• BMB Reports
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• v.56 no.9
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• pp.520-525
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• 2023

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline. Several recent studies demonstrated that impaired adult neurogenesis could contribute to AD-related cognitive impairment. Adult subventricular zone (SVZ) neurogenesis, which occurs in the lateral ventricles, plays a crucial role in structural plasticity and neural circuit maintenance. Alterations in adult SVZ neurogenesis are early events in AD, and impaired adult neurogenesis is influenced by the accumulation of intracellular Aβ. Although Aβ-overexpressing transgenic 5XFAD mice are an AD animal model well representative of Aβ-related pathologies in the brain, the characterization of altered adult SVZ neurogenesis following AD progression in 5XFAD mice has not been thoroughly examined. Therefore, we validated the characterization of adult SVZ neurogenesis changes with AD progression in 2-, 4-, 8-, and 11-monthold male 5XFAD mice. We first investigated the Aβ accumulation in the SVZ using the 4G8 antibody. We observed intracellular Aβ accumulation in the SVZ of 2-month-old 5XFAD mice. In addition, 5XFAD mice exhibited significantly increased Aβ deposition in the SVZ with age. Next, we performed a histological analysis to investigate changes in various phases of adult neurogenesis, such as quiescence, proliferation, and differentiation, in SVZ. Compared to age-matched wild-type (WT) mice, quiescent neural stem cells were reduced in 5XFAD mice from 2-11 months of age. Moreover, proliferative neural stem cells were decreased in 5XFAD mice from 2 to 8 months of age. Furthermore, differentiations of neuroblasts were diminished in 5XFAD mice from 2-11 months of age. Intriguingly, we found that adult SVZ neurogenesis was reduced with aging in healthy mice. Taken together, our results revealed that impairment of adult SVZ neurogenesis appears with aging or AD progression.

• Journal of the Korean Society of Clothing and Textiles
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• v.21 no.2
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• pp.292-301
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• 1997

The purpose of this study was to consider the bodyshape factor of adult women according to their age groups. Age groups were 20's, the first half of 30's, the last half of 30's, 40's, 50's. Factor analysis was performed and bodyshape factors were abstracted at sight of front and side line of the body. Results indicate that the bodyshape factors were different to each age groups, so, age is very important component to the change of body shape of adult women. A suggestion is when they make standard sizes of women's ready-made clothes, it is important to reflect thier characteristics of body shape according to each age groups and age can be a standard to classify the body types of adult women.

• Journal of Fashion Business
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• v.10 no.1
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• pp.132-147
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• 2006

The purpose of this study is to provide for the basic data useful to the effective production and marketing of the foundation garment befitting adult women's shapes and preferences, and thereby, help them improve their apparel life. For this purpose, 563 Korean women aged between 20-59 were sampled to survey their recognition and actual wearing condition of foundation garments and positively identify the factors affecting the practices and thereupon, determine the correlations among them by age group. The raw data of this study is processed by SPSS Win(10.1) and analyzed by using frequency, percentage, $x^2$-test, ANOVA, Duncan-test. The most of adult women were aware of their foundation size and the absolute majority of them wore brassieres, while a half of them used the girdles. The adult women had 5.7 Brassieres and 2.2 Girdles. The use of the foundation depended much on user's age or seasons. They had begun to wear Brassieres at their age of 15 on an average and Girdle around their age of 19 depending their individual needs. It has been found through this study that adult women's is actual wearing condition of foundation garments differ by age group, which may well suggest that foundation production need to consideration this age-wise practices when setting up their foundation production and marketing strategies.

• Journal of Nutrition and Health
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• v.36 no.5
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• pp.491-499
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• 2003

Selenium is a strong antioxidant trace mineral, scavenging free radicals. The prevalence of chronic degenerative diseases is increasing in Korean adults with increasing age. The increased cell damage from free radicals has been implicated in the etiology of these diseases, and evidence is accumulating that the low selenium status that comes with advanced aged is involved in the prevalence of age-associated diseases. However, little is known about the selenium status of Koreans, its age-related change and its relationship to dietary nutrient intake. In this study, the serum selenium levels of healthy adult females according to life cycle and its association with blood albumin levels and nutrient intake were examined. Serum selenium level was measured with the Huwo research reactor using the neutron activation analysis method (NAA). The overall proportion of women with selenium deficiency, serum selenium concentrations below 7.0 $\mu\textrm{g}$/dl, was 9.4%. The average serum selenium levels were 12.39 $\mu\textrm{g}$/dl, 9.45 $\mu\textrm{g}$/dl and 9.16 $\mu\textrm{g}$/dl in the young adult, middle-aged and elderly groups, respectively, showing a reduction of selenium status with advancing age. Selenium deficiency was seen only in the elderly group. Generally, serum selenium levels positively or negatively correlated with nutrient intake, but these association patterns differed depending on the age. The nutrients that showed positive correlations with selenium levels were proteins and phosphate in the young adult group (p < 0.05, p < 0.05), and total calcium, potassium and vegetable-origin calcium in the middle-aged group. Vitamin C and fiber were the negative correlated nutrients with serum selenium levels in the elderly group (p < 0.05, p < 0.05). Multiple stepwise regression analysis of the determining factors responsible for selenium status showed that age and serum albumin levels were important factors which explained up to 26.9% variances in serum selenium levels. The average selenium concentrations of Korean adult female subjects were above the deficiency levels in all three age groups. There was a tendency toward decreasing selenium levels as the age of the subjects increased. The factors with the strongest in-fluence on selenium status in healthy adult Korean females were age and serum protein status. (Korean J Nutrition 36(5): 491~499, 2003)

