• The Korean Journal of Physiology
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• v.20 no.1
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• pp.89-102
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• 1986

It has long been suggested that the change of renin-angiotensin system is responsible for the increased arterial blood pressure in the experimental hypertension. But the exact nature of the cause and maintenance of early and late Phase of renal hypertension is still controversial. Increased renin-angiotensin system has been suggested. To clarify the altered renin-angiotensin system in the early phase of two kidney one clip Goldblatt hypertension(2K1C GH), experiments were carried out in the rats of 3,7, and 14 days of 2K1C GH rats, sham-operated, and control rats. Responses of the plasma renin activity to the intravenous infusion of L-isoproterenol were dose-dependent. Responses of the plasma renin activity to the intravenous L-isoproterenol in 2K1C GH rats were not different from sham-operated control rats. Hypotensive responses of the 2K1C GH rats were not different from sham-operated rats. Suppression by intravenous infusion of angiotensin II of plasma renin activity showed a dose-dependent manner. Suppression by angiotensin ll of plasma renin activity was attenuated or abolished in the early phase of 2K1C GH rats. Intravenous infusion of arginine vasopressin(AVP) showed a dose-dependent suppression of plasma renin activity, Attenuated responses by AVP of plasma renin activity were noticed in the early phase of 2K1C GH rats. These results suggest that the altered renin-angiotensin system in the early phase of the two kidney one clip Goldblatt hypertension may be caused by failure of the short loop negative feedback control mechanism.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.44 no.5
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• pp.30-37
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• 2007

Hardware for monitoring the water quality is developed using water fleas. Water flea is a frequently used biological sensor for monitoring the water quality. Water fleas quickly respond to the incoming toxic water by changing their activity when they are exposed. By measuring the activity of water fleas, the incoming toxic water is instantly detected in real time. So far the measurement of activity of water fleas has been done with a system equipped with a light source of LED and a light detector of photo transistor. Water flea itself is, however, sensitive to light resulting in incorrect response and the system has two inconvenient separate parts of the light source and the detector. This paper suggests a system using a CCD camera instead of a light source and a detector. The suggested system processes the image data from the CCD camera in real time without any delay. The developed system becomes a part of the remote water monitoring embedded system.

• The KIPS Transactions:PartD
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• v.13D no.5 s.108
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• pp.749-754
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• 2006

Recently, many enterprises are introducing information systems for their competitive advantages. For enhancing the utilization level of enterprise information system, it is quite important to monitor the usage states of the information systems continuously. However, most enterprise information systems lack this functionality. Proposed in this paper is the framework of IAM (Information Activity Monitoring), which is defined as real-time reporting and alerting of significant information-related activities. This IAM framework provides 4 different views about the information system (data, IT system, business process, and participant) and is implemented as a part of integrated design/manufacturing information system developed by aerospace parts manufacturer. By using the IAM function, IT personnel can monitor significant information-related activities systematically and feedback to their users timely, and ultimately enhance the utilization level of information system.

• Journal of Korean Academy of Nursing Administration
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• v.8 no.1
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• pp.17-29
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• 2002

The purpose of this study was to examine the application of the Activity-based Costing(ABC) system to analyze the cost of nursing services in the delivery room in a major medical center.The results of this study are as follows;1. In order to calculate the cost of nursing activities, 67 activities of staff nurses on a delivery room were identified and classified as direct nursing activities(45.2%), the indirect activities(32.1%), general management activities(13.9%) and others(8.8%).2. Nursing cost in the delivery room was classified into activity cost(29.9%) and common cost(70.1%). Activity cost involved direct activity cost of staff nurses. The common costs were categorized into indirect activity & general management cost of staff nurses, management cost of the head nurse and activity cost of assistants.3. The final cost objects of nursing services in the delivery room were nursing service for women who had normal vaginal deliveries and nursing service for women who had preterm labor.The total cost of nursing service for a woman who had a normal vaginal delivery was 165,710 won (100.0%). The cost incurred through direct activity cost of staff nurses(58,242 won, 35.1%), indirect activity & general management cost of staff nurses (55,643 won, 33.6%), management cost of head nurse (16,211 won, 9.8%), activity cost of assistants (35,614 won, 21.5%).If the number of days of hospitalization was presumed to be 14 days, the total cost of nursing service for woman who had preterm labor would be 1,845,901 won (100.0%). The cost incurred by direct activity cost of staff nurses in the activity cost (341,349 won, 18.5%), indirect activity & general management cost of staff nurses in the common cost(779,002 won, 42.2%), management cost of head nurse(226,954won, 12.3%), activity cost of assistants in the common cost(498,596 won, 27.0%).In this study, the cost of the nursing services in the delivery room was calculated based on the ABC system. The results of this study showed that resources are assigned to the nursing activities in the delivery room and the mechanisms for assigning the cost of activities for nursing services.

