteristics of aged farmers older than 60 years with greatly decreased physical strength and muscle strength are insufficient. Method: To evaluate appropriate weight for handling of heavy livestock feed in bags, physical techniques for measuring recognized levels of physical work loads, the NLE (NIOSH lifting equation) a method that is an observation type technique, and an ergonomic modeling technique to predict compressive force imposed on L5/S1 were used. Subjects who participated in the experiment were organized into two groups of males/females with mean age exceeding 60 years, and lifting tasks were evaluated for nine weight levels. Results: Based on the results of psychophysical measurement, females showed a tendency of more drastic increases compared to males when weight was over 19kg. The results of estimation of regression models for the weight, 18.0 kg ($r^2=0.97$) and 15.3kg ($r^2=0.97$) were evaluated as stable load for males and females, respectively. In addition, both the observation type evaluation and ergonomic model evaluation showed stable loads in a range of 15~18kg. Conclusion: Given the results of the study, the weight of the feed in bags currently distributed to farms can become a cause of not only overexertion but also farm work related disasters such as musculoskeletal disorders and safety accidents. Providing livestock feed in bags weighing not more than 19kg for aged farmers is judged desirable, and managerial improvement for this matter is considered necessary. Application: The results of the present study can be utilized as useful data for institutional improvement of the weight of livestock feed in bags.

• 한국환경보건학회지
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• 제33권5호
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• pp.365-371
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• 2007

To evaluate the effect of air pollution on respiratory health in children, We conducted a longitudinal study in which children were asked to record their daily levels of Peak Expiratory Flow Rate(PEFR) using potable peak flow meter(mini-Wright) for 4 weeks. The relationship between daily PEFR and ambient air particle levels was analyzed using a mixed linear regression models including gender, age in year, weight, the presence of respiratory symptoms, and relative humidity as an extraneous variable. The daily mean concentrations of $PM_{10}$ and $PM_{2.5}$ over the study period were $64.9{\mu}g/m^3$ and $46.1{\mu}g/m^3$, respectively. The range of daily measured PEFR in this study was $182{\sim}481\;l/min$. Daily mean PEFR was regressed with the 24-hour average $PM_{10}(or\;PM_{2.5})$ levels, weather information such as air temperature and relative humidity, and individual characteristics including sex, weight, and respiratory symptoms. The analysis showed that the increase of air particle concentrations was negatively associated with the variability in PEFR. We estimated that the IQR increment of $PM_{10}$ or $PM_{2.5}$ were associated with 1.5 l/min (95% Confidence intervals -3.1, 0.1) and 0.8 l/min(95% CI -1.8, 0.1) decline in PEFR. Even though this study showed negative findings on the relationship between respiratory function and air particles, it was worth noting that the findings must be interpreted cautiously because exposure measurement based on monitoring of ambient air likely resulted in misclassification of true exposure levels and this was the first Korean study that $PM_{2.5}$ measurement was applied as an index of air quality.

• 한국산림과학회지
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• 제99권6호
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• pp.827-835
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• 2010

기후변화협약 대응을 위한 산림의 임목축적량과 변화량 탐지의 측면에서 국가산림자원조사는 신뢰성있는 산림통계량을 산출하기 위한 기반자료로서의 결정적인 역할을 담당하고 있다. 그러나 많은 정보들이 아직 행정구역단위 통계로만 산출되고 있어 산림 통계량의 공간적 분포와 같은 정보를 제공해주지는 못하고 있다. 따라서 본 연구는 국가산림자원조사 자료를 이용해 임상특성별 임분재적 추정모델을 개발하고, 임상도와 통합하여 임분재적의 공간분포를 추정하는 것을 목표로 하였다. 산림의 임분재적 추정모델 개발을 위해 연구대상지에 포함된 국가산림자원조사 자료를 이용하여 표본점별 임분재적과 흉고단면적합을 산출하고, 표본점의 임황정보(수종, 경급, 영급, 소밀도)를 모델개발에 활용했다. 결과적으로 수종, 영급, 소밀도 기준에 따른 임분재적 모델이 구축되었으며, 본 모델을 임상도에 적용해 임분재적 주제도와 불확실성 주제도를 제작했다. 임분재적 주제도에 의한 연구대상지의 평균 임분재적은 85.7 $m^3$/ha이며, 95% 신뢰구간을 고려했을 때 약 79.7~91.8 $m^3$/ha 구간에 포함되는 것으로 나타났다.

