• 제목/요약/키워드: Ag(I) analysis

검색결과 125건 처리시간 0.032초

Meta-analysis of Associations Between four Polymorphisms in the Matrix Metalloproteinases Gene and Gastric Cancer Risk

  • Yang, Teng-Fei;Guo, Lin;Wang, Qiang
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권3호
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    • pp.1263-1267
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    • 2014
  • Background: Matrix metalloproteinases (MMPs) play important roles in pathogenesis and development of cancer. Recently, many studies have show associations between polymorphisms in the promoter regions of MMPs and risk of gastric cancer. The present meta-analysis was conducted in order to investigate the potential association between four polymorphisms in the MMP gene and gastric cancer risk. Methods: A computerized literature search was conducted in databases of Med-line, Embase, Science Citation Index and PubMed till June 2013 for any MMP genetic association study of gastric cancer. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated for each gene under dominant and recessive models, and heterogeneity between studies was assessed using the Q test and $I^2$ value. Overall and subgroup analyses according to ethnicity were carried out with Stata 12.0. Results: 14 reports covering 8,146 patients (2,980 in the case group and 5,166 in the control group) were included in the present meta-analysis. We found that the MMP-7 (-181A>G) polymorphism increased the gastric cancer risk in therecessive model (GG vs. AA/AG, OR=1.768, 95% CI =1.153-2.712). For MMP2 -1306 C>T, MMP1-1607 1G/2G, and MMP9-1 562 C>T, there were no associations between these polymorphisms and the risk of gastric cancer under dominant or recessive models. Conclusion: This meta-analysis suggested that the MMP7-181 A>G polymorphism may contribute to gastric cancer susceptibility. More studies are needed, especially in Europeans, in the future.

플라스틱 BGA 솔더접합부의 고신뢰성에 관한 연구 (A Study of the High Reliability in Plastic BGA Solder Joints)

  • 김경섭;신영의;이혁
    • Journal of Welding and Joining
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    • 제17권3호
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    • pp.90-95
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    • 1999
  • The increase in high speed, multi-function and high I/O pin semiconductor devices highly demands high pin count, very thin, and high density packages. BGA is one of the solutions, but the package has demerits in package reliability, surface mounting problems due to the PCB warpage and solder joint crack related with TCE mismatch between the materials. On this study to verify the thermal fatigue lifetime of the solder joint FEM and experiments were performed after surface mounting BGA with different solder composition and reliability conditions. FEM showed optimum composition of Ag3.2-Sn96.5 and under the composition minimum creep deformation of the solder joint was calculated, and the thermal fatigue lifetime was improved. In view of temperature cycle condition, the conditions of $-65^{\circ}C$to $150^{\circ}C$ showed minimum lifetime and t was 1/3 of $0^{\circ}C$ to $125^{\circ}C$ condition. Test board was prepared and solder joint crack was verified. Until 1000cycle on soder joint crack was observed.

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비정질 $Se_{75}Ge_{25}$박막으로의 이온침투 현상 해석 (An analysis of the ion penetration phenomena in amorphous $Se_{75}Ge_{25}$ thin film)

  • 이현용;정홍배
    • E2M - 전기 전자와 첨단 소재
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    • 제7권5호
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    • pp.389-396
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    • 1994
  • The bilayer film of Ag/a-S $e_{75.G}$ $e_{25}$ and the monolayer film of a-S $e_{75.G}$ $e_{25}$ act as a negative-type and a positive-type resist in focused ion beam lithography, respectively. Using a model which takes into account the ion stopping power, the ion projected range, the ion concentration implanted into resists and the ion transmission coefficient, etc., the ion resist parameters are calculated for a broad range of ion energies and implanted doses. Ion sources of A $r^{+}$, S $i^{++}$ and G $a^{+}$ are used to expose resists. As the calculated results, the energy loss per unit distance by Ga'$^{+}$ ion is about 10$^{3}$[keV/.mu.M] and nearly constant for all energy range. Especially, the projected range and struggling for 80[keV] G $a^{+}$ ion energy are 0.0425[.mu.m] and 0.020[.mu.m], , respectively and the resist thickness of a-S $e_{75}$ G $e_{25}$ to minimize the ion penetration rate into a substrate is 0.118[.mu.m].u.m]..u.m].

