• Genomics & Informatics
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• 제19권1호
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• pp.9.1-9.5
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• 2021

Mammalian olfactory receptors are a family of G protein-coupled receptors (GPCRs) that occupy a large part of the genome. In human genes, olfactory receptors account for more than 40% of all GPCRs. Several types of GPCR structures have been identified, but there is no single olfactory receptor whose structure has been determined experimentally to date. The aim of this study was to model the interactions between an olfactory receptor and its ligands at the molecular level to provide hints on the binding modes between the OR2W1 olfactory receptor and its agonists and inverse agonists. The results demonstrated the modes of ligand binding in a three-dimensional model of OR2W1 and showed a statistically significant difference in binding affinity to the olfactory receptor between agonists and inverse agonists.

• 한국해양공학회지
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• 제33권1호
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• pp.61-67
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• 2019

Recently, a perforated caisson breakwater with turning wave blocks was developed to improve the water affinity and public safety of a rubble mound armored by TTP. In this study, hydraulic model tests were performed to examine the hydraulic performance of a non-porous caisson and new caisson breakwater with perforated blocks for attacking waves in a small fishery harbor near Busan. The model test results showed that the new caisson was more effective in dissipating the wave energy under normal wave conditions and in reducing the wave overtopping rates under design wave conditions than the non-porous caisson. It was found that the horizontal wave forces acting on the perforated caisson were slightly larger than those on the non-porous caisson because of the impulsive forces on the caisson with the turning wave blocks.

• Bulletin of the Korean Chemical Society
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• 제5권5호
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• pp.175-178
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• 1984

Two series of membranes have been prepared by postcrosslinking highly syndiotactic and isotactic poly (2-hydroxyethyl methacrylate), P(HEMA). The crosslinker used was hexamethylene diisocyante (HMDIC). The distribution coefficients (K$_{D2}$) of the model solutes such as urea (and thiourea), their derivatives, homologous alcohol series and amide sreies in water-swollen tactic P(HEMA) membranes at $25^{\circ}C$ were mesaured. In addition, the concentration effects of acetamide and butyramid were also measured. On the basis of hydrophobic interaction and the structural factors of tactic P(HEMA) membranes, the hydrophobic adsorption of the solutes in the polymer matrix were discussed. The results showed that the more hydrphobic the solute is, the higher the $K_{D2}$ value is. And the polymer conformation also affects the distribution of solvents.

• Journal of Microbiology and Biotechnology
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• 제34권8호
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• pp.1551-1562
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• 2024

Fungi employ diverse mechanisms for iron uptake to ensure proliferation and survival in iron-limited environments. Siderophores are secondary metabolite small molecules with a high affinity specifically for ferric iron; these molecules play an essential role in iron acquisition in fungi and significantly influence fungal physiology and virulence. Fungal siderophores, which are primarily hydroxamate types, are synthesized via non-ribosomal peptide synthetases (NRPS) or NRPS-independent pathways. Following synthesis, siderophores are excreted, chelate iron, and are transported into the cell by specific cell membrane transporters. In several human pathogenic fungi, siderophores are pivotal for virulence, as inhibition of their synthesis or transport significantly reduces disease in murine models of infection. This review briefly highlights siderophore biosynthesis and transport mechanisms in fungal pathogens as well the model fungi Saccharomyces cerevisiae and Schizosaccharomyces pombe. Understanding siderophore biosynthesis and transport in pathogenic fungi provides valuable insights into fungal biology and illuminates potential therapeutic targets for combating fungal infections.

• 대한수학회지
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• 제57권5호
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• pp.1167-1186
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• 2020

This paper considers the case of pricing discretely-sampled variance swaps under the class of equity-interest rate hybridization. Our modeling framework consists of the equity which follows the dynamics of the Heston stochastic volatility model, and the stochastic interest rate is driven by the Cox-Ingersoll-Ross (CIR) process with full correlation structure imposed among the state variables. This full correlation structure possesses the limitation to have fully analytical pricing formula for hybrid models of variance swaps, due to the non-affinity property embedded in the model itself. We address this issue by obtaining an efficient semi-closed form pricing formula of variance swaps for an approximation of the hybrid model via the derivation of characteristic functions. Subsequently, we implement numerical experiments to evaluate the accuracy of our pricing formula. Our findings confirm that the impact of the correlation between the underlying and the interest rate is significant for pricing discretely-sampled variance swaps.

