• Title/Summary/Keyword: Advanced age

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Factors associated with Advanced Bone Age in Overweight and Obese Children

  • Oh, Min-Su;Kim, Sorina;Lee, Juyeon;Lee, Mu Sook;Kim, Yoon-Joo;Kang, Ki-Soo
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.23 no.1
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    • pp.89-97
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    • 2020
  • Purpose: Obese children may often present with advanced bone age. We aimed to evaluate the correlation between factors associated with childhood obesity and advanced bone age. Methods: We enrolled 232 overweight or obese children. Anthropometric and laboratory data, and the degree of nonalcoholic fatty liver disease (NAFLD) were measured. We analyzed factors associated with advanced bone age by measuring the differences between bone and chronological ages. Results: The normal and advanced bone age groups were comprised of 183 (78.9%) and 49 (21.1%) children, respectively. The prevalence of advanced bone age significantly increased as the percentiles of height, weight, waist circumference, and body mass index (BMI) increased. BMI z-score was higher in the advanced bone age group than in the normal bone age group (2.43±0.52 vs. 2.10±0.46; p<0.001). The levels of insulin (27.80±26.13 μU/mL vs. 18.65±12.33 μU/mL; p=0.034) and homeostatic model assessment-insulin resistance (6.56±6.18 vs. 4.43±2.93; p=0.037) were significantly higher, while high density lipoprotein-cholesterol levels were lower (43.88±9.98 mg/dL vs. 48.95±10.50 mg/dL; p=0.005) in the advanced bone age group compared to those in the normal bone age group, respectively. The prevalence of advanced bone age was higher in obese children with metabolic syndrome than in those without (28.2% vs. 14.7%; p=0.016). The prevalence of advanced bone age was higher in obese children with a more severe degree of NAFLD. Conclusion: Advanced bone age is associated with a severe degree of obesity and its complications.

Life Stress of Advanced Maternal Age (고령임부의 생활스트레스)

  • Lee, Yumi;Chung, Eunja
    • Journal of the Korean Society of Industry Convergence
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    • v.21 no.2
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    • pp.79-86
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    • 2018
  • The purpose of this study is to compare life stress between primigravida and multigravida in advanced maternal age. A cross-sectional study was performed for 133 pregnancy women (primigravida group 53, multigravida group 80). The all women were old age (${\geq}35years$) and pregnant. We used the questionnaire to self-report general characteristics, obstetric characteristics and life stress. The average of participants age was 36.15 years old, primigravida was 36.08 and multigravida was 36.19. The mean of total life stress score was 2.68 and the total life score for pregnant women of lower education level was higher. The marital relationship of primigravida was lower than multigravida(mean, .06 vs. .26; p=.021). As our study shows that stress of marital relationship is higher in the multigravida than primigravida, the life stress care for advanced maternal age is important.

Lifestyle, nutrient intake, iron status, and pregnancy outcome in pregnant women of advanced maternal age

  • Bae, Hyun-Sook
    • Nutrition Research and Practice
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    • v.5 no.1
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    • pp.52-59
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    • 2011
  • The purpose of this study was to investigate how advanced maternal age influences lifestyle, nutrient intake, iron status, and pregnancy outcomes in pregnant women. The subjects of this study were 112 pregnant women who were receiving prenatal care at gynecologists located in Seoul. The subjects were divided into two groups according to their ages: those over age 35 were the advanced age group of pregnant women (AP) and those under age 35 were the young age group of pregnant women (YP). General factors, nutrient intakes, iron status, and pregnancy outcomes of the two groups were then compared. It was found that 72.5% of the YP group and 51.2% of the AP group had pre-pregnancy alcohol drinking experience; indicating that the YP group had more pre-pregnancy alcohol consumption than the AP group (P<0.05). The only difference found in nutrient intake between the two groups was their niacin intakes which were $16.83{\pm}8.20\;mg$/day and $13.76{\pm}5.28\;mg$/day, respectively. When gestational age was shorter than 38.7 weeks, the average infant birth weight was $2.95{\pm}0.08\;kg$, and when gestational age was longer than 40 weeks, it averaged at about $3.42{\pm}0.08\;kg$. In other words, as gestational age increased, infant birth weight increased (P<0.0001), and when maternal weight increased more than 15 kg, the infant birth weight increased significantly (P<0.05). In conclusion, in order to secure healthy human resources, with respect to advanced aged women, it is necessary to intervene by promoting daily habits that consist of strategic increases in folate and calcium intake along with appropriate amounts of exercise.

