• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.23 no.1
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• pp.1-10
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• 2013

Objectives: The present study investigated the potential subacute toxicity of 1,4-dichlorobutane (1,4-DCB) by a 2-week repeated oral dose in male Sprague-Dawley rats. Materials and Methods: The test chemical was administered once daily by gavage to male rats at dose levels of 0, 74, 222, 667, and 2000 mg/kg/day for 2 weeks. All rats were sacrificed at the end of treatment period. During the test period, clinical signs, mortality, body weights, food and water consumption, urinalysis, hematology, serum biochemistry, gross findings, and organ weights were examined. Results: At 2000 mg/kg/day, treatment-related clinical signs, as evidenced by hypothermia, decreased locomotor activity, piloerection, lying on side, and prone position were observed. All the rats were found dead on test day 2. At 667 mg/kg/day, polyuria, suppressed body weight gain, food consumption, and spleen and thymus weights, and increased adrenal gland and liver weights were observed.Hematological and serum biochemical investigations revealed increases in the alanine aminotransferase, alkaline phosphataseand total bilirubinand decreases in the serum $Na^+$ level, white blood cell count and lymphocyte ratio. There were no treatment-related adverse effects in the 74 and 222 mg/kg/day groups. Conclusions: In the present experimental conditions, target organs were determined to be spleen, thymus,and liver. The no-observed-adverse-effect level was considered to be 222 mg/kg/day in male rats.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.203_204
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• 2009

In this paper, we propose a Fourier transform-based modified phasor estimation method to eliminate the adverse influence of exponentially decaying DC offsets. Discrete Fourier Transform (DFT) is generally used to calculate the phasor of the fundamental frequency component in digital protective relays. However, the output of the DFT contains an error due to exponentially decaying DC offsets. Therefore, the decaying DC components should be taken into consideration when calculating the phasor of the fundamental frequency component of a relaying signal. In this paper, the error due to DC offsets in a DFT is calculated and eliminated using the outputs of quaternity DFT, so that the phasor of the fundamental component can be accurately estimated. The performance of the proposed algorithm is evaluated by using computer-simulated signals and EMTP-generated signals. A performance evaluation showed that the proposed algorithm was not affected by system and fault conditions. Thus, the proposed algorithm can effectively suppress the adverse influence of DC offsets in a relaying signal.

• Structural Engineering and Mechanics
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• v.65 no.1
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• pp.121-128
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• 2018

Three structure-dependent integration methods with no numerical dissipation have been successfully developed for time integration. Although these three integration methods generally have the same numerical properties, such as unconditional stability, second-order accuracy, explicit formulation, no overshoot and no numerical damping, there still exist some different numerical properties. It is found that TLM can only have unconditional stability for linear elastic and stiffness softening systems for zero viscous damping while for nonzero viscous damping it only has unconditional stability for linear elastic systems. Whereas, both CEM and CRM can have unconditional stability for linear elastic and stiffness softening systems for both zero and nonzero viscous damping. However, the most significantly different property among the three integration methods is a weak instability. In fact, both CRM and TLM have a weak instability, which will lead to an adverse overshoot or even a numerical instability in the high frequency responses to nonzero initial conditions. Whereas, CEM possesses no such an adverse weak instability. As a result, the performance of CEM is much better than for CRM and TLM. Notice that a weak instability property of CRM and TLM might severely limit its practical applications.

• Korean Journal of Adult Nursing
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• v.29 no.2
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• pp.154-165
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• 2017

Purpose: This study was designed to evaluate a patient safety application in the prevention of adverse event among surgical patients. Seventy three surgical patients with thirty six of them using the patient safety application and the rest (N=37) were provided educational booklet. Further, the instrument would measure patients' right to know, knowledge about patient safety, and attitude toward patient safety. Methods: The patient safety application was developed by the ADDIE along with input from experts, patients and an extensive literature review. Data were collected from 7 September through 20 October 2015. Results: The experimental group had significantly higher scores in patients' right to know (t=2.01, p=.024), knowledge on patient safety (t=3.80, p<.001) and attitude toward patient safety (t=2.74, p=.004) than those of the control group. Conclusion: The patient safety application developed using Smartphone could be an effective tool enhancing patient involvement in preventing adverse events that may occur to patients. Further studies are recommended with diverse subjects with varying medical conditions.

• Journal of Power Electronics
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• v.16 no.5
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• pp.1939-1949
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• 2016

This paper presents an alternative frequency adaptive grid synchronization technique named HDN-FLL, which can accurately extract the fundamental positive- and negative-sequence components and interested harmonics in adverse three-phase grid voltage. The HDN-FLL is based on the harmonic decoupling network (HDN) consisting of multiple first order complex vector filters (FOCVF) with a frequency-locked loop (FLL), which makes the system frequency adaptive. The stability of the proposed FLL is strictly verified to be global asymptotically stable. In addition, the linearization and parameters tuning of the FLL is also discussed. The structure of the HDN has been widely used as a prefilter in grid synchronization techniques. However, the stability of the general HDN is seldom discussed. In this paper, the transfer function expression of the general HDN is deduced and its stability is verified by the root locus method. To show the advantages of the HDN-FLL, a simulation comparison with other gird synchronization methods is carried out. Experimental results verify the excellent performance of the proposed synchronization method.

