• Title/Summary/Keyword: Addition factor adaptation

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Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice

  • Choi, Ha-Neul;Jang, Yang-Hee;Kim, Min-Joo;Seo, Min Jeong;Kang, Byoung Won;Jeong, Yong Kee;Kim, Jung-In
    • Nutrition Research and Practice
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    • v.8 no.2
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    • pp.172-176
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    • 2014
  • BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. MATERIALS/METHODS: Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined. RESULTS: Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels. CONCLUSIONS: These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.

Variability of Hydrologic Partitioning revisiting Horton Index (Horton 지수의 재논의를 통한 수문분할의 변동성)

  • Choi, Dae-Gyu;Choi, Min-Ha;Ahn, Jae-Hyeon;Park, Moo-Jong;Kim, Sang-Dan
    • Journal of Wetlands Research
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    • v.13 no.1
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    • pp.35-44
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    • 2011
  • In order to explore vegetation adaptation to climate variability and the impacts on water balance dynamics, the inter-regional and the inter-annual variability of both water availability and vegetation productivity are investigated. The Horton index, which is the ratio between actual evapotranspiration and catchment wetting as a measure of vegetation water use at catchment-scale, is revisited to quantify the effects of growing-season water availability on hydrologic partitioning at catchment scale. It is shown that the estimated Horton index is relatively constant irrespective of inter-annual climate variability. In addition, the Horton index is compared with catchment-scale vegetation rain use efficiency. The results show that there is an interesting pattern in the response of vegetation water use to water availability. When water becomes the limiting factor for vegetation productivity, the catchment-scale vegetation rain use efficiency converges to a common maximum value in agreement with earlier findings at the ecosystem level.

An Implementation of Network Intrusion Detection Engines on Network Processors (네트워크 프로세서 기반 고성능 네트워크 침입 탐지 엔진에 관한 연구)

  • Cho, Hye-Young;Kim, Dae-Young
    • Journal of KIISE:Information Networking
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    • v.33 no.2
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    • pp.113-130
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    • 2006
  • Recently with the explosive growth of Internet applications, the attacks of hackers on network are increasing rapidly and becoming more seriously. Thus information security is emerging as a critical factor in designing a network system and much attention is paid to Network Intrusion Detection System (NIDS), which detects hackers' attacks on network and handles them properly However, the performance of current intrusion detection system cannot catch the increasing rate of the Internet speed because most of the NIDSs are implemented by software. In this paper, we propose a new high performance network intrusion using Network Processor. To achieve fast packet processing and dynamic adaptation of intrusion patterns that are continuously added, a new high performance network intrusion detection system using Intel's network processor, IXP1200, is proposed. Unlike traditional intrusion detection engines, which have been implemented by either software or hardware so far, we design an optimized architecture and algorithms, exploiting the features of network processor. In addition, for more efficient detection engine scheduling, we proposed task allocation methods on multi-processing processors. Through implementation and performance evaluation, we show the proprieties of the proposed approach.

Assessing Vulnerability to Agricultural Drought of Pumping Stations for Preparing Climate Change (기후변화 대응을 위한 양수장의 농업가뭄 취약성 실태 평가)

  • Jang, Min-Won;Kim, Soo-Jin;Bae, Seung-Jong;Yoo, Seunghwan;Jung, Kyunghun;Hwang, Syewoon
    • Journal of The Korean Society of Agricultural Engineers
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    • v.61 no.6
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    • pp.31-40
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    • 2019
  • In order to implement practical alternatives to proactively cope with the agricultural drought, the potential vulnerability of irrigation pumping stations to agricultural drought was quantitatively evaluated. Data for the 124 pumping stations which are correlatable to the three proxy variables, i.e. exposure, sensitivity, and adaptive capacity was collected by the Korea Rural Community Corporation, and then standardized considering distribution of each data set. Finally, the vulnerability index was calculated by multiplying the weights determined by the expert survey. The results showed that the vulnerability index ranged from 0.709 to 0.331 and the most vulnerable pumping stations such as Judam, Wongoo and Jinahn were mostly located in Gyeongbuk province likely because of the climatological characteristics with high temperature and low rainfall around this area. In addition, it was found that the adaptive capacity was a dominant factor comparing to exposure or sensitivity proxy variables in contributing to the vulnerability. It is therefore recommended that more practical alternatives should be employed to effectively reduce the vulnerability of an individual pumping station to agricultural drought. Furthermore, the corresponding data related to adaptive capacity should be systematically organized and managed at a field level to design reliable adaptation strategies.

