• Journal of Yeungnam Medical Science
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• 제38권3호
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• pp.251-257
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• 2021

Vedolizumab (VDZ) has been approved for the treatment of inflammatory bowel diseases (IBDs) in patients aged ≥18 years. We report a case of a pediatric patient with Crohn disease (CD) who was successfully treated with VDZ. A 16-year-old female developed severe active pulmonary tuberculosis (TB) during treatment with infliximab (IFX). IFX was stopped, and TB treatment was started. After a 6-month regimen of standard TB medication, her pulmonary TB was cured; however, gastrointestinal symptoms developed. Due to the concern of the patient and parents regarding TB reactivation on restarting treatment with IFX, VDZ was started off-label. After the second dose of VDZ, the patient was in clinical remission and her remission was continuously sustained. Ileocolonoscopy at 1-year after VDZ initiation revealed endoscopic healing. Therapeutic drug monitoring conducted during VDZ treatment showed negative antibodies to VDZ. No serious adverse events occurred during the VDZ treatment. This is the first case report in Korea demonstrating the safe and effective use of VDZ treatment in a pediatric CD patient. In cases that require recommencement of treatment with biologics after recovery of active pulmonary TB caused by anti-tumor necrosis factor agents, VDZ may be a good option even in pediatric IBD.

• 대한치과교정학회지
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• 제27권2호
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• pp.173-180
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• 1997

본 연구는 교정환자를 대상으로 chlorhexidine varnish를 치면에 도포했을 때 치태내 균주의 변화양상을 관찰하여 교정치료환자에 있어 치아우식증예방을 위한 chlorhexidine 사용의 효용성을 평가하고자 하는데 그 목적이 있다. 서울대학교 병원 치과진료부 교정과에 내원한 신환 26명을 대상으로 각 13명씩을 실험군과 대조군으로 구분하여 실험군에는 chlorhexidine varnish를 1주일 간격으로 4희 도포하고 대조군에는 같은 방법으로 placebo varnish를 도포하여 처치 전과 처치 4주후, 처치 8주후의 치태내 균주 변화양상을 간접면역형광현미경법으로 분석하였다. 결과는 다음과 같다. 1. Chlorhexidine varnish 처치에 의해 Streptococcus mutans는 처치 8주후 까지 강력히 억제되었다(p<0.01). 2. Streptococcus sanguis는 chlorhexidine varnish처치 4주후에 일시적으로 증가하였다가(p<0.05) 8주후에 원상으로 회복되었다. 3. Streptococcus mitis, Actinomyces viscosus, Actinomyces naeslundii는 chlorhexidine varnish 처치에 의해 별 다른 변화를 나타내지 않았다.

• Journal of Periodontal and Implant Science
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• 제34권2호
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• pp.449-459
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• 2004

Bacterial byproducts and volatile sulfur compounds(VSC) have been found to be the leading intra-oral agents, specifically, the byproducts of gram negative anaerobic bacteria have been implicated as primary factors of halitosis in patients presenting with periodontal disease. The objective of this study was to determine the correlation between periodontal treatment and the subsequent reduction in the level of halitosis. Forty-three subjects presenting with periodontal disease were examined before periodontal treatment, one week after treatment, one month after treatment, and finally, two months after treatment, using a portable sulfide monitoring $Halimeter^{(R)}$ to measure the VSC concentrations at the prescribed intervals. The results of the study were as follows: 1. Significant decreases in the mean VSC concentration were observed at the one week, one month, and two month post-op intervals relative to the pre-op measurement. (p<0.05) 2. Significant decreases in the mean VSC concentration were observed in subjects after completion of flap operations. Significant decreases in the mean VSC concentration were observed at the one and two month post-flap operation measurement relative to the VSC concentration at one week (p<0.05), but no significant differences between the one month and two month VSC concentrations were found. (p<0.05) 3. Significant decreases in the mean VSC concentration were observed in subjects after completion of subgingival curettage (p<0,05). Significant decreases were found between the one week and one month measurements and between the one month and two month measurements, but significant differences were not observed between the one week and two month measurements. (p<0.05) The results of this study show significant decreases in VSC concentration in test subjects after periodontal treatment. It can be inferred from the results above, that periodontal disease is a significant contributing factor of halitosis, and that treatment of periodontal disease can been an effective means of reducing VSC concentration in patients presenting with halitosis concurrent with periodontal disease.

