• 한국수의병리학회:학술대회논문집
• /
• 한국수의병리학회 2003년도 추계학술대회초록집
• /
• pp.28-28
• /
• 2003

Hepatitis E virus (HEV), previously referred to as enterically transmitted non-A, non-B hepatitis, is responsible for sporadic infections as well as large epidemics of acute viral hepatitis in developing countries. The disease generally affects young adults and reportedly has a mortality rate of up to 20％ in infected pregnant women. HEV was once considered to be a member of the family Caliciviridae, but the unique genomic organization of HEV has led to the removal of HEV from the family and it was provisionally classified in an unassigned family of HEV-like viruses. In situ hybridization provides any cellular detail and histological architecture.[1] However, use of in situ hybridization is largely restricted to the laboratories because this technique is the greater technical complexity and expense compared with immunohistochemistry. Therefore, the objective of this study is to develop the immunohistochemistry for the detection of swine HEV from formalin-fixed, paraffin-embedded hepatic tissues. (omitted)

• Biomolecules & Therapeutics
• /
• 제2권2호
• /
• pp.108-113
• /
• 1994

Toxicity study of recombinant hepatitis B vaccine (LBD-008), a newly developed drug for acute and chronic hepatitis, was investigated in mice and guinea pigs. 1. Mice showed no production of antibodies against LBD-008 inoculated with aluminum hydroxide gel (Alum) as an adjuvant, judged by the heterologous anaphylaxis (PCA) test using rats. On the other hand, antibodies against ovalbumin (OVA) inoculated with alum were definitely detected. 2. In the studies with guinea pigs, both the inoculation of LBD-008 only and of LBD-008 with complete Freund's adjuvant (CFA) as an adjuvant did not produce positive reactions in any of homologous active systemic anaphylaxis (ASA). On the other hand, the inoculation of ovalbumin with complete Freund's adjuvant (CFA) produced positive reaction in both of PCA and ASA. 3. These findings suggested that LBD-008 has no antigenic potential in mice or guinea pigs.

• Journal of Yeungnam Medical Science
• /
• 제2권1호
• /
• pp.211-220
• /
• 1985

저자들은 급성간염 39예, 만성간염 79예, 간경변증 30예, 원발성간암 16예, 보유자 14예 및 비교군 129예의 모두 307명을 대상으로 하여 SGOT, SGPT 및 HBV 표식자를 조사하여 다음의 결과를 얻었다. 1. HBsAg의 발현율은 급성간염의 66.7%, 만성간염의 63.3%, 간경변증의 36.7%, 원발성간암의 81.3% 및 비교군에서 27.1%인 것으로 나타났다. 2. AntiHBc의 발현율은 급성간염의 0%, 만성간염의 21.5%, 간경변증의 36.7%, 원발성간암의 31.3%, 보유자의 0% 및 비교군에서 44.2%로 나타났다. 3. HBeAg은 만성간질환중 만성간염에서 45.6%로 가장 높게 나타났고 AntiHBe는 원발성간암에서 56.3%로 가장 높았다. 4. AntiHBc는 각종 간질환, 보유자 및 비교군에서 높게 나타났으며 이는 AntiHBc자체는 간질환에 직접 관계가 없는 감염의 흔적으로 생각된다. 5. HBsAg 보유자 14명중 6명(42.3%)에서 혈청 GOT, SPT 치의 이상 상승이 있었다. 6. HBV에 감염된 혈청학적 증거가 있으면서 간기능에 이상이 있을 때, HBV 이외에 non-A, non-B 바이러스, Delta agent 또는 타 바이러스나 관련된 다른 요인과의 관계가 있을 수 있는 점을 고려하여야 할 것으로 생각된다. HBV의 5 가지 표식 자가 모두 음성으로 나타난 환자는 급성간염의 5.1%, 만성간염의 5.1%에 달했으며, 이것은 HBV 이외의 다른 원인이 병인이 될 수 있음을 시사하며 비교군 중 SGOT, SGPT치의 증가를 보인 군에서는 17.6%, 정상 SGOT, SGPT치를 나타낸 군에서는 12.8%에서 모든 HBV 표식자가 음성으로 나타났다.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제15권2호
• /
• pp.91-99
• /
• 2012

Purpose: The aims of this study was to compare and evaluate the clinical characteristics, laboratory data, and prognosis for infants under age 1 year with CMV hepatitis and those with viral hepatitis of unknown etiology. Methods: A retrospective study was conducted of infants under age 1 year who were admitted with acute hepatitis. The exclusion criteria consisted of: autoimmune, genetic, metabolic, toxic, HAV, HBV, HCV, toxoplasma, rubella, herpes simplex, and Epstein-Barr virus. The 30 patients included were divided into two groups based on markers for CMV (IgM anti-CMV, CMV PCR in urine, CMV culture in urine). Results: The median age of patients (n=15) was 2.8 months. No other organ involvement was detected in any patient. Peak serum total bilirubin levels (n=4) ranged from 2.6 to 6.7 mg/dL. Peak serum ALT levels ranged from 51 to 1,581 IU/L. The duration of ALT elevation ranged from 1.5 weeks to 26 weeks (median 9 weeks). All had recovered in full without ganciclovir; there were no cases of hearing loss. The median age of controls (n=15) was 2.5 months. Peak serum total bilirubin levels (n=4) ranged from 1.6 to 9.1 mg/dL. Peak serum ALT levels ranged from 26 to 1,794 IU/L. No significant differences were observed between both groups regarding the peak serum ALT levels, peak serum total bilirubin levels, duration of hyperbilirubinemia and ALT elevation. Conclusion: Although it was not possible to differentiate congenital infection with perinatal infection in this study, the prognosis of patients with CMV hepatitis without other organ involvement was good without ganciclovir treatment.