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Uncertainty analyses of spent nuclear fuel decay heat calculations using SCALE modules

  • Shama, Ahmed;Rochman, Dimitri;Pudollek, Susanne;Caruso, Stefano;Pautz, Andreas
    • Nuclear Engineering and Technology
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    • 제53권9호
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    • pp.2816-2829
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    • 2021
  • Decay heat residuals of spent nuclear fuel (SNF), i.e., the differences between calculations and measurements, were obtained previously for various spent fuel assemblies (SFA) using the Polaris module of the SCALE code system. In this paper, we compare decay heat residuals to their uncertainties, focusing on four PWRs and four BWRs. Uncertainties in nuclear data and model inputs are propagated stochastically through calculations using the SCALE/Sampler super-sequence. Total uncertainties could not explain the residuals of two SFAs measured at GE-Morris. The combined z-scores for all SFAs measured at the Clab facility could explain the resulting deviations. Nuclear-data-related uncertainties contribute more in the high burnup SFAs. Design and operational uncertainties tend to contribute more to the total uncertainties. Assembly burnup is a relevant variable as it correlates significantly with the SNF decay heat. Additionally, burnup uncertainty is a major contributor to decay heat uncertainty, and assumptions relating to these uncertainties are crucial. Propagation of nuclear data and design and operational uncertainties shows that the analyzed assemblies respond similarly with high correlation. The calculated decay heats are highly correlated in the PWRs and BWRs, whereas lower correlations were observed between decay heats of SFAs that differ in their burnups.

유기성폐기물의 회분식 혐기성 최종생분해도와 다중분해속도 해석 (Determination of Ultimate Biodegradability and Multiple Decay Rate Coefficients in Anaerobic Batch Degradation of Organic Wastes)

  • 강호;신경숙
    • 대한환경공학회지
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    • 제27권5호
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    • pp.555-561
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    • 2005
  • 본 연구에서는 유기성폐기물의 최종생분해도를 평가하여 혐기소화조의 정확한 효율평가를 위한 기초자료를 확보하고 유기물의 분해경향을 보다 정확히 평가할 수 있는 다중 분해속도분석(Multiple k analysis)기법을 개발하여 다중 분해속도상수와 각각의 분해속도에 관여하고 있는 기질의 분율을 산정하려는데 목적이 있다. 연구 결과 폐활성슬러지의 최종생분해도는 50%, 농축슬러지는 40%로 평가되어 85%내외의 생분해도를 나타낸 Sorghum이나 Swine Waste에 비해 현저히 낮았다. 활성슬러지의 경우 생분해가능한 기질의 71%가 22일내에 초기분해속도상수 $k_1$인, $0.151\;day^{-1}$로 빠르게 분해되고 그 이후로 남아 있는 29%의 기질이 분해속도상수 $k_2$인, $0.021\;day^{-1}$로 아주 느리게 분해되었다. 반면 농축슬러지의 경우는 기질의 39%만이 $k_1$인, $0.123\;day^{-1}$로 빠르게 분해되었으며 60% 이상이 $k_2$인, $0.001\;day^{-1}$로 매우 느리게 분해되었다. 한편 Sorghum은 초기분해속도상수($k_1$)인 $0.248{\sim}0.358\;day^{-1}$ 범위로 기질의 약 90%($S_1$)가 16일 이내에 빠르게 분해되었으며 축분의 경우 $k_1$인, $0.155{\sim}0.209\;day^{-1}$ 범위로 기질의 $84{\sim}91%(S_1)$가 14일 이내에 빠르게 분해됨을 알 수 있다. 따라서 Multi k Analysis방법을 이용하여 도출된 하수 슬러지의 분해속도상수와 기질의 분율 및 분해패턴을 토대로 혐기성소화시 효율적이고 경제적인 HRT의 산정이 가능하다.

Clinicopathologic and Prognostic Significance of Carboxyl Terminus of Hsp70-interacting Protein in HBV-related Hepatocellular Carcinoma

