• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.11B
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• pp.1005-1012
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• 2008

According to an aging population has dramatically increased in over the world, silver care becomes more important than other field. In this paper, we design and implement an old age patient care system that allows a carer to instantly monitor the status of proteges and notifies emergency of a patient to a medical institute. The system uses RFIDs and infrared sensors implemented in embedded software to analyze the activity and movement detection of the elderly. And the home gateway allows easy integration with heterogeneous devices by employing OSGi that is a middleware standard for home gateways. We can verify the information on the activity per day and the activity per week by Web browsers and view realtime video on the elderly by Web Cam using the implemented system. The system also can send us cell phone messages and E-mail in case of emergency.

• Korean Journal of Applied Biomechanics
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• v.17 no.4
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• pp.141-148
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• 2007

Falls associated with tripping over an obstacle can be dangerous, yet little is known about the strategies used for stepping over obstacles in older Parkinson disease. The purpose of this study was to investigate the lower extremity muscle activity on the obstacle gait according to obstacle height in older Parkinson diseases. The obstacle gait of 7 older Parkinson disease was examined during a 5.0 m approach to, and while stepping over, obstacles of 0, 25, 52, and 152mm. Seven pairs of surface electrodes(Noraxon MyoResearch, USA) were attached to the right-hand side of the body to monitor the adductor longus(AL), gluteus medius(GME), gluteus maximus(GMA), biceps femoris(BF), rectus femoris(RF), gastrocnemius(GA), tibialis anterior(TA). Electromyography data were filtered using a 10Hz to 350 Hz Butterworth band-pass digital filter and normalized to the maximum value in the analyzed phases. A one-way ANOVA for repeated measures was employed for selected electromyography variables to analyze the differences of the height of four obstacles. The results showed significant differences between 0.0mm and 25, 52, and 152mm obstacle height in TA and GA activities during the second phase(swing phase). But the more increase obstacle height, the more not increase the muscle activities. This means that the Parkinson disease stepping over obstacle inefficiency. To prevent and reduce the frequency of falls, elderly Parkinson disease maintained and improved their balance, muscular strength, neuromuscular control and mobility.

• Korean Journal of Medicinal Crop Science
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• v.22 no.1
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• pp.38-45
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• 2014

This study was performed to investigate the physiological responses of Oplopanax elatus by water condition. Drought stress was induced by withholding water for 26 days. The results show that $P_{N\;max}$, SPAD, gs, E and Ci were significantly decreased with decreasing of soil moisture contents. However, AQY and WUE were decreased slightly only at 26 day. This implies that photosynthetic rate is reduced due to an inability to regulate water and $CO_2$ exchange through the stomatal. According to JIP analysis, ${\Phi}_{PO}$, ${\Psi}_O$, ${\Phi}_{EO}$ and $PI_{ABS}$ were dramatically decreased at 21 day and 26 day, which reflects the relative reduction state of the photosystem II. On the other hand, the relative activities per reaction center such as ABS/RC, TRo/RC were significantly increased at 26 day. Particularly, Dio/RC and DIo/CS increased substantially under drought stress, indicating that excessive energy was consumed by heat dissipation. These results of chlorophyll a fluorescence show that the sensitivity changes photosystem II activity. Thus, according to the results, O. elatus was exhibited a strong reduction of photosynthetic activity to approximately 10% soil moisture contents, and JIP parameters could be useful indicator to monitor the physiological states of O. elatus under drought stress.

• Journal of Embryo Transfer
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• v.33 no.2
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• pp.61-68
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• 2018

The major focus of this study is to analyze the expression of bovine MMPs and to monitor their activity during the estrus cycle and pregnancy. During pregnancy, MMP-2 expression was detectable around 30 days but became insignificant by 60 days, then started to increase again around 90 days and reached the maximum at 250 days. The activity of MMP-2 protein changed in accordance with its expression level. As expected, the level of TIMP-2 exhibited a reverse pattern. About MMP-9, high level expression was observed as early as 30 days and gradually increase until 90 days. Then started to decrease after 250 days. Again, the sites of MMP-9 expression were similar to those of MMP-2. On the other hand, expression of TIMP-3 remained low until 90 days but showed a small and temporal increase around 250 days. In summary, expression of different MMPs were differentially regulated during estrus cycle and pregnancy. While the expression of MMP-2 was high in estrus cycle, MMP-9 slowly takes over with the progression of pregnancy. These results indicated that the luteal tissue perform distinct functions during pregnancy and estrus. Perhaps the activity of MMP-2 is required for the structural remodeling of luteum, resulting the suppression of P4 inflow from blood. On the other hand, steady maintenance of MMP-9 throughout luteal development is important for the activation of cell proliferation, maturation and angiogenesis.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.8
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• pp.1297-1301
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• 2003

