• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 춘계학술대회 논문집
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• pp.43-44
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• 2003

The subacute toxicity and toxicokinetics of a type IV phosphodiesterase inhibitor, CJ-10882, were evaluated after single (on the 1st day) and 4-week (on the 27th day) oral administration of the drug, in doses of 0 (to serve as a control), 2, 10 and 50 mg/kg/d, to male and female dogs (n = 3 for male and female dogs for each dose). During the test period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross findings, organ weight and histopathology were examined.(omitted)

• 한국환경보건학회지
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• 제15권2호
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• pp.85-95
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• 1989

An experimental study on the selenium effects on toxicity of lead (4ppm intraperitoneal injection) in adult male rats of Spragne-Dawley strain was performed. This study was carried out to reveal the selenium effects concerning treatment and prevention of lead intoxication and differences of the selenium effects according to the administration method between oral and subcutanous. The changes of body weight, liver and kidney weight per body weight, hemoglobin values, hematocrit values, TBA values in serum, and $\delta$-ALAD activity in blood were determined. The results were as follows 1. There were no significant differences among groups about the change of body weight. 2. In the liver weight per body weight, the group of Pb administration after the oral administration of selenium was significantly high, different from the group of Pb administration alone (p < 0.05). 3. There .were no significant differences among groups about the kidney weight per body weight. 4. On the hemoglobin values, the group of Pb administration with selenium was significantly high,different from the group of Pb administration alone (p < 0.05). 5. There were no significant differences among groups about the hematocrit values. 6. On TBA values in serum, all the selenium treated groups were significantly low different from the group of Pb administration alone (p < 0.01). 7. On $\delta$-ALAD activity, all selenium treated groups were significantly high different from the group of Pb adminsitration alone (p < 0.01). Considering from the results of this experiment, selenium seems to reduce Pb toxicity and preventive administration of selenium seems to be also effective. And the difference of selenium effect according to the administration method between oral and subcutaneous could not be found.

• 생약학회지
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• 제32권1호통권124호
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• pp.72-78
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• 2001

This study was performed to elucidate the influence on the plasma decursinol concentration after administration of combined decursin and Cnidii Rhizoma or decurisin and Bupleuri Radix extracts in comparison with single decursin administration. The identification of decursinol isolated from Angelica gigas was carried out by GC/MS and the concentration of decursinol in the plasma after oral administration was determined by HPLC. The value of area under the plasma concentration (AUC) and the maximal concentration (Cmax) of decursinol after administration of methanol and ether Angelicae Gigantis Radix extract was higher than those of single decursin-treated group. It was also found that the AUC and the Cmax of decursinol after combined administration with decursin and Cnidii Rhizoma were higher than those of decursin administration, whereas those of combined with decursin and Bupleuri Radix was lower. Moreover, the studies were performed with decursinol only or with combined decursinol and Cnidii Rhizoma/Bupleuri Radix, both of combined treatment increased the plasma decursinol concentrations compared with decursinol-treated group in rats. On the basis of these results, it is concluded that co-existing substances or co-administration with other drugs may influence the plasma levels of decurisinol after oral administration.

• Journal of Oral Medicine and Pain
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• 제20권1호
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• pp.127-131
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• 1995

A patient who showed atypical orofacial pain after an endodontic treatment for a long time, was treated with non-analgesics such as vitamin $B_1, B_2, $ and Oral Balance, moisturizing gel. 1. It is important to manage xerostomic condition properly in the treatment of patients who have atypical orofacial pain 2. Simultaneous administration of vitamin $B_1 and B_2$ was effective in increasing pain threshold of the patient.

• 대한의생명과학회지
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• 제8권3호
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• pp.167-172
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• 2002

Effect of single administration of Polygala tenuipolia was examined on short-term memory in step through test and the intensity of the immunoreactive c-Fos protein induced by oral administration of ethanol. The acquisition of memory was significantly reduced by ethanol, and ethanol amnesia was remarkably reversed following oral administration of Polygala tenuifolia. c-Fos protein in normal rat brain was highly expressed in order of thalamus, pariental cortex, hippocampus, hypothalamus, amygdaloid and cingulate cortex. The expression of Fos protein was remarkably suppressed by single administration of ethanol. The inhibitory effect of ethanol on expression of Fos protein was reversed by single administration of Polygara tenuipolia, especially tissues of limbic areas such as amygdala, parietal cortex and CA3 of hippocampus. These results suggested that the amelioration process of Polygala tenuipolia on ethanol amnesia seems to be involve the expression of c-Fos protein in partly.

