• 한국환경성돌연변이발암원학회지
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• 제26권4호
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• pp.125-132
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• 2006

Previous studies showed that epigallocatechin gallate(EGCG) have substantial effects of suppressing the N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)-initiated cell transformation process on the bases of foci formation frequency and loss of anchorage dependency. In this study we tried to clarify the molecular mechanism of suppressing the cell transformation process. Mouse cell line balb/c 3T3 A31-1-1 was exposed 2 days to MNNG followed by 15 days 12-O-tetradecanoylphorbol-13-acetate(TPA) treatment for our transformation process. EGCG was added after the time point of 24 hours exposure to TPA and incubated for 19 days. 2029 genes were selected in our transformation process that showed fold change value of 1.5 or more in the microarray gene expression analysis covering the mouse full genome. These genes were found to be involved mainly in the cell cycle pathway, focal adhesion, adherens junction, TGE-$\beta$ signaling, apoptosis, lysine degradation, insulin signaling, ECM-receptor interaction. Among the genes, we focused on the 631 genes(FC>0.5) reciprocally affected by EGCG treatment. Our study suggest that EGCG down-regulate the gene expressions of up stream signaling factors such as nemo like kinase with MAPK activity and PI3-Kinase, Ras GTPase and down stream factors such as cyclin D1, D2, H, T2, cdk6.

• International Journal of Quality Innovation
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• 제8권3호
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• pp.173-187
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• 2007

Many 6-sigma innovation companies are obtaining ISO9000 series or ISO/TS16949 certifications. However, not many of them have considered the integrated management of ISO/TS16949 at the time of 6-sigma introduction. ISO/TS16949 focuses on the process of an overall company. In particular, APQP (Advanced Product Quality Planning) requires that from the beginning all the planning should have a clear quality planning business process. Each company can decide the best course of action to suit its individual needs. Lean DFSS in 6-sigma offers the concrete development steps of the product development process. And if analyses of Input, Output, Target, Process, KSF, KPI, and FMEA is done in each process and clearly defined in APQP, mutual organic and effective systems can be initially achieved.

• 간호행정학회지
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• 제12권2호
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• pp.287-294
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• 2006

Purpose: The purpose of this study was to identify the change of critical thinking disposition and problem solving process in students who experienced problem-based learning. Method: This research design was one group pre-post test design. Twenty-five nursing students who participated in ‘'Nursing Process' course with two PBL packages for a semester in 2004 were the subjects of this study. The data were analyzed by repeated measures of ANOVA, and content analysis. Result: The problem defining in problem solving process was improved significantly, but there was no significant difference in the critical thinking disposition. Conclusion: The results of this study suggest that PBL has a positive effect on nursing students' problem solving process, But for a more significant effect on a continuous base for critical thinking of nursing students, faculties should use web based and simulation-based education for self directed learning along with clinical situation-based scenarios.

• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2003년도 추계학술대회
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• pp.167-174
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• 2003

BPO(Business Process Outsourcing) is defined as outsourcing the management and operation of the IT intensive business process to another company that has specialty in managing the process. In the outsourcing arrangement, the design of the effective control mechanisms is essential to the success of the outsourcing. The purpose of this study is to investigate the effective control mechanisms between two organizations in a BPO arrangement. The specific research questions put forth are as follows: (1)What are the control issues in relation to BPO? (2)How the control mechanisms in the successful BPO arrangement are designed? and (3)What kind of effect or change do the designed control mechanisms have on the buyer's job process in terms of BPO? The results of this study found that the following mechanisms are effected in BPO setting: (1)Automation (2)Standardization & Modularity (3)Embedding (4)Balanced control (5)control segmentation (6)hierarchy (7)output/behavior control 8)back-end control 9)informal control.

• 안보군사학연구
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• 통권3호
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• pp.169-196
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• 2005

The point of Bush administraion’s foreign policy is to support the promotion and stability of Democracy in Iraq and counter terrorism and spread of WMD with his strong propulsive force caused by his reelection. In such an environment, there are his leadership, his team, himself, Kim Jung Il, and a new understanding of North Korea after September 11 as the effective factors of Bush administration’s policy toward Pyongyang. Bush administration’s foreign policy of North Korea also shows the process of North Korea’s nuclear weapon program and the future scenario of the Korean Peninsula with "the persistence of solving North Korea’s nuclear weapon program such as the method having done in Lybia", "the holding unconditional talks with Pyongyang, and "the continual concerns with human rights in North Korea." The purpose of Bush administration’s foreign policy of North Korea is to make North Korea do not support terrorism rather than remove the nuclear weapon in North Korea. The process of outlining South Korea’s policy toward North Korea must be considered for "national interest" with reasonable analyses not just hopes For this, South Korea must access systematically human rights of North Korea, prepare projects for a daring approach on North Korea, and strengthen South Korea’s defense ability toward North Korea with deep alliance with U.S and systematize the mutual understanding channel between U.S and South Korea. In conclusion, South Korea must try to get specific methods and practices about Bush administration’s foreign policy of North Korea with national wisdom

