• 한국식품위생안전성학회지
• /
• 제10권3호
• /
• pp.181-187
• /
• 1995

Water extract, and methanol extract, its chloroform and hexane fractions, and estragole from Agastache rugosa O. Kuntze were tested to find the inhibition effect on the growth of several microorganisms. The organisms used were Escherichia coli ATCC 1129, Staphylococcus aureus IAM 1011, Vibrio parahaemolyticus WP, Bacillus subtilis ATCC6633, Aspergillus oryzae KFCC 890, Aspergillus niger KCCM 11240. Water and methanol extracts at the concentration of 0.5%, and chloroform and hexane fraction at the concentration of 0.05% inhibited the growth of microorganisms from 1/5 to 2/3 of the control group. Estragole identified from the hexane faction as a major component, its authentic compound completely inhibited the growth of Vibrio parahaemolyticus completely at the concentration of 0.03%, and the other bacteria were at 0.05%.

• 한국식품위생안전성학회지
• /
• 제12권1호
• /
• pp.63-70
• /
• 1997

The extracts from Agastache rugosa O. Kuntze, their chloroform and hexane fractions, and estragole identified from hexane fraction were tested to investigate the effects on the growth and metabolic activities of several true fungi. The fungi used were: Aspergillus oryzae KFCC 890, Aspergillus niger KCCM 11240, Saccharomyces cerevisiae IAM 4597, Saccharomyces ellipsoideus PNU 2215. The growth of S. Cerevisiae by treatment of water extract(1%), hexane fraction (0.05%), and estragole (0.05%) were inhibited 93%, 50%, and 33% respectively, and S. ellipsoideus was also inhibited markedly with delaying the alg phase maximum 12 hrs. The growth of A. oryzae was inhibited by treatment of extracts and fractions. The echanol production by S. cerevisiae was increased more than two times in the highest value around 42 hrs incubation by water extract, but chloroform fraction inhibited its production. The glucoamylase actibities by A. niger were strongly inhibited by hexane and chloroform fractions (0.05%). The invertase activity by S. cerevisiae using estragole (0.05%) reached to 57.5% of control group. S. cerevisiae treated with the estragole was damaged the cell wall and cell membrane, leaked the protoplasm, and observed broken pieces of cell.

• 한국식품과학회지
• /
• 제32권1호
• /
• pp.9-16
• /
• 2000

본 연구에서는 전자코를 이용하여 추출용매, 추출온도 등의 추출조건에 따른 배초향의 부위별 추출물들에 대한 향기성분의 차이를 측정하고 그 데이터를 관능검사와 비교 분석하였다. 같은 배초향 부위라도 추출온도가 다르면 추출물들간의 향기 차이가 있었으며, 배초향 부위에 따라서도 추출물들의 향기 차이가 있는 것으로 나타났다. 동일한 부위에 대한 에탄올추출물과 다른 용매추출과는 향기차이가 있는 것처럼 보이지만 그 차이는 에탄을 자체의 향에 의한 차이로서 실질적으로 같은 배초향 부위에 대해서는 추출용매에 따른 추출물간의 향기 차이는 별로 없는 것으로 판단된다. 전체적으로 배초향 추출물들의 관능적 특성은 박하냄새, 풀냄새, 박하맛, 한약맛, 단맛 등이 대표적으로 강하게 느껴지며, 추출용매, 추출온도, 추출부위에 따라 관능적 특성이 다르게 나타났다. 종합적으로 판단하면 전자코에 의한 향기성분의 차이를 분석한 결과를 관능검사 결과와 연계하여 비교 분식해 보면 전자코에서 차이가 나는 향기성분의 실체가 박하냄새, 단맛 등과 같이 구체적으로 어떤 맛이나 냄새가 더 강하고 약한지를 분성하게 알 수 있었다.

• 한국자원식물학회지
• /
• 제22권6호
• /
• pp.498-505
• /
• 2009

The plant Agastache rugosa Kuntze has various physiological and pharmacological activities. Especially, it has been regarded as a valuable source for the treatment of anti-inflammatory and oxidative stress-induced disorders. However, little has been known about the functional role of it on oxidative damage in mammalian cells by ROS. In this study, we investigated the DPPH radical, hydroxyl radical, hydrogen peroxide and intracellular ROS scavenging capacity, and $Fe^{2+}$ chelating activity of the extracts from Agastache rugosa. In addition, we evaluated whether the extract can be capable of reducing $H_2O_2$-induced DNA and cell damage in NIH 3T3 cells. These extracts showed a dose-dependent free radical scavenging capacity and a protective effect on DNA damage and the lipid peroxidation causing the cell damage by $H_2O_2$. Therefore, these results suggest that Agastache rugosa is useful as a herbal medicine for the chemoprevention against oxidative carcinogenesis.

