• Journal of Korean Society for Quality Management
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• v.50 no.3
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• pp.517-532
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• 2022

Purpose: The purpose of this study is to propose useful suggestions by analyzing causal effect relationship between perceived usefulness (PU), perceived ease-of-use (PEOU), symbolic adoption (SA) which have four constructs, and ATCIS-II usage in mandatory context. Methods: Based on prior research, a research model was constructed using the variables of Technology Acceptance Model (TAM), the symbolic adoption theory, and the post-adoptive behavior variables. A structured questionnaire was conducted for those who use ATCIS-II in Republic of Korea Army (ROKA), and a total of 183 usable responses were collected and empirically analyzed using SmartPLS 3.3.9. Results: The results of this study are as follows; PEOU have a significant effect on PU and two constructs of SA (heightened enthusiasm, effort worthiness). PU have a significant effect on every construct of SA (heightened enthusiasm, mental acceptance, effort worthiness, use commitment). In addition, it was found that heightened enthusiasm have a significant effect on both expanded usage and exploratory usage. Also, mental acceptance and use commitment have a significant effect on exploratory usage. Conclusion: The findings of this empirical study have implications for proposing SA can explain mandated user's behavior and giving possible way that improve organization performance which adopt Information System (IS) by motivating end-user to extend IS's feature and explore new ways of using IS at work.

• The Journal of the Korea Contents Association
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• v.12 no.4
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• pp.407-416
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• 2012

The primary purpose of this paper is to identify the development of education and training for the human resource development in the view of technology management. For this purpose, a research is developed based on the relevant literature reviews and empirical studies. Data have been collected from 110 firms in Daejeon city and tested by the frequency analysis and various statistical methods. The results of this empirical studies are summarized as follows. We classified in company competitive power as innovators, leading chasers and late chasers. The innovators, leading chasers and late chasers demanded the management of technology. They also demanded the middle manager, the CEO and R&D researchers as a important position in this demanding of the management of technology and its human resources of the market and technologies. Department of marketing and the executives and staff members find it important. We departmentalized the management of technology with the Daejeon region's strategic industries. Information technology(IT) industries thought that the middle manager, CEO and R&D department were important. Bio-industries thought that the CEO and the middle manager and R&D department were important. The high-tech parts materials industries thought that the middle manager, R&D department and marketing department considered as important.

• IMMUNE NETWORK
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• v.22 no.5
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• pp.40.1-40.24
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• 2022

Mesenchymal stem cells (MSCs) are attractive alternatives to conventional anti-asthmatic drugs for severe asthma. Mechanisms underlying the anti-asthmatic effects of MSCs have not yet been elucidated. This study evaluated the anti-asthmatic effects of intravenously administered MSCs, focusing on macrophages and monocytes. Seven-week-old transgenic (Tg) mice with lung-specific overexpression of IL-13 were used to simulate chronic asthma. MSCs were intravenously administered four days before sampling. We examined changes in immune cell subpopulations, gene expression, and histological phenotypes. IL-13 Tg mice exhibited diverse features of chronic asthma, including severe type 2 inflammation, airway fibrosis, and mucus metaplasia. Intravenous administration of MSCs attenuated these asthmatic features just four days after a single treatment. MSC treatment significantly reduced SiglecF^-CD11c^-CD11b⁺ monocyte-derived macrophages (MoMs) and inhibited the polarization of MoMs into M2 macrophages, especially M2a and M2c. Furthermore, MSCs downregulated the excessive accumulation of Ly6c^- monocytes in the lungs. While an intravenous adoptive transfer of Ly6c^- monocytes promoted the infiltration of MoM and Th2 inflammation, that of MSC-exposed Ly6c^- monocytes did not. Ex vivo Ly6c^- MoMs upregulated M2-related genes, which were reduced by MSC treatment. Molecules secreted by Ly6c^- MoMs from IL-13 Tg mice lungs upregulated the expression of fibrosis-related genes in fibroblasts, which were also suppressed by MSC treatment. In conclusion, intravenously administered MSCs attenuate asthma phenotypes of chronic asthma by modulating macrophages. Identifying M2 macrophage subtypes revealed that exposure to MSCs transforms the phenotype and function of macrophages. We suggest that Ly6c^- monocytes could be a therapeutic target for asthma management.