Estimation of Future Land Cover Considering Shared Socioeconomic Pathways using Scenario Generators (Scenario Generator를 활용한 사회경제경로 시나리오 반영 미래 토지피복 추정)

  • Song, Cholho;Yoo, Somin;Kim, Moonil;Lim, Chul-Hee;Kim, Jiwon;Kim, Sea Jin;Kim, Gang Sun;Lee, Woo-Kyun
    • Journal of Climate Change Research
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    • v.9 no.3
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    • pp.223-234
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    • 2018
  • Estimation of future land cover based on climate change scenarios is an important factor in climate change impact assessment and adaptation policy. This study estimated future land cover considering Shared Socioeconomic Pathways (SSP) using Scenario Generators. Based on the storylines of SSP1-3, future population and estimated urban area were adopted for the transition matrix, which contains land cover change trends of each land cover class. In addition, limits of land cover change and proximity were applied as spatial data. According to the estimated land cover maps from SSP1-3 in 2030, 2050, and 2100, respectively, urban areas near a road were expanded, but agricultural areas and forests were gradually decreased. More drastic urban expansion was seen in SSP3 compared to SSP1 and SSP2. These trends are similar with previous research with regard to storyline, but the spatial results were different. Future land cover can be easily adjusted based on this approach, if econometric forecasts for each land cover class added. However, this requires determination of econometric forecasts for each land cover class.

The effect of water restriction on physiological and blood parameters in lactating dairy cows reared under Mediterranean climate

  • Benatallah, Amel;Ghozlane, Faissal;Marie, Michel
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.1
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    • pp.152-158
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    • 2019
  • Objective: This study was conducted to evaluate the effect of water restriction (WR) on physiological and blood parameters in lactating dairy cows reared under Mediterranean climate. Methods: The trial lasted 16 days preceded by two weeks of adaptation to the experimental condition in spring 2014 on 6 dairy cows in mid-lactation. These cows were allowed water ad libitum for 4 days (W100) (hydration period), then split into 2 groups, one group has received 25% and the other 50% of water compared to their mean water consumption during the hydration period; then rehydrated for 4 days. Feed intake and physiological parameters: respiratory rate (RR), heart rate (HR), and rectal temperature (RT) were recorded twice a day. Blood was collected once a day and analyzed for serum concentration of glucose (Glc), triglycerides (TG), cholesterol (Chol), urea (Ur), creatinine (Crea), and total protein (TP) by enzymatic colorimetric method and cortisol (Cort) by radioimmunoassay. Results: Total dry matter intake (TDMI) was affected by WR. A decrease in TDMI was observed in WR groups compared to W100 group (effect, group, period, day, $group{\times}day$, $period{\times}day$: p<0.001). Also, WR resulted in a significant increase in RR, HR, RT in WR groups than in W100 group (effect, group: p<0.001). In addition, an increase in the serum concentration of Glc, TG, Chol, Ur, Crea, TP, and Cort was noted in WR groups (effect, group, period, day: p<0.001). Conclusion: This study has shown the ability of cows raised in a Mediterranean climate to cope with different levels of WR and thus reach a new equilibrium. As result, elucidates the important role of water as a limiting factor for livestock in environments with low water availability.

Ginsenosides Rg1 regulate lipid metabolism and temperature adaptation in Caenorhabditis elegans

  • Hao Shi ;Jiamin Zhao ;Yiwen Li ;Junjie Li ;Yunjia Li;Jia Zhang ;Zhantu Qiu ;Chaofeng Wu ;Mengchen Qin ;Chang Liu ;Zhiyun Zeng ;Chao Zhang ;Lei Gao
    • Journal of Ginseng Research
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    • v.47 no.4
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    • pp.524-533
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    • 2023
  • Background: Obesity is a risk factor for aging and many diseases, and the disorder of lipid metabolism makes it prominent. This study aims to investigate the effect of ginsenoside Rg1 on aging, lipid metabolism and stress resistance Methods: Rg1 was administered to Caenorhabditis elegans (C. elegans) cultured in NGM or GNGM. The lifespan, locomotory activity, lipid accumulation, cold and heat stress resistance and related mRNA expression of the worms were examined. Gene knockout mutants were used to clarify the effect on lipid metabolism of Rg1. GFP-binding mutants were used to observe the changes in protein expression Results: We reported that Rg1 reduced lipid accumulation and improved stress resistance in C. elegans. Rg1 significantly reduced the expression of fatty acid synthesis-related genes and lipid metabolism-related genes in C. elegans. However, Rg1 did not affect the fat storage in fat-5/fat-6 double mutant or nhr-49 mutant. Combined with network pharmacology, we clarified the possible pathways and targets of Rg1 in lipid metabolism. In addition, Rg1-treated C. elegans showed a higher expression of anti-oxidative genes and heat shock proteins, which might contribute to stress resistance Conclusion: Rg1 reduced fat accumulation by regulating lipid metabolism via nhr-49 and enhanced stress resistance by its antioxidant effect in C. elegans.

