[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.7314/APJCP.2014.15.3.1263

Meta-analysis of Associations Between four Polymorphisms in the Matrix Metalloproteinases Gene and Gastric Cancer Risk

Yang, Teng-Fei (Department of Gastroenterology Surgery, Affiliated Shengjing Hospital of China Medical University)
Guo, Lin (Department of Gastroenterology Surgery, Affiliated Shengjing Hospital of China Medical University)
Wang, Qiang (Department of Gastroenterology Surgery, Affiliated Shengjing Hospital of China Medical University)

Publication Information

Asian Pacific Journal of Cancer Prevention / v.15, no.3, 2014 , pp. 1263-1267 More about this Journal

Abstract

Background: Matrix metalloproteinases (MMPs) play important roles in pathogenesis and development of cancer. Recently, many studies have show associations between polymorphisms in the promoter regions of MMPs and risk of gastric cancer. The present meta-analysis was conducted in order to investigate the potential association between four polymorphisms in the MMP gene and gastric cancer risk. Methods: A computerized literature search was conducted in databases of Med-line, Embase, Science Citation Index and PubMed till June 2013 for any MMP genetic association study of gastric cancer. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated for each gene under dominant and recessive models, and heterogeneity between studies was assessed using the Q test and $I^2$ value. Overall and subgroup analyses according to ethnicity were carried out with Stata 12.0. Results: 14 reports covering 8,146 patients (2,980 in the case group and 5,166 in the control group) were included in the present meta-analysis. We found that the MMP-7 (-181A>G) polymorphism increased the gastric cancer risk in therecessive model (GG vs. AA/AG, OR=1.768, 95% CI =1.153-2.712). For MMP2 -1306 C>T, MMP1-1607 1G/2G, and MMP9-1 562 C>T, there were no associations between these polymorphisms and the risk of gastric cancer under dominant or recessive models. Conclusion: This meta-analysis suggested that the MMP7-181 A>G polymorphism may contribute to gastric cancer susceptibility. More studies are needed, especially in Europeans, in the future.

Keywords

Matrix metalloproteinases (MMPs); polymorphism; gastric cancer; risk; meta analysis;

