• Journal of Sasang Constitutional Medicine
• /
• v.12 no.2
• /
• pp.184-194
• /
• 2000

1.Purpose This study was researched in order to investigate the effect of Hyungbangdojucksan-Gami and Kamsuchunilhwan on the obesity in rats. 2. Methods The rats were divided into 10 groups - The normal group fed with normal diet. One of the sample groups fed with high fat diet, and since fifth week had fed with Hyungbangdojucksan-Gami. The other sample groups fed with high fat diet, and since fifth week had fed with Kamsuchunilhwan. The control group fed with high fat diet, and since fifth week had fed sodium chloride. 3. Results 1. The rate of increasing weight was significantly decreased after oral administration of Hyungbangdojucksan-Gami and Kamsuchunilhwan. 2. The rate of feeding effect was not significantly decreased after oral administration of Hyungbangdojucksan-Gami and Kamsuchunilhwan. 3. After oral administration of Hyungbangdojucksan-Gami, the quantities of total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride on the serum were significantly decreased but that of lipid peroxide on the serum was significantly increased. 4. After oral administration of Kamsuchunilhwan., the quantities of glucose, total cholesterol, LDL cholesterol and triglyceride on the serum were significantly decreased but those of HDL cholesterol, lipid peroxide on the serum were significantly increased. 4.Conclusion Hyungbangdojucksan-Gami and Kamsuchunilhwan have significant effects on the obesity in the rats.

• Journal of Dental Anesthesia and Pain Medicine
• /
• v.18 no.2
• /
• pp.89-95
• /
• 2018

Background: Incorrect administration of an anesthetic during local anesthesia is one of the most important causes of pain symptoms in patients scheduled for dental procedures. The current study assessed the severity of damage to periodontal tissue following different rates of anesthetic administration. Methods: The research was conducted on 50 outbred male rats with a body mass of 180-240 g. The anesthetic used was 1% articaine. Results: The results showed that administration of the anesthetic at a rapid pace caused structural damage to the periodontal tissue. Further, signs of impaired microcirculation were noted at all rates of administration. Biochemical studies demonstrated changes in the level of glucose and enzymes with the rapid introduction of the anesthetic, indicating severe systemic stress response of the body. Conclusions: Injection of local anesthetic at any rate of introduction induces vascular congestion in the microcirculatory bloodstream and exudative reactions. Rapid introduction of an anesthetic causes progression of structural changes in the gingival tissue.

• Journal of Biosystems Engineering
• /
• v.25 no.3
• /
• pp.227-232
• /
• 2000

A natural air in-bin grain dryer with a grain circulator was developed for on farm use. Natural air drying test for rough rice was carried out to evaluate drying rate, uniformity of moisture content distribution in grain bed and energy consumption. It took 10 days to dry 8 ton of paddy rice from 21.9%(w.b) of moisture contents to 16.7%(w.b), by prototype dryer and the average drying rate was 0.52%/day. The uniformity of moisture content after drying was superior to a conventional natural air dryer in which grains were not mixed during drying periods. The dryer performance evaluation index was 738.3kJ/(kg.water), which was more effective than that of grain circulation type hot air dryer(3,500∼5,000 kJ/kg.water)

• The Journal of Fisheries Business Administration
• /
• v.38 no.2
• /
• pp.1-24
• /
• 2007

The improvement and richness of research in a particular domain are fundamentally based on their own various research topics and scientific or systematic research methodology. Especially considering fisheries business administration as a branch of business administration, the interdisciplinary concept will be a important factor in the research of fisheries business administration. This study analyzes fisheries business administration research through bibliometric analysis and meta-analysis to examine meta-data including research trends, researcher characteristics, and keywords. The 225 source articles are all papers published from 1990 to 2006 in the Journal of Fisheries Business Administration Society of Korea. Comparing previous research from the 80s, the major areas of Korean fisheries business administration research have changed and the rate of co-researched papers has also increased. In keyword-based meta-analysis, the topics of recent research are well balanced and diversified but some structural and editorial problems still remain. The result from meta-data and bibliometric information gathered in this study will help create guidelines for carrying out further rigorous research and enhancing the quality of research in fisheries business administration.