  • Jin, Ye;Zhou, Li;Liang, Zhi-Yong;Jin, Ke-Min;Zhou, Wei-Xun;Xing, Bao-Cai
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권9호
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    • pp.3709-3713
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    • 2015
  • Background: Many factors, including molecular ones, were demonstrated to be associated with long-term prognosis of hepatocellular carcinoma (HCC). Thus far, the expression and clinicopathologic and prognostic significance of the carboxyl terminus of Hsp70-interacting protein (CHIP) in B-type hepatitis virus (HBV)-related HCC remain unknown. Materials and Methods: CHIP expression was detected by immunohistochemical staining of surgical samples from 79 patients with HCC with HBsAg positivity. In addition, correlations with clinicopathologic parameters and patient survival were evaluated. Results: It was found that positive CHIP staining was observed in tumor, but not non-tumor, tissues. High expression of CHIP was significantly related to larger tumor size, with marginally significant associations noted for presence of portal vein invasion and higher serum a-fetoprotein level. In addition, univariate analysis showed that high CHIP expression was a powerful predictor for dismal overall and disease-free survival. However, independent prognostic implications of CHIP were not proven in multivariate Cox regression test. Conclusions: CHIP is overexpressed in HBV-related HCC and is associated with unfavorable biological behavior as well as poor prognosis. However, its prognostic role needs to be further validated.

인간 $\alpha$-fetoprotein에 대한 모노클로날 항체의 제조 및 모노클로날 항체를 이용한 효소면역분석법의 개발 (Production of a Monoclonal Antibody to Human $\alpha$-Fetopotein and Development of Monoclonal Antibody-Based Enzyme-Linked Immunosorbent Assays for Human $\alpha$-Fetoprotein)

  • Michung Yoon;Hyun-Hee Lee;Youngwon Lee
    • 대한의생명과학회지
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    • 제5권1호
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    • pp.1-10
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    • 1999
  • 본 연구에서는 혈장이나 양수에 있는 $\alpha$-fetoprotein (AFP)을 인식 할 수 있는 모노클로날 항체를 제조하고, 모노클로날 항체를 이용한 효소면역분석법을 개발하고자 하였다. 양수로부터 얻은 AFP를 쥐에 주사한 후 비장을 분리하여 종양세포 (Sp2/O-Ag-14)와 융합하였고, 하이브리도마 기술을 이용하여 모노클로날 항체를 제조하였다. 모노클로날 항체를 클로닝하였으며, 생성된 항체를 MabF22로 명명하였고, IgG1 중사슬과 k 경사슬의 isotype을 나타냈다. 또한 immunoblotting 방법과 ELISA로 특이도를 조사한 결과 모노클로날 항체는 AFP와만 반응하였고, 결합 친화상수는 0.8$\times$$10^{-10}$M이었다. 두 종류의 효소면역분석법 -경쟁적 또는 비경쟁적 분석 -을 이용하여 항체의 효용성을 조사하였으며, 두 방법 모두 AFP와 농도에 비례하여 반응하였다. 따라서 본 연구에서 생산된 모노클로날 항체는 연구목적으로 뿐만 아니라 AFP 농도를 측정하기 위한 면역진단시약의 개발에도 유용할 것으로 생각된다.

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은이온을 첨가한 장석계 도재의 분광 측색학적 평가 (Spectrophotometric analysis of feldspathic porcelain with silver ion)

  • 김지현;송경우;노세라;윤계림;윤귀덕
    • 구강회복응용과학지
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    • 제31권1호
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    • pp.20-25
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    • 2015
  • 목적: 이 실험의 목적은 장석계 도재에 항균성을 부여하기 위해 은을 다양한 농도로 첨가하였을 때, 은 첨가가 장석계 도재의 색조에 영향을 미치는지 알아보기 위함이다. 연구 재료 및 방법: 대조군은 은을 포함하지 않은 일반 장석계 도재를 이용하고, 은이 5%, 10%, 20%, 30%의 농도로 첨가된 장석계 도재를 4개의 실험군으로 하여 총 5개의 그룹을 이용하였고, 각 그룹당 각 5개씩 디스크 형태로 시편을 제작하였다. 각 시편은 색차계를 이용하여 L, a, b값을 2번씩 측정하였다. 각 값은 SPSS를 이용하여 일원분산 통계 분석을 시행하였다. 결과: 은의 함량이 높아짐에 따라 각 그룹간 L값은 거의 비슷하였고, a값은 점차 증가하고, b값은 점점 감소하는 양상을 보여주었다. 은의 함량이 높아짐에 따라 ${\Delta}E$ 값은 유의하게 증가하였다. 5% 은 이온이 함유된 도재와 10%의 은 이온이 함유된 도재는 ${\Delta}E$값이 3.7 이하였다. 결론: 장석계 도재에 은을 첨가하는 것은 도재의 색조에 영향을 준다. 하지만 10% 이하의 이온을 첨가한 장석계 도재는 임상적으로 받아들여질만 하다.