• 한국임상약학회지
• /
• 제3권1호
• /
• pp.45-53
• /
• 1993

Biphenyl Dimethyl dicarboxylate(DDB) has been regarded as a safe, effective drug for decreasing serum aminotransferase levels from elevated serum aminotransferase levels, which cause acute or chronic hepatitis and chronic liver diseases. This study was designed to low dose(22.5mg/day) & short-term therapy effectiveness for 4 weeks of DDB in 30 chronic hepatitis patients with elevated serum aminotransferases. The following results were observed. 1. Serum alanine aminotransferase(ALT) levels significantly decresed from 173. $97\pm130.62(U/L)$ of pretreatment level to $32.23\pm19.22(U/L)$ after treatment for 4 weeks(p<0.00l) and normalized patients by $73\%$ 2. Serum aspartate (AST) aminotransferase levels significantly decreased from $94.90\pm49.17(U/L)$ of pretreatment level to $45.30\pm23.25(U/L)4 after treatment(p0<0.01). 3. However, no significant effects in the serum AST & ALT changes by which cause hepatitis and hepatitis duration (p>0.05). 4. No significant adverse effects were observed except for mild epigastric discomfort in one patient during DDB treatment It is suggested that DDB small dosage administration can result effectively decreasing serum aminotransferase levels from chronic hepatitis patients with elevated serum aminotransferase levels.

• 생명과학회지
• /
• 제23권2호
• /
• pp.175-181
• /
• 2013

우리나라에서 A형 간염바이러스는 IA 유전자형이 주된 양상이었으나 최근 일부 다른 유전자형이 점차 늘어나는 보고들이 발표되고 있다. 따라서 본 연구의 목적은 최근 우리나라에서 유행한 A형 간염의 바이러스 유전자형을 분석하고자 하였다. 2010년 4월에서 2011년 4월까지 광주광역시에 위치한 K 병원에 입원한 급성 A형 간염환자 20명의 검체와 서울에 위치한 S 검사센터에 의뢰된 Anti-HAV IgM 양성인 36개의 검체를 대상으로 하여 검사를 실시하였다. 또한 Anti-HAV IgM 양성인 56개의 검체인 serum에서 RNA를 분리한 후 VP1/P2A junction 부위에 대해서 RT-PCR을 통하여 증폭 한 후 염기서열을 분석하여 기존의 발표된 유전자형과 비교하였다. 유전자형 분석결과 바이러스가 분리된 50명에서 4명(8%)은 IA 유전자형을, 46명(92%)은 IIIA 유전자형을 보였다. 이번 연구를 통하여 우리나라에서 발생한 A형 간염환자의 유전자형 분석에서 과거와는 달리 IA 유전자형이 아닌 IIIA 유전자형으로 변하였다는 것을 확인 할 수 있었다.

• 대한한방내과학회지
• /
• 제32권3호
• /
• pp.444-450
• /
• 2011

Recently, acute toxic liver injury has been reported to be the most common cause of acute hepatitis. We witnessed one case of hepatic injury which suggested drug-induced hepatitis by herbal medication (Gamiyukgunja-tang). This patient, diagnosed cerebral infarction, was treated with herbal medication and physical therapy for improvement of right hemiparesis. In the course of treatment, this patient showed elevation of serum transaminase (ALT 129 IU/L, AST 150 IU/L), alkaline phosphatase (ALP 261 IU/L), and total bilirubin (2.0 IU/L), so we supposed toxic hepatitis by herbal medication. Saenggangeonbi-tang was administered for 8 days, ALT, AST, ALP, total bilirubin decreased within normal limits.

• Toxicological Research
• /
• 제17권4호
• /
• pp.297-301
• /
• 2001

The acute toxicity of CJ-50005, an inactivated whole virus vaccine derived from hepatitis A virus (HM175) grown in human MRC-5 diploid fibroblast culture, was tested in Sprague Dawley (SD) rats and beagle dogs. CJ-50005 was orally and intramuscularly administered up to the maximum dose of 81$\mu\textrm{g}$/kg. as much as 3,000 times of the expected clinical dose, in SD rats and was intramuscularly administered up to 27 $\mu\textrm{g}$/kg, as much as 1,000 times of the expected clinical dose, in beagle dogs. In these experiments, there were no death and clinical changes which were related to CJ-50005 administration. In addition, there were no significant changes between control and treated groups in body weights and autopsy findings. In conclusion, the administration of CJ-50005 over 81$\mu\textrm{g}$/kg in SD rats and over 27$\mu\textrm{g}$/kg in beagle dogs was proved to be safe, and it is thought that CJ-50005 may not show any toxicity in its clinical use.

• Clinical and Experimental Pediatrics
• /
• 제50권9호
• /
• pp.841-847
• /
• 2007

Acute liver failure (ALF) is a very rare but devastating illness in children. Specific treatment to recovery is often not available, and the underlying cause of the liver failure is often unknown and diverse especially in children. Liver transplantation has increased the chance of survival; however it needs an optimal timing to reach the best result which is not familiar to pediatrician. This article discusses the current knowledge of the epidemiology, backgrounds and factors to be considered before establishing the treatment of ALF in children.

• Toxicological Research
• /
• 제5권1호
• /
• pp.49-52
• /
• 1989

Acute inhalation intoxication of CS (O-chlorobenzylidene malononitrile) occurred among the 192 animals in confined animal cages of farm as the result of prolonged exposure. A total of 8 animals (3 silver foxes, 3 fitches and 2 minks) died in 15 hours after the exposure. Distinct evidences of pulmonary atelectasis were observed as with hepatorenal damages. The lethal toxicity of CS was considered to be due to early severelung damages leading to asphyxia, accompanying acute toxic hepatitis and nephritis.