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 1989년도 추계학술발표회 발표논문초록집; 이화여자대학교, 서울; 23 Sep. 1989
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• pp.91-107
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• 1989

New product concept evaluation is one of the most important activities among many possible evaluation activities involved in the whole new product process. This paper aims at exploring the applicability of the Analytic Hierarchy Process(AHP) to this new product concept evaluation. To this aim, an AHP based concept evaluation model was formulated and explained using an illustrative example. A number of issues were also raised and discussed concerning the applicability of AHP to out problem. Finally, some further research areas were identified.

• 디지털융복합연구
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• 제3권2호
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• pp.159-186
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• 2005

Local decentralization and administration innovation is the most important problem the government confronted with at the present time. So local government must be follow them. Therefore, local government need to prepare whole process on this. From now on, local government must be develop own innovation model and strategy then, forward with innovation plan classified by step. This study reviewed the significance and necessary of local administration innovation and examined the necessary of level diagnosis of local administration innovation. And We diagnosed administration innovation of C province, then analyzed the result and proposed Altitude plans of administration innovation.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 추계학술대회
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• pp.177-177
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• 2003

Tumor cell invasion and metastasis are a complex multistep process that involves the degradation of extracellular matrix proteins by matrix metalloproteinases (MMPs). Tissue inhibitor of metalloproteinase-1 (TIMP-1) acts as a negative regulator of matrix metalloproteinase and thus prevents tumor cell invasion and metastasis by preserving extracellular matrix integrity.(omitted)

• 간호행정학회지
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• 제8권3호
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• pp.411-430
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• 2002

Purpose : This study was to develop Nursing Process Model of abdominal surgery patient using nursing diagnoses of NANDA, Nursing Interventions Classification(NIC), and Nursing Outcomes Classification(NOC). Method : The data in database were collected from nursing records in sixty patients with abdominal surgery admitted in a university hospital and open questionnaires of thirteen nurses. Systematic nursing process resulting from each nursing diagnoses, most common, was developed by the statistical analysis through database query from clinical database of abdominal surgery patients. Result : 51 nursing diagnoses were identified in abdominal surgery patients. The most commonly occurred nursing diagnoses were Pain, Risk for Infection, Sleep Pattern Disturbance, Hyperthermia, Altered Nutrition: Less Than Body Requirements in order. The linkage lists of NANDA to NIC and NANDA to NOC, and the nursing activities according to nursing diagnoses of abdominal surgery patients were identified in unit. Conclusion : Nursing Process of abdominal surgery patients was comprised of core nursing diagnoses, core nursing interventions, core nursing outcomes which provides the most reliable data in unit and could make nurses facilitate nursing process easily without full consideration of knowledge about nursing language classification system. Therefore, it could support nurses' decision making and recording of nursing process especially in the computerized patient record system if unit nursing process model using standardized nursing language system which contains of their own core nursing process data was developed.

• 품질경영학회지
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• 제45권1호
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• pp.129-138
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• 2017

Purpose: This research aims to analyze the service process of corporate courier services in order to offer service providers possible directions for adaptation of new technologies and assurance of better quality services. Methods: Through the analysis on the parcel service process of company Y by applying service blueprinting method, the overall process and failure service points of corporate courier services can be recognized and investigated. Next, the several newer technologies, augmented reality glasses, exoskeleton, and drone are applied to the service process of company Y as they are suggested by the literature review and referenced to DHL's report on the Fourth Industrial Revolution. Then, service options to overcome the service failure points to improve the service process can be produced. Results: The parcel service process of the company Y is utilized as a hub-and-spoke structure by having distribution and delivery centers which separates customers into two types, ones using the total services and the others only using the delivery service. In addition, the main cause of the service failures is determined that it is due to the limited working hours of delivery centers compared to the workload. Conclusion: This research contributes in better understanding of corporate courier services and providing information for benchmarking. An empirical research on the costs and the efficiencies of applying the new technologies is suggested for the further improvement in the processes of corporate courier services.