• Journal of Microbiology and Biotechnology
• /
• v.34 no.4
• /
• pp.828-837
• /
• 2024

Vancomycin (VAN) and metronidazole (MTR) remain the current drugs of choice for the treatment of non-severe Clostridioides difficile infection (CDI); however, while their co-administration has appeared in clinical treatment, the efficacy varies greatly and the mechanism is unknown. In this study, a CDI mouse model was constructed to evaluate the therapeutic effects of VAN and MTR alone or in combination. For a perspective on the intestinal ecology, 16S rRNA amplicon sequencing and non-targeted metabolomics techniques were used to investigate changes in the fecal microbiota and metabolome of mice under the co-administration treatment. As a result, the survival rate of mice under co-administration was not dramatically different compared to that of single antibiotics, and the former caused intestinal tissue hyperplasia and edema. Co-administration also significantly enhanced the activity of amino acid metabolic pathways represented by phenylalanine, arginine, proline, and histidine, decreased the level of deoxycholic acid (DCA), and downregulated the abundance of beneficial microbes, such as Bifidobacterium and Akkermansia. VAN plays a dominant role in microbiota regulation in co-administration. In addition, co-administration reduced or increased the relative abundance of antibiotic-sensitive bacteria, including beneficial and harmful microbes, without a difference. Taken together, there are some risks associated with the co-administration of VAN and MTR, and this combination mode should be used with caution in CDI treatment.

• Korean Journal of Agricultural Science
• /
• v.44 no.4
• /
• pp.558-565
• /
• 2017

This study was conducted to determine the effect of inoculation of microorganism isolated from pig feces on nutrient contents of fermented hulless barley. The microbial flora in feces of a total of four crossbred piglets ($Landrace{\times}Yorkshire{\times}Duroc$) was analyzed by 16s rRNA sequencing. The most abundant strain was then selected for fermentation of hulless barley. Lactobacillus plantarum (L. plantarum) was dominant (64.56%) in intestinal microbial flora in the pig feces. The selected candidate strain showed significantly higher survival rate at pH 7 than at pH 2.5 and 3.0 (p < 0.05). Incubated culture containing the candidate strain showed an increased growth rate with lower pH levels after 7.5 h incubation compared to initial incubation period (p < 0.05). When compared with commercial multiple probiotics which were used as control, the selected strain showed faster growth rate at 5 h post-incubation (p < 0.05). During the fermentation period, neither inoculated nor non-inoculated control hulless barley showed any change in pH value. Crude fat, fiber and ash contents were lower (p < 0.05) in hulless barley inoculated by the selected strain compared to control. However, moisture, energy, NDF and ADF were not affected by the inoculation of strain or fermentation period. Lactic acid was increased and acetic acid was decreased in the hulless barley inoculated with the selected strain during the fermentation period (p < 0.05). Taken together, our results suggest that L. plantarum derived from the pigs could be utilized as a new microorganism for manufacturing fermented feed stuffs.

• Journal of fish pathology
• /
• v.10 no.2
• /
• pp.143-152
• /
• 1997

The effect of $\beta$-glucan as an immunostimulant to increase resistance to bacterial diseases by enhancing non-specific defense mechanism in rockfish (Sebastes schlegeli) was examined by oral and bath administration. After oral or bath administration with $\beta$-glucan, the injection challenges with Vibro ordalii, Staphylococcus epidermidis and Edwardsiella tarda were performed to assess $\beta$-glucan efficacy. After injection of V. ordalii, oral administration for 30 days with 1% $\beta$-glucan showed 25% of survival rate. But all control fish died within 3 days after the injection. After injection of S, epidermidis, oral administration group for 20 and 30 days showed a remarkably increased survival rate of 95%. But oral administration of $\beta$-glucan to rockfish did not induce protection against experimental E. tarda infection. $\beta$-Glucan bath administration with or without formalin-killed V. ordalii showed that no protection was observed at 10 days after challenge. The results show that $\beta$-glucan to rockfish was effective to increase survival rate of bacterial infections of S. epidermidis and V. ordalii but not against E. tarda.