• 대한치과교정학회지
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• 제23권4호
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• pp.565-606
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• 1993

The purpose of this study was to evaluate the change of before and after treatment of anterior openbite malocclusions treated by Multiloop Edgewise Archwire technique. The openbite sample consisted of 4 male and 12 female adults, treated with nonextraction or third molar extraction. The normal sample consisted of 58 subjects, which have pleasing facial profile and normal occlusion and no experience of orthodontic or prosthodontic treatment. The 58 subjects of normal sample were subdivided by cephalemetric vertical relationship of face. The 40 subjects, cephalometric vertical relationship of face was in normal range, classified as Normal Sample group 1. The 18 subjects, increased cephalometric vertical relationship of face, classified as Normal Sample group 2. The computerized cephalometric analysis was accomplished with 50 reference points for 22 skeletal measurements, 46 dentoalveolar measurements, 8 soft tissue measurements. Statistical analysis of the data was carried out with paired t-test, Student's t-test, and DUNCAN test using SAS(PC version), The results were as follows : 1. There were no statistically significant differences in skeletal measurement between before and after treatment. The major changes were in dentoalveolar region. 2. After treatment, the long axis of maxillary and mandibular posterior teeth were distally tipped-back, and uprighted to bisected occlusal plane. The interincisal angle was increased. 3. There were no statistically significant increase in the upper posterior dental height and statistically significant decrease in the lower posterior dental height. The upper anterior dental height was increased, but there was no statistically significant increase in the absolute upper anterior dental hight. The lower anterior dental height was increased. 4. After treatment, the maxillary occlusal plane to palatal plane angle and the mandibular occlusal plane to mandibular plane angle were statistically significant increased. Then, there were no statistically significant difference between after treatment group and normal sample group 2. 5. After treatment, the percentage of upper lip length to upper anterior dental height was decreased. Then, There were no statistically significant difference between after treatment group and normal sample group 2.

• 동아시아식생활학회지
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• 제11권2호
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• pp.104-111
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• 2001

The first purpose of this study was to determine the changes in the allergenicity of milk and egg with heat treatment. The allergenicity of milk and egg is known to have a strong antigen. The second purpose of this study was to observe changes of disestibility of milk and egg after heat treatment. For this study, passive cutaneous anaphylaxis(PCA) inhibition experiment by using guinea pig and nonprotein nitrogen(NPN)experiment were attempted. The result were following: 1. The allergenicity of both milk and egg was reduced by heat treatment. 2. The degree of hydrolysis and PCA inhibition increased with longer heating time. 3. The increse in both the degree of hydrolysis and PCA inhibition of milk was higher than that of egg. 4. Egg contained a greater amount of allergen than milk after heat treatment. 5. The digestibility of both milk and egg was reduced by heat treatment. 6. The digestibility was reduced further by increasing heating time. 7. The digestibility of egg was lower than that of milk after the treatment.

• Korean Journal of Acupuncture
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• 제33권2호
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• pp.84-88
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• 2016

Objectives : To assess and compare the effectiveness of acupuncture treatment of depression in epilepsy children and adolescent's parents. Methods : 20 cases of depression in epilepsy children and adolescent's parents were investigated in Southern TCM Centre, Southern University College, Malaysia. Subjects were randomly divided into two groups; Acupuncture treatment group and Herbal medication treatment group. Family relationships questionnaires and Hamilton Depression Rating Scale were used before, after 4 weeks and 8 weeks treatments in order to investigate the effectiveness of treatment. Results : After 4 weeks Acupuncture treatment group showed significant reduction in the Hamilton Depression Rating Scale. On the other hand, after 8 weeks both groups showed significant reduction in Hamilton Depression Rating Scale. Conclusions : The result suggests that the effectiveness of Acupuncture treatment is comparable with treat of Herbal medication treatment to reduce parent's Hamilton Depression Rating Scale.

