• 한국분말재료학회지
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• 제20권5호
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• pp.332-337
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• 2013

Recently, self-propagating high-temperature synthesis (SHS), related to metallic and ceramic powder interactions, has attracted huge interest from more and more researchers, because it can provide an attractive, energy-efficient approach to the synthesis of simple and complex materials. The adiabatic temperature $T_{ad}$ and apparent activation energy analysis of different thermit systems plays an important role in thermodynamic studies on combustion synthesis. After establishing and verifying a mathematic calculation program for predicting adiabatic temperatures, based on the thermodynamic theory of combustion synthesis systems, the adiabatic temperatures of the NiO/Al aluminothermic system during self-propagating high-temperature synthesis were investigated. The effect of a diluting agent additive fraction on combustion velocity was studied. According to the simulation and experimental results, the apparent activation energy was estimated using the Arrhenius diagram of $ln(v/T_{ad}){\sim}/T_{ad}$ based on the combustion equation given by Merzhanov et al. When the temperature exceeds the boiling point of aluminum (2,790 K), the apparent activation energy of the NiO/Al aluminothermic system is $64{\pm}14$ kJ/mol. In contrast, below 2,790 K, the apparent activation energy is $189{\pm}15$ kJ/mol. The process of combustion contributed to the mass-transference of aluminum reactant of the burning compacts. The reliability of the simulation results was experimentally verified.

• 한국대기환경학회지
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• 제26권1호
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• pp.48-56
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• 2010

Recently it has reported that the motorcycle is a major source of air pollution in urban area by many studies. But the air pollution emission from motorcycle has been high uncertainty due investigation of a lack of activity data and emission factors in Korea. So in this study, the population of moped and VKT (Vehicle kilometers travelled) of motorcycle are investigated for calculation of the emission from this source categories. As the results, the population of moped is estimated as about 400, 000 and corresponded as 23% of registrated motorcycle which is larger than 50 cc in engine displacement. And it is found that the VKT of moped and motorcycle are investigated as 19.1 km/day and 32.3 km/day. Annual air pollution emission from motorcycle and moped are estimated by investigated VKT and updated emission factors. The nationwide emissions of PM_{10}, CO, $NO_x$, VOC are calculated as 910 ton/yr, 208, 198 ton/yr, 3, 032 ton/yr and 25, 575 ton/yr in 2008. The contribution ratio of CO, VOC emission from these sources are estimated as 29%, 24% in on-road transport sector and it is confirmed that motorcycle and moped are major air pollution sources in urban area.

• 한국콘텐츠학회논문지
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• 제17권1호
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• pp.233-241
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• 2017

세계은행에서 매년 배포되는 비즈니스 실행편의성 보고서는 경제단위별로 중소기업의 비즈니스 활동을 향상시키고 제약하는 규제들을 비즈니스 수명주기의 10개 분야(평가요소)별로 측정하고, 이를 바탕으로 분야별 및 종합 점수와 순위를 산출한다. 이 종합 점수는 10개 분야별 점수를 모두 더한 것으로, 모든 분야별 점수가 동일한 비중을 가지고 있는 것을 의미한다. 사용하는 평가요소와 가중치에 따라서 평가 결과가 크게 달라질 수 있기 때문에 세계은행의 보고서가 우리나라 기업들이 중요시하는 평가요소들을 제대로 반영하지 못한 것일 수 있고, 그 결과를 직접 활용하기 어려운 측면이 있다. 이 논문에서는 대한민국 중소기업의 관점에서 이들 10개 평가요소의 가중치를 산정하여 경제단위의 비즈니스 실행 편의성을 비교하고자 한다. 국내 경영학부 교수 및 중소기업 CEO를 대상으로 AHP 기반의 설문을 실시하여 평가요소별 가중치를 산정하고, 이를 2016년 세계은행 보고서 자료에 적용하여 종합 점수와 순위를 산출하였다. 상위권과 하위권에서는 변화가 상대적으로 적었던 반면에, 중위권에서는 큰 변화가 나타나는 경우들도 확인되었다.

• 대한핵의학회지
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• 제38권2호
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• pp.198-204
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• 2004