Overexpression of CD44 Standard Isoform Upregulates HIF-1α Signaling in Hypoxic Breast Cancer Cells

  • Ryu, Dayoung;Ryoo, In-geun;Kwak, Mi-Kyoung
    • Biomolecules & Therapeutics
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    • v.26 no.5
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    • pp.487-493
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    • 2018
  • Cluster of differentiation 44 (CD44), a cell surface receptor for hyaluronic acid (HA), is involved in aggressive cancer phenotypes. Herein, we investigated the role of the CD44 standard isoform (CD44s) in hypoxia-inducible $factor-1{\alpha}$ ($HIF-1{\alpha}$) regulation using MCF7 overexpressing CD44s (pCD44s-MCF7). When pCD44s-MCF7 was incubated under hypoxia, levels of $HIF-1{\alpha}$, vascular endothelial growth factor, and the $HIF-1{\alpha}$ response element-derived luciferase activity were significantly increased compared to those in the control MCF7. Incubation of pCD44s-MCF7 cells with HA further increased $HIF-1{\alpha}$ accumulation, and the silencing of CD44s attenuated $HIF-1{\alpha}$ elevation, which verifies the role of CD44s in $HIF-1{\alpha}$ regulation. In addition, the levels of phosphorylated extracellular signal-regulated kinase (ERK) was higher in hypoxic pCD44s-MCF7 cells, and $HIF-1{\alpha}$ accumulation was diminished by the pharmacological inhibitors of ERK. CD44s-mediated $HIF-1{\alpha}$ augmentation resulted in two functional outcomes. First, pCD44s-MCF7 cells showed facilitated cell motility under hypoxia via the upregulation of proteins associated with epithelial-mesenchymal transition, such as SNAIL1 and ZEB1. Second, pCD44s-MCF7 cells exhibited higher levels of glycolytic proteins, such as glucose transporter-1, and produced higher levels of lactate under hypoxa. As a consequence of the enhanced glycolytic adaptation to hypoxia, pCD44s-MCF7 cells exhibited a higher rate of cell survival under hypoxia than that of the control MCF7, and glucose deprivation abolished these differential responses of the two cell lines. Taken together, these results suggest that CD44s activates hypoxia-inducible $HIF-1{\alpha}$ signaling via ERK pathway, and the $CD44s-ERK-HIF-1{\alpha}$ pathway is involved in facilitated cancer cell viability and motility under hypoxic conditions.

Effects of dietary inactivated probiotics on growth performance and immune responses of weaned pigs

  • Kang, Joowon;Lee, Jeong Jae;Cho, Jin Ho;Choe, Jeehwan;Kyoung, Hyunjin;Kim, Sung Hun;Kim, Hyeun Bum;Song, Minho
    • Journal of Animal Science and Technology
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    • v.63 no.3
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    • pp.520-530
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    • 2021
  • This experiment was performed to verify whether dietary heat-killed Lactobacillus rhamnosus (LR) improves growth performance and modulates immune responses of weaned pigs. Ninety-six weaned pigs ([Landrace × Yorkshire] × Duroc; 6.95 ± 0.25 kg body weight [BW]; 28 d old) were randomly allocated to four treatments: 1) a basal diet without heat-killed LR (CON), 2) T1 (CON with 0.1% heat-killed LR), 3) T2 (CON with 0.2% heat-killed LR), and 4) T3 (CON with 0.4% heat-killed LR). Each treatment had six pens with four pigs (6 replicates per treatment) in a randomized completely block design. The heat-killed LR used in this study contained 1 × 109 FU/g of LR in a commercial product. Pigs were fed each treatment for four weeks using a two-phase feeding program to measure growth performance and frequency of diarrhea. During the last week of this study, all diets contained 0.2% chromic oxide as an indigestible marker. Fecal sampling was performed through rectal palpation for the consecutive three days after the four adaptation days to measure apparent total tract digestibility (ATTD) of dry matter, crude protein, and gross energy (GE). Blood sampling was also performed on day 1, 3, 7, and 14 after weaning to measure immune responses such as serum tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), C-reactive protein (CRP), and cortisol. The heat-killed LR increased (p < 0.05) growth rate, feed efficiency, and ATTD of GE for overall experimental period compared with CON, but reduced (p < 0.05) post-weaning diarrhea. In addition, pigs fed diets contained heat-killed had lower concentrations of serum TNF-α (d 7; p < 0.05), TGF-β1 (d 7; p < 0.10), and cortisol (d 3 and 7; p < 0.05) than pigs fed CON. In conclusion, dietary heat-killed LR improved growth rate, modified immune responses of weaned pigs, and alleviated post-weaning diarrhea.

