• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.29 no.1
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• pp.30-36
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• 2018

Background and Objectives : The effect of palliative injection laryngoplasty in cancer-related unilateral vocal cord paralysis patients on voice and swallowing function is uncertain and there are few previous studies of its suitability, benefits as a palliative treatment option. The purpose of this study is to confirm the objective results of voice and swallowing function after palliative office-based hyaluronic acid injection laryngoplasty in cancer-related unilateral vocal cord paralysis patients. Materials and Method : 36 patients who had unilateral vocal cord paralysis from non-thyroidal, extralaryngeal neoplasms were included in this study. To evaluate the clinical outcome, we analyzed perceptual GRBAS grading, acoustic analysis, aerodynamic study, Electroglottography (EGG), Voice Handicap Index (VHI-30) about voice function and disability rating scale (DRS), gastric tube dependency, aspiration pneumonia about swallowing function and 36-Item Short Form Survey version 2 (SF-36v2) about quality of life. Results : In GRBAS scale, G (p<0.001), R (p=0.004), B (p=0.001), A (p=0.011), and S (p=0.007) showed significant improvement. Jitter, shimmer, speaking fundamental frequency, maximal phonation time, VHI-30, DRS score, gastric tube dependency, aspiration pneumonia, and SF-36v2 were significantly improved after injection (p=0.016, p=0.011, p=0.045, p=0.005, p<0.001, p<0.001 p=0.003, p<0.001, and p<0.001 respectively). Conclusion : From this study we concluded office-based hyaluronic acid injection can be used as a useful palliative treatment option in cancer-related ill patients with unilateral vocal cord paralysis. Palliative hyaluronic acid injection laryngoplasty avoids the need for tube feeding, thus reducing the risk of aspiration pneumonia. These outcomes are accompanied by significant improvement in voice quality.

• Journal of Korea Water Resources Association
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• v.40 no.7
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• pp.571-583
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• 2007

The effects of climatic changes owing to urbanization, geographical and topographical conditions on Penman-Monteith reference evapotranspiration, and energy and aerodynamic terms of Penman-Monteith reference evapotranspiration have been studied. In this study, 56 climatological stations including the Seoul metropolis in South Korea have been selected, and the area of study site was set at $314\;km^2$. The climatological station is centrally located In the study area with a 10 km radius. The geographical and topographical characteristics of these sites were examined using GIS analysis. Land use status of the study area was also examined to estimate the extent of urbanization. The study results indicated that the variation of reference evapotranspiration rate is closely related to urbanization in most climatological stations. The level of change in reference evapotranspiration was higher in areas with higher urbanization rates. The change in reference evapotranspiration appears to be caused by temperature rises following heat island phenomena due to urbanization, and by the decrease in humidity, wind speed and sunshine duration due to the Increase in residential areas in urban districts. Especially, the humidity decrease causes a significant decrease in evapotranspiration rate. The study results showed that climatic change due to urbanization and proximity to the coast had the greatest effect on reference evapotranspiration.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.34 no.1
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• pp.32-41
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• 2006

In this study, the thrust generation by simultaneous flapping airfoils in tandem configuration is parametrically studied with respect to flapping frequency, amplitude and relative location. Navier-Stokes solver with overset grid topology is employed to calculate the unsteady flowfields. The computation results indicate that when the two airfoils stroke in-phase - flapping phase lag is zero - the maximum propulsive efficiency and thrust can be obtained for most frequency and amplitude range. At a flapping amplitude of 0.2 chord and a reduced frequency of 0.75, the propulsive efficiency of aft airfoil is enhanced by about 37 % compared with that of forward airfoil. However, if flapping frequency exceeds some critical value, the strength of the leading edge vortex of aft airfoil is fortified by the trailing edge vortex of the forward airfoil, resulting in poor propulsive efficiency. It is also found that out-of-phase flapping has relatively low propulsive efficiency and thrust since vortical wake of the forward airfoil interacts with the leading edge vortex of aft airfoil in the unfavorable fashion. The total thrust and propulsive efficiency are shown to decrease with the horizontal miss distance of the aft airfoil. On the contrary, the vertical miss distance has little effect on the overall aerodynamic performance.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.9
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• pp.712-722
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• 2018