• 한국가스학회지
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• 제19권2호
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• pp.37-44
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• 2015

본 연구에서는 CBM의 1차 생산뿐 아니라 $CO_2$나 $N_2$ 주입을 통한 ECBM, 혹은 지중저장을 목적으로 석탄층에 $CO_2$를 주입할 때 발생할 수 있는 암체의 부피변화 영향을 고려하여 기존의 Langmuir 흡착 관계식을 개선하였다. 본 모델의 검증을 위해 $CO_2$나 $CH_4$, $N_2$의 단일성분 흡착실험 데이터에 기존 Langmuir 모델값과 본 모델의 결과값을 비교하였다. 그 결과, 기존 모델에서는 흡착용량이 큰 석탄일수록, 흡착친화도가 큰 가스일수록 실험값과 모델값 사이의 오차가 커지는 경향이 나타났지만 본 모델에서는 모든 조건에서 실험결과를 잘 묘사하였고 본 모델을 통해 예측한 부피변형률 역시 실험값과 유사함을 확인하였다. 이렇게 개선된 단일성분 흡착모델을 혼합가스의 흡착모델인 IAS 모델에 적용하여 부피변화가 고려된 IAS모델로 개선하였다. 그 결과 혼합가스에 대한 흡착거동 역시 기존 모델에 비해 정확도를 높였고 이는 Hall 등(1994)이 수행한 혼합가스의 흡착실험결과와의 매칭을 통해 확인하였다.

• Bulletin of the Korean Chemical Society
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• 제34권9호
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• pp.2629-2634
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• 2013

Fisetin is a naturally occurring flavonoid with some anti-cancer and anti-inflammation capabilities. In this study, we perform docking studies between human c-Jun N-terminal kinase 1 (JNK 1) and fisetin and proposed a binding model of fisetin and JNK 1, in which the hydroxyl groups of the B ring and oxygen at the 4-position of the C ring play key roles in binding interactions with JNK. Fluorescence quenching and saturation-transfer difference (STD) NMR experiments showed that fisetin exhibits good binding affinity to JNK, $1.32{\times}10^8M^{-1}$. The anti-inflammatory activity of fisetin was also investigated. Fisetin significantly suppressed tumor necrosis factor, the NO production, and macrophage inflammatory cytokine release in LPS-stimulated RAW264.7 mouse macrophages. We found that the anti-inflammatory cascade of fisetin was mediated through the JNK, and cyclooxygenase (COX)-2 pathways. Our findings suggest the potential of fisetin as an anti-inflammatory agent.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2015년도 추계 학술논문 발표대회
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• pp.62-63
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• 2015

In this paper, to prevent overspending of the CM Fee, Agent CM for the normal work-oriented, Willing to separate order model being used in the construction, using a multi-national grouping Go to offer the right company, a number of groups according to the appropriate CM Fee setting is aimed to suggest a reasonable basis. This paper does not use the domestic point of order characteristic of the model, and using a different theory of affinity grouping projection method is presented. The main disadvantage of the domestic order model because it is a contractual relationship, the contractual relationship as unified as possible by the most reasonable way of construction and construction capabilities and commercialization agreement upon the ability of companies also expect to be very helpful. The grouping by using the multi-order construction of the separation problem of the increase and thus the management object construction type administration was to solve the problem.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송공학회 2011년도 하계학술대회
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• pp.437-438
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• 2011

Spectral segmentation is a major trend in image segmentation. Specially, constrained spectral segmentation, inspired by the user-given inputs, remains its challenging task. Since it makes use of the spectrum of the affinity matrix of a given image, its overall quality depends mainly on how to design the graphical model. In this work, we propose a sparse, multi-layer graphical model, where the pixels and the over-segmented regions are the graph nodes. Here, the graph affinities are computed by using the must-link and cannot-link constraints as well as the likelihoods that each node has a specific label. They are then used to simultaneously cluster all pixels and regions into visually coherent groups across all layers in a single multi-layer framework of Normalized Cuts. Although we incorporate only the adjacent connections in the multi-layer graph, the foreground object can be efficiently extracted in the spectral framework. The experimental results demonstrate the relevance of our algorithm as compared to existing popular algorithms.

• 품질경영학회지
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• 제30권1호
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• pp.1-21
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• 2002

The purpose of this study was to empirically examine the customer oriented quality creation by considering quality elements required by customers in the product design process. The study tried to extract attractive quality elements by using Kano's model. After identifying the elements HOQ(the house of quality) of QFD(quality function deployment) was used to identify the trend of quality elements evaluation. Test for equal means (t-test) was applied to verify the attractive quality elements of adult shoes. It made us find the customer oriented quality elements from the customer needs and latent dissatisfaction. We collected the opinions of experts on shoes and complete the cause and effect diagram and affinity diagram (KJ method). The data of the questionnaire was put to the QFD and the contents of quality elements was identified by brain storming method. We calculated indexes which were the multiplication of weight and marks of quality elements in the cross table of the HOQ by QFD. Then we tested for the equality of means between the indexes and the sum of attractive quality elements. The results for equal means were statistically significant. To create the customer quality the product design should be differentiated between the age groups over attractive quality elements.