• Journal of Nutrition and Health
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• v.19 no.4
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• pp.255-265
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• 1986

This study was designed to investigate the effect of age on the lipid metabolism in the rats fed different diets. In experiment A male Wistar rats of 5 weeks of age and of 32 weeks of age were divided into low fat diet groups and high fat-cholesterol groups. The rats were sacrificed 1 week, 2 weeks and 4 weeks after experiment begins. Also after 4 weeks. the rats in low and high fat diet groups were tube-fed 500mg of choelsterol and were sacrified 3 days later. In experiment b, male Wistar rats of 4 weeks of age and of 6 months of age were divided into 2 groups of butter and cron oil groups. And then eachgroup were divided into 2 subgroups ; meal feeding and nibbling groups . Each diet was fed for 4 weeks. In experiment A, age of the rats and experimental diets did not affect the serum cholesterol and triglycerides concentrations were higher in rats fed high fat cholesterol diet than in those fed low-fat or high -fat diets, but age of the animals had no effect on liver lipid content. The weight and cholesterol content of epidymal fat pad, however were higher in adult rats than in young ones regardless of the diets fed. When the rats were challenged with 500mg cholesterol, the rates of increase in serum and hepatic cholesterol level were higher in adult rats compared to young rats regardless of the diets . On the other hand, the rate of increase of small intestinal cholesterol content was lower in adult rats than in young rats. In experiment B, serum cholesterol and triglyceride content were relatively higher in young rats than adult ones. Stored body lipid was higher in adult rats, as judged by epididymal fat pad weight and total carcass lipid. Meal frequency and the kinds of fat in the diet did not affect the serum choelstero concentration . The serum triglyceride levels. however, was higher in butter fed rats thancron oil fed ones. The cholesterol content of live rand epididymal fat pad was lower in butter fed groups than corn oil groups for both young and adult rats, but there was no difference in liver triglycerides livel.

• Journal of the Korean Home Economics Association
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• v.44 no.8
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• pp.13-21
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• 2006

The objective of this study was to investigate the fit preference for ready-to-wear clothes(jackets and slacks) of adult men and to determine the respective differences by the age range and obesity level. The study method was a questionnaire survey with 465 male subjects aged from 20 to 59 years old. The questionnaire was composed of fit preference tendency, physical measurements, age, and occupation. The findings were as follows. 1. Regarding the fit preferred for each part of jackets and slacks, among ready-to-wears, the 'thing with some extra width' in every part was most favored, followed by the 'thing fitting perfectly'. 2. Differences were found in the fit preference tendency by the age of adult men. The fit preference tendency was higher among those in their 20's than among those of the other age ranges. 3. Differences were also found in the fit preference tendency by the obesity level of adult men. The fit preference tendency was higher in the order of the emaciation, normalcy, and obesity types. 4. The fit preference tendency was more affected by age than by obesity level. Clothing companies should consider ease to offer the proper clothing desired by consumers.

• Journal of the Korean Home Economics Association
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• v.41 no.9
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• pp.17-29
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• 2003

The objective of this study is to investigate the fit preference tendency for ready-to-wears(jackets, skirts, and slacks) of adult women and to find out the respective differences by the age range and the obesity level. The study method was the questionnaire survey with the subjects of 699 women of 20 up to 59 years of age. The questionnaire is composed of fit preference tendency, physical measurements, age, and occupation. For the data analysis, SPSS 90. program was used, and descriptive statistics, Crosstabs, ANOVA, Duncan's test, and t-test were conducted. The findings are as follows. 1. Regarding the fit preferred for each part of jackets, skirts, and slacks, among ready-to-wears, the 'thing with some extra width' in every part was most favored, followed by the 'thing fitting perfectly'. 2. The differences were found in the fit preference tendency by the age of adult women. The fit preference tendency was higher among those in their 20's than among those of the other age range, and those in their 30's and 40's preferred the clothes with less extra width in comparison with those in their 50's. 3. The differences were also found in the fit preference tendency by the obesity level of adult women. The fit preference tendency was high in the order of the emaciation, normalcy, and obesity types. 4. The fit preference tendency was found to be more affected by the obesity level than by the age. The fit preference tendency by the obesity level of each age range showed the differences in all of the age range. However, the normal type did not show the preference difference among the age ranges, in the fit preference tendency by the age range of each obesity level. Clothing manufacturing firms should understand the characteristics of consumers, such as their age, body type, extra width preferred, to provide the consumers of target market with suitable leeway, and they should design the clothing products which meet up these needs in style and silhouette.