Tumor cell proliferation is considered to be a useful prognostic indicator of tumor aggressiveness and tumor response to therapy but in vitro measurement of individual proliferation is complex and tedious work. PET imaging provides a noninvasive approach to measure tumor growth rate in situ. Early approaches have used $^{18}F$-FDG or methionine to monitor proliferation status. These 2 tracers detect changes in glucose and amino acid metabolism, respectively, and therefore provide only an indirect measure of proliferation status. More recent studies have focused on DNA synthesis itself as a marker of cell proliferation. Cell lines and tissues with a high proliferation rate require high rates of DNA synthesis. $[^{11}C]Thymidine$ was the first radiotracer for noninvasive imaging of tumor proliferation. The short half-life of $^{11}C$ and rapid metabolism of $[^{11}C]Thymidine$ in vivo make the radiotracer less suitable for routing use. Halogenated thymidine analogs such as 5-iodo-2-deoxyuridine (IUdR) can be successfully used as cell proliferation markers for in vitro studies because these compounds are rapidly incorporated into newly synthesized DNA. IUdR has been evaluated as a potential in vivo tracer in nuclear medicing but the image qualify and the calculation of proliferation rates are impaired by its rapid in vivo degradation. Hence, the thymidine analog $3'-deoxy-3'-^{18}F-fluorothymidine$ (FLT) was recently introduced as a stable proliferation marker with a suitable nuclide half-life and stable in vivo. $[^{18}F]FLT$ is phosphorylated to 3-fluorothymidine monophosphate by thymidine kinase 1 and reflects thymidine kinase 1 activity in proliferating cell. $[^{18}F]FLT$ PET is feasible in clincal use and well correlates with cellular proliferation. Choline is a precursor for the biosynthesis of phospholipids (in particular, phosphatidylcholine), which is the essential component of all eukaryotic cell membranes and $[^{11}C]choline$, which is a new marker for cellular proliferation.

• 농업과학연구
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• 제11권1호
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• pp.176-181
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• 1984

살충성 O,O-diethylphenylphosphate (A)와 3,5-dimethylphenyl-O,O-diethylphosphate 유도체 (B)에 의한 acetylcholinesterase(Ach E)의 phosphorylation 반응에 미치는 정량적인 자유에너지 관계(LFER)를 알아보기 위하여 Ach E의 두 작용점인 esteratic-anionic site에 대응하는 (A) 및 (B)의 P원자 및 meta 위치간의 공간직선 거리 및 알짜전하를 확장 H$\ddot{u}$ckel이론(EHT)에 의한 MO 계산 방법으로 계산하고 여러 가지 치환기상수와 $pI_{50}$ 상수를 Hammett 및 Okamoto-Brown식, Taft와 Swaln-Lupton의 DSP식에 적용한 회귀분석 결과로부터 살충작용에 미치는 정량적인 자유에너지 관계, %R과 %F를 계산하여 검토하였다. 즉, (A) 및 (B)의 살충효과는 서로 비슷하였으며 blending coefficient (${\lambda}$)는 모두 ${\lambda}$<1의 값을 나타내었다. (A) 및 (B)의 resonance effect (%R)와 field effect (%F)는 각각 %R=33.5, %F=66.5 그리고 %R=2, %F=98로 각각 계산되었는데(B)와 같이 phenyl group에 bulky한 소수성의 methyl group이 결합될수록 resonance effect($R_{\pi}$)보다는 direct through space field effect ($F_D$)가 아닌 through space field effect가 더 크게 영향을 미치게 된다는 사실을 알 수 있었다.

• 한국컴퓨터정보학회논문지
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• 제10권2호
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• pp.49-57
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• 2005

본 논문은 상관관계(trade-off)에 의한 CLB구조의 CPLD 저전력 기술 매핑 알고리즘을 제안하였다. 제안한 저전력 기술 매핑 알고리즘은 주어진 불린 네트워크를 DAG로 구성하여 소모전력 계산을 위한 TD(Transition Density) 계산 단계와 매핑 가능 클러스터 생성, CLB 패킹의 단계로 구성하였다. TD 계산 단계는 DAG를 구성하고 있는 각 노드들에 대한 스위칭 동작을 계산하여 전체 소모 전력을 계산하는 단계이다. 매핑 가능 클러스터 생성 단계는 주어진 CPLD의 CLB에 대한 입출력의 수와 OR 텀수를 고려하여 매핑 가능 클러스터를 생성하는 단계이다. 매핑 가능 클러스터를 생성하기 위하여 공통 노드 클러스터 병합과 노드 분할, 노드 복제의 방법을 이용한다. 제안된 알고리즘을 SIS에서 제공되는 벤치마크에 적용하여 실험한 결과 OR 텀수를 5로 했을 경우 기존의 CPLD 기술 매핑 알고리즘인 TEMPLA에 비해 30.73$\%$의 소모전력이 감소되었으며, PLAmap에 비해 17.11$\%$감소되었다.

• 자원환경지질
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• 제39권4호
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• pp.473-483
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• 2006

비록 2차 세계대전 이전에 자연전위가 관측되었다는 기록도 있기는 하지만, 한국에서 대전 이후 서서히 발전하던 전기탐사가 본격적으로 보급된 것은 1980년대 이후의 일이다. 다른 선진국과 달리 한국의 경우 전기비저항법을 환경문제보다 토목 건설 문제에 상대적으로 더 많이 적용하고 있다. 다른 모든 기술분야와 마찬가지로 반도체산업의 발전은 자료 수집과 잡음 감쇄처리에서 혁신을 가져왔으며, 지난 25년 동안 전기비저항 자료의 수집, 처리 및 해석에 있어서 두드러진 발전이 있었다. 평활화제약 모델에 의한 2차원 전기비저항 역산의 개발은 지난 40년 동안 물리탐사 자료해석에서 가장 현저한 변화 중 하나이며, 지금은 겉보기비저항 자료에 일반적으로 적용되고 있다. 전기비저항 분포를 가단면도가 아니라 단면도로 나타낼 수 있게 된 것은 자료해석에 혁신을 가져왔다. 일반적인 전자기 문제에서는 감도 계산을 위해 대단히 많은 전진 모델링을 필요로 하지만, 전기비저항법에서는 전류원과 수신점이 같은 위치를 차지하기 때문에 계산효율이 높아서 이전에는 처리하기 어려웠던 3차원 역산도 이제는 가능해졌다.