• The Korean Journal of Pesticide Science
• /
• v.12 no.3
• /
• pp.229-235
• /
• 2008

Lack of honey bee toxicity data for most pesticide products used for strawberry restricts to predict the adverse effects to foraging honey bee after treatment of pesticide in plastic house. This study was conducted to evaluate the actual risk of worker honey bees (Apis mellifera L.) through acute contact toxicity test, acute oral toxicity test and toxicity of residues on foliage test with 21 pesticide products. The mortality of honeybee sprayed with 6 pesticides including dichlofluanid WP showed significantly different from control at recommended application rate in acute contact toxicity test at 24 hours after treatment. Fenpropathrin EC and milbemectin EC treatment groups showed more than 25% mortalities at recommended application rate in acute oral toxicity test. In toxicity of residues on foliage test, only fenpropathrin EC treatment group showed more than 25% mortalities at 10 days after treatment at recommended application rate. It was concluded that the most toxic route to exposure for honey bee is direct contact exposure to sprayed pesticides. Safety interval for honey bee was established by concerning the results of these tests.

• Korean Journal of Plant Resources
• /
• v.37 no.3
• /
• pp.263-269
• /
• 2024

Embryos of early-ripening peaches could not achieve physiological maturation or undergo abortion before harvest. Embryo rescue is an effective strategy to rescue embryos from early-ripening peaches. Thus, the current study was carried out to determine the appropriate developmental stage and optimal medium composition for embryo rescue in early-ripening peach. Development of open-pollinated 'Yumi' fruit was investigated from 20 to 90 days after full bloom (DAFB) to explore period occurring endocarp hardening. After endocarp hardening, embryo development was observed by light microscopes. Shoot and root meristems were observed at 65 DAFB and embryo size rapidly increased at 75 DAFB. Embryos collected at 75, 80, 85, and 90 DAFB were cultured on four media based on Driver and Kuniyuki (DKW) medium. Germination rate of embryos cultured on four media gradually increased from 75 to 90 DAFB and reached 100% at 90 DAFB. Notably, M3 medium (0.5 DKW supplemented with 6-benzylaminopurine (BAP) 1.0 ㎎/L) displayed the highest germination rate at 75 and 80 DAFB stages. Growth and development of shoot and root were pronounced in plantlet cultured at 90 DAFB stage. While delayed shoot growth was evident in plantlets cultured at 75, 80, and 85 DAFB stages, this retardation could be overcome through the application of growth regulators, particularly in M3 and M4 (0.5 DKW supplemented with BAP 1.0 ㎎/L and indole-3-butyric acid 0.5 ㎎/L) media. Remarkably, roots of plantlet grown in M4 medium exhibited limited elongation. In conclusion, germination rate of embryo and growth of embryo cultured plantlet can be enhanced by collecting seeds from early-ripening 'Yumi' at the 90 DAFB stage and conducting embryo culture using the M3 medium.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
• /
• 2003.11a
• /
• pp.71-73
• /
• 2003

본 연구에서는 안정 상태에서 일반 공기 중에 산소 농도(21％) 환경에 비해 외부에서 고 농도(35％)의 산소 공급이 혈중 산소 포화도(SPO2), 심박동율(Heart rate), 피부전도도(Galvanic skin response)에 어떠한 영향을 미치는지를 검증하고자 한다. 35％의 고농도 산소를 2L/min의 양으로 일정하게 공급할 수 있는 산소 공급 장치를 이용하였고, 뇌 질병이 없는 5명의 대학생들이 피험자로 참여하였다. 21％의 비해 35％ 산소 농도에서 모든 실험 참여자의 3분 동안의 평균 심박동율은 감소하였고 평균 혈중 산소 포화도는 증가하였다. 그러나 피부전도도는 차이가 없었다.