• 대한공간정보학회지
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• 제25권1호
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• pp.19-27
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• 2017

본 연구의 목적은 인제읍을 대상으로 빈도비와 로지스틱 회귀분석 모델을 통합한 앙상블 모델을 이용하여 산사태 취약성을 분석하고, 예측 정확도를 비교하는 것이다. 산사태 위치는 산사태 발생 전 후에 촬영된 항공사진을 이용하여 추출되었다. 추출된 총 422개의 산사태는 산사태 취약성 분석을 위해 훈련용 (70%)과 검증용 (30%) 자료로 랜덤하게 분류되었다. 산사태 관련인자는 고도, 경사도, 경사향, 배수로부터의 거리, 토양수분지수, 하천강도지수, 토질, 유효토심, 영급, 경급, 밀도, 임상 등 총 12개의 인자를 이용하였다. 산사태 및 산사태 관련인자는 공간데이터베이스로 구축된 뒤 빈도비와 앙상블 모델을 이용하여 산사태와 산사태 관련 인자 간 상관관계를 분석하였다. 그 결과를 바탕으로 각 모델별 산사태 취약성 지도를 작성하였고, relative operating characteristics(ROC) 곡선을 이용하여 예측 정확도를 검증 및 비교하였다. 분석 결과, 앙상블 모델에 의해 작성된 산사태 취약성 지도는 75.2%의 예측 정확도를 보였고, 이 결과는 빈도비 모델에 의해 작성된 산사태 취약성 지도와 비교하여 예측 정확도가 약 2% 향상된 것으로 나타났다. 본 연구에서 작성된 산사태 취약성 지도는 향후 효과적인 토지이용 계획을 수립하고, 재난재해로 인한 피해를 경감시키는데 활용 가능할 것으로 판단된다.

• 한국방사선학회논문지
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• 제8권7호
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• pp.461-466
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• 2014

체외 충격파 쇄석술시 쇄석기종에 따라 각각 장단점이 있으며, 전 처치로 인한 여러 가지 부작용이 보고되고 있다. 이에 전자기식 ESWL시 하부결석환자에서 적합한 충격파의 강도를 찾아보고, C-arm의 총 가동시간을 측정해 보았다. 본 연구는 2014년 1월부터 6월까지 경북지역 일개시의 C대학병원에서 전 처치를 시행하지 않고 ESWL을 받은 65명의 환자를 대상으로 하였다. 성비는 남자가 48명, 여자가 17명으로 남자가 더 많았으며, 연령은 50대가 가장 많았다. 하부요로결석의 발생은 왼쪽이 더 많았으며, 결석의 크기는 5mm 이하가 39명으로 가장 많았다. 적합한 충격강도는 1의 강도이며 통증을 호소하는 경우 C의 강도로 전환하여 충격을 가할 수 있다. 또한 C-arm의 총 가동시간은 $241.73{\pm}30.37$초로 나타났으며, 이것은 하부요로결석의 크기와 유의한 차이를 보였다(p<0.05). 따라서, ESWL시 전처치를 시행하지 않고 시술을 할 경우 요관 결석의 부위에 따라 적합한 충격강도와 충격빈도의 기준이 필요로 하며, C-arm 총 가동시간도 요관 결석의 발생부위에 따라 방사선으로 인한 피폭을 최소화하기 위한 총 가동시간에 대한 기준이 필요할 것으로 사료된다.