• Journal of The Korean Society of Grassland and Forage Science
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• v.37 no.2
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• pp.108-115
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• 2017

The aim of this study was to evaluate different herbicides in corn-soybean intercropping for optimum growth, yield and nutritive value of forage under Korean environment conditions. Herbicidal treatments were randomly applied over five plots, viz. (1) Control treatment: no herbicide; (2) Alachlor; (3) Simazine; (4) Pendimethalin and (5) Mixture of alachlor and simazine herbicides in RCBD have three replications. Results depicted that treated herbicides exhibited significant effect over control of weeds. Simazine herbicide alone or mixed with alachlor had adverse effects on soybean but enhanced (p<0.05) corn production in terms of survivability, dry matter and digestible nutrients yield. Corn-soybean coupling and total dry matter yield were greater (p<0.05) in pendimethalin. Simazine-alachlor mixture reduced (p<0.05) soybean height. Conclusively, simazine could not be suitable for corn soybean intercropping because of having an adverse effect on soybean component. Pendimethalin could maintain growth and yield of corn and soybean both components. Effect of alachlor was comparable to that of pendimethalin.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.03a
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• pp.874-882
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• 2009

Continuous monitoring of dam performance is essential to earth and rockfill dams safety because it has to be guaranteed for safety during construction period of course and from initial impounding to a long term maintenance period of dam. Among the 31 dams managed by Kwater at present, the proportion of dams being over 20 years after completion of construction is 42% and it is estimated that the loss rate of monitoring devices will be increase as times. Monitoring devices would be impossible to repair since those are mostly installed in the dam body and foundation. If repairing of monitoring devices is possible, the expenditure will be expensive. Therefore reasonable decision making for abandonment, repair and alternation for loss of monitoring devices would be needed through the establishment of key instrument for earth and rockfill dam safety. In this study the process of monitoring for safety were modeled by failure modes of dams, adverse conditions related to failure mode, indicators of adverse condition and monitoring devices The relationship between failure mode and monitoring devices were systematically analyzed and established and evaluation technique for qualifying the importance of monitoring devices were presented.

• Journal of Acupuncture Research
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• v.39 no.4
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• pp.317-322
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• 2022

Gold thread therapy (GTT) continuously stimulates acupoints and is used to treat chronic conditions/diseases such as chronic lumbar pain. During the procedure gold thread is embedded into the skin and although gold thread is medically pure, GTT is an irreversible treatment where there is limited evidence on its safety. Here, we report a case of a 79-year-old woman being treated for low back pain who developed side effects following moving cupping therapy at a site of GTT (performed in the 1970s). Adverse reactions causing radiating pain persisted more than at least 9 days following moving cupping therapy. The symptoms of pain were evaluated using the numerical rating scale, and changes in tenderness and the state of bruising was recorded. Low back pain improved but the radiating low leg pain did not improve. This case highlights the need for caution when performing moving cupping therapy where GTT has been previously performed.

• Tuberculosis and Respiratory Diseases
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• v.85 no.4
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• pp.289-301
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• 2022

Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammation characterized by fixed airflow limitation and chronic respiratory symptoms, such as cough, sputum, and dyspnea. COPD is a progressive disease characterized by a decline in lung function. During the natural course of the disease, acute deterioration of symptoms leading to hospital visits can occur and influence further disease progression and subsequent exacerbation. Moreover, COPD is not only restricted to pulmonary manifestations but can present with other systemic diseases as comorbidities or systemic manifestations, including lung cancer, cardiovascular disease, pulmonary hypertension, sarcopenia, and metabolic abnormalities. These pulmonary and extrapulmonary conditions lead to the aggravation of dyspnea, physical inactivity, decreased exercise capacity, functional decline, reduced quality of life, and increased mortality. In addition, pneumonia, which is attributed to both COPD itself and an adverse effect of treatment (especially the use of inhaled and/or systemic steroids), can occur and lead to further deterioration in the prognosis of COPD. This review summarizes the long-term outcomes of patients with COPD. In addition, recent studies on the prediction of adverse outcomes are summarized in the last part of the review.

• Geomechanics and Engineering
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• v.33 no.5
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• pp.519-528
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• 2023

In this paper, we present the results of an experimental study on the effect of polymer support fluid on shaft resistance of offshore bored piles. A series of pullout tests were performed on bored piles installed under various boundary conditions considering different types of grounds and support fluids, and a range of support fluid exposure times. Contrary to previous studies concerning onshore bored piles, a time dependent effect of polymer fluid on shaft resistance was observed in all ground types. The adverse effect of polymer support fluid on the shaft resistance, however, was considerably less than bentonite support fluid for a given exposure time. No significant reduction in shaft resistance was evident when limiting the exposure time of the polymer support fluid to the side wall of the borehole within 2-3 hours. The degree to which the polymer fluid affects shaft resistance seemed to vary with the ground type. A proper consideration should be given to the time dependent effect of polymer fluid on shaft resistance of bored piles installed in offshore construction environment to limit its adverse effect on the pile performance. The practical implications of the findings are discussed.