• 한국지하수토양환경학회지:지하수토양환경
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• 제17권3호
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• pp.49-58
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• 2012

Batch experiments using indigenous and commercialized adventive microorganisms were performed to investigate the feasibility of the biodegradation process for the diesel contaminated soil, which was taken in US Military Camp 'Hialeah', Korea. TPH concentration of the soil was determined as 3,819 mg/kg. Four indigenous microorganisms having high TPH degradation activity were isolated from the soil and by 16S rRNA gene sequence analysis, they were identified as Arthrobacter sp., Burkholderia sp., Cupriavidus sp. and Bacillus sp.. Two kinds of commercialized solutions cultured with adventive microorganisms were also used for the experiments. Various biodegradation conditions such as the amount of microorganism, water content and the temperature were applied to decide the optimal bioavailability condition in the experiments. In the case of soils without additional microorganisms (on the natural attenuation condition), 35% of initial TPH was removed from the soil by inhabitant microorganisms in soil for 30 days. When the commercialized microorganism cultured solutions were added into the soil, their average TPH removal efficiencies were 64%, and 54%, respectively, which were higher than that without additional microorganisms. When indigenous microorganisms isolated from the contaminated soil were added into the soil, TPH removal efficiency increased up to 95% (for Bacillus sp.). According to the calculation of the average biodegradation rates for Bacillus sp., the remediation goal (87% of the removal efficiency: 500 mg/kg) for the soil would reach within 24 days. Results suggested that TPH removal efficiency of biodegradation by injecting indigenous microorganisms is better than those by injecting commercialized adventive microorganisms and only by using the natural attenuation.

• Biomolecules & Therapeutics
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• 제25권6호
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• pp.648-658
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• 2017

7-O-Succinyl macrolactin A (SMA) exerts several pharmacological effects including anti-bacterial, anti-inflammation, and anti-cancer activities. Recently, SMA has been extensively evaluated as an anti-cancer drug. Thus, the objectives of the present study were to characterise the pharmacokinetics of SMA via both non-compartmental and compartmental analysis in mice, rats, and dogs, and to derive an appropriate first-in-man dose based on allometric scaling of the animal data. The time courses of plasma SMA concentrations after intravenous administration to rats and dogs were analysed retrospectively, as were data collected after intraperitoneal SMA injection in mice. Pharmacokinetic parameters were estimated via both noncompartmental and compartmental analysis, and were correlated with body weight and/or the potential maximum life-span. The clearance and distribution volume of SMA in humans were predicted, and a first-in-man dose proposed. A two-compartment model best described the time courses of SMA plasma concentrations after a saturation elimination process was applied to fit the dataset obtained from rats. Incorporation of the maximum potential life-span during allometric scaling was required to improve the estimation of human clearance. The SMA clearance and the distribution volume in the steady state, in a 70-kg adult male, were estimated to be 30.6 L/h and 19.5 L, respectively. To meet the area under the curve (AUC) required for anti-tumour activity, a dose of 100 mg (~1.5 mg/kg) was finally proposed as the first dose for a 70-kg human. Although toxicological profiles derived from non-clinical studies must be considered before any final decision is made, our work will facilitate clinical studies on SMA.

• Applied Biological Chemistry
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• 제15권2호
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• pp.143-162
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• 1972

Based on the concentration of $^{40}K$ naturally occurring radioisotope of potassium, a method for the determination of total potassium in soils and plants was developed. The method was extended to evaluate the potassium supplying power of soils by taking the ratio of exchangeable potassium to total potassium $(K_{ex}/K_t)$, termed the potassium buffering capacity. Using this as index, it was observed that the release of potassium from soil fellows the from order reaction. A linear relationship was found between the potassium buffering capacity and the release constant of potassium or mica content of the clay. Similarly the potassium buffering capacity was also closely correlated with total uptake of potassium by rice plant. Hence it is concluded that the method for determining of the potassium buffering capacity could be veil applied to characterize the potassium availability of soils. The method for the determination of potassium is characterized by (1) The efficient measurement of the weak beta activity emissions from the samples, (2) identification of $^{40}K$, (3) calculation of total potassium content using the proportional constant of $^{40}K$ of samples to that of the standard. Difference in the potassium supplying power of soils due to soil types was also evaluated with the use of this technique. The degree of the potassium supplying power was in the order of soil types as red-yellow podzolic and lateric soils, basaltic materials(Rvd)> low-humic gley and alluvial soils, alluvial plains and food plains(Apa)> low-humic gley soils, nearly level to sloping local alluvial plains and slopes(Afb)> low-humic gley and alluvial soils, fluvio-marine plains (Fma).