• The Journal of Pediatrics of Korean Medicine
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• v.22 no.2
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• pp.155-170
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• 2008

Objectives : The purpose of this study was to have better data and to make efficient clinical reviews about children's growth based on two methods; X-ray of hand, and ultrasound of calcaneus. Methods : The study was composed of 100 patients(50 of boys and 50 of girls) who visited in department of pediatrics, O O university oriental hospital considering growth and their development. Bone age was measured by the TW3 method's RUS score in simple X-ray image of hand and bone density through ultrasonic image of calcaneus. To predict children's estimated height, their parent's height, bone age, and present height's percentile was measured. Results and Conclusions : 1. The bone age results from X-ray image of hand and ultrasonic image of calcaneus were correlated. Younger children have older bone age from hand's X-ray than the one from calcaneus's ultrasound. Older children have older bone age from calcaneus's ultrasound than one from hand's X-ray. 2. Predicted adult height by bone age(BH) of hand's X-ray and BH of calcaneus's ultrasound were correlated, but predicted adult height by inheritance(IH) was not correlated with others. 3. Bone age and predicted adult height were correlated with age, height, weight, BMI, and especially with age and height. 4. Measuring bone age by X-ray image of hand and ultrasonic image of calcaneus was simple and effective way of estimating children's growth and development.

• Childhood Kidney Diseases
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• v.21 no.2
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• pp.61-68
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• 2017

Purpose: To investigate differences in clinical features, blood/urinary findings, and prognosis in different age groups of patients with Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP). Methods: A total of 469 patients with HSP were analyzed retrospectively from June 2003 to February 2016. We classified patients into child or adult groups based on their age. Results: The adult group had more patients with anemia (child vs. adult; 7.5% vs. 16.4%), and higher immunoglobulin A (IgA) (30.0% vs. 50.0%) levels, C-reactive protein (34.2% vs. 54.0%) and uric acid (3.1% vs. 12.1%) levels than the child group. The child group was highly positive for Mycoplasma pneumoniae immunoglobulin M (IgM) (34.4%). More patients in the child group presented with high levels of antistreptolysin O (24.7% vs. 2.9%) and high C4 (11.5% vs. 4.2%). Low C3 (1.1% vs. 10.2%) levels, and renal involvement with gross hematuria (8.6% vs. 21.5 %), nonnephrotic proteinuria (1.1% vs. 11.2%), and nephrotic syndrome (1.1% vs. 6.0%) were common in the adult group. Adults also had poorer renal outcomes [persistent hematuria/proteinuria (10.5% vs. 32.8%), and chronic kidney disease (0% vs. 11.2%)] than the child group. Risk factors for renal involvement such as older age and higher level of uric acid were only found in the child group. The risk factors for poor renal outcome were nephrotic syndrome in the child group and gross hematuria in the adult group. Conclusion: In this study, child and adult groups presented with different clinical manifestations of HSP. We found that risk factors for renal involvement included age and high uric acid level in the child group. Moreover, nephrotic syndrome in the child group and gross hematuria in the adult group increased the risk of poor renal outcome.

• Journal of Fashion Business
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• v.2 no.3
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• pp.98-108
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• 1998

The purpose of this study is to provide for the basic data useful to the effective production and marketing of the foundation garments befitting adult women's body shapes and preferences, and thereby, help them improve their apparel life. For this purpose, 563 Korean adult women aged between 20-59 were sampled to survey their recognition and actual wearing condition of foundation garments and positively identify the factors affecting the practices and thereupon, determine the correlations among them by age group. Data is processed by a computer (SAS) and analyzed by using frequency, percentage, ${\chi}^2$-test, ANOVA, Duncan-test. The main results of this study are as follows; 1. The most of the adult women were aware of the basic underwear terminologies and the absolute majority of them wore brassieres, while a half of them used the girdles. In contrast, only a small portion of them wore body suites or waste-nippers and the absolute minority of them had garterbelts. 2. The use of the foundations depended much on users' ages or seasons. They had begun to wear brassieres and girdles at their age of 15 on average, and bodysuites, waist-nippers or garterbelts around their age of 20 depending on their individual needs. 3. The adult women had 3-6 brassieres and 2-3 girdles on average, but only a minority of them owned one or two body suites, waist-nippers or garterbelts. They had ever used the functional foundations (11.5%) or imported foundations (35.9%), It has been found through this study that adult women's recognition and actual wearing condition of their foundation garments differ by age group, which may well suggest that foundation production need to take such age-wise practices into consideration in setting up their foundation production and marketing strategies.