• Proceedings of the Korean Society of Tobacco Science Conference
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• 1999.05a
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• pp.15-15
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• 1999

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.271.1-271.1
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• 2001

• Korean Journal of Food Science and Technology
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• v.49 no.3
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• pp.331-337
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• 2017

To evaluate the antioxidant activity of hexane, ethyl acetate, and butanol fractions obtained from Agastache rugosa extract, we measured the total polyphenol levels, DPPH radical scavenging activity, and reducing power. The ethyl acetate fraction of A. rugosa (AREA) displayed high phenolic levels, potent DPPH radical scavenging effect, and powerful reducing power. In addition, we examined the ability of AREA to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 microglia. AREA suppressed NO production and inducible nitric oxide synthase (iNOS) expression and downregulated interleukin-6 (IL-6) mRNA level in LPS-stimulated BV-2 microglia. Furthermore, we detected rosmarinic acid in AREA by HPLC, which suggested that rosmarinic acid could be one of the bioactive materials responsible for the antioxidant and anti-inflammatory activities of AREA. These results suggested that AREA may be a good source of functional foods with antioxidant and anti-inflammatory activities.

• 한국약용작물학회:학술대회논문집
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• 2008.11a
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• pp.370-371
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• 2008

• The Korea Journal of Herbology
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• v.21 no.4
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• pp.43-49
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• 2006

Objectives : The purpose of this study is to determine the original source of Gwackhyang(藿香) newly. Methods : Compare the growing district, figure and etc. of Gwackhyang included in the books on herbal medicine with those of present. Results : 1. The growing district of Gwackhyang is south of China or southern place than China. 2. In the picture of the leaf of Gwackhyang, its end is round and it is similar to Mori folium or the leaf of Solanum melongena. 3. We can propagate it by planting a piece of stem. 4. At the Dynasty of the Sejong king, japan sent it 18 times for diplomacy present, and according to Sejongsillockzirizi(世宗實錄地理志), it was planted for the test one time. 5. Baechohyang, another name of Gwackhyang, is rhizome and root of Anisochilus carnosus according to Bonchogangmok(本草綱目). Conclusion : Provide a basis for these results, Gwackhyang in the books on herbal medicine means Pogostemon cablin. It is a mistake to use Agastache rugosa in GwackhyangJeonggisan(震香正氣散) etc. in Korea.

• Proceedings of the Plant Resources Society of Korea Conference
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• 1995.01a
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• pp.31-31
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• 1995

• Proceedings of the Korean Nutrition Society Conference
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• 2001.05a
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• pp.305.2-305
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• 2001

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.182.2-182.2
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• 2000

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.2
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• pp.138-144
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• 2017

The pharmacological rationale of Agastache rugosa (AR) or Pogostemon cablin (PC), which have been used in traditional Korean medicine to treat dampness pattern or syndrome in gastrointestinal tract, was investigated on the gastrointestinal disorders. In-vivo model studies that examined the effect on the gastrointestinal disorders of AR or PC were collected. They were classified into disease-induced in-vivo models or non-disease in vivo models. The target disease, animal species, induction method, administration, and outcomes (changes in morphological and histological parameter, or blood and fluid) of each study were analyzed. The therapeutic mechanism of AR or PC extract was evaluated by the induced diseases and the changes in outcomes. There were contradictory reports on gastrointestinal motility of AR or PC in disease non-disease in-vivo model. AR or PC inhibited gastrointestinal motility in disease model of increased gastrointestinal motility, while promoted motility in disease model of decreased gastrointestinal motility. AR or PC also inhibited inflammatory changes in gastrointestinal inflammation model. These results suggest that the bidirectional regulation of gastrointestinal motility and the improvement of gastrointestinal inflammatory disorders might underpin traditional therapeutic effect of AR or PC, that is effect to resolve dampness of gastrointestinal tract.

• Korean Journal of Medicinal Crop Science
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• v.2 no.2
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• pp.168-173
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• 1994

Contents of essential oil and its composition in aerial part of Agastache rugosa were investigated. Essential oil was obtained from the dried stems, leaves and flowers by steam distillation and fractionated into hydrocarbon and oxygenated hydrocarbon by silica gel column chromatography. Each isolate or fraction was identified by GC and GC-MS. The contents of essential oil were 0.29% in leaves of Agastache rugosa on dry basis, 0.38% in flowers. Major components were ${\beta}-caryophyllene(59.3%)$, limonene(13.1%), ${\delta}-cadinene(10.7%)$ among 13 kinds of components confirmed in hydrocarbon fraction of essential oil isolated from leaves. Also, major components in oxygenated hydrocarbon fraction were methyl chavicol (79.1%) and cis-3(1-propenyl) phenol(4.5%) among 44 kinds components confirmed. The highest content among the components identified was methyl chavicol in both leaves and flowers. On the other hand, limonene, trans-2-hexenal, 1-octen-3-one, 6, 10, 14- trimethyl pentadecane- 2-one and phytol were detected typically in leaves, but jasmone and ${\rho}-methoxyacetophenone$ were detected mainly in flowers with small quantity.