• 제목/요약/키워드: Administration department

검색결과 16,297건 처리시간 0.049초

METHAMPHETAMINE-INDUCED CYTOTOXICITY IN HUMAN SEROTONERGIC CELLS

  • Kim, Kyu-Bong;Suh, Soo-Kyung;Lee, Bo-Kyung;Park, Chang-Won;Seo, Kyung-Won;Kim, Jong-Won;Kim, Kwang-Jin;Kim, Jae-Hee;Park, Chan-Woong
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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    • pp.190-190
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    • 2002
  • Methamphetamine (META) is a psychostimulant and has become popular recreational drug of abuse in many countries. The neurotoxic damage caused by METH is characterized by degeneration of the dopaminergic and serotonergic systems in striatum and hippocampus.(omitted)

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Agronomic and Chemical Properties of a New Black Waxy Giant Embryo Mutant, Milyang 263, in Rice (Oryza sativa L.)

  • Park, Dong-Soo;Park, Soo-Kwon;Yi, Gihwan;Hwang, Un-Ha;Kim, Sang-Min;Han, Sang-Ik;Seo, Woo-Duck;Lee, Jong-Hee;Cho, Jun-Hyun;Song, You-Chun;Yeo, Un-Sang;Jang, Ki-Chang;Kwon, Taek-Min;Nam, Min-Hee;Park, Sung-Tae;Kang, Hang-Won
    • 한국육종학회지
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    • 제42권5호
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    • pp.463-469
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    • 2010
  • Rice is a staple food for more than 50% of the world's population. Embryo comprises only 2 to 3% of the weight distribution of the entire pericarp but has higher concentration of vitamins, proteins, and essential fatty acids than the other parts of grains. Moreover, ${\alpha}$-tocoperol, ${\gamma}$-oryzanol, phytic acid and ${\gamma}$-aminobutric acid that have nutraceutical value are abundant. Increasing the volume of embryo assures the fortification of nutritional value of rice grain. We developed new black waxy giant embryo rice, Milyang 263 by crossing Josaengheugchal, a black waxy rice variety, and $ge^t$, a giant embryo mutant generated by tissue culture. The nutrient contents and physical properties of Milyang 263 were compared with several giant embryo mutants and normal embryo rice varieties. Changes in the nutrient properties after germination were also observed. Results indicated that this new black waxy giant embryo rice, Milyang 263, offers a promising source for improving nutritional quality of rice especially anthocyanin, essential minerals, and GABA.

THE EFFECTS OF TCDD ON THE TRANSFORMATION AND MICRONUCLEUS FORMATION IN CHANG LIVER, HACAT AND MCF10A CELLS

  • Haikwan Jung;Park, Miyoung;Miok Eom;Hoil Kang;Park, Misun;Seungwan Jee;Taikyung Ryeom;Hyeyoung Oh;Kim, Okhee
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.154-154
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    • 2001
  • 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin(TCDD), a prototype of many halogenated aromatic hydrocarbons, is a ubiquitous, persistent environmental contaminant and the most powerful carcinogen categorized by IARC. Despite extensive research, the mechanisms of TCDD-induced carcinogenesis are poorly understood, and its carcinogenic potential in human is not clear.(omitted)

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Identification of New Isolates of Phytophthora sojae and Selection of Resistant Soybean Genotypes

  • Su Vin Heo;Hye Rang Park;Yun Woo Jang;Jihee Park;Beom Kyu Kang;Jeong Hyun Seo;Jun Hoi Kim;Ji Yoon Lee;Man Soo Choi;Jee Yeon Ko;Choon Song Kim;Sungwoo Lee;Tae-Hwan Jun
    • The Plant Pathology Journal
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    • 제40권3호
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    • pp.329-335
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    • 2024
  • Phytophthora root and stem rot (PRR), caused by Phytophthora sojae, can occur at any growth stage under poorly drained and humid conditions. The expansion of soybean cultivation in South Korean paddy fields has increased the frequency of PRR outbreaks. This study aimed to identify four P. sojae isolates newly collected from domestic fields and evaluate race-specific resistance using the hypocotyl inoculation technique. The four isolates exhibited various pathotypes, with GJ3053 exhibiting the highest virulence complexity. Two isolates, GJ3053 and AD3617, were screened from 205 soybeans, and 182 and 190 genotypes (88.8 and 92.7%, respectively) were susceptible to each isolate. Among these accessions, five genotypes resistant to both isolates were selected. These promising genotypes are candidates for the development of resistant soybean cultivars that can effectively control PRR through gene stacking.

국내 의약품 첨가제 정보체계 연구 (Survey and Classification of Pharmaceutical Excipients)

  • 박인숙;박상애;김은정;박효민;홍정희;정주연;김호정;이지현;한의식;강신정;이선희
    • Journal of Pharmaceutical Investigation
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    • 제36권4호
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    • pp.239-243
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    • 2006
  • Due to the development of new dosage forms and the improvement or pharmaceutics, the pharmaceutical excipients have become more specified and diverse, and the reclassification on them became necessary. Also with the increasing interests on the kinds and usage amount, related provisions, and evaluation of the pharmaceutical excipients, the systemic and effective control of them was in its demand. Therefore, in this research, we provided the following information on excipients: the type, amount and specification. In order to provide the information, we investigated, analysed and summarized the excipients that are approved by KFDA and published $\ulcorner$Handbook of Pharmaceutical Excipients$\lrcorner$). This handbook is expected to be used as a reference in the development of the pharmaceutics and evaluation in them. As the importance of excipients in pharmaceutics are increasing, IPEC which consist of IPEC-America, IPEC-Europe and JPEC, PDG and ICH have tried to make an international harmonization on excipient. This current status was not an exception to Korea, therefore, the result of this research is expected to make a progress in the evaluation on the excipients to an advanced level.