• Journal of Life Science
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• v.20 no.6
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• pp.853-860
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• 2010

The DevSR two-component system is a major regulatory system involved in redox sensing in Mycobacterium smegmatis. The DevSR system consists of the DevS histidine kinase and its cognate DevR response regulator. When exposed to hypoxic conditions, the DevS histidine kinase is activated to phosphorylate the DevR response regulator, leading to the transcriptional activation of the DevR regulation. The ligand-binding state of the heme embedded in the N-terminal GAF domain of DevS determines the kinase activity of DevS. In this study, we demonstrated that the redox-responsive cysteine (C547) in the C-terminal kinase domain is involved in the redox-dependent control of DevS kinase activity. The formation of an intersubunit disulfide bond between the C547 residues in the presence of $O_2$ led to inactivation of DevS kinase activity. The reduction of the oxidized DevS with reductants such as $\beta$-mercaptoethanol and dithiothreitol resulted in the restoration of DevS kinase activity. It was demonstrated in vivo by complementation test that the substitution of C547 to alanine partially impaired the sensory function of DevS in M. smegmatis.

• Journal of the Korean Society for Railway
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• v.8 no.2
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• pp.161-169
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• 2005

In this paper, we provide safety requirements and advices to guarantee the safety of an interface in a level crossing system which is an interface between the conventional facilities and the new ATP (Automatic Train Protection) system, as well as we accomplish a safety management for the facilities of a country that has a different standard with already standardized ATP system. The system model has been made based on a safety activity of the international standard, and then a tolerance of a risk by the safety activity through PHA (Preliminary Hazard Analysis) has been analyzed. finally we achieved HIA (Hazard Identification and Analysis) for the assumptions that have been produced from a operating scenario and a functional interface. Thus, the safety requirements for the interface has been provided from the safety plan of HIA, and we showed the safety activity to guarantee the system safety through HIA which was depend on the design.

• Journal of the Korea Society of Computer and Information
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• v.21 no.12
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• pp.81-89
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• 2016

In this paper, we design and implement a mouse movement measurement system using an infrared sensor called MAMS (Mouse Activity Measurement System). Unlike existing systems, MAMS can measure movements between IREDs. MAMS is removable allowing convenient portability and is also low cost. MAMS automatically measures mouse activity during a pre-set time interval. Since the measured data can be easily stored in a computer system, it is much simpler and more efficient than the Ugo 47420 model. Moreover, MAMS can be used in medical and veterinary field to eliminate manual observations.

• Journal of Integrative Natural Science
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• v.14 no.3
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• pp.95-98
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• 2021

By far, studies on the effect of oral administration of peppermint essential oil on blood pressure are not consistent, increasing or decreasing. And the effect of inhalation of peppermint essential oil on blood pressure was not reported. This study was designed to clarify the effect of peppermint essential oil inhalation on the blood pressure and autonomic nervous system. Blood pressure and heart rate variability (HRV) as an indicator of autonomic nervous system activity were measured. The systolic and diastolic blood pressure was not changed significantly by inhalation of peppermint essential oil. Standard deviation of normal to normal (SDNN), a parameter of total activity of autonomic nervous system also was not changed significantly. High frequency (HF) power level, an indicator of parasympathetic nervous system activity was not changed by peppermint. These results indicate that action mechanism of peppermint essential oil on blood pressure is different by the method of administration, oral or inhalation.

• Proceedings of the KSR Conference
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• 2011.10a
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• pp.861-864
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• 2011

Since national GHG reduction target by 2020 has been presented in Korea, the role of railroad has been reinforced within transport system due to the allocation of reduction target into sector. So, it is necessary to manage activity data systematically for the calculation of GHG emission in railroad. Now, the activity data of diesel consumption for NIR(National Inventory Report) are provided from oil supply and demand statistics. On the other hands, the activity data collected directly from railroad operating companies are used for GHG & Energy Target Management Act. This study aimed to assess the GHG emissions using two kinds of activity data related to the diesel consumption of railroad in 2009 and 2010. As a result, GHG emissions based on oil supply and demand statistics was 636 thousands ton $CO_{2e}$, but the activity data collected from railroad operating companies showed 649 thousands ton $CO_{2e}$ in 2009. Also, the gap of $CO_{2e}$ emission was increased in 2010. These trends were caused because oil supply and demand statistics included total diesel sales volume during 1 year and the activity data collected from railroad operating companies were the amount of diesel consumption only at railcar operation and maintenance step. In conclusion, it is important to develop the management and verification system of activity data with high reliability to substitute oil supply and demand statistics in railroad sector.

• Archives of Pharmacal Research
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• v.28 no.8
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• pp.892-896
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• 2005

In order to isolate substances that inhibit the hemolytic activity of human serum against eryth-rocytes, we have evaluated whole plants of the Orostachys japonicus species with regard to its anti-complement activity, and have identified its active principles following activity-guided isolation. A methanol extract of the O. japonicus, as well as its n-hexane soluble fraction, exhibited significant anti-complement activity on the complement system, which was expressed as total hemolytic activity. A bioassay-guided chromatographic separation of the constituents resulted in the isolation of three known compounds 1-3 from the active n-hexane fraction. The structure of these compounds were analyzed, and they were identified as hydroxyhopanone (1), $\beta-sitosteryl-3-O-\beta-D-glucopyranosyl-6'-O-palmitate$ (2), and $\beta-sitosteryl-3-O-\beta-D-glucopyranoside$ (3), respectively. Of these compounds, compound 2 exhibited potent anti-complement activity $(IC_{50}=1.0\pm0.1{\mu}M)$ on the classical pathway of the complement, as compared to tiliroside $(IC_{50}=76.5\pm1.1{\mu}M)$, which was used as a positive control. However, compounds 1 and 3 exhibited no activity in this system.