The investigation of an age as a prognostic factor of breast cancer (유방암의 예후인자로서 젊은 연령에 대한 고찰)

  • No, Dong-Yeong
    • Journal of Korea Association of Health Promotion
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    • v.2 no.1
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    • pp.39-46
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    • 2004
  • Purpose:It has been known that the prognosis of a young woman's breast cancer is Poorer than the other woman However, the effect of age on the prognosis is not well-defined We performed this study to investigate age as a prognostic factor of breast cancer. Materials and Methods : A retrospective study was conducted for 3209 breast cancer patients who underwent operations in Department of Surgery, Seoul National University Hospital from January 1981 to December 2000. Patients were divided into two groups, young age(≤35) and old age(>35) groups. And tumor stage, histopathologic characteristics(such as histology, nuclear grade, histologic grade, hormonal receptor, etc), overall survival and disease free survival rates were compared between age groups. Results . The age ranged from 17 to 88 years. 396 patients(12.3%) were included in young age group(median=32) and 2813 Patients(87.7%) in old age group(median=47).There are more advanced stages and poor nuclear grades in young age group(p=0.000, p=0.003), By log-rank test, the young age group had poorer overall survival and disease free survival rates(p<0.05, p=0.0002). Although, the young age group had more advanced TMN stages(p=0.000) and poorer nuclear grade than the old age group(p=0.003) in multi variate analysis, the age was not a significant independent prognostic factor. (P=0.642)Conclusion: Our study showed that the age was not a significant independent prognostic factor.

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Comparing Nutrition Knowledge, Eating Habits, and Neonatal Health Status of Primipara for Pregnant Women of Advanced Maternal Age Compared to Those of Younger Ages (고령 초산모와 비고령 초산모의 임신영양지식, 식습관 및 신생아 건강상태 비교)

  • Lee, Sun-Ok;Park, Kyung-Yeon;Han, Mi-Jung
    • Women's Health Nursing
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    • v.21 no.4
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    • pp.253-261
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    • 2015
  • Purpose: The aim of this study was to examine differences in nutrition knowledge, eating habits during pregnancy, and neonatal health status between primipara for pregnant women of advanced maternal age in comparison to those under the age of 35. Methods: This study used a comparative survey design. Data were collected through self-report questionnaires and patients medical records. A total of 127 participants, mothers after delivery were recruited from metropolitan city B. Results: Primipara in advanced maternal age (n=32) reported significantly higher scores of eating habits (Z=-2.96, p=.003) than younger ages (n=95). There were no significant differences in scores of pregnancy nutrition knowledge (Z=-0.44, p=.660), duration of gestation (Z=-0.28, p=.778), neonatal birth height (Z=-0.10, p=.924), neonatal birth weight (Z=-0.28, p=.777), Apgar score 1 minute (Z=-0.53, p=.599) and 5 minutes (Z=-0.23, p=.816) between two groups. Conclusion: It concludes that age is not the obstacle to the best nutritional status of women and their newborns.

Periodic Replacement Policies with Minimal Repair Cost Limit

  • Yun, W.Y.;Bai, D.S.
    • Journal of Korean Institute of Industrial Engineers
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    • v.11 no.1
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    • pp.3-10
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    • 1985
  • Periodic replacement policies are proposed for a system whose repair cost, when it fails, can be estimated by inspection. The system is replaced when it reaches age T (Policy A), or when it fails for the first time after age T (Policy B). If it fails before reaching age T, the repair cost is estimated and minimal repair is then undertaken if the estimated cost is less than a predetermined limit L; otherwise, the system is replaced. The expected cost rate functions are obtained, their behaviors are examined, and ways of obtaining optimal T and L are explored.