치과용(齒科用) 은(銀)-파라디움합금(合金)의 합금원소(合金元素)가 제성질(諸性質)에 미치는 영향(影響)에 관(關)한 연구(硏究) (EFFECTS OF ALLOYING ELEMENTS ON VARIOUS PROPERTIES OF DENTAL SILVER-PALLADIUM ALLOYS)

  • 김춘진;박남수
    • 대한치과보철학회지
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    • 제22권1호
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    • pp.95-108
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    • 1984
  • Even though the tarnishing and corrosion problems characteristic with dental silver-palladium alloy are not yet fully solved, it is recently widely used because of its low cost. However the effects of major alloying elements on the various properties of this system are not fully understood. The object of this research is to clarify the effects of In and Zn additives on the corrosion and tarnishing resistances and precipitation hardening behavior of this sytem, using electrodynamic polarization, immersion, and Vicker's microhardness test and X-ray diffraction and electron probe micro analysis methods. The obtained results were as follows: I. As indium content is increased, both the corrosion resistance in Cl-solution and microhardness are also increased while the tarnishing resistance is decreased. 2. As Zinc content is increased, the corrosion resistance is decreased, but tarnishing resistance is increased 3. At 70Ag-25Pd-2.5Zn-2.5In composition, the precipitation harding behavior was mot significant. The optimum aging temperature was $450^{\circ}C$ and the time was 2 hrs. The resulting specimen of this work carried 180VHN. 4. Under the heat treatment, the changes in the mechanical property are due to the changes in the shape and composition of dendrite matrix, namely, it is because of the precipitation hardening behavior which has been proved by electron probe micro analysis and optical microscopic finding.

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Analysis of Broken Rice Separation Efficiency of a Laboratory Indented Cylinder Separator

  • Kim, Myoung Ho;Park, Seung Je
    • Journal of Biosystems Engineering
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    • 제38권2호
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    • pp.95-102
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    • 2013
  • Purpose: Using a laboratory indented cylinder separator, broken rice separation experiments were conducted and the characteristics of the separation process were studied to provide information for developing a prototype indented cylinder broken rice separator. Methods: Rice (Ilmi variety) milled in a local RPC was used for the experiment. Rice kernels were classified into four groups according to their length l; whole kernels (I > 3.75 mm), semi-whole kernels (2.5 < I < 3.75 mm), broken kernels (1.75 < I < 2.5 mm), and foreign matters (I < 1.75 mm). A laboratory grain cleaner, Labofix '90 (Schmidt AG, Germany) was used for the experiments. Experiments were designed as a $4{\times}4$ factorial arrangement in randomized blocks with three replications. Cylinder rotational speeds (17, 34, 51, 68 rpm) and trough angles (15, 37.5, 60, $82.5^{\circ}$) were the two factors and feed rates (25, 50 kg/h), indent shapes (Us, $S_1$ type), and indent sizes (2.5, 3.75 mm) were treated as the blocks. Two 125 g samples and one 125 g sample were taken at the cylinder outlet and from the trough, respectively. The whole, semi-whole, and broken kernel weight ratio of the samples and feed was determined by a rice sizing device. From these weight ratios, purities, degrees of extraction and coefficient of separation efficiency were calculated. Results: Trough angle, cylinder speed, and their interaction on the coefficient of separation efficiency were statistically significant. Cylinder speed of 17, 34, and 51 rpm made the most effective separation when the trough angle was $15^{\circ}$ or $37.5^{\circ}$, $60^{\circ}$, and $82.5^{\circ}$, respectively. Maximum values of coefficient of separation efficiency were in the range of 60 to 70% except when the indent size was 2.5 mm and were recorded for the combinations of low cylinder speed (17 rpm) with medium trough angle ($37.5^{\circ}$ or $60^{\circ}$). Indent shape did not appear to make any noticeable difference in separation efficiency. Conclusions: Due to the interaction effect, the trough angle needs to be increased appropriately when an increase in cylinder speed is made if a rapid drop of effectiveness of separation should be avoided. In commercial applications, $S_1$ type indents are preferred because of their better manufacturability and easier maintenance. For successful separation of broken kernels, the indent size should be set slightly bigger than the actual sizes of broken kernels: an indent size of 3.0 mm for separating broken kernels shorter than 2.5 mm.