This paper conducts parametric studies on flapping wing design, one of the most important design parameters of insect-mimicking aerial vehicles. Experimental study on wing shape was done through comparison and analysis of thrust, pitching moment, power consumption, and thrust-to-power ratio. A two-axis balance and hall sensor measure force and moment, and flapping frequency, respectively. Wing configuration is biplane configuration which can develop clap and fling effect. A reference wing shape is a simplified dragonfly's wing and studies on aspect ratio and wing area were implemented. As a result, thrust, pitching moment, and power consumption tend to increase as aspect ratio and area increase. Also, it is found that the flapping mechanism was not normally operated when the main wing has an aspect ratio or area more than each certain value. Finally, the wing shape is determined by comparing thrust-to-power ratio of all wings satisfying the required minimum thrust. However, the stability is not secured due to moment generated by disaccord between thrust line and center of gravity. To cope with this, aerodynamic dampers are used at the top and bottom of the fuselage; then, indoor flight test was attempted for indirect performance verification of the parametric study of the main wing.

• 재활복지
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• v.18 no.4
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• pp.237-255
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• 2014

Idiopathic Parkinson disease(IPD) is an neurodegenerative disease caused by the loss of dopamine cells in the substantia nigra, a region of midbrain. Its major symptoms are muscular rigidity, bradykinesia, resting tremor, and postural instability. An estimated 70~90% of patients with IPD also have hypokinetic dysarthria. Subthalamic nucleus deep brain stimulation (STN-DBS) has been reported to be successful in relieving the core motor symptoms of IPD in the advanced stages of the disease. However, data on the effects of STN-DBS on speech performance are inconsistent. A medline literature search was done to retrieve articles published from 1987 to 2012. The results were narrowed down to focus on speech performance under STN-DBS based perceptual, acoustic, and/or aerodynamic analyses. Among the 32 publications which dealt with speech performance after STN-DBS indicated improvement(42%), deterioration(29%), mixed results(26%), or no change(3%). The most favorite method was found to be based upon acoustic analysis by using a vowel prolongation and Unified Parkinson's Disease Rating Scale(UPDRS). For the purpose of verifying the effect of the STN-DBS, speech evaluation should be undertaken on all speech components such as articulation, resonance, phonation, respiration, and prosody by using a contextual speech task.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.7
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• pp.1059-1066
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• 2021

In Korea, the importance of marine activities is great, and automatic weather observation facilities are operating on land to investigate abnormal weather phenomena caused by industrialization; however, the number of facilities at sea is insufficient. Marine survey ships are operated to establish marine safety information, but there are many places where marine survey ships are difficult to access and operating costs are high. Therefore, a small, unmanned vessel capable of marine surveys must be developed. The sail has a significant impact on the sailing performance, so much research has been conducted. In this study, the camber effect, which is a design variable of the twin curvy sail known to have higher aerodynamic performance than existing airfoil shapes, was investigated. Flow analysis results for five cases with different camber sizes show that the lift coefficient is highest when the camber size is 9%. Curvy twin sails had the highest lift coefficient at an angle of attack of 23° because of the interaction of the port and starboard sails. The port sail had the highest lift coef icient at an angle of attack of 20°, and the starboard sail had the lowest lift coef icient at an angle of attack of 15°. In addition, the curvy twin sail had a higher lift coefficient than NACA 0018 at all angles of attack.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.33 no.3
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• pp.166-171
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• 2022