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Reference
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1	Sugimoto M, Furuta T, Kodaira C, et al (2008). Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan. J Gastroenterol, 43, 751-61. DOI ScienceOn
2	Wu CY, Wu MS, Chen YJ, et al (2007). Clinicopathological significance of MMP-2 and TIMP-2 genotypes in gastric cancer. Eur J Cancer, 43, 799-808. DOI ScienceOn
3	Zhang B, Ye S, Herrmann SM, et al (1999). Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis. Circulation, 99, 1788-94. DOI ScienceOn
4	Zhang J, Jin X, Fang S, et al (2005). The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma. Carcinogenesis, 26, 1748-53. DOI ScienceOn
5	Zhang X M, Miao X P, Xiong P, et al (2004). Association of functional polymorphisms in matrix metalloproteinase-2 (MMP-2). and MMP-9 genes with risk of gastric cancer in a Chinese population. Ai Zheng, 23, 1233-37.
6	Zhou P, Du LF, Lv GQ, et al (2011). Current evidence on the relationship between four polymorphisms in the matrix metalloproteinases (MMP). gene and breast cancer risk: a meta-analysis. Breast Cancer Res Treat, 127, 813-18. DOI
7	McColgan P, Sharma P (2009). Polymorphisms of matrix metalloproteinases 1, 2, 3 and 9 and susceptibility to lung, breast and colorectal cancer in over 30,000 subjects. Int J Cancer, 125, 1473-78. DOI ScienceOn
8	Malik M A, Zargar S A, Mittal B (2011). Role of the metalloproteinase-7 (181A>G). polymorphism in gastric cancer susceptibility: a case control study in Kashmir valley. Asian Pac J Cancer Prev, 12, 73-76.
9	Matsumura S, Oue N, Kitadai Y, et al (2004). A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer. J Cancer Res Clin Oncol, 130, 259-65. DOI ScienceOn
10	Matsumura S, Oue N, Nakayama H, et al (2005). A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer. J Cancer Res Clin Oncol, 131, 19-25. DOI
11	Miao X, Yu C, Tan W, et al (2003). A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T). is associated with risk of development but not metastasis of gastric cardia adenocarcinoma. Cancer Res, 63, 3987-90.
12	Noe V, Fingleton B, Jacobs K, et al (2001). Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J Cell Sci, 114, 111-18.
13	Peng B, Cao L, Ma X, et al (2010). Meta-analysis of association between matrix metalloproteinases 2, 7 and 9 promoter polymorphisms and cancer risk. Mutagenesis, 25, 371-79. DOI ScienceOn
14	Price S J, Greaves D R, Watkins H (2001). Identification of novel, functional genetic variants in the human matrix metalloproteinase-2 gene: role of Sp1 in allele-specific transcriptional regulation. J Biol Chem, 276, 7549-58. DOI ScienceOn
15	Rutter JL, Mitchell TI, Buttice G, et al (1998). A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription. Cancer Res, 58, 5321-25.
16	Kim J, Pyun J A, Cho S W, et al (2011). Lymph node metastasis of gastric cancer is associated with the interaction between poly (ADP-ribose). polymerase 1 and matrix metallopeptidase 2. Dna Cell Biol, 30, 1011-17. DOI ScienceOn
17	Kubben F J, Sier C F, Meijer M J, et al (2006). Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer. Br J Cancer, 95, 744-51. DOI ScienceOn
18	Hu C, Wang J, Xu Y, et al (2013). Current evidence on the relationship between five polymorphisms in the matrix metalloproteinases (MMP). gene and lung cancer risk: a meta-analysis. Gene, 517, 65-71. DOI ScienceOn
19	Jin X, Kuang G, Wei LZ, et al (2005). No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China. World J Gastroenterol, 11, 2385-89. DOI
20	Ke P, Wu ZD, Wen HS, et al (2013). Current evidence on associations between the MMP-7 (-181A>G). polymorphism and digestive system cancer risk. Asian Pac J Cancer Prev, 14, 2269-72. 과학기술학회마을 DOI ScienceOn
21	Lee Y Y, Derakhshan M H (2013). Environmental and lifestyle risk factors of gastric cancer. Arch Iran Med ,16, 358-65.
22	Li X, Qu L, Zhong Y, et al (2013). Association between promoters polymorphisms of matrix metalloproteinases and risk of digestive cancers: a meta-analysis. J Cancer Res Clin Oncol, 139, 1433-47. DOI ScienceOn
23	Li Y, Sun DL, Duan YN, et al (2010). Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China. Mol Biol Rep, 37, 197-205. DOI
24	Lin X D, Chen G, Li C, et al (2011). Association of polymorphism in matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 with genetic susceptibility of gastric cancer. Zhonghua Yu Fang Yi Xue Za Zhi, 45, 711-16.
25	de Martel C, Ferlay J, Franceschi S, et al (2012). Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol, 13, 607-15. DOI ScienceOn
26	Alakus H, Afriani N, Warnecke-Eberz U, et al (2010). Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer. World J Surg, 34, 2853-59. DOI ScienceOn
27	Carneiro F, Huntsman D G, Smyrk T C, et al (2004). Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening. J Pathol, 203, 681-87. DOI ScienceOn
28	Companioni O, Bonet C, Munoz X, et al (2013). Polymorphisms of H. pylori signaling pathway genes and gastric cancer risk in the European EPIC-eurgast cohort. Int J Cancer, 134, 92-101.
29	Egeblad M, Werb Z (2002). New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer, 2, 161-74. DOI ScienceOn
30	Fingleton B, Vargo-Gogola T, Crawford H C, et al (2001). Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis. Neoplasia, 3, 459-68. DOI ScienceOn

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2	(2015) Molecular Medicine Reports Tanshinone IIA decreases the migratory ability of AGS cells by decreasing the protein expression of matrix metalloproteinases, nuclear factor κB-p65 and cyclooxygenase-2 / 13 (2) , 1263
12	Muhammad Daniyal. (2015) Asian Pacific Journal of Cancer Prevention Risk Factors and Epidemiology of Gastric Cancer in Pakistan / 16 (12) , 4821
2	Sebnem Ozemri Sag. (2015) Asian Pacific Journal of Cancer Prevention MMP2 Gene-735 C/T and MMP9 gene -1562 C/T Polymorphisms in JAK2V617F Positive Myeloproliferative Disorders / 16 (2) , 443
4	Nilufer Avcı. (2015) Pathology & Oncology Research Association and Prognostic Significance of the Functional −1562C/T Polymorphism in the Promoter Region of MMP-9 in Turkish Patients with Gastric Cancer / 21 (4) , 1243
3	E. Kh. Shaymardanova. (2016) Russian Journal of Genetics Role of allelic genes of matrix metalloproteinases and their tissue inhibitors in the risk of peptic ulcer disease development / 52 (3) , 320
2	Rieko Okada. (2017) Gastric Cancer Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer / 20 (2) , 246
10	Liu Tao. (2015) Genetic Testing and Molecular Biomarkers MMP1, 2, 3, 7, and 9 Gene Polymorphisms and Urinary Cancer Risk: A Meta-Analysis / 19 (10) , 548
15821838	(2018) Journal of Cellular and Molecular Medicine Prognostic value of gastric cancer-associated gene signatures: Evidence based on a meta-analysis using integrated bioinformatics methods / (15821838)