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Fluvastatin inhibits advanced glycation end products-induced proliferation, migration, and extracellular matrix accumulation in vascular smooth muscle cells by targeting connective tissue growth factor

  • Hwang, Ae-Rang;Nam, Ju-Ock;Kang, Young Jin
    • The Korean Journal of Physiology and Pharmacology
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    • v.22 no.2
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    • pp.193-201
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    • 2018
  • Connective tissue growth factor (CTGF) is a novel fibrotic mediator, which is considered to mediate fibrosis through extracellular matrix (ECM) synthesis in diabetic cardiovascular complications. Statins have significant immunomodulatory effects and reduce vascular injury. We therefore examined whether fluvastatin has anti-fibrotic effects in vascular smooth muscle cells (VSMCs) and elucidated its putative transduction signals. We show that advanced glycation end products (AGEs) stimulated CTGF mRNA and protein expression in a time-dependent manner. AGE-induced CTGF expression was mediated via ERK1/2, JNK, and Egr-1 pathways, but not p38; consequently, cell proliferation and migration and ECM accumulation were regulated by CTGF signaling pathway. AGE-stimulated VSMC proliferation, migration, and ECM accumulation were blocked by fluvastatin. However, the inhibitory effect of fluvastatin was restored by administration of CTGF recombinant protein. AGE-induced VSMC proliferation was dependent on cell cycle arrest, thereby increasing G1/G0 phase. Fluvastatin repressed cell cycle regulatory genes cyclin D1 and Cdk4 and augmented cyclin-dependent kinase inhibitors p27 and p21 in AGE-induced VSMCs. Taken together, fluvastatin suppressed AGE-induced VSMC proliferation, migration, and ECM accumulation by targeting CTGF signaling mechanism. These findings might be evidence for CTGF as a potential therapeutic target in diabetic vasculature complication.

Advanced Glycation Endproduct-induced Diabetic Complications

  • Lee, Hyun-Sun;Hong, Chung-Oui;Lee, Kwang-Won
    • Food Science and Biotechnology
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    • v.17 no.6
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    • pp.1131-1138
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    • 2008
  • Diabetic complications are a leading cause of blindness, renal failure, and nerve damage. Additionally, diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke, and limb amputation. At the present time, 4 main molecular mechanisms have been implicated in hyperglyceamia-mediated vascular damage. In particular, advanced glycation endproducts (AGE), which are formed by complex, heterogeneous, sugar-derived protein modifications, have been implicated as a major pathogenic process for diabetic complications. Recently, AGE inhibitors such as aminoguanidin, ALT-946, and pyridoxamine have been reported. Such an integrating paradigm provides a new conceptual framework for future research on diabetes complications and on discovering drugs to prevent the progression of AGE-induced maladies.

A Study on the present state of the Elderly informatization Education and the practical plan for creating jobs through human training (고령층 정보화교육의 현 실태 및 인력양성을 통한 일자리창출 실용화 방안에 관한 연구)

  • Kim, Ki-Hyuk;Park, Young-Sik;Jung, Dek-Kil
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2014.10a
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    • pp.237-240
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    • 2014
  • Recent information and technology is strongly targeted at the young generation, but little research has been undertaken on the older generation. The 55~79 age group was over 1,000,000 people in 2012. As a result, the problems of the information gap and of job creation for older people is becoming a critical social challenge. Because of this need, this research aims to suggest study method to reduce the information gap through informatization education for people of advanced age. Through this, older people can be mentors and play a key role in society as well as contributing to reduce social conflicts. This research is undertaken based on elderly IT volunteers, and is expected to solve the information gap problem through advanced age IT education and job creation with talent donation.

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No Late Effect of Ionizing Radiation on the Aging-Related Oxidative Changes in the Mouse Brain

  • Jang, Beom-Su;Kim, Seolwha;Jung, Uhee;Jo, Sung-Kee
    • Journal of Radiation Industry
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    • v.4 no.3
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    • pp.203-207
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    • 2010
  • Radiation-induced late injury to normal tissue is a primary area of radiation biology research. The present study was undertaken to investigate whether the late effect of the ionizing radiation appears as an age-related oxidative status in the brain. Three groups of 4-month old C57BL/6 mice that were exposed to $^{137}Cs$ ${\gamma}-rays$ at a single dose (5 Gy) or fractionated doses ($1Gy{\times}5times$, or $0.2Gy{\times}25times$) at 2 months old were investigated for the oxidative status of their brains with both young (2-month) and old (24-month) mice. A significant (p<0.05) decrease in superoxide dismutase (SOD) activity was observed in old mice brains compared with that of the young mice. malondialdehyde (MDA) content was significantly (p<0.05) increased in the old mice brain. However, any significant difference in SOD activity and MDA contents of the irradiated brain was not observed compared to age-matched control group mice. SOD activity and MDA content were observed within good parameters of brain aging and there were no late effects on the age-related oxidative level in the ${\gamma}-ray$ irradiated mice brains.