The response surface methodology was peformed by central composite design based on drying temperature and time of Citrus, to monitor quality property change caused by drying and make dried products with a good overall palatability. In result, water activity, hardness and softness were affected by drying temperature; water activity decreased and hardness increased with increase of drying temperature. Softness was also high at low temperature and short time of drying. In the range of overall palatability having high score, hardness was shown in 2.01 ∼ 3.20${\times}$10$^{6}$ dyn/$\textrm{cm}^2$ and softness was 62.54 ∼ 146.37 cm/kg. Drying conditions satisfying this range were predicted as 66 ∼ 75$^{\circ}C$ of drying temperature and 8 ∼ 14 hr of drying time.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.63.3-63.3
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• 2019

Active asteroids are celestial bodies that distinctively have asteroid-like orbital elements but show comet-like activity. They exhibit the activities due to the sublimation of volatile ices, impacts with small objects or break-up by rapid rotations. As of 2019 February, 30 active asteroids are detected in the outer main belt (i.e., the semimajor axes a>2.5 au) while only 3 of them in the inner main belt (a<2.5 au), suggesting that sublimation of remaining icy volatiles can be one of the most fundamental mechanisms for the activities. A sudden activity of (6478) Gault was reported in early 2019. The asteroid was discovered in 1988 and has exhibited its inactive appearance until the end of last year. Soon after the report, we have conducted imaging observations using the Seoul National University Observatory 1.0-m telescope and the Korea Microlensing Telescope Network (KMTNet) to monitor the activity. The observed images showed a primary dust tail that consists of dust grains ejected early November in 2018. Later, another tail developed, indicating further dust ejection occurred around late December 2018. Our model simulation to reproduce the morphology of the dust cloud suggests that the slightly-curved primary dust tail results from a continuous dust ejection over weeks. The total mass of ejecta was estimated to XX kg (XX% of the asteroid mass). Such continuous dust ejection for the inner active asteroids was unexpected because ice might have already sublimated from subsurfaces of inner main belt. Based on our observational evidence, we will discuss how inner asteroids are activated and eject dust continuously.

• Journal of Microbiology and Biotechnology
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• v.31 no.12
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• pp.1615-1623
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• 2021

Picropodophyllotoxin (PPT), an epimer of podophyllotoxin, is derived from the roots of Podophyllum hexandrum and exerts various biological effects, including anti-proliferation activity. However, the effect of PPT on colorectal cancer cells and the associated cellular mechanisms have not been studied. In the present study, we explored the anticancer activity of PPT and its underlying mechanisms in HCT116 cells. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to monitor cell viability. Flow cytometry was used to evaluate cell cycle distribution, the induction of apoptosis, the level of reactive oxygen species (ROS), assess the mitochondrial membrane potential (Δψm), and multi-caspase activity. Western blot assays were performed to detect the expression of cell cycle regulatory proteins, apoptosis-related proteins, and p38 MAPK (mitogen-activated protein kinase). We found that PPT induced apoptosis, cell cycle arrest at the G1 phase, and ROS in the HCT116 cell line. In addition, PPT enhanced the phosphorylation of p38 MAPK, which regulates apoptosis and PPT-induced apoptosis. The phosphorylation of p38 MAPK was inhibited by an antioxidant agent (N-acetyl-L-cysteine, NAC) and a p38 inhibitor (SB203580). PPT induced depolarization of the mitochondrial inner membrane and caspase-dependent apoptosis, which was attenuated by exposure to Z-VAD-FMK. Overall, these data indicate that PPT induced G1 arrest and apoptosis via ROS generation and activation of the p38 MAPK signaling pathway.