• 한국치위생학회지
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• 제18권4호
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• pp.525-533
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• 2018

Objectives: This retrospective study evaluated the changes in the airway width after the orthognathic surgery associated with the skeletal Class III malocclusion. Methods: The lateral cephalograms of 30 adult patients were taken before and immediately after the operation, and after the orthodontic treatment. The angles and distances of them were measured and compared. Results: Before the surgery, the mean value of mandibular (S-B) setback was 9.66 mm, and moved by 1.56 mm anteriorly after the orthodontic treatment. The ANB increased by 5.42 degrees, since then it decreased by 0.68 degree. The hyoid bone (S-APH) moved by 5.05 mm posteriorly, but then moved by 2.26 mm anteriorly. The soft tissue width of laryngeal pharynx (apw2-ppw2) was narrowed by 1.04 mm, and decreased by additional 0.83 mm after the orthodontic treatment. Conclusions: As the mandible was moved back, the location of hyoid bone and laryngeal pharynx were moved backward.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9713-9717
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• 2014

Background: Colon cancer (CRC) is perhaps the second most common cause of cancer mortality. This study determined the clinical significance of serum vascular endothelial growth factor (VEGF) and serum complement 3a (C3a) levels in patients with CRC in Fars province, southern Iran. Materials and Methods: Between June 2010 and June 2012, 110 patients with CRC of both genders and different age groups were divided into 3 groups. Group A included patients who had just undergone surgery; Group B had undergone chemotherapy after surgery; and Group C had undergone chemotherapy and radiotherapy after surgery. Twenty one healthy subjects with normal colonoscopy were considered as a control group. ELISA was undertaken to determine VEGF and C3a levels before and after treatment measures. Results: The mean age of patients was $53.9{\pm}14.1$ years. Considering VEGF level, a significant decrease was visible after treatment measures in groups A and B, but not Group C. For VEGF level, the difference was not statistically significant between two genders and various age groups before and after treatment. No significant difference was found for VEGF level between patients and normal group before any treatment. Regarding C3a levels in 101 subjects, they significantly decreased after treatment measures. Before and after treatment, the difference was statistically significant between two genders, but was not statistically significant among various age groups. Conclusions: As VEGF and C3a levels were significantly lower in patients after treatment, these may be beneficial markers in assessment of CRC therapy especially in early stages.

• 한국동물학회지
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• 제21권3호
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• pp.79-86
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• 1978

약 20g 되는 생쥐에 인삼사포닌은 매일 체중 20g 당 0.02 mg을, 디을계와 트리올계 사포닌은 0.01 mg을 피하주사하여 in vivo에서의 Tryptophan Pyrrolase(TP) 활성의 변화를 측정하여 다음의 결과를 얻었다. 1. 인삼 사포닌을 주사한 3시간 후에 TP 활성은 약간 증가하였으나 통계학적으로 유의성이 없었으며, 24시간 후에는 정상수준으로 복귀하였다. 1 주간 처리군은 61.11%의 유의성 있는 증가를 나타내었다. 2. 디올계 사포닌 처리로 TP 활성은 3시간 후에 12.10% 증가하였으나 유의성이 없었으며, 12시간에 64.96%의 유의성 있는 증가를 보였으며, 24시간에 30.78%로 감소하였으나 유의성이 없었다. 1주간 처리군은 100.58%의 유의성 있는 증가를 나타내었다. 3. 트리올계 사포닌 처리는 3시간에 59.17%의 유의성 있는 활성증가를 일으켰으며, 24시간에 거의 대조군의 수준으로 복귀하였다. 1주간 처리군은 66.98%의 유의성 있는 증가를 나타내었다.

• 대한치과의사협회지
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• 제46권5호
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• pp.308-314
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• 2008

The risk of temporomandibular joint disorder (TMD) can be increased during dental treatment due to excessive mouth opening and change of occlusion. The aim of this study is to find the relationship between dental treatment and TMD in the patients who developed TMD after dental treatment. The subjects of this study were 21 patients, who developed TMD after dental treatment and were treated with active TMD therapy in Seoul National University Bundang Hospital from June 2003 to February 2007. The subjects were examined with preceding dental treatment, symptom, diagnosis, treatment method of TMD and prognosis of TMD. The obtained results were as follows. 1. Preceding dental treatments were : Implant treatment, 14 cases ; Tooth extraction, 3 cases and others. 2. TMD symptoms were : pain on TMJ, 12cases : Sound on TMJ, 3cases ; Mouth opening limitation, Headache and others. 3. Diagnoses of TMD were : Synovitis and/or capsulitis, 10 cases ; 8 cases of Internal derangement and others. 4. Most TMD were treated by stabilization splint. 5. Prognoses of TMD were : Improvement, 6cases ; sustained 11 cases. In conclusion, the risk of TMD is increased during implant treatment. Prognoses of TMD after dental treatment were bad. It might be that these patients were non-cooperative and have distrust of dental treatment. Because the overloading on TMJ is possible in dental treatment of patients with underlying TMD, prior explanation and knowledge TMJ treatment are very important in these cases.