Background and Objectives Vocal fold (VF) scar is known to be the most common cause of dysphonia after laryngeal microsurgery (LMS). Steroids reduce postoperative scar formation by inhibiting inflammation and collagen deposition. However, the clinical evidence of whether steroids are helpful in reducing VF scar formation after LMS is still lacking. The purpose of this study is to determine whether intralesional VF steroid injection after LMS helps to reduce postoperative scar formation and voice quality. Materials and Method This study was conducted on 80 patients who underwent LMS for VF polyp, Reinke's edema, and leukoplakia. Among them, 40 patients who underwent VF steroid injection after LMS were set as the injection group, and patients who had similar sex, age, and lesion size and who underwent LMS alone were set as the control group. In each group, stroboscopy, multi-dimensional voice program, Aerophone II, and voice handicap index (VHI) were performed before and 1 month after surgery, and the results were statistically analyzed. Results There were no statistically significant differences in the distribution of sex, age, symptom duration, occupation and smoking status between each group. Both groups consisted of VF polyp (n=21), Reinke's edema (n=11), and leukoplakia (n=9). On stroboscopy, the lesion disappeared after surgery, and the amplitude and mucosal wave were symmetrical on both sides of the VFs in all patients. Acoustic parameters and VHI significantly improved after surgery in all patients. However, there was no significant difference between the injection and control group in most of the results. Conclusion There was no significant difference in the results of stroboscopy, acoustic, aerodynamic, and subjective evaluation before and after surgery in the injection group and the control group.

• Tuberculosis and Respiratory Diseases
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• v.52 no.6
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• pp.616-626
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• 2002

Background : The present study was performed to further improve our understanding of molecular mechanisms involved in the activation of NFkB, a major transcriptional factor involved in the inflammatory response in the lung, by particulate matter in lung epithelial cells with an aerodynamic diameter of less than $2.5{\mu}m$(PM2.5). Materials and Methods : Immediate production of reactive oxygen species (ROS) and nitrogen species (RNS), with the PM2.5 induced expression of inducible nitric oxide synthase (iNOS), $I{\kappa}B$ degradation and $NF{\kappa}B$-dependent transcriptional activity, in 549 cells, were monitored. Addition, we also examined the effect of the iNOS inhibitor, L-N6-(1-iminoethyl) lysine hydrochloride (L-NIL), on the PM2.5-induced $NF{\kappa}B$ activation in A549 cells. Results : The rapid degradation of $I{\kappa}B$ and the increase of transcriptional activity of the $NF{\kappa}B$-dependent promotor were observed in A549 cells exposed to PM2.5. The immediate production of ROS in response to PM2.5 in A549 cells was not clearly detected, although immediate responses were observed in RAW264.7 cells. A 549 cells, cultured in the presence of PM2.5, produced an increase in NO, which was noticeably significant after 15 min of exposure with the expression of iNOS mRNA. The addition of L-NIL, an iNOS inhibitor, significantly inhibited the PM2.5-induced $I{\kappa}B$ degradation and the increase of the $NF{\kappa}B$-dependent transcriptional activity. Conclusion : These results suggest that PM2.5 stimulates the immediate production of RNS, leading to the activation of $NF{\kappa}B$ in the pulmonary epithelium.

• Journal of Bio-Environment Control
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• v.15 no.4
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• pp.296-305
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• 2006

The heterogeneity of crop transpiration is important to clearly understand the microclimate mechanisms and to efficiently handle the water resource in greenhouses. A computational fluid dynamic program (Fluent CFD version 6.2) was developed to study the internal climate and crop transpiration distributions of greenhouses. Additionally, the global solar radiation model and a crop heat exchange model were programmed together. Those models programmed using $C^{++}$ software were connected to the CFD main module using the user define function (UDF) technology. For the developed CFD validity, a field experiment was conducted at a $17{\times}6 m^2$ plastic-covered mechanically ventilated single-span greenhouse located at Pusan in Korea. The CFD internal distributions of air temperature, relative humidity, and air velocity at 1m height were validated against the experimental results. The CFD computed results were in close agreement with the measured distributions of the air temperature, relative humidity, and air velocity along the greenhouse. The averaged errors of their CFD computed results were 2.2%,2.1%, and 7.7%, respectively.