• Journal of Biomedical Engineering Research
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• v.44 no.2
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• pp.147-156
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• 2023

Efforts to employ smart home sensors to monitor the indoor activities of elderly single residents have been made to assess the feasibility of a safe and healthy lifestyle. However, the bathroom remains an area of blind spot. In this study, we have developed and evaluated a new edge computer device that can automatically detect water usage activities in the bathroom and record the activity log on a cloud server. Three kinds of sound as flushing, showering, and washing using wash basin generated during water usage were recorded and cut into 1-second scenes. These sound clips were then converted into a 2-dimensional image using MEL-spectrogram. Sound data augmentation techniques were adopted to obtain better learning effect from smaller number of data sets. These techniques, some of which are applied in time domain and others in frequency domain, increased the number of training data set by 30 times. A deep learning model, called CRNN, combining Convolutional Neural Network and Recurrent Neural Network was employed. The edge device was implemented using Raspberry Pi 4 and was equipped with a condenser microphone and amplifier to run the pre-trained model in real-time. The detected activities were recorded as text-based activity logs on a Firebase server. Performance was evaluated in two bathrooms for the three water usage activities, resulting in an accuracy of 96.1% and 88.2%, and F1 Score of 96.1% and 87.8%, respectively. Most of the classification errors were observed in the water sound from washing. In conclusion, this system demonstrates the potential for use in recording the activities as a lifelog of elderly single residents to a cloud server over the long-term.

• International Journal of Computer Science & Network Security
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• v.23 no.11
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• pp.99-109
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• 2023

The darknet is frequently referred to as the hub of illicit online activity. In order to keep track of real-time applications and activities taking place on Darknet, traffic on that network must be analysed. It is without a doubt important to recognise network traffic tied to an unused Internet address in order to spot and investigate malicious online activity. Any observed network traffic is the result of mis-configuration from faked source addresses and another methods that monitor the unused space address because there are no genuine devices or hosts in an unused address block. Digital systems can now detect and identify darknet activity on their own thanks to recent advances in artificial intelligence. In this paper, offer a generalised method for deep learning-based detection and classification of darknet traffic. Furthermore, analyse a cutting-edge complicated dataset that contains a lot of information about darknet traffic. Next, examine various feature selection strategies to choose a best attribute for detecting and classifying darknet traffic. For the purpose of identifying threats using network properties acquired from darknet traffic, devised a hybrid deep learning (DL) approach that combines Recurrent Neural Network (RNN) and Bidirectional LSTM (BiLSTM). This probing technique can tell malicious traffic from legitimate traffic. The results show that the suggested strategy works better than the existing ways by producing the highest level of accuracy for categorising darknet traffic using the Black widow optimization algorithm as a feature selection approach and RNN-BiLSTM as a recognition model.

• Nutrition Research and Practice
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• v.18 no.1
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• pp.110-118
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• 2024

BACKGROUND/OBJECTIVES: Depression and anxiety are common mental health problems. Anthocyanins from berries might have an inhibitory effect on monoamine oxidase (MAO) enzymes and alleviate various mood and anxiety symptoms. This study examined the effects of a daily supplement of an anthocyanin-rich product on mental health problems. SUBJECTS/METHODS: This study was a secondary analysis from a randomized, 6-week, open-label trial in 300 healthy participants aged 18-60 years who consumed 1 or 2 servings of anthocyanin-rich mulberry milk daily. The General Health Questionnaire-28 (GHQ-28) and Hospital Anxiety and Depression Scale (HADS) were used to monitor mental health problems. In addition, the saliva activity levels of MAO-A, MAO-B, and cortisol were examined at the baseline and after 6 weeks. RESULTS: The total scores of the GHQ-28 and HADS and all their subscales decreased in both groups (all P < 0.05). The cortisol, MAO-A, and MAO-B activities decreased significantly (all P < 0.05), but there were no significant differences between the groups (all P > 0.05). Significant correlations were noted between the decreased activity level of MAO-A enzyme and decreased scores from the GHQ-28 somatic subscale and the HADS depression subscale (all P < 0.05). CONCLUSIONS: Daily consumption of anthocyanin-rich mulberry milk possibly improves mental health problems by reducing depressive and anxiety symptoms in the working population. The suppression of MAO-A activity is a possible underlying mechanism.