Menstrual Experience of Adolescent Girls (사춘기 여성들의 월경경험)

  • 정현숙
    • Journal of Korean Academy of Nursing
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    • v.26 no.2
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    • pp.257-270
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    • 1996
  • Studies on menstruation have focused only on menstruation itself and menstrual disorders. The menstruating girls or women have been neglected. So, the purpose of this study was to understand menstrual experience of adolescent girls in their perspective and build a theory on it, The specific purpose of this study were to find initial reaction of the girls, their strategies to adapt to menstruation. consequences of their efforts, influencing factor, and patterns of experience. The subjects of this study were eleven adolescent girls who experienced menarche three months to twenty-six months before the interview time. They were selected purposively. Their ages were in range of twelve and sixteen. One of them was a elementary school girl, three high school girls, and seven middle school girls. Two girls were handicapped because of cerebral palsy. All of them had some knowledge about menstrual physiology and hygiene during menstruation. Data were collected from September, 1994 to July, 1995. Data collection & analysis were done according to the grounded theory methodology by Strauss & Corbin(1990). Data collecting method was the long interviews and observation. Each interview took from 1 hour to 2 hours. Interview were tape-recorded and transcribed later by author. Data were analyzed immediately after interviews. Based on the results of previous interview, next interview were planned until gathered data reached the saturation point. Results were as follows. One hundred and six concepts were found. Those concepts were grouped into twenty eight categories and then fourteen higher categories. Twenty eight categories were as follows. “want to hide”, “bewildered”, “sense of burden”, “sense of heterogeneity”. “gladness”. “sense of superiority”, “negative empathy”, “positive empathy”, “limited hygenic control”, “sense of timing”, “lack of knowledge”, “lack of support”, “advance knowledge”, “informational support”, “emotional support”, “endurance”, “prayer”, “disclosing”, “avoidance”, “diversion”, “sense of powerlessness”, “discovery of sex identity”, “sense of maturation”, “sense of stability”, “acceptance of menstruation ”. fourteen higher categories were as follows. “negative feeling”, “posive feeling”, “exchange of feeling”, “limited hygenic control”, “sense of timing”, “accumulated experience”, “dysmenorrhea”, “level of knowledge”, “need for support”, “perceived support”, “sharing of feeling”, “self-control”, “passive acceptance”, “active acceptance”. The core category was “emotional shaking”, which consisted of “positive feeling” and “negative feeling”. “Emotional shaking”comes up to every adolescent girls experiencing menarche, independently of any contextual conditions, and its dimension has two directions : positive one and negative one. Its influencing factors were time of menarche, advance knowledge, support from the significant persons, expression and self-regulation. Even if they showed different process of adaptation to menstruation, general process of adaptation were as follows : 1. stage of emotional shaking 2. stage of acceptance 3. stage of internalization of the menstrual experience. Seven patterns existed on the process of adaptation to menstruation after menarche. Those are as follows. 1. If girls thought their menarche came too early and they had not much knowledge on menstruation, they had a kind of negative feeling. If they did not get enough support and dysmenorrhea superimposed, they came to accept menstruation passively. 2. If girls had menarche too early. they had negative feeling, even though they had enough advance knowledge. But support helped them accept menstruation easily. 3. If girls had menarche too early, they had negative feeling, even though they had enough advance knowledge on menstruation. But by experiencing subsequent menstruations and disclosing feeling, they began to accept menstruation. 4. If girls had menarche too lately and they had enough advance knowledge on menstruation. they had positive feeling. If dysmenorrhea superimposed later, their feeling turned in to negative one. But they came to accept menstruation positively by disclosing feeling and getting support. 5. If girls had menarche too early, they had negative feeling, even though they had enough advance knowledge on menstruation. In addition to this. if dysmenorrhes superimposed while they did not get enough support, they felt powerless and came to accept menstruation passively. 6. If girls had menarche too early and did not get enough advance knowledge, they had negative feeling. But disclosing feeling and support made them get sense of homogeneity and began to accept menstruation. 7. If girls had handicap, they had negative feeling, even though they had enough advance knowledge and menarche was late. But Menarche made them get feel sexual identity. Their limited hygenic control and negative empathy from their mothers made them accept menstruation passively. To let adolescent girls take their menstrual experience as a part of their lives forming a positive sense of feminine identity, it needs qualified teaching and, support and deep concern of the significant others. Nurses including school nurses should try to develop an educational program, which include menstrual physiology. hygiene during menstrual period, meaning of menstruation and impact of menstruation on the development of female sexual identity.

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