• Journal of Pharmaceutical Investigation
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• 제18권1호
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• pp.1-3
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• 1988

Effect of hydrochlorothiazide on serum potassium level was studied in the hypokalemia-induced rats by the oral administration of glycyrrhiza extract (GE) for 4 weeks. According to the concentration of GE, serum potassium levels were found to be $5.8{\pm}0.2,\;5.4{\pm}0.2\;and\;5.5{\pm}0.2\;mM/l$ after oral administration of 0.1, 0.2 and 0.5% GE solutions for 4 weeks, respectively, comparing $6.4{\pm}0.2\;mM/l$ in normal rats. The i.p. administration of hydrochlorothiazide (100mg/kg) showed no significant difference $(5.1{\pm}0.3-5.2{\pm}0.3\;mM/l)$ in the decrease of serum potassium levels between these hypokalemia-induced rats and normal rats, regardless of the concentration of pretreated GE solutions. Therefore it was considered that the administration of hydrochlorothiazide did not worsen the hypokalemia induced by the long term administration of GE in rats.

• Journal of Dental Anesthesia and Pain Medicine
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• 제20권5호
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• pp.281-291
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• 2020

Background: Corticosteroids have been widely used by oral surgeons for reducing swelling caused by wisdom teeth surgery. However, they have not been proven to decrease pain. This study was aimed at analyzing previous studies pertaining to corticosteroids and pain reduction following wisdom teeth surgery. Methods: The Science Direct, PubMed, and MEDLINE databases were searched for relevant journals according to a systematic search strategy (Patient Intervention Comparison Outcome Study). Randomized controlled trials published in English from 1998 to 2017 were extracted. Results: Twenty-seven articles were included, with a total of 36 comparative cases. Methylprednisolone and dexamethasone were the most commonly used corticosteroids. Intramuscular injections of corticosteroids were optimal for pain reduction, regardless of the time of administration. Conclusions: Corticosteroids can be used as an adjuvant for pain reduction following wisdom teeth surgery. Methylprednisolone and dexamethasone delivered via the intramuscular route is the best method for effective pain reduction. The ideal time for administration of corticosteroids is the preoperative period.

• 대한치과의료관리학회지
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• 제9권1호
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• pp.44-50
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• 2021

Owing to the Corona virus (COVID-19) crisis, virtual education has been expanded. Accordingly, this study was conducted to determine the direction of oral health education by examining participants' satisfaction with virtual education and educational media preferences. This study collected data from a Naver Form online survey targeting 290 university students across the country, from May 10 to 31, 2021. The collected data were analyzed using IBM SPSS 20.0. According to the data, satisfaction with virtual classes was 3.36 points in 5-point Likert scale, satisfaction factors were reduced commuting time and money expenditure, and the highest dissatisfaction factor was a decrease in lecture concentration. The media platform that most interested students pursing oral health education was YouTube. The oral health education that participants wished to receive through virtual education included how to prevent tooth decay, how to prevent gum disease, and how to brush teeth. In conclusion, it is necessary to develop various media like Zoom, YouTube, and virtual reality programs so that students feel motivated to utilize oral health education and improve oral health.

• International Journal of Oral Biology
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• 제38권4호
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• pp.135-140
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• 2013

이상의 실험 결과들을 요약하면, 포르말린을 측두하악관절 내로 주입하여 발생한 염증성 통증 행위반응은 QX-314의 투여로 감소할 수 있었다. 저농도의 QX-314의 진통작용은 TRPV1 통로를 이용하여 세포막 내로 이동하여 작용이 나타났으며 고농도의 QX-314는 TRPV1 통로와 무관하게 진통작용을 나타내었다. 이와 같은 결과는 측두하악관절 장애로 인해 발생되는 염증성 통증에 QX-314가 효과적인 치료제로 사용할 수 있다는 것을 말해주며, 특히 고농도의 QX-314가 세포막을 이동하는 경로에 대한 연구가 더 진행된다면 임상에서 QX-314가 진통제로서 사용할 수 있는 계기가 될 것으로 판단된다.

• IMMUNE NETWORK
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• 제13권4호
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• pp.157-162
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• 2013

Application of vaccine materials through oral mucosal route confers great economical advantage in animal farming industry due to much less vaccination cost compared with that of injection-based vaccination. In particular, oral administration of recombinant protein antigen against foot-and- mouth disease virus (FMDV) is an ideal strategy because it is safe from FMDV transmission during vaccine production and can induce antigen-specific immune response in mucosal compartments, where FMDV infection has been initiated, which is hardly achievable through parenteral immunization. Given that effective delivery of vaccine materials into immune inductive sites is prerequisite for effective oral mucosal vaccination, M cell-targeting strategy is crucial in successful vaccination since M cells are main gateway for luminal antigen influx into mucosal lymphoid tissue. Here, we applied previously identified M cell-targeting ligand Co1 to VP1 of FMDV in order to test the possible oral mucosal vaccination against FMDV infection. M cell-targeting ligand Co1-conjugated VP1 interacted efficiently with M cells of Peyer's patch. In addition, oral administration of ligand-conjugated VP1 enhanced the induction of VP1-specific IgG and IgA responses in systemic and mucosal compartments, respectively, in comparison with those from oral administration of VP1 alone. In addition, the enhanced VP1-specific immune response was found to be due to antigen-specific Th2-type cytokine production. Collectively, it is suggested that the M cell-targeting strategy could be applied to develop efficient oral mucosal vaccine against FMDV infection.