• 생약학회지
• /
• 제18권2호
• /
• pp.99-102
• /
• 1987

A new diterpene, mp $178{\sim}180^{\circ}$, $C_{21}H_{28}O_5$, was isolated from the root of Agastache rugosa O. Kuntze in the family of Labiatae. The structure of this compound was postulated as $19(4{\rightarrow}3)-abeo-12,14,15-trihydroxy-11-methoxy-abiet-4(18)$, 8,11,13-tetraen-7-one by spectroscopic methods.

• 한국식품과학회지
• /
• 제23권5호
• /
• pp.582-586
• /
• 1991

방아의 휘발성 향기성분을 수증기 증류장치로 추출한 후 GC 및 GC/MS에 의하여 비교 분석하였다. 확인된 성분을 기능기 별로 보면 hydrocarbon류 14종, aldehyde류 6종, ketone류 5종, alcohol류 3종, phenol류 5종, ester류 2종, 기타 1종으로 총 36종의 향기성분이 확인 되었다. 이중에서 estragole이 90% 이상으로 가장 많이 함유되었고 그밖에 limonene($0.7{\sim}4.7%$), caryophyllene($0.9{\sim}1.1%$), eugenol($1.4{\sim}1.9%$), anethol($0.2{\sim}0.3%$)등이 주요성분이었다. 그러고 이들 향기성분의 종류 및 함량을 채취시기 별로 보면 어린잎보다 성숙된 잎에서 높게 나타났고, 부위별로는 꽃대에서 가장 높았고 잎, 줄기의 순으로 남아졌다.

• 한국약용작물학회지
• /
• 제28권2호
• /
• pp.95-110
• /
• 2020

Background: In Korea, Agastache rugosa (Fisch. & C. A. Mey.) O. Kuntze is one of the well-known perennial plants belonging to Lamiaceae. This mint-fragranced plant has long been used for the treatment of abdominal pain, congestion, chills, and diarrhea since the Goryeo Dynasty. Although this plant has various medicinal properties, it is only used as a spice and for landscape purposes. Methods and Results: The objective of this paper was to review the chemical composition and biological properties of the essential oil of A. rugosa. Several studies reported that the essential oil contains more than 60 different chemical components of monoterpene and sesquiterpene hydrocarbons and oxygenated hydrocarbons. The major component is methyl chavicol (estragole), accounting for 64% - 88% of the oil. The chemical composition of this essential oil vaired widely according to the planting time, environmental conditions, planting distance, fertilizer application, and harvesting time. Conclusions: The essential oil of A. rugosa possesses various pharmacological properties such as antioxidant, antibacterial, anticancer, antiviral, nematicidal, antifungal, insecticidal, wrinkle improver, stress reliever, and Alzheimer's disease alleviator. Hence, the essential oil from A. rugosa could be used for the development of high value-added industrial products in the near future.

• 한국연초학회:학술대회논문집
• /
• 한국연초학회 1999년도 23회 정기총회 및 41회 학술발표회
• /
• pp.15-15
• /
• 1999

• Natural Product Sciences
• /
• 제7권4호
• /
• pp.120-123
• /
• 2001

To develop systems for economic production of useful essential oil compounds, callus was induced from the seedlings of Agastache rugosa and cultured on MS medium. The volatile oil fraction was extracted from the callus and investigated by mean of GC-MS. The composition of the oil was compared with that of the mother plant. As a result, sixty five compounds including ferruginol were identified in the essential oil fraction. The main component of the oil from the leaves of Agastache rugosa was methyl chavichol (53.6%). Methyl jasmonate and jasmonic acid were added to the culturing cell suspension, separately and the composition of induced oil were compared. The oils from cultured cells treated with jasmonates showed considerably different patterns. Especially, the peak of estragole was found in callus oil after treatment with methyl jasmonate as though the amount was limited to 0.58%. In general, the TIC pattern of GC-MS of the callus oil became more similar to the oil from the leaves after elicitation.

• 한국자원식물학회지
• /
• 제6권2호
• /
• pp.147-154
• /
• 1993

The experiment was carried out to study the influence of seeding dates, planting densities and fertilizer application levels on some agronmic characters and yield of fresh weight in Agastache rugosa. The results obtained are summarized as follow; Fresh weight was increased on Apr. 1 seeding date. Therefore, optimum time for sowing was on Apr. 1. Stem length was long in dense planting and short in spacious planting. Stem diameter was thick in spacious planting, and was thin in dense planting. Yield was higher in dense planting densities($10{\times}20cm:50\;plants/m^2,\;20{\times}20cm:25\;plants/m^2,\;(30{\times}20cm:17\;plants/m^2$) Fertilizing ($N:P_2O_5;K_2O=6:6:6kg/10a$) was increased than without